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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1991 1
1992 2
1993 1
1994 1
1995 2
1996 3
1997 5
1998 4
1999 7
2000 2
2001 7
2002 13
2003 8
2004 17
2005 19
2006 26
2007 26
2008 19
2009 21
2010 29
2011 41
2012 47
2013 38
2014 54
2015 76
2016 64
2017 82
2018 53
2019 66
2020 80
2021 86
2022 64
2023 67
2024 97
2025 139
2026 109

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1,202 results

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Page 1
Adipose-Joint Crosstalk in Obesity-Induced Osteoarthritis: Mechanisms, Biomarkers, and Translational Therapeutic Opportunities.
Hang W, Triantafilou K, Zhou Y. Hang W, et al. Curr Rheumatol Rep. 2026 Aug 8;28(1):22. doi: 10.1007/s11926-026-01229-9. Curr Rheumatol Rep. 2026. PMID: 42570127 Free PMC article. Review.
PURPOSE OF REVIEW: Obesity-induced osteoarthritis (OA) is emerging as a distinct metabolic phenotype fundamentally different from mechanically driven OA. ...Recent findings also point to metabolic modulators (GLP-1 receptor agonists), anti-adipokine agents, and regenerativ …
PURPOSE OF REVIEW: Obesity-induced osteoarthritis (OA) is emerging as a distinct metabolic phenotype fundamentally different from mec …
Exploring the intricate relationship between IL-1beta and IL-18 in the context of osteoarthritis.
Kumari A, Rasool M. Kumari A, et al. Front Immunol. 2026 Jul 23;17:1870390. doi: 10.3389/fimmu.2026.1870390. eCollection 2026. Front Immunol. 2026. PMID: 42564392 Free PMC article. Review.
Interleukin-1beta (IL-1beta) and interleukin-18 (IL-18) are key members of the IL-1 cytokine family that contribute to the initiation and progression of osteoarthritis (OA). Although both cytokines share structural similarities and use MyD88-dependent signaling path …
Interleukin-1beta (IL-1beta) and interleukin-18 (IL-18) are key members of the IL-1 cytokine family that contribute to the initiation and …
Identifcation of extracellular matrix-associated signatures to establish a risk model in rheumatoid arthritis and osteoarthritis through transcriptomic analysis.
Huang B, Huang Y, Lv R, Wang W, Hu Z, Li G, Wei C, Chen X, Li Z, Zhang X. Huang B, et al. Transl Res. 2026 Aug 5:S1931-5244(26)00169-6. doi: 10.1016/j.trsl.2026.08.003. Online ahead of print. Transl Res. 2026. PMID: 42556611
BACKGROUND: Rheumatoid arthritis (RA) and osteoarthritis (OA) frequently coexist, complicating diagnosis and treatment. The extracellular matrix (ECM) serves as a critical modulator of disease progression, coordinating multilayered matrix degradation and infl …
BACKGROUND: Rheumatoid arthritis (RA) and osteoarthritis (OA) frequently coexist, complicating diagnosis and treatment. The extracell …
Cytokine-mediated pathophysiology of equine and human joint disease: mechanisms, biomarkers, and therapeutic targets.
Nelson TB, Elane GL, Barnhardt E, Hobbs KJ. Nelson TB, et al. Front Vet Sci. 2026 Jul 17;13:1886084. doi: 10.3389/fvets.2026.1886084. eCollection 2026. Front Vet Sci. 2026. PMID: 42539835 Free PMC article. Review.
Cytokine-mediated inflammation plays a central role in the pathogenesis of joint disease across species, contributing to synovial activation, cartilage degradation, and structural remodeling. ...Comparative evaluation reveals that while cytokine profiles are largely conser …
Cytokine-mediated inflammation plays a central role in the pathogenesis of joint disease across species, contributing to synovial act …
Epigenetic regulation in osteoarthritis: recent updates and emerging mechanisms.
Zhao Y, Liu X. Zhao Y, et al. Front Genet. 2026 Jul 14;17:1862466. doi: 10.3389/fgene.2026.1862466. eCollection 2026. Front Genet. 2026. PMID: 42517028 Free PMC article. Review.
Osteoarthritis (OA) is a common chronic degenerative joint disease characterized by progressive cartilage destruction, synovial inflammation, subchondral bone remodeling, and functional decline. Current treatments remain largely symptomatic and are unable to effecti …
Osteoarthritis (OA) is a common chronic degenerative joint disease characterized by progressive cartilage destruction, synovia …
Functional Imaging in Osteoarthritis: Bridging Mechanistic Insight and Therapeutic Translation.
Fan X, Yuan F, Gao F, Liu C, Prasadam I, Sun AR, Crawford R, Wang Y, Chen S, Long Q, Mao X. Fan X, et al. Aging Dis. 2026 Jul 3. doi: 10.14336/AD.2026.0304. Online ahead of print. Aging Dis. 2026. PMID: 42508394
Functional imaging provides a decision-oriented framework for evaluating osteoarthritis (OA) beyond late structural morphology. OA is a heterogeneous, aging-associated whole-joint disease in which cartilage matrix disruption, synovial inflammation, subchondral bone …
Functional imaging provides a decision-oriented framework for evaluating osteoarthritis (OA) beyond late structural morphology. OA is …
Signal-driven interplay between lipid peroxidation and ferroptosis orchestrates osteoarthritis degeneration.
Kulyar MF, Pachaleva J, Brazaite S, Akhtar M, Hasan MM, Kaboli S, Lebedis I, Bernotiene E. Kulyar MF, et al. J Orthop Translat. 2026 Jul 10;60:101178. doi: 10.1016/j.jot.2026.101178. eCollection 2026 Sep. J Orthop Translat. 2026. PMID: 42471867 Free PMC article. Review.
By integrating mechanotransduction, iron metabolism, ferroptosis and lipid peroxidation, inter-tissue communication into a unified mechanistic framework, this review highlights emerging diagnostic biomarkers and translational strategies for the development of disease …
By integrating mechanotransduction, iron metabolism, ferroptosis and lipid peroxidation, inter-tissue communication into a unified mechanist …
Proteomic Analyses of Early Versus Advanced Primary Open Angle Glaucoma Uncover Biochemical Signatures Associated with Disease Staging.
Zhou TE, Mathew D, Wigg K, Chan D, Zhang JW, Balian C, Kherani I, Schlenker M, Jurisica I, Sivak JM. Zhou TE, et al. Mol Cell Proteomics. 2026 Jul 17:101625. doi: 10.1016/j.mcpro.2026.101625. Online ahead of print. Mol Cell Proteomics. 2026. PMID: 42468813 Free article.
Primary open-angle glaucoma (POAG) is a leading cause of blindness, yet the biochemical mechanisms underlying disease progression remain poorly understood. This study characterized aqueous humor (AH) across early and advanced stages of POAG using large-scale proteom …
Primary open-angle glaucoma (POAG) is a leading cause of blindness, yet the biochemical mechanisms underlying disease progression …
Mechanisms and research progress of statins in osteoarthritis.
Dong H, Zhang X, Luo Y, Jin J, Luo Z, Lu Y. Dong H, et al. Int Immunopharmacol. 2026 Oct 1;186:117141. doi: 10.1016/j.intimp.2026.117141. Epub 2026 Jul 17. Int Immunopharmacol. 2026. PMID: 42468167 Review.
Osteoarthritis (OA) is a chronic degenerative joint disease characterized predominantly by articular cartilage degeneration, synovial inflammation, subchondral bone remodeling, and progressive impairment of joint function. ...At present, OA management remains largel …
Osteoarthritis (OA) is a chronic degenerative joint disease characterized predominantly by articular cartilage degeneration, s …
Identification of potential biomarkers and therapeutic targets for osteoarthritis associated with arginine and proline metabolism based on transcriptome sequencing and bioinformatics.
Chen XH, Liu J, Qiu L, Zhan Y, Zheng ZM, Chen P, Su YX, Guo JM, Weng SJ. Chen XH, et al. Front Genet. 2026 Jul 3;17:1795267. doi: 10.3389/fgene.2026.1795267. eCollection 2026. Front Genet. 2026. PMID: 42466303 Free PMC article.
BACKGROUND AND OBJECTIVES: Osteoarthritis (OA) is a chronic degenerative joint disease. Approximately 300 million people worldwide suffer from OA, which shows a high incidence in middle-aged and elderly populations, with a prevalence of 50% among individuals aged ov …
BACKGROUND AND OBJECTIVES: Osteoarthritis (OA) is a chronic degenerative joint disease. Approximately 300 million people world …
1,202 results