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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 3
1981 3
1982 1
1983 3
1984 2
1985 2
1986 1
1987 8
1988 8
1989 21
1990 18
1991 25
1992 35
1993 39
1994 58
1995 98
1996 136
1997 149
1998 211
1999 232
2000 320
2001 344
2002 422
2003 422
2004 531
2005 616
2006 715
2007 804
2008 922
2009 985
2010 1113
2011 1095
2012 1228
2013 1355
2014 1419
2015 1409
2016 1586
2017 1601
2018 1654
2019 1820
2020 2099
2021 2156
2022 2122
2023 2127
2024 2420
2025 3174
2026 1112

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32,542 results

Results by year

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Page 1
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.
Lin MT, Beal MF. Lin MT, et al. Nature. 2006 Oct 19;443(7113):787-95. doi: 10.1038/nature05292. Nature. 2006. PMID: 17051205 Review.
Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. Mitochondria are critical regulators of cell death, a key feature of neurodegeneration. Mutations in mitochondrial DNA and oxidative stress both …
Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. Mitochondria are c …
Oxidants, oxidative stress and the biology of ageing.
Finkel T, Holbrook NJ. Finkel T, et al. Nature. 2000 Nov 9;408(6809):239-47. doi: 10.1038/35041687. Nature. 2000. PMID: 11089981 Review.
Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span....
Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to …
From discoveries in ageing research to therapeutics for healthy ageing.
Campisi J, Kapahi P, Lithgow GJ, Melov S, Newman JC, Verdin E. Campisi J, et al. Nature. 2019 Jul;571(7764):183-192. doi: 10.1038/s41586-019-1365-2. Epub 2019 Jul 10. Nature. 2019. PMID: 31292558 Free PMC article. Review.
For several decades, understanding ageing and the processes that limit lifespan have challenged biologists. Thirty years ago, the biology of ageing gained unprecedented scientific credibility through the identification of gene variants that extend the lifespan of mu …
For several decades, understanding ageing and the processes that limit lifespan have challenged biologists. Thirty years ago, the bio …
REST and stress resistance in ageing and Alzheimer's disease.
Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM, Drake D, Liu XS, Bennett DA, Colaiácovo MP, Yankner BA. Lu T, et al. Nature. 2014 Mar 27;507(7493):448-54. doi: 10.1038/nature13163. Epub 2014 Mar 19. Nature. 2014. PMID: 24670762 Free PMC article.
Chromatin immunoprecipitation with deep sequencing and expression analysis show that REST represses genes that promote cell death and Alzheimer's disease pathology, and induces the expression of stress response genes. Moreover, REST potently protects neurons from oxidat …
Chromatin immunoprecipitation with deep sequencing and expression analysis show that REST represses genes that promote cell death and Alzhei …
Ageing and the pathogenesis of osteoarthritis.
Loeser RF, Collins JA, Diekman BO. Loeser RF, et al. Nat Rev Rheumatol. 2016 Jul;12(7):412-20. doi: 10.1038/nrrheum.2016.65. Epub 2016 May 19. Nat Rev Rheumatol. 2016. PMID: 27192932 Free PMC article. Review.
Although ageing and OA are closely linked, they are independent processes. Several potential mechanisms by which ageing contributes to OA have been elucidated. This Review focuses on the contributions of the following factors: age-related inflammation (also referred …
Although ageing and OA are closely linked, they are independent processes. Several potential mechanisms by which ageing contri …
Mitochondrial dysfunction and oxidative stress in aging and cancer.
Kudryavtseva AV, Krasnov GS, Dmitriev AA, Alekseev BY, Kardymon OL, Sadritdinova AF, Fedorova MS, Pokrovsky AV, Melnikova NV, Kaprin AD, Moskalev AA, Snezhkina AV. Kudryavtseva AV, et al. Oncotarget. 2016 Jul 19;7(29):44879-44905. doi: 10.18632/oncotarget.9821. Oncotarget. 2016. PMID: 27270647 Free PMC article. Review.
Increasing ROS levels and products of the oxidative stress, which occur in aging and age-related disorders, were also found in cancer. This review focuses on the similarities between ageing-associated and cancer-associated oxidative stress …
Increasing ROS levels and products of the oxidative stress, which occur in aging and age-related disorders, were also f …
Decreased oxidative stress response and oxidant detoxification of skin during aging.
Dai X, Hu Y, Jiang L, Lei L, Fu C, Wu S, Zhang X, Zhu L, Zhang F, Chen J, Zeng Q. Dai X, et al. Mech Ageing Dev. 2023 Dec;216:111878. doi: 10.1016/j.mad.2023.111878. Epub 2023 Oct 11. Mech Ageing Dev. 2023. PMID: 37827221
Oxidative stress plays an important role in the skin aging process; however, the mechanisms are not fully elucidated. ...Annexin A1 (ANXA1) and Apolipoprotein E (APOE) may be key oxidative stress-related genes affecting skin aging....
Oxidative stress plays an important role in the skin aging process; however, the mechanisms are not fully elucidated. . …
Oxidative stress in neurodegenerative diseases and ageing.
Pereira MD, Ksiazek K, Menezes R. Pereira MD, et al. Oxid Med Cell Longev. 2012;2012:796360. doi: 10.1155/2012/796360. Epub 2012 Nov 5. Oxid Med Cell Longev. 2012. PMID: 23259028 Free PMC article. No abstract available.
Aging exacerbates oxidative stress and liver fibrosis in an animal model of Down Syndrome.
Giallongo S, Ferrigno J, Caltabiano R, Broggi G, Alanazi AM, Distefano A, Tropea E, Tramutola A, Perluigi M, Volti GL, Barone E, Barbagallo IA. Giallongo S, et al. Aging (Albany NY). 2024 Jun 26;16(12):10203-10215. doi: 10.18632/aging.205970. Epub 2024 Jun 26. Aging (Albany NY). 2024. PMID: 38942607 Free PMC article.
Additionally, chronic oxidative stress contributes to cardiovascular diseases and certain cancers prevalent in DS individuals. This study investigates the impact of ageing on oxidative stress and liver fibrosis using a DS murine model (Ts2Cje mi …
Additionally, chronic oxidative stress contributes to cardiovascular diseases and certain cancers prevalent in DS individuals. …
32,542 results
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