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1957 1
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1972 23
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1974 41
1975 65
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1981 138
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1984 224
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1998 385
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2002 422
2003 382
2004 361
2005 425
2006 439
2007 455
2008 429
2009 461
2010 476
2011 479
2012 507
2013 479
2014 569
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16,778 results

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Page 1
Unwinding of a eukaryotic origin of replication visualized by cryo-EM.
Henrikus SS, Gross MH, Willhoft O, Pühringer T, Lewis JS, McClure AW, Greiwe JF, Palm G, Nans A, Diffley JFX, Costa A. Henrikus SS, et al. Nat Struct Mol Biol. 2024 Aug;31(8):1265-1276. doi: 10.1038/s41594-024-01280-z. Epub 2024 May 17. Nat Struct Mol Biol. 2024. PMID: 38760633 Free PMC article.
To prevent detrimental chromosome re-replication, DNA loading of a double hexamer of the minichromosome maintenance (MCM) replicative helicase is temporally separated from DNA unwinding. ...
To prevent detrimental chromosome re-replication, DNA loading of a double hexamer of the minichromosome maintenance (MCM) replicative …
Do Archaea Need an Origin of Replication?
Kelman LM, Kelman Z. Kelman LM, et al. Trends Microbiol. 2018 Mar;26(3):172-174. doi: 10.1016/j.tim.2017.12.001. Trends Microbiol. 2018. PMID: 29268981 Free PMC article. Review.
Chromosomal DNA replication starts at a specific region called an origin of replication. Until recently, all organisms were thought to require origins to replicate their chromosomes. It was recently discovered that some archaeal species do not utilize …
Chromosomal DNA replication starts at a specific region called an origin of replication. Until recently, all org …
Streptomycete origin of chromosomal replication with two putative unwinding elements.
Płachetka M, Żyła-Uklejewicz D, Weigel C, Donczew R, Donczew M, Jakimowicz D, Zawilak-Pawlik A, Zakrzewska-Czerwinska J. Płachetka M, et al. Microbiology (Reading). 2019 Dec;165(12):1365-1375. doi: 10.1099/mic.0.000859. Epub 2019 Oct 8. Microbiology (Reading). 2019. PMID: 31592764 Free article.
DNA replication is controlled mostly at the initiation step. In bacteria, replication of the chromosome starts at a single origin of replication called oriC. ...This process has been thoroughly examined in model bacteria, including Escherichia c …
DNA replication is controlled mostly at the initiation step. In bacteria, replication of the chromosome starts at a single …
Epigenetic regulation of replication origin assembly: A role for histone H1 and chromatin remodeling factors.
Falbo L, Costanzo V. Falbo L, et al. Bioessays. 2021 Jan;43(1):e2000181. doi: 10.1002/bies.202000181. Epub 2020 Nov 9. Bioessays. 2021. PMID: 33165968
During early embryonic development in several metazoans, accurate DNA replication is ensured by high number of replication origins. This guarantees rapid genome duplication coordinated with fast cell divisions. ...Consistent with this regulation, somatic nuclei repl …
During early embryonic development in several metazoans, accurate DNA replication is ensured by high number of replication ori …
Chromosomal origin of replication coordinates logically distinct types of bacterial genetic regulation.
Kosmidis K, Jablonski KP, Muskhelishvili G, Hütt MT. Kosmidis K, et al. NPJ Syst Biol Appl. 2020 Feb 17;6(1):5. doi: 10.1038/s41540-020-0124-1. NPJ Syst Biol Appl. 2020. PMID: 32066730 Free PMC article.
Our structural analysis reveals the outstanding relevance of the symmetry axis defined by the origin (Ori) and terminus (Ter) of replication for the network embedding and, thus, suggests the co-evolution of two regulatory infrastructures, namely the transcriptional …
Our structural analysis reveals the outstanding relevance of the symmetry axis defined by the origin (Ori) and terminus (Ter) of r …
In vivo DNA replication dynamics unveil aging-dependent replication stress.
Rossetti GG, Dommann N, Karamichali A, Dionellis VS, Asensio Aldave A, Yarahmadov T, Rodriguez-Carballo E, Keogh A, Candinas D, Stroka D, Halazonetis TD. Rossetti GG, et al. Cell. 2024 Oct 31;187(22):6220-6234.e13. doi: 10.1016/j.cell.2024.08.034. Epub 2024 Sep 17. Cell. 2024. PMID: 39293447 Free article.
Old mice displayed the same replication initiation sites, but origin firing was inefficient and accompanied by a replication stress response. ...These findings unveil aging-dependent replication stress and a crucial role of ATR in mitigating the stress …
Old mice displayed the same replication initiation sites, but origin firing was inefficient and accompanied by a replicatio …
iORI-ENST: identifying origin of replication sites based on elastic net and stacking learning.
Yao Y, Zhang S, Liang Y. Yao Y, et al. SAR QSAR Environ Res. 2021 Apr;32(4):317-331. doi: 10.1080/1062936X.2021.1895884. Epub 2021 Mar 18. SAR QSAR Environ Res. 2021. PMID: 33730950
DNA replication is not only the basis of biological inheritance but also the most fundamental process in all living organisms. ...Hence, the accurate identification of the origin of replication sites (ORIs) has a great meaning for further understanding …
DNA replication is not only the basis of biological inheritance but also the most fundamental process in all living organisms. ...Hen …
Mapping the Single Origin of Replication in the Naegleria gruberi Extrachromosomal DNA Element.
Mullican JC, Chapman NM, Tracy S. Mullican JC, et al. Protist. 2019 Apr;170(2):141-152. doi: 10.1016/j.protis.2019.02.001. Epub 2019 Feb 13. Protist. 2019. PMID: 30954840
Using neutral/neutral two-dimensional agarose electrophoresis, the region in the element enclosing the single replication origin using DNA from asynchronous and axenically propagated N. gruberi populations was localized within a 2.1 kbp fragment located approximatel …
Using neutral/neutral two-dimensional agarose electrophoresis, the region in the element enclosing the single replication origin …
Experimental and theoretical definition of geminivirus origin of replication.
Argüello-Astorga G, Herrera-Estrella L, Rivera-Bustamante R. Argüello-Astorga G, et al. Plant Mol Biol. 1994 Oct;26(2):553-6. doi: 10.1007/BF00013742. Plant Mol Biol. 1994. PMID: 7948911 Review.
Recent reports provide important progress in understanding the structure and functioning of replication origin from these viruses. We have used these data to propose models for the initiation of replication in dicot- and monocot-infecting geminiviruses …
Recent reports provide important progress in understanding the structure and functioning of replication origin from the …
Decoupling Growth and Production by Removing the Origin of Replication from a Bacterial Chromosome.
Kasari M, Kasari V, Kärmas M, Jõers A. Kasari M, et al. ACS Synth Biol. 2022 Aug 19;11(8):2610-2622. doi: 10.1021/acssynbio.1c00618. Epub 2022 Jul 7. ACS Synth Biol. 2022. PMID: 35798328 Free PMC article.
Here, we describe a novel growth switch based on the permanent removal of the origin of replication (oriC) from the Escherichia coli chromosome. Without oriC, cells cannot initiate a new round of replication, and they stop growing while their metabolis …
Here, we describe a novel growth switch based on the permanent removal of the origin of replication (oriC) from the Esc …
16,778 results
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