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Tissue plasminogen activator induces pancreatic cancer cell proliferation by a non-catalytic mechanism that requires extracellular signal-regulated kinase 1/2 activation through epidermal growth factor receptor and annexin A2.
Ortiz-Zapater E, Peiró S, Roda O, Corominas JM, Aguilar S, Ampurdanés C, Real FX, Navarro P. Ortiz-Zapater E, et al. Among authors: roda o. Am J Pathol. 2007 May;170(5):1573-84. doi: 10.2353/ajpath.2007.060850. Am J Pathol. 2007. PMID: 17456763 Free PMC article.