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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 2
1953 2
1954 2
1955 1
1956 5
1957 3
1958 3
1959 4
1960 5
1961 3
1962 4
1963 6
1964 5
1965 10
1966 7
1967 16
1968 15
1969 22
1970 24
1971 25
1972 16
1973 32
1974 20
1975 34
1976 44
1977 45
1978 55
1979 46
1980 56
1981 72
1982 88
1983 64
1984 71
1985 77
1986 74
1987 81
1988 92
1989 87
1990 100
1991 93
1992 85
1993 97
1994 85
1995 122
1996 94
1997 112
1998 113
1999 140
2000 114
2001 115
2002 100
2003 116
2004 122
2005 123
2006 118
2007 127
2008 144
2009 123
2010 129
2011 181
2012 155
2013 176
2014 220
2015 223
2016 208
2017 219
2018 225
2019 239
2020 248
2021 251
2022 240
2023 206
2024 257
2025 311
2026 119

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6,501 results

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Page 1
Ototoxic effects of hydroxychloroquine.
Gonçalves LF, Patatt FSA, de Paiva KM, Haas P. Gonçalves LF, et al. Rev Assoc Med Bras (1992). 2021 Jul 9;67Suppl 1(Suppl 1):108-114. doi: 10.1590/1806-9282.67.Suppl1.20200677. eCollection 2021. Rev Assoc Med Bras (1992). 2021. PMID: 34259762 Free article.
Of these, two answered the research question, which consisted of seeking evidence of the ototoxic effects of hydroxychloroquine. These studies scored 11 in their quality assessment with the modified protocol by Pithon et al.13. ...The improvement in the audiological …
Of these, two answered the research question, which consisted of seeking evidence of the ototoxic effects of hydroxychloroquin …
Ototoxic effects of antineoplastic drugs: a systematic review.
Patatt FSA, Gonçalves LF, Paiva KM, Haas P. Patatt FSA, et al. Braz J Otorhinolaryngol. 2022 Jan-Feb;88(1):130-140. doi: 10.1016/j.bjorl.2021.02.008. Epub 2021 Mar 13. Braz J Otorhinolaryngol. 2022. PMID: 33757754 Free PMC article.
INTRODUCTION: Platinum-based chemotherapeutics play an important role in the treatment of cancer at different levels and are the most cited ototoxic agents when scientific evidence is analyzed. OBJECTIVE: To present scientific evidence based on a systematic literature revi …
INTRODUCTION: Platinum-based chemotherapeutics play an important role in the treatment of cancer at different levels and are the most cited …
Mechanisms of Ototoxicity and Otoprotection.
Steyger PS. Steyger PS. Otolaryngol Clin North Am. 2021 Dec;54(6):1101-1115. doi: 10.1016/j.otc.2021.08.007. Otolaryngol Clin North Am. 2021. PMID: 34774227 Free PMC article. Review.
This article reviews the fundamental mechanisms underlying ototoxicity by clinically relevant, hospital-prescribed medications (ie, aminoglycoside antibiotics or cisplatin, as illustrative examples). Also reviewed are current strategies to prevent prescribed medication-ind …
This article reviews the fundamental mechanisms underlying ototoxicity by clinically relevant, hospital-prescribed medications (ie, a …
Exploring Embryo-Ototoxic Effects: Insights into Deodorant-Induced Hair Cell Damage in Zebrafish.
Yoon HS, Hyun KT, Hong S, Park S, Han E, Baek HW, Lee YK, Lim KH, Rah YC, Choi J. Yoon HS, et al. Int J Mol Sci. 2024 Jan 12;25(2):948. doi: 10.3390/ijms25020948. Int J Mol Sci. 2024. PMID: 38256022 Free PMC article.
Our study investigated the embryo-ototoxic effects of deodorant2 (DA2) on zebrafish embryos, which serve as valuable model organisms due to genetic and physiological similarities to humans. ...Although not statistically significant, differences in distances traveled …
Our study investigated the embryo-ototoxic effects of deodorant2 (DA2) on zebrafish embryos, which serve as valuable model org …
Macrophage depletion protects against cisplatin-induced ototoxicity and nephrotoxicity.
Sung CYW, Hayase N, Yuen PST, Lee J, Fernandez K, Hu X, Cheng H, Star RA, Warchol ME, Cunningham LL. Sung CYW, et al. Sci Adv. 2024 Jul 26;10(30):eadk9878. doi: 10.1126/sciadv.adk9878. Epub 2024 Jul 24. Sci Adv. 2024. PMID: 39047106 Free PMC article.
Cisplatin is a widely used anticancer drug with notable side effects including ototoxicity and nephrotoxicity. Macrophages, the major resident immune cells in the cochlea and kidney, are important drivers of both inflammatory and tissue repair responses. ...Mechanis …
Cisplatin is a widely used anticancer drug with notable side effects including ototoxicity and nephrotoxicity. Macrophages, th …
Association of Sodium Thiosulfate With Risk of Ototoxic Effects From Platinum-Based Chemotherapy: A Systematic Review and Meta-analysis.
Chen CH, Huang CY, Lin HH, Wang MC, Chang CY, Cheng YF. Chen CH, et al. JAMA Netw Open. 2021 Aug 2;4(8):e2118895. doi: 10.1001/jamanetworkopen.2021.18895. JAMA Netw Open. 2021. PMID: 34338793 Free PMC article.
IMPORTANCE: Platinum-induced ototoxic effects are a significant issue because platinum-based chemotherapy is one of the most commonly used therapeutic medications. ...CONCLUSIONS AND RELEVANCE: This meta-analysis found that concurrent STS delivery was associated wit …
IMPORTANCE: Platinum-induced ototoxic effects are a significant issue because platinum-based chemotherapy is one of the most c …
Unveiling the ototoxic effects of paraquat on zebrafish larva.
Tantry MSA, Santhakumar K. Tantry MSA, et al. Aquat Toxicol. 2024 Aug;273:107030. doi: 10.1016/j.aquatox.2024.107030. Epub 2024 Jul 23. Aquat Toxicol. 2024. PMID: 39067264
We treated sub-lethal concentrations (125 muM to 1000 muM) of paraquat to 3 and 4 dpf zebrafish larvae to investigate its ototoxic effects via rheotaxis behavioral assay, neuromast staining and scanning electron microscopy. ...The scanning electron microscope data r …
We treated sub-lethal concentrations (125 muM to 1000 muM) of paraquat to 3 and 4 dpf zebrafish larvae to investigate its ototoxic …
Molecular Characteristics of Cisplatin-Induced Ototoxicity and Therapeutic Interventions.
Tan WJT, Vlajkovic SM. Tan WJT, et al. Int J Mol Sci. 2023 Nov 20;24(22):16545. doi: 10.3390/ijms242216545. Int J Mol Sci. 2023. PMID: 38003734 Free PMC article. Review.
However, its clinical use is limited by severe side effects, including ototoxicity, nephrotoxicity, neurotoxicity, hepatotoxicity, gastrointestinal toxicity, and retinal toxicity. ...Other pharmacological treatments for cisplatin ototoxicity are in various st …
However, its clinical use is limited by severe side effects, including ototoxicity, nephrotoxicity, neurotoxicity, hepatotoxic …
Is Methotrexate Ototoxic? Investigating the Ototoxic Late Effects of Pediatric Cancer Treatment.
Moore B, Sheets G, Doss J, Umrigar A, Norman M, Fang Z, Prasad P, Musso A, Clay S, Tsien F. Moore B, et al. Am J Audiol. 2023 Sep 6;32(3):657-664. doi: 10.1044/2023_AJA-22-00157. Epub 2023 Aug 2. Am J Audiol. 2023. PMID: 37532243 Free PMC article.
PURPOSE: Pediatric cancer survivors often experience long-term adverse health conditions or late effects, including hearing loss, that are attributable to cancer therapy. Ototoxic late effects have been documented in patients with cancer treated with cisplati …
PURPOSE: Pediatric cancer survivors often experience long-term adverse health conditions or late effects, including hearing loss, tha …
A Systematic Review of the Chemo/Radioprotective Effects of Melatonin against Ototoxic Adverse Effects Induced by Chemotherapy and Radiotherapy.
Basirat U, Bin Tariq U, Moeen N, Jawhar ZH, Shoja SJ, Kareem AK, Ramírez-Coronel AA, Romero-Parra RM, Zabibah RS, Gupta J, Mustafa YF, Farhood B. Basirat U, et al. Curr Pharm Des. 2023 Jun 6;29(15):1218-1229. doi: 10.2174/1381612829666230503145707. Curr Pharm Des. 2023. PMID: 37138418
BACKGROUND: Although chemotherapy and radiotherapy are effective in cancer treatment, different adverse effects induced by these therapeutic modalities (such as ototoxicity) restrict their clinical use. ...CONCLUSION: According to the findings, it was shown t …
BACKGROUND: Although chemotherapy and radiotherapy are effective in cancer treatment, different adverse effects induced by the …
6,501 results