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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
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1982 4
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1988 11
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1998 45
1999 65
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2004 65
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2008 98
2009 82
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2011 88
2012 98
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2,377 results

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Page 1
Nonreplicative functions of the origin recognition complex.
Popova VV, Brechalov AV, Georgieva SG, Kopytova DV. Popova VV, et al. Nucleus. 2018;9(1):460-473. doi: 10.1080/19491034.2018.1516484. Nucleus. 2018. PMID: 30196754 Free PMC article. Review.
Origin recognition complex (ORC), a heteromeric six-subunit complex, is the central component of the eukaryotic pre-replication complex. ...Along with the growth of evolutionary complexity of organisms, ORC complex functions become more e …
Origin recognition complex (ORC), a heteromeric six-subunit complex, is the central component of the eukaryotic …
Origins of DNA replication in eukaryotes.
Hu Y, Stillman B. Hu Y, et al. Mol Cell. 2023 Feb 2;83(3):352-372. doi: 10.1016/j.molcel.2022.12.024. Epub 2023 Jan 13. Mol Cell. 2023. PMID: 36640769 Free PMC article. Review.
This review focuses on the current understanding of how the origin recognition complex (ORC) contributes to determining the location of replication initiation in the multiple chromosomes within eukaryotic cells, as well as methods for mapping the location and …
This review focuses on the current understanding of how the origin recognition complex (ORC) contributes to determining …
Origin recognition complex harbors an intrinsic nucleosome remodeling activity.
Li S, Wasserman MR, Yurieva O, Bai L, O'Donnell ME, Liu S. Li S, et al. Proc Natl Acad Sci U S A. 2022 Oct 18;119(42):e2211568119. doi: 10.1073/pnas.2211568119. Epub 2022 Oct 10. Proc Natl Acad Sci U S A. 2022. PMID: 36215487 Free PMC article.
Eukaryotic DNA replication is initiated at multiple chromosomal sites known as origins of replication that are specifically recognized by the origin recognition complex (ORC) containing multiple ATPase sites. In budding yeast, ORC binds to specific DNA sequen …
Eukaryotic DNA replication is initiated at multiple chromosomal sites known as origins of replication that are specifically recognized by th …
The origin recognition complex protein family.
Duncker BP, Chesnokov IN, McConkey BJ. Duncker BP, et al. Genome Biol. 2009;10(3):214. doi: 10.1186/gb-2009-10-3-214. Epub 2009 Mar 17. Genome Biol. 2009. PMID: 19344485 Free PMC article. Review.
Origin recognition complex (ORC) proteins were first discovered as a six-subunit assemblage in budding yeast that promotes the initiation of DNA replication. ...Following association with Cdc6 in G1 phase, the sequential hydrolysis of Cdc6 - then ORC-bound AT …
Origin recognition complex (ORC) proteins were first discovered as a six-subunit assemblage in budding yeast that promo …
Humanizing the yeast origin recognition complex.
Lee CSK, Cheung MF, Li J, Zhao Y, Lam WH, Ho V, Rohs R, Zhai Y, Leung D, Tye BK. Lee CSK, et al. Nat Commun. 2021 Jan 4;12(1):33. doi: 10.1038/s41467-020-20277-y. Nat Commun. 2021. PMID: 33397927 Free PMC article.
The Origin Recognition Complex (ORC) is an evolutionarily conserved six-subunit protein complex that binds specific sites at many locations to coordinately replicate the entire eukaryote genome. ...
The Origin Recognition Complex (ORC) is an evolutionarily conserved six-subunit protein complex that binds speci …
The origin recognition complex in human diseases.
Shen Z. Shen Z. Biosci Rep. 2013 Jun 11;33(3):e00044. doi: 10.1042/BSR20130036. Biosci Rep. 2013. PMID: 23662735 Free PMC article. Review.
ORC (origin recognition complex) serves as the initiator for the assembly of the pre-RC (pre-replication complex) and the subsequent DNA replication. ...
ORC (origin recognition complex) serves as the initiator for the assembly of the pre-RC (pre-replication complex …
The origin recognition complex: a biochemical and structural view.
Li H, Stillman B. Li H, et al. Subcell Biochem. 2012;62:37-58. doi: 10.1007/978-94-007-4572-8_3. Subcell Biochem. 2012. PMID: 22918579 Free PMC article. Review.
The origin recognition complex (ORC) was first discovered in the baker's yeast in 1992. Identification of ORC opened up a path for subsequent molecular level investigations on how eukaryotic cells initiate and control genome duplication each cell cycle. ...
The origin recognition complex (ORC) was first discovered in the baker's yeast in 1992. Identification of ORC opened up …
Origin recognition complex 6 overexpression promotes growth of glioma cells.
Yang WL, Zhang WF, Wang Y, Lou Y, Cai Y, Zhu J. Yang WL, et al. Cell Death Dis. 2024 Jul 6;15(7):485. doi: 10.1038/s41419-024-06764-w. Cell Death Dis. 2024. PMID: 38971772 Free PMC article.
We here explored the expression patterns, biological functions, and underlying mechanisms associated with ORC6 (origin recognition complex 6) in glioma. Through the bioinformatics analyses, we found a significant increase in ORC6 expression within human gliom …
We here explored the expression patterns, biological functions, and underlying mechanisms associated with ORC6 (origin recognition …
Origin recognition complex subunit 1(ORC1) is a potential biomarker and therapeutic target in cancer.
Wu L, Chen H, Yang C. Wu L, et al. BMC Med Genomics. 2023 Oct 13;16(1):243. doi: 10.1186/s12920-023-01691-9. BMC Med Genomics. 2023. PMID: 37833711 Free PMC article.
BACKGROUND: The origin recognition complex 1 (ORC1) is a large subunit of the origin recognition complex and acts as the master subunit of the precoding complex. ...
BACKGROUND: The origin recognition complex 1 (ORC1) is a large subunit of the origin recognition compl …
Origin Recognition Complex (ORC) Evolution Is Influenced by Global Gene Duplication/Loss Patterns in Eukaryotic Genomes.
Ocaña-Pallarès E, Vergara Z, Desvoyes B, Tejada-Jimenez M, Romero-Jurado A, Galván A, Fernández E, Ruiz-Trillo I, Gutierrez C. Ocaña-Pallarès E, et al. Genome Biol Evol. 2020 Feb 1;12(2):3878-3889. doi: 10.1093/gbe/evaa011. Genome Biol Evol. 2020. PMID: 31990293 Free PMC article.
The conservation of orthologs of most subunits of the origin recognition complex (ORC) has served to propose that the whole complex is common to all eukaryotes. ...First, we identified ORC subunits previously undetected in divergent lineages, which all …
The conservation of orthologs of most subunits of the origin recognition complex (ORC) has served to propose that the w …
2,377 results