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Did you mean osmotic therapeutic (12,072 results)?
Osmotin attenuates LPS-induced neuroinflammation and memory impairments via the TLR4/NFkappaB signaling pathway.
Badshah H, Ali T, Kim MO. Badshah H, et al. Sci Rep. 2016 Apr 20;6:24493. doi: 10.1038/srep24493. Sci Rep. 2016. PMID: 27093924 Free PMC article.
Osmotin also prevented LPS-induced apoptotic neurodegeneration via inhibition of PARP-1 and caspase-3. Overall, our studies demonstrated that osmotin prevented neuroinflammation-associated memory impairment and neurodegeneration and suggest AdipoR1 as a therapeut
Osmotin also prevented LPS-induced apoptotic neurodegeneration via inhibition of PARP-1 and caspase-3. Overall, our studies demonstra
Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer's disease neuropathological deficits.
Shah SA, Yoon GH, Chung SS, Abid MN, Kim TH, Lee HY, Kim MO. Shah SA, et al. Mol Psychiatry. 2017 Mar;22(3):407-416. doi: 10.1038/mp.2016.23. Epub 2016 Mar 22. Mol Psychiatry. 2017. PMID: 27001618 Free PMC article.
Extensive evidence has indicated that a high rate of cholesterol biogenesis and abnormal neuronal energy metabolism play key roles in Alzheimer's disease (AD) pathogenesis. Here, for we believe the first time, we used osmotin, a plant protein homolog of mammalian adiponect …
Extensive evidence has indicated that a high rate of cholesterol biogenesis and abnormal neuronal energy metabolism play key roles in Alzhei …
Adiponectin homolog novel osmotin protects obesity/diabetes-induced NAFLD by upregulating AdipoRs/PPARalpha signaling in ob/ob and db/db transgenic mouse models.
Ahmad A, Ali T, Kim MW, Khan A, Jo MH, Rehman SU, Khan MS, Abid NB, Khan M, Ullah R, Jo MG, Kim MO. Ahmad A, et al. Metabolism. 2019 Jan;90:31-43. doi: 10.1016/j.metabol.2018.10.004. Epub 2018 Oct 25. Metabolism. 2019. PMID: 30473057
OBJECTIVE: To the best of our knowledge, here, we reported for the first time the underlying mechanistic therapeutic efficacy of the novel osmotin, a homolog of mammalian adiponectin, against NAFLD in leptin-deficient ob/ob and db/db mice. ...CONCLUSION: Our finding …
OBJECTIVE: To the best of our knowledge, here, we reported for the first time the underlying mechanistic therapeutic efficacy of the …
Osmotin: a plant sentinel and a possible agonist of mammalian adiponectin.
Anil Kumar S, Hima Kumari P, Shravan Kumar G, Mohanalatha C, Kavi Kishor PB. Anil Kumar S, et al. Front Plant Sci. 2015 Mar 16;6:163. doi: 10.3389/fpls.2015.00163. eCollection 2015. Front Plant Sci. 2015. PMID: 25852715 Free PMC article. Review.
Protective efforts of osmotin in plants range from high temperature to cold and salt to drought. ...In experimental mice, adiponectin inhibits endothelial cell proliferation and migration, primary tumor growth, and reduces atherosclerosis. This retrospective work examines …
Protective efforts of osmotin in plants range from high temperature to cold and salt to drought. ...In experimental mice, adiponectin …
Adiponectin homolog osmotin, a potential anti-obesity compound, suppresses abdominal fat accumulation in C57BL/6 mice on high-fat diet and in 3T3-L1 adipocytes.
Jo MG, Kim MW, Jo MH, Bin Abid N, Kim MO. Jo MG, et al. Int J Obes (Lond). 2019 Dec;43(12):2422-2433. doi: 10.1038/s41366-019-0383-3. Epub 2019 Jun 4. Int J Obes (Lond). 2019. PMID: 31164725
To analyze the role of Osmotin in controlling energy metabolism by suppressing abdominal fat accumulation. ...CONCLUSION: These results reveal the role of osmotin in AMPK downstream signaling. These results provide the first indication that osmotin exerts …
To analyze the role of Osmotin in controlling energy metabolism by suppressing abdominal fat accumulation. ...CONCLUSION: These resul …
Novel phytopeptide osmotin mimics preventive effects of adiponectin on vascular inflammation and atherosclerosis.
Takahashi Y, Watanabe R, Sato Y, Ozawa N, Kojima M, Watanabe-Kominato K, Shirai R, Sato K, Hirano T, Watanabe T. Takahashi Y, et al. Metabolism. 2018 Jun;83:128-138. doi: 10.1016/j.metabol.2018.01.010. Epub 2018 Feb 2. Metabolism. 2018. PMID: 29410350
INTRODUCTION: The novel phytohormone, osmotin, has been reported to act like mammalian adiponectin through PHO36/AdipoR1 in various in vitro and in vivo models. ...CONCLUSIONS: This study provided the first evidence that osmotin exerts preventive effects on vascular …
INTRODUCTION: The novel phytohormone, osmotin, has been reported to act like mammalian adiponectin through PHO36/AdipoR1 in various i …
The Adiponectin Homolog Osmotin Enhances Neurite Outgrowth and Synaptic Complexity via AdipoR1/NgR1 Signaling in Alzheimer's Disease.
Yoon G, Shah SA, Ali T, Kim MO. Yoon G, et al. Mol Neurobiol. 2018 Aug;55(8):6673-6686. doi: 10.1007/s12035-017-0847-1. Epub 2018 Jan 15. Mol Neurobiol. 2018. PMID: 29335844
Osmotin reduced the expression of NgR1 without affecting Nogo-A expression. ...These results suggest that osmotin can enhance neurite outgrowth and synaptic complexity through AdipoR1 and NgR1 signaling, implying that osmotin might be an effective therapeu
Osmotin reduced the expression of NgR1 without affecting Nogo-A expression. ...These results suggest that osmotin can enhance
Molecular Cloning and Expression of Osmotin in a Baculovirus-Insect System: Purified Osmotin Mitigates Amyloid-beta Deposition in Neuronal Cells.
Abid NB, Yoon G, Kim MO. Abid NB, et al. Sci Rep. 2017 Aug 15;7(1):8147. doi: 10.1038/s41598-017-08396-x. Sci Rep. 2017. PMID: 28811634 Free PMC article.
The therapeutic properties of osmotin have been explored in recent years as it exhibits neuroprotective effects against amyloid beta-, glutamate- and ethanol-induced synaptic dysfunction and neurodegeneration. ...The present method will be an excellent approach for …
The therapeutic properties of osmotin have been explored in recent years as it exhibits neuroprotective effects against amyloi …
Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus.
Ali T, Yoon GH, Shah SA, Lee HY, Kim MO. Ali T, et al. Sci Rep. 2015 Jun 29;5:11708. doi: 10.1038/srep11708. Sci Rep. 2015. PMID: 26118757 Free PMC article.
These results revealed that osmotin reverses Abeta1-42 injection-induced synaptic deficits, Abeta accumulation and BACE-1 expression. ...Furthermore, osmotin attenuated Abeta1-42-induced neurotoxicity in vitro.To our knowledge, this study is the first to investigate …
These results revealed that osmotin reverses Abeta1-42 injection-induced synaptic deficits, Abeta accumulation and BACE-1 expression. …
Neuroprotective effect of osmotin against ethanol-induced apoptotic neurodegeneration in the developing rat brain.
Naseer MI, Ullah I, Narasimhan ML, Lee HY, Bressan RA, Yoon GH, Yun DJ, Kim MO. Naseer MI, et al. Cell Death Dis. 2014 Mar 27;5(3):e1150. doi: 10.1038/cddis.2014.53. Cell Death Dis. 2014. PMID: 24675468 Free PMC article.
Osmotin is a homolog of adiponectin, and it controls energy metabolism via phosphorylation. ...Osmotin exerted its neuroprotection via Bcl-2 family proteins and activation of AMPK signaling pathway. ...
Osmotin is a homolog of adiponectin, and it controls energy metabolism via phosphorylation. ...Osmotin exerted its neuroprotec
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