Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1948 2
1949 2
1952 4
1953 6
1954 3
1955 3
1956 3
1957 3
1958 4
1959 4
1960 6
1961 9
1962 8
1963 10
1964 11
1965 17
1966 12
1967 22
1968 23
1969 23
1970 21
1971 31
1972 20
1973 25
1974 25
1975 82
1976 96
1977 95
1978 94
1979 96
1980 95
1981 100
1982 121
1983 173
1984 187
1985 165
1986 172
1987 177
1988 172
1989 182
1990 174
1991 168
1992 174
1993 177
1994 150
1995 175
1996 202
1997 219
1998 195
1999 224
2000 195
2001 215
2002 217
2003 259
2004 280
2005 299
2006 344
2007 406
2008 431
2009 422
2010 539
2011 623
2012 661
2013 781
2014 881
2015 884
2016 912
2017 883
2018 890
2019 954
2020 1051
2021 1038
2022 1056
2023 877
2024 967
2025 1049
2026 633

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

19,984 results

Results by year

Filters applied: . Clear all
Page 1
PXR Activation Relieves Deoxynivalenol-Induced Liver Oxidative Stress Via Malat1 LncRNA m(6)A Demethylation.
Feng Y, Shen J, Lin Z, Chen Z, Zhou M, Ma X. Feng Y, et al. Adv Sci (Weinh). 2024 Jul;11(25):e2308742. doi: 10.1002/advs.202308742. Epub 2024 Apr 24. Adv Sci (Weinh). 2024. PMID: 38654691 Free PMC article.
Deoxynivalenol (DON) is a prevalent toxin causing severe liver damage through hepatocellular oxidative stress. However, the underlying mechanisms and effective therapeutic approaches remain unknown. Here, the unique role of the xenobiotic metabolism factor pregnane X recep …
Deoxynivalenol (DON) is a prevalent toxin causing severe liver damage through hepatocellular oxidative stress. However, the underlyin …
Puerarin alleviates cerebral ischemia/reperfusion (CIR)-induced neurocyte oxidative stress and apoptosis via DNA demethylation-mediated PI3K/Akt activation.
Xu G, Zhang J, Shao C, Wu H, Li C, Yu L, Zhou H, An H, Wang T, Pu J, Yang J, Wan H. Xu G, et al. Phytomedicine. 2025 Sep;145:157094. doi: 10.1016/j.phymed.2025.157094. Epub 2025 Jul 22. Phytomedicine. 2025. PMID: 40714421
RESULTS: Our findings demonstrate that Pue exerts neuroprotection against CIR injury by attenuating oxidative stress, apoptosis, and mitochondrial dysfunction through DNA demethylation. Mechanistically, Pue directly binds to DNMT3A/B, inhibiting their enzymatic acti …
RESULTS: Our findings demonstrate that Pue exerts neuroprotection against CIR injury by attenuating oxidative stress, apoptosis, and …
RNA m(6)A regulates transcription via DNA demethylation and chromatin accessibility.
Deng S, Zhang J, Su J, Zuo Z, Zeng L, Liu K, Zheng Y, Huang X, Bai R, Zhuang L, Ye Y, Li M, Pan L, Deng J, Wu G, Li R, Zhang S, Wu C, Lin D, Chen J, Zheng J. Deng S, et al. Nat Genet. 2022 Sep;54(9):1427-1437. doi: 10.1038/s41588-022-01173-1. Epub 2022 Sep 7. Nat Genet. 2022. PMID: 36071173
Here, we show that METTL3-mediated RNA N(6)-methyladenosine (m(6)A) formation leads to DNA demethylation in nearby genomic loci in normal and cancer cells, which is mediated by the interaction between m(6)A reader FXR1 and DNA 5-methylcytosine dioxygenase TET1. ...Therefor …
Here, we show that METTL3-mediated RNA N(6)-methyladenosine (m(6)A) formation leads to DNA demethylation in nearby genomic loci in no …
Single-cell multi-omics sequencing of human spermatogenesis reveals a DNA demethylation event associated with male meiotic recombination.
Huang Y, Li L, An G, Yang X, Cui M, Song X, Lin J, Zhang X, Yao Z, Wan C, Zhou C, Zhao J, Song K, Ren S, Xia X, Fu X, Lan Y, Hu X, Wang W, Wang M, Zheng Y, Miao K, Bai X, Hutchins AP, Chang G, Gao S, Zhao XY. Huang Y, et al. Nat Cell Biol. 2023 Oct;25(10):1520-1534. doi: 10.1038/s41556-023-01232-7. Epub 2023 Sep 18. Nat Cell Biol. 2023. PMID: 37723297
In particular, we identified a set of transcription factors and cis elements with potential functions. A round of DNA demethylation was uncovered upon meiosis initiation in human spermatogenesis, which was associated with male meiotic recombination and conserved between hu …
In particular, we identified a set of transcription factors and cis elements with potential functions. A round of DNA demethylation w …
Structural mechanism of H3K27 demethylation and crosstalk with heterochromatin markers.
Lin CC, Zhao Y, Foley CA, Hawkins AT, James LI, Frye SV, McGinty RK. Lin CC, et al. Mol Cell. 2025 Aug 7;85(15):2869-2884.e6. doi: 10.1016/j.molcel.2025.06.025. Epub 2025 Jul 18. Mol Cell. 2025. PMID: 40683254
However, the molecular mechanisms governing H3K27 demethylation to reactivate silenced chromatin remain poorly understood. Here, we report the cryoelectron microscopy (cryo-EM) structure of mouse KDM6B bound to the nucleosome. ...We further show that linker histones and H2 …
However, the molecular mechanisms governing H3K27 demethylation to reactivate silenced chromatin remain poorly understood. Here, we r …
Oxidative stress-induced TET1 upregulation mediates active DNA demethylation in human gastric epithelial cells.
Zuo M, He J, Yin Q, He X, Liu Y, Liu Y, Liu J, Liu S, Ma L. Zuo M, et al. J Toxicol Sci. 2023;48(5):273-283. doi: 10.2131/jts.48.273. J Toxicol Sci. 2023. PMID: 37121742 Free article.
The gastrointestinal (GI) tract is more vulnerable to effects by the outside environment, and experiences oxidative stress. A wide diversity of GI disorders can be partially attributed to oxidative stress. ...The present study presents a mechanism by which oxidat …
The gastrointestinal (GI) tract is more vulnerable to effects by the outside environment, and experiences oxidative stress. A wide di …
FTO inhibits oxidative stress by mediating m6A demethylation of Nrf2 to alleviate cerebral ischemia/reperfusion injury.
Hou L, Li S, Li S, Wang R, Zhao M, Liu X. Hou L, et al. J Physiol Biochem. 2023 Feb;79(1):133-146. doi: 10.1007/s13105-022-00929-x. Epub 2022 Nov 3. J Physiol Biochem. 2023. PMID: 36327034
Current therapies are of limited efficacy in cerebral ischemia/reperfusion (I/R) injury. Based on the important role of oxidative stress in cerebral I/R injury, this study aimed to explore how the N6-adenosine methylation (m6A) demethylase FTO affects oxidative stre …
Current therapies are of limited efficacy in cerebral ischemia/reperfusion (I/R) injury. Based on the important role of oxidative str …
Cooperative demethylation.
Song Y. Song Y. Nat Chem Biol. 2023 Aug;19(8):921. doi: 10.1038/s41589-023-01398-z. Nat Chem Biol. 2023. PMID: 37500897 No abstract available.
OGG1 is essential in oxidative stress induced DNA demethylation.
Zhou X, Zhuang Z, Wang W, He L, Wu H, Cao Y, Pan F, Zhao J, Hu Z, Sekhar C, Guo Z. Zhou X, et al. Cell Signal. 2016 Sep;28(9):1163-1171. doi: 10.1016/j.cellsig.2016.05.021. Epub 2016 May 29. Cell Signal. 2016. PMID: 27251462
In this manuscript, we demonstrated that 8-oxoguanine DNA glycosylase-1 (OGG1) is the essential protein involved in oxidative stress-induced DNA demethylation. Oxidative stress induced the formation of 8-oxoguanine (8-oxoG). We found that OGG1, the 8-oxoG bin …
In this manuscript, we demonstrated that 8-oxoguanine DNA glycosylase-1 (OGG1) is the essential protein involved in oxidative stress- …
19,984 results
You have reached the last available page of results. Please see the User Guide for more information.