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Deconditioning does not explain orthostatic intolerance in ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome).
van Campen CLMC, Rowe PC, Visser FC. van Campen CLMC, et al. J Transl Med. 2021 May 4;19(1):193. doi: 10.1186/s12967-021-02819-0. J Transl Med. 2021. PMID: 33947430 Free PMC article.
BACKGROUND: Orthostatic intolerance (OI) is a frequent finding in individuals with myalgic encephalomyelitis /chronic fatigue syndrome (ME/CFS). ...No difference in the degree of CBF reduction was shown in those three groups. CONCLUSION: This study sho …
BACKGROUND: Orthostatic intolerance (OI) is a frequent finding in individuals with myalgic encephalomyelitis /chronic fatigue …
Cerebral Blood Flow in Orthostatic Intolerance.
Khan MS, Miller AJ, Ejaz A, Molinger J, Goyal P, MacLeod DB, Swavely A, Wilson E, Pergola M, Tandri H, Mills CF, Raj SR, Fudim M. Khan MS, et al. J Am Heart Assoc. 2025 Feb 4;14(3):e036752. doi: 10.1161/JAHA.124.036752. Epub 2025 Feb 3. J Am Heart Assoc. 2025. PMID: 39895557 Free PMC article. Review.
Because CBF is not easy to measure, rises in heart rate or drops in blood pressure are used as proxies for abnormal CBF. These result in diagnoses such as postural orthostatic tachycardia syndrome and orthostatic hypotension. However, in many other OI …
Because CBF is not easy to measure, rises in heart rate or drops in blood pressure are used as proxies for abnormal CBF. These …
Phenylephrine alters phase synchronization between cerebral blood velocity and blood pressure in ME/CFS with orthostatic intolerance.
Medow MS, Stewart JM. Medow MS, et al. Am J Physiol Regul Integr Comp Physiol. 2024 Jun 1;326(6):R599-R608. doi: 10.1152/ajpregu.00071.2024. Epub 2024 Apr 29. Am J Physiol Regul Integr Comp Physiol. 2024. PMID: 38682242 Free PMC article.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) with orthostatic intolerance (OI) is characterized by neurocognitive deficits perhaps related to upright hypocapnia and loss of cerebral autoregulation (CA). ...A 10-min 60 head-up tilt (HUT) …
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) with orthostatic intolerance (OI) is characterized b …
Orthostatic chronotropic incompetence in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
van Campen CLMC, Verheugt FWA, Rowe PC, Visser FC. van Campen CLMC, et al. IBRO Neurosci Rep. 2023 May 2;15:1-10. doi: 10.1016/j.ibneur.2023.04.005. eCollection 2023 Dec. IBRO Neurosci Rep. 2023. PMID: 37303862 Free PMC article.
BACKGROUND: Orthostatic intolerance (OI) is a core diagnostic criterion in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). ...Chronotropic incompetence was more common in more severely affected ME/CFS patients. CONCLUSION: Th …
BACKGROUND: Orthostatic intolerance (OI) is a core diagnostic criterion in myalgic encephalomyelitis/chronic fatigue syndrome …
Detection of Elevated Level of Tetrahydrobiopterin in Serum Samples of ME/CFS Patients with Orthostatic Intolerance: A Pilot Study.
Gottschalk CG, Whelan R, Peterson D, Roy A. Gottschalk CG, et al. Int J Mol Sci. 2023 May 13;24(10):8713. doi: 10.3390/ijms24108713. Int J Mol Sci. 2023. PMID: 37240059 Free PMC article.
Many patients with ME/CFS experience orthostatic intolerance (OI), which is characterized by frequent dizziness, light-headedness, and feeling faint while maintaining an upright posture. ...OI is often manifested by cardiovascular alterations, such as …
Many patients with ME/CFS experience orthostatic intolerance (OI), which is characterized by frequent dizziness, …
Two Different Hemodynamic Responses in ME/CFS Patients with Postural Orthostatic Tachycardia Syndrome During Head-Up Tilt Testing.
van Campen CLMC, Rowe PC, Visser FC. van Campen CLMC, et al. J Clin Med. 2024 Dec 18;13(24):7726. doi: 10.3390/jcm13247726. J Clin Med. 2024. PMID: 39768649 Free PMC article.
Introduction: While the diagnosis of postural orthostatic tachycardia syndrome (POTS) is based on heart rate (HR) and blood pressure (BP) criteria, the pathophysiology of POTS is not fully understood as multiple pathophysiological mechanisms have been recogni …
Introduction: While the diagnosis of postural orthostatic tachycardia syndrome (POTS) is based on heart rate (HR) and b …
Pyridostigmine improves hand grip strength in patients with myalgic encephalomyelitis/chronic fatigue syndrome.
Schlömer E, Stein E, Kedor C, Rust R, Brock A, Wittke K, Scheibenbogen C, Kim L. Schlömer E, et al. Front Neurosci. 2025 Sep 3;19:1637838. doi: 10.3389/fnins.2025.1637838. eCollection 2025. Front Neurosci. 2025. PMID: 40970182 Free PMC article.
BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystemic disease characterized by exertional intolerance and fatigue which is often accompanied by muscle weakness and fatiguability. A study showed efficacy of the acetylcholin …
BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystemic disease characterized by exertional …
Physiological assessment of orthostatic intolerance in chronic fatigue syndrome.
Natelson BH, Lin JS, Blate M, Khan S, Chen Y, Unger ER. Natelson BH, et al. J Transl Med. 2022 Feb 16;20(1):95. doi: 10.1186/s12967-022-03289-8. J Transl Med. 2022. PMID: 35172863 Free PMC article.
BACKGROUND: Orthostatic intolerance-OI is common in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-ME/CFS. ...Hypocapnia was eTCO(2) 32 mmHg. Orthostatic tachycardia was heart rate increase 30 beats per minute compared with …
BACKGROUND: Orthostatic intolerance-OI is common in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-ME/CFS. . …
Systematic literature review: treatment of postural orthostatic tachycardia syndrome (POTS).
Schiweck N, Langer K, Maier A, Vilser D, Spiegler J. Schiweck N, et al. Clin Auton Res. 2026 Feb;36(1):3-16. doi: 10.1007/s10286-025-01172-2. Epub 2025 Nov 12. Clin Auton Res. 2026. PMID: 41225175 Free PMC article. Review.
Postural orthostatic tachycardia syndrome (POTS) is a condition defined by symptoms of orthostatic intolerance and a sustained heart rate (HR) increment of 30 beats per minute (bpm) upon postural change to the upright position in the absence o …
Postural orthostatic tachycardia syndrome (POTS) is a condition defined by symptoms of orthostatic intolerance and a su …
Dysautonomia and small fiber neuropathy in post-COVID condition and Chronic Fatigue Syndrome.
Azcue N, Del Pino R, Acera M, Fernández-Valle T, Ayo-Mentxakatorre N, Pérez-Concha T, Murueta-Goyena A, Lafuente JV, Prada A, López de Munain A, Ruiz Irastorza G, Martín-Iglesias D, Ribacoba L, Gabilondo I, Gómez-Esteban JC, Tijero-Merino B. Azcue N, et al. J Transl Med. 2023 Nov 15;21(1):814. doi: 10.1186/s12967-023-04678-3. J Transl Med. 2023. PMID: 37968647 Free PMC article.
RESULTS: Statistically significant differences were found between groups in heart rate using the Kruskal-Wallis test (H), with ME/CFS group presenting the highest (H = 18.3; p .001). The Postural Orthostatic Tachycardia Syndrome (POTS), and pa …
RESULTS: Statistically significant differences were found between groups in heart rate using the Kruskal-Wallis test (H), with …
23 results