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The role of oxidative stress in an equine model of human asthma.
Deaton CM. Deaton CM. Redox Rep. 2006;11(2):46-52. doi: 10.1179/135100006X101057. Redox Rep. 2006. PMID: 16686994 Review.
Consequently, a greater oxidative load is likely to be required to induce oxidative stress in horses compared to human beings. Induction of acute neutrophilic airway inflammation in RAO horses by exposure to organic dust does not result in marke …
Consequently, a greater oxidative load is likely to be required to induce oxidative stress in horses compared to …
The Contribution of Oxidative Stress and Inflamm-Aging in Human and Equine Asthma.
Bullone M, Lavoie JP. Bullone M, et al. Int J Mol Sci. 2017 Dec 5;18(12):2612. doi: 10.3390/ijms18122612. Int J Mol Sci. 2017. PMID: 29206130 Free PMC article. Review.
Aging is associated with a dysregulation of the immune system, leading to a general pro-inflammatory state of the organism, a process that has been named inflamm-aging. Oxidative stress has an important role in aging and in the regulation of immune responses, probab …
Aging is associated with a dysregulation of the immune system, leading to a general pro-inflammatory state of the organism, a process that h …
Effects of a propriety oiled mixed hay feeding system on lung function, neutrophilic airway inflammation and oxidative stress in severe asthmatic horses.
Jochmans-Lemoine A, Picotte K, Beauchamp G, Vargas A, Lavoie JP. Jochmans-Lemoine A, et al. Equine Vet J. 2020 Jul;52(4):564-571. doi: 10.1111/evj.13218. Epub 2020 Feb 14. Equine Vet J. 2020. PMID: 31802526 Clinical Trial.
OBJECTIVES: We compared airflow obstruction and airway inflammation in horses with SEA fed oiled hay or alfalfa pellet regimen. STUDY DESIGN: Controlled trial in asthmatic research horses. METHODS: Twelve horses in exacerbation of SEA from a research herd wer …
OBJECTIVES: We compared airflow obstruction and airway inflammation in horses with SEA fed oiled hay or alfalfa pellet regimen. STUDY …
Studies of molecular pathways associated with blood neutrophil corticosteroid insensitivity in equine asthma.
Pourali Dogaheh S, Boivin R, Lavoie JP. Pourali Dogaheh S, et al. Vet Immunol Immunopathol. 2021 Jul;237:110265. doi: 10.1016/j.vetimm.2021.110265. Epub 2021 May 9. Vet Immunol Immunopathol. 2021. PMID: 33989854
We hypothesized that hypoxia or oxidative stress in the microenvironment of the lung contributes to this insensitivity of neutrophils to corticosteroids in asthmatic horses. Blood neutrophils isolated from horses with severe asthma (N = 8) and from hea …
We hypothesized that hypoxia or oxidative stress in the microenvironment of the lung contributes to this insensitivity of neut …
Immune sensitization of equine bronchus: glutathione, IL-1beta expression and tissue responsiveness.
Matera MG, Calzetta L, Peli A, Scagliarini A, Matera C, Cazzola M. Matera MG, et al. Respir Res. 2005 Sep 15;6(1):104. doi: 10.1186/1465-9921-6-104. Respir Res. 2005. PMID: 16164745 Free PMC article.
BACKGROUND: Increasing clinical epidemiological and experimental evidence indicates that excess of production of reactive oxygen free radicals (ROS) induced by an oxidative stress is involved in the pathogenesis of a number of human airway disorders, as well as equi …
BACKGROUND: Increasing clinical epidemiological and experimental evidence indicates that excess of production of reactive oxygen free radica …
Effects of 8-epi-PGF2alpha on isolated bronchial smooth muscle of healthy and heaves-affected horses.
Kirschvink N, Art T, Lekeux P, Roberts C, Gustin P. Kirschvink N, et al. J Vet Pharmacol Ther. 2001 Jun;24(3):215-21. doi: 10.1046/j.1365-2885.2001.00330.x. J Vet Pharmacol Ther. 2001. PMID: 11442801
8-Epi-PGF2alpha, a prostaglandin-like compound generated by oxidative stress, has been shown to be an in vitro bronchoconstrictor in airways from healthy laboratory animals and healthy humans, but it has never been studied in diseased airways. ...A subthreshold conc …
8-Epi-PGF2alpha, a prostaglandin-like compound generated by oxidative stress, has been shown to be an in vitro bronchoconstric …
Bronchoconstrictive properties of inhaled 8-epi-PGF2alpha in healthy and heaves-susceptible horses.
Kirschvink N, Bureau F, Art T, Lekeux P. Kirschvink N, et al. Vet Res. 2001 Sep-Oct;32(5):397-407. doi: 10.1051/vetres:2001132. Vet Res. 2001. PMID: 11592610 Free article.
The 8-epi-PGF2alpha is a marker of oxidative stress which is increased in lungs of asthmatic humans and heaves-susceptible horses. 8-Epi-PGF2alpha has also been demonstrated to be an in vitro and in vivo bronchoconstrictor in humans and rodents. ...Our result …
The 8-epi-PGF2alpha is a marker of oxidative stress which is increased in lungs of asthmatic humans and heaves-susceptible …