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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 1
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5,934 results

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Page 1
Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives.
Roehlen N, Crouchet E, Baumert TF. Roehlen N, et al. Cells. 2020 Apr 3;9(4):875. doi: 10.3390/cells9040875. Cells. 2020. PMID: 32260126 Free PMC article. Review.
Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global health. ...Scientific discoveries within the last decade have transformed the understanding of the mechanisms of liver fibrosis. Removal or eliminatio …
Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global health. ...Scientific di …
Lithospermic acid improves liver fibrosis through Piezo1-mediated oxidative stress and inflammation.
Luo S, Yang B, Xu H, Pan X, Chen X, Jue X, Liu S, Wan R, Tan Q, Yao Y, Chen X, Jiang J, Deng B, Li J. Luo S, et al. Phytomedicine. 2024 Nov;134:155974. doi: 10.1016/j.phymed.2024.155974. Epub 2024 Aug 22. Phytomedicine. 2024. PMID: 39217657
BACKGROUND: Hepatic fibrosis is becoming an increasingly serious public health issue worldwide. Although liver transplantation is the only and definitive treatment for end-stage liver fibrosis, traditional Chinese medicine offers certain benefits in th …
BACKGROUND: Hepatic fibrosis is becoming an increasingly serious public health issue worldwide. Although liver transplantation …
Inflammation-Responsive Cell Membrane-Camouflaged Nanoparticles against Liver Fibrosis via Regulating Endoplasmic Reticulum Stress and Oxidative Stress.
Bai Y, Chen J, Zhang S, Xu G, Mao Z, Ding Y, Wang W. Bai Y, et al. Adv Mater. 2024 May;36(19):e2310443. doi: 10.1002/adma.202310443. Epub 2024 Feb 26. Adv Mater. 2024. PMID: 38372054
Liver fibrosis represents a reversible stage of various chronic liver diseases that progresses to cirrhosis. This condition is characterized by an imbalance between tissue damage and repair, and the production of fibers in the liver exceeds thei …
Liver fibrosis represents a reversible stage of various chronic liver diseases that progresses to cirrhosis. Thi …
Aloin Attenuates Oxidative Stress, Inflammation, and CCl(4)-Induced Liver Fibrosis in Mice: Possible Role of TGF-beta/Smad Signaling.
Bai J, Qian B, Cai T, Chen Y, Li T, Cheng Y, Wu Z, Liu C, Ye M, Du Y, Fu W. Bai J, et al. J Agric Food Chem. 2023 Dec 13;71(49):19475-19487. doi: 10.1021/acs.jafc.3c01721. Epub 2023 Dec 1. J Agric Food Chem. 2023. PMID: 38038700 Free PMC article.
Liver fibrosis refers to the excessive buildup of extracellular matrix (ECM) components in liver tissue. ...Thus, the findings of this study provided theoretical data support and a new possible treatment strategy for liver fibrosis....
Liver fibrosis refers to the excessive buildup of extracellular matrix (ECM) components in liver tissue. ...Thus, the f …
Oxidative stress promotes liver fibrosis by modulating the microRNA-144 and SIN3A-p38 pathways in hepatic stellate cells.
Hao Y, Song S, Li T, Zai Q, Ma N, Li Y, Yang L, Xiao P, Xu T, Ji L, Tan J, Ahmed YA, Xiang X, Wang X, Lafdil F, Xie Q, He Y. Hao Y, et al. Int J Biol Sci. 2024 Apr 8;20(7):2422-2439. doi: 10.7150/ijbs.92749. eCollection 2024. Int J Biol Sci. 2024. PMID: 38725842 Free PMC article.
MiR-144 downregulated Sin3A, and in line with this result, specific knockdown of Sin3a in HSCs remarkedly activated p38 MAPK signaling pathway to promote HSC activation, eventually exacerbating liver fibrosis. Conclusions: Oxidative stress-driven miR-1 …
MiR-144 downregulated Sin3A, and in line with this result, specific knockdown of Sin3a in HSCs remarkedly activated p38 MAPK signaling pathw …
Targeting Oxidative Stress for the Treatment of Liver Fibrosis.
Luangmonkong T, Suriguga S, Mutsaers HAM, Groothuis GMM, Olinga P, Boersema M. Luangmonkong T, et al. Rev Physiol Biochem Pharmacol. 2018;175:71-102. doi: 10.1007/112_2018_10. Rev Physiol Biochem Pharmacol. 2018. PMID: 29728869 Review.
In this review, we overview the role of ROS in liver fibrosis and discuss the promising therapeutic interventions related to oxidative stress. ...In addition, challenges for targeting oxidative stress in the management of liver …
In this review, we overview the role of ROS in liver fibrosis and discuss the promising therapeutic interventions related to …
Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis.
Kumar S, Duan Q, Wu R, Harris EN, Su Q. Kumar S, et al. Adv Drug Deliv Rev. 2021 Sep;176:113869. doi: 10.1016/j.addr.2021.113869. Epub 2021 Jul 16. Adv Drug Deliv Rev. 2021. PMID: 34280515 Free PMC article. Review.
The progression of NAFL to NASH and liver fibrosis is closely associated with a series of liver injury resulting from lipotoxicity, oxidative stress, redox imbalance (excessive nitric oxide), ER stress, inflammation and apoptosis that occ …
The progression of NAFL to NASH and liver fibrosis is closely associated with a series of liver injury resulting from l …
Mechanisms of liver fibrosis and its role in liver cancer.
Dhar D, Baglieri J, Kisseleva T, Brenner DA. Dhar D, et al. Exp Biol Med (Maywood). 2020 Jan;245(2):96-108. doi: 10.1177/1535370219898141. Epub 2020 Jan 10. Exp Biol Med (Maywood). 2020. PMID: 31924111 Free PMC article. Review.
Advanced liver fibrosis and cirrhosis are also major risk factors for hepatocellular carcinoma (HCC). Hepatic stellate cells (HSCs) play a pivotal role in the pathogenesis of liver fibrosis. In this review, we summarize the basic mechanisms that …
Advanced liver fibrosis and cirrhosis are also major risk factors for hepatocellular carcinoma (HCC). Hepatic stellate …
SIRT3: A potential therapeutic target for liver fibrosis.
Ning Y, Dou X, Wang Z, Shi K, Wang Z, Ding C, Sang X, Zhong X, Shao M, Han X, Cao G. Ning Y, et al. Pharmacol Ther. 2024 May;257:108639. doi: 10.1016/j.pharmthera.2024.108639. Epub 2024 Mar 30. Pharmacol Ther. 2024. PMID: 38561088 Review.
In addition, SIRT3 is involved in critical biological processes, including oxidative stress, inflammation, DNA damage, and apoptosis, all of which are closely related to the progression of liver disease. ...Second, the roles of SIRT3 in major cells in the …
In addition, SIRT3 is involved in critical biological processes, including oxidative stress, inflammation, DNA damage, and apo …
Aging exacerbates oxidative stress and liver fibrosis in an animal model of Down Syndrome.
Giallongo S, Ferrigno J, Caltabiano R, Broggi G, Alanazi AM, Distefano A, Tropea E, Tramutola A, Perluigi M, Volti GL, Barone E, Barbagallo IA. Giallongo S, et al. Aging (Albany NY). 2024 Jun 26;16(12):10203-10215. doi: 10.18632/aging.205970. Epub 2024 Jun 26. Aging (Albany NY). 2024. PMID: 38942607 Free PMC article.
This study investigates the impact of ageing on oxidative stress and liver fibrosis using a DS murine model (Ts2Cje mice). Our results show that DS mice show increased liver oxidative stress and impaired antioxidant defenses, as ev …
This study investigates the impact of ageing on oxidative stress and liver fibrosis using a DS murine model (Ts2 …
5,934 results