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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1966 1
1967 3
1968 5
1969 1
1970 5
1971 9
1972 4
1973 10
1974 12
1975 15
1976 12
1977 14
1978 6
1979 15
1980 26
1981 15
1982 15
1983 7
1984 10
1985 4
1986 7
1987 5
1988 3
1989 2
1990 2
1992 4
1993 1
1994 4
1995 3
1996 1
1997 2
1998 2
1999 6
2000 4
2001 1
2002 3
2003 6
2004 7
2005 4
2006 10
2007 5
2008 3
2009 7
2010 10
2011 19
2012 29
2013 60
2014 78
2015 103
2016 140
2017 209
2018 251
2019 294
2020 452
2021 520
2022 484
2023 499
2024 312

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3,355 results

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Page 1
Impaired intestinal free fatty acid transport followed by chylomicron malformation, not pancreatic insufficiency, cause metabolic defects in cystic fibrosis.
Teng L, Dedousis N, Adeshirlarijaney A, Kanshana JS, Liu M, Hodges CA, Kohan AB. Teng L, et al. J Lipid Res. 2024 Jul 12;65(7):100551. doi: 10.1016/j.jlr.2024.100551. Online ahead of print. J Lipid Res. 2024. PMID: 39002195
We hypothesized that defects in chylomicron production could explain why CF body weights and nutrition are so resistant to clinical treatments. We used gold standard intestinal lipid absorption and metabolism approaches, including mouse mesenteric lymph cannulation, in viv …
We hypothesized that defects in chylomicron production could explain why CF body weights and nutrition are so resistant to clinical treatmen …
Obesity-enriched gut microbe degrades myo-inositol and promotes lipid absorption.
Wu C, Yang F, Zhong H, Hong J, Lin H, Zong M, Ren H, Zhao S, Chen Y, Shi Z, Wang X, Shen J, Wang Q, Ni M, Chen B, Cai Z, Zhang M, Cao Z, Wu K, Gao A, Li J, Liu C, Xiao M, Li Y, Shi J, Zhang Y, Xu X, Gu W, Bi Y, Ning G, Wang W, Wang J, Liu R. Wu C, et al. Cell Host Microbe. 2024 Jul 9:S1931-3128(24)00230-0. doi: 10.1016/j.chom.2024.06.012. Online ahead of print. Cell Host Microbe. 2024. PMID: 38996548
Megamonas rupellensis possessed genes for myo-inositol degradation, as demonstrated in vitro and in vivo, and the addition of myo-inositol effectively inhibited fatty acid absorption in intestinal organoids. Furthermore, mice colonized with M. rupellensis or E. coli …
Megamonas rupellensis possessed genes for myo-inositol degradation, as demonstrated in vitro and in vivo, and the addition of myo-inositol e …
Hydrogel-Integrated Millifluidic Systems: Advancing the Fabrication of Mucus-Producing Human Intestinal Models.
Almalla A, Alzain N, Elomaa L, Richter F, Scholz J, Lindner M, Siegmund B, Weinhart M. Almalla A, et al. Cells. 2024 Jun 21;13(13):1080. doi: 10.3390/cells13131080. Cells. 2024. PMID: 38994934 Free PMC article.
The luminal surface of the intestinal epithelium is protected by a vital mucus layer, which is essential for lubrication, hydration, and fostering symbiotic bacterial relationships. ...The chamber is designed to accommodate nine hydrogel scaffolds, 3D-printed as flat disks …
The luminal surface of the intestinal epithelium is protected by a vital mucus layer, which is essential for lubrication, hydration, …
Drug-induced senescence by aurora kinase inhibitors attenuates innate immune response of macrophages on gastric cancer organoids.
Yang R, Kwan W, Du Y, Yan R, Zang L, Li C, Zhu Z, Cheong IH, Kozlakidis Z, Yu Y. Yang R, et al. Cancer Lett. 2024 Jul 9:217106. doi: 10.1016/j.canlet.2024.217106. Online ahead of print. Cancer Lett. 2024. PMID: 38992487
It is of great significance to find sensitive drugs for DGC. In the current study, a total of 20 patient-derived organoids (PDOs) were analyzed for screening the therapeutic efficacy of small molecule kinases inhibitors on gastric cancers, especially the therapeutic differ …
It is of great significance to find sensitive drugs for DGC. In the current study, a total of 20 patient-derived organoids (PDOs) wer …
Exploring cell death mechanisms in spheroid cultures using a novel application of the RIP3-caspase3-assay.
Philippi CI, Hagens J, Heuer KM, Schmidt HC, Schuppert P, Pagerols Raluy L, Trochimiuk M, Li Z, Bunders MJ, Reinshagen K, Tomuschat C. Philippi CI, et al. Sci Rep. 2024 Jul 11;14(1):16032. doi: 10.1038/s41598-024-66805-4. Sci Rep. 2024. PMID: 38992075 Free PMC article.
Our findings demonstrate the assay's capability to differentiate between RIP1-independent apoptosis, necroptosis, and RIP1-dependent apoptosis, marking a significant advancement in organoid research. Additionally, we investigate the effects of TNFalpha on isolated intes
Our findings demonstrate the assay's capability to differentiate between RIP1-independent apoptosis, necroptosis, and RIP1-dependent apoptos …
Simple aneuploidy evades p53 surveillance and promotes niche factor-independent growth in human intestinal organoids.
Johnson BA, Liu AZ, Bi T, Dong Y, Li T, Zhou D, Narkar A, Wu Y, Sun SX, Larman TC, Zhu J, Li R. Johnson BA, et al. Mol Biol Cell. 2024 Jul 10:mbcE24040166. doi: 10.1091/mbc.E24-04-0166. Online ahead of print. Mol Biol Cell. 2024. PMID: 38985518
Here, by inducing heterogeneous aneuploidy in non-transformed human colon organoids (colonoids), we investigated how the effects of aneuploidy on cell growth and differentiation may promote malignant transformation. ...
Here, by inducing heterogeneous aneuploidy in non-transformed human colon organoids (colonoids), we investigated how the effects of a …
The application of organoids in colorectal diseases.
Liu Y, Wang D, Luan Y, Tao B, Li Q, Feng Q, Zhou H, Mu J, Yu J. Liu Y, et al. Front Pharmacol. 2024 Jun 25;15:1412489. doi: 10.3389/fphar.2024.1412489. eCollection 2024. Front Pharmacol. 2024. PMID: 38983913 Free PMC article. Review.
Intestinal organoids are a three-dimensional cell culture model derived from colon or pluripotent stem cells. ...It has shown great potential in the research and treatment of colorectal diseases. Organoid technology has been widely applied in research on colo
Intestinal organoids are a three-dimensional cell culture model derived from colon or pluripotent stem cells. ...It has shown
Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance.
Zutshi N, Mohapatra BC, Mondal P, An W, Goetz BT, Wang S, Li S, Storck MD, Mercer DF, Black AR, Thayer SP, Black JD, Lin C, Band V, Band H. Zutshi N, et al. iScience. 2024 May 8;27(6):109912. doi: 10.1016/j.isci.2024.109912. eCollection 2024 Jun 21. iScience. 2024. PMID: 38974465 Free PMC article.
Functionally, Cbl/Cblb iDKO impaired the recovery from radiation-induced intestinal epithelial injury. In vitro, Cbl/Cblb iDKO led to inability to maintain intestinal organoids. Single-cell RNA sequencing in organoids identified Akt-mTOR (mammalian tar …
Functionally, Cbl/Cblb iDKO impaired the recovery from radiation-induced intestinal epithelial injury. In vitro, Cbl/Cblb iDKO led to …
CL429 enhances the renewal of intestinal stem cells by upregulating TLR2-YAP1.
Fang L, Cheng Y, Fang D, Feng Z, Wang Y, Yu Y, Zhao J, Huang D, Zhai X, Liu C, Du J. Fang L, et al. Int Immunopharmacol. 2024 Jul 6;138:112614. doi: 10.1016/j.intimp.2024.112614. Online ahead of print. Int Immunopharmacol. 2024. PMID: 38972212
In addition, CL429 protected intestinal organoids against IR-induced injury. Mechanistically, RNA sequencing and Western blot analysis revealed the activation of the Wnt and Hippo signaling pathways by CL429. ...Furthermore, knockdown of YAP1 significantly attenuate …
In addition, CL429 protected intestinal organoids against IR-induced injury. Mechanistically, RNA sequencing and Western blot …
WNT Oncogenic Transcription Requires MYC Suppression of Lysosomal Activity and EPCAM Stabilization in Gastric Tumours.
Mulè P, Fernandez-Perez D, Amato S, Manganaro D, Oldani P, Brandini S, Diaferia G, Cuomo A, Recordati C, Soriani C, Dondi A, Zanotti M, Rustichelli S, Bisso A, Pece S, Rodighiero S, Natoli G, Amati B, Ferrari KJ, Chiacchiera F, Pasini D. Mulè P, et al. Gastroenterology. 2024 Jul 4:S0016-5085(24)05182-5. doi: 10.1053/j.gastro.2024.06.029. Online ahead of print. Gastroenterology. 2024. PMID: 38971196 Free article.
BACKGROUND AND AIMS: WNT signaling is central to spatial tissue arrangement, regulating stem cell activity, and represents the hallmark of gastrointestinal cancers. While its role in driving intestinal tumors is well characterized, WNT's role in gastric tumorigenesis remai …
BACKGROUND AND AIMS: WNT signaling is central to spatial tissue arrangement, regulating stem cell activity, and represents the hallmark of g …
3,355 results