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1997 2
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1999 2
2000 1
2001 2
2002 2
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2005 2
2006 3
2007 2
2008 1
2009 2
2010 2
2011 3
2012 3
2013 2
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2015 4
2016 2
2017 3
2018 5
2019 4
2020 2
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Page 1
OSU-6162, a Sigma1R Ligand in Low Doses, Can Further Increase the Effects of Cocaine Self-Administration on Accumbal D2R Heteroreceptor Complexes.
Borroto-Escuela DO, Romero-Fernandez W, Wydra K, Zhou Z, Suder A, Filip M, Fuxe K. Borroto-Escuela DO, et al. Neurotox Res. 2020 Feb;37(2):433-444. doi: 10.1007/s12640-019-00134-7. Epub 2019 Nov 28. Neurotox Res. 2020. PMID: 31782100 Free PMC article.
It therefore becomes of interest to test if the monoamine stabilizer (-) OSU-6162 (OSU-6162) with a nanomolar affinity for the Sigma1R can acutely modulate in low doses the effects of cocaine self-administration. In behavioral studies, OSU-61
It therefore becomes of interest to test if the monoamine stabilizer (-) OSU-6162 (OSU-6162) with a nanomolar af …
(-)-OSU 6162 inhibits levodopa-induced dyskinesias in a monkey model of Parkinson's disease.
Ekesbo A, Andrén PE, Gunne LM, Tedroff J. Ekesbo A, et al. Neuroreport. 1997 Jul 28;8(11):2567-70. doi: 10.1097/00001756-199707280-00029. Neuroreport. 1997. PMID: 9261828
We have studied the effects of two D2 dopamine receptor-selective compounds, (-)-OSU 6162 and raclopride, on levodopa-induced dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned common marmosets (Callithrix jacchus). ...However, in contrast t …
We have studied the effects of two D2 dopamine receptor-selective compounds, (-)-OSU 6162 and raclopride, on levodopa-induced …
Effects of the dopamine stabilizer, OSU-6162, on brain stimulation reward and on quinpirole-induced changes in reward and locomotion.
Benaliouad F, Kapur S, Natesan S, Rompré PP. Benaliouad F, et al. Eur Neuropsychopharmacol. 2009 Jun;19(6):416-30. doi: 10.1016/j.euroneuro.2009.01.014. Epub 2009 Mar 9. Eur Neuropsychopharmacol. 2009. PMID: 19269794
In this study, we investigated the effects of several doses of OSU-6162, a drug that belongs to a new class named "DA stabilizers", on brain stimulation reward. ...The observed functional antagonism of OSU-6162 on these DA-dependent behaviors suggests …
In this study, we investigated the effects of several doses of OSU-6162, a drug that belongs to a new class named "DA stabiliz …
Pharmacotherapy for chronic cognitive impairment in traumatic brain injury.
Dougall D, Poole N, Agrawal N. Dougall D, et al. Cochrane Database Syst Rev. 2015 Dec 1;(12):CD009221. doi: 10.1002/14651858.CD009221.pub2. Cochrane Database Syst Rev. 2015. PMID: 26624881 Review.
Effects of the monoamine stabilizer (-)OSU6162 on cognitive function in alcohol dependence.
Khemiri L, Steensland P, Guterstam J, de Manzano Ö, Franck J, Jayaram-Lindström N. Khemiri L, et al. Psychopharmacology (Berl). 2020 Jan;237(1):69-82. doi: 10.1007/s00213-019-05345-6. Epub 2019 Oct 18. Psychopharmacology (Berl). 2020. PMID: 31628507 Free PMC article. Clinical Trial.
Dopaminergic drugs can both impair and improve cognitive functions, and the aim of the current study was to investigate the effect of OSU treatment on cognitive functioning in AD patients. METHOD: In a randomized double-blind placebo-controlled study, 56 individuals with A …
Dopaminergic drugs can both impair and improve cognitive functions, and the aim of the current study was to investigate the effect of OSU
Open study with (-)-OSU6162 in multiple sclerosis-related fatigue.
Haghighi S, Forsmark S, Carlsson A, Nilsson MKL, Carlsson ML, Schuit RC, Gottfries CG. Haghighi S, et al. Acta Neurol Scand. 2018 Dec;138(6):482-489. doi: 10.1111/ane.13007. Epub 2018 Aug 22. Acta Neurol Scand. 2018. PMID: 30132786 Clinical Trial.
Schizophrenia: from dopamine to glutamate and back.
Carlsson ML, Carlsson A, Nilsson M. Carlsson ML, et al. Curr Med Chem. 2004 Feb;11(3):267-77. doi: 10.2174/0929867043456034. Curr Med Chem. 2004. PMID: 14965231 Review.
The monoamine stabilizer (-)-OSU6162 prevents the alcohol deprivation effect and improves motor impulsive behavior in rats.
Fredriksson I, Wirf M, Steensland P. Fredriksson I, et al. Addict Biol. 2019 May;24(3):471-484. doi: 10.1111/adb.12613. Epub 2018 Feb 26. Addict Biol. 2019. PMID: 29480646 Free PMC article.
Effects of the monoamine stabilizer (-)-OSU6162 on locomotor and sensorimotor responses predictive of antipsychotic activity.
da Silveira VT, Röpke J, Matosinhos AL, Issy AC, Del Bel EA, de Oliveira AC, Moreira FA. da Silveira VT, et al. Naunyn Schmiedebergs Arch Pharmacol. 2018 Jul;391(7):761-768. doi: 10.1007/s00210-018-1500-x. Epub 2018 Apr 24. Naunyn Schmiedebergs Arch Pharmacol. 2018. PMID: 29691608
Partial dopamine agonists and dopaminergic stabilizers, in the treatment of psychosis.
Tamminga CA, Carlsson A. Tamminga CA, et al. Curr Drug Targets CNS Neurol Disord. 2002 Apr;1(2):141-7. doi: 10.2174/1568007024606195. Curr Drug Targets CNS Neurol Disord. 2002. PMID: 12769623 Review.
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