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1981 1
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1986 14
1987 9
1988 6
1989 18
1990 20
1991 12
1992 22
1993 10
1994 5
1995 7
1996 4
1997 2
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2000 4
2002 2
2004 3
2005 1
2009 1
2010 3
2013 4
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2020 8
2021 3
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[Oxiracetam].
Gava R, Schifano F. Gava R, et al. G Clin Med. 1989 Jan;70(1):69-72. G Clin Med. 1989. PMID: 2668093 Review. Italian. No abstract available.
Oxiracetam Offers Neuroprotection by Reducing Amyloid beta-Induced Microglial Activation and Inflammation in Alzheimer's Disease.
Zhang H, Jia L, Jia J. Zhang H, et al. Front Neurol. 2020 Jul 17;11:623. doi: 10.3389/fneur.2020.00623. eCollection 2020. Front Neurol. 2020. PMID: 32765394 Free PMC article.
Thus, a therapeutic approach targeting this sustained microglia-induced inflammatory response deserves investigation. Here, we examined whether oxiracetam (ORC), a nootropic of the racetam family, can indirectly prevent Abeta-induced neurotoxicity by attenuating microglial …
Thus, a therapeutic approach targeting this sustained microglia-induced inflammatory response deserves investigation. Here, we examined whet …
Oxiracetam and Zinc Ameliorates Autism-Like Symptoms in Propionic Acid Model of Rats.
Paudel R, Raj K, Gupta YK, Singh S. Paudel R, et al. Neurotox Res. 2020 Apr;37(4):815-826. doi: 10.1007/s12640-020-00169-1. Epub 2020 Feb 5. Neurotox Res. 2020. PMID: 32026359
Thus, present study aimed to find the protective effects of oxiracetam alone and in combination with zinc on brain behavioral, biochemical, pro-inflammatory cytokines and neurotransmitters level. Rats were administered with propionic acid (250 mg/kg p.o.) for 3 days and im …
Thus, present study aimed to find the protective effects of oxiracetam alone and in combination with zinc on brain behavioral, bioche …
Using HPLC to analyze (S)-oxiracetam and four related substances in the bulk drug of (S)-oxiracetam.
Wang C, Dong H, Liu H, Sun Z, Yuan A, Wu J, Hu Y. Wang C, et al. J Pharm Biomed Anal. 2020 Feb 20;180:113072. doi: 10.1016/j.jpba.2019.113072. Epub 2019 Dec 23. J Pharm Biomed Anal. 2020. PMID: 31891873
(S)-oxiracetam is undergoing clinical trials as an active ingredient in the racemic oxiracetam. Here, we report a specific analytical method for analyzing (S)-oxiracetam and four related impurities in the bulk drug of (S)-oxiracetam by using high-perfo …
(S)-oxiracetam is undergoing clinical trials as an active ingredient in the racemic oxiracetam. Here, we report a specific ana …
Oxiracetam or fastigial nucleus stimulation reduces cognitive injury at high altitude.
Hu S, Shi J, Xiong W, Li W, Fang L, Feng H. Hu S, et al. Brain Behav. 2017 Aug 23;7(10):e00762. doi: 10.1002/brb3.762. eCollection 2017 Oct. Brain Behav. 2017. PMID: 29075554 Free PMC article.
BACKGROUND: Cognitive impairment is common in people travelling to high altitude. Oxiracetam and electrical stimulation of cerebellar fastigial nucleus may have beneficial impacts. This study was to investigate the effects of preconditioning with Oxiracetam or fasti …
BACKGROUND: Cognitive impairment is common in people travelling to high altitude. Oxiracetam and electrical stimulation of cerebellar …
(S)-Oxiracetam is the Active Ingredient in Oxiracetam that Alleviates the Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats.
Li W, Liu H, Jiang H, Wang C, Guo Y, Sun Y, Zhao X, Xiong X, Zhang X, Zhang K, Nie Z, Pu X. Li W, et al. Sci Rep. 2017 Aug 30;7(1):10052. doi: 10.1038/s41598-017-10283-4. Sci Rep. 2017. PMID: 28855592 Free PMC article.
However, oxiracetam is currently used as a racemic mixture whose effective ingredient has not been identified to date. In this study, we first identified that (S)-oxiracetam, but not (R)-oxiracetam, was the effective ingredient that alleviated the impairments …
However, oxiracetam is currently used as a racemic mixture whose effective ingredient has not been identified to date. In this study, …
Comparative toxicity and toxicokinetic studies of oxiracetam and (S)-oxiracetam in dogs.
Liu TT, Guo XM, Rong ZY, Ye XF, Wei JF, Wang AP, Jin HT. Liu TT, et al. Xenobiotica. 2019 Sep;49(9):1054-1062. doi: 10.1080/00498254.2018.1528027. Epub 2019 Jan 4. Xenobiotica. 2019. PMID: 30351213
Oxiracetam (ORT) is known as a derivative of piracetam in the family of nootropics for treating memory impairment and cognition disorders. Given the chiral toxicological concerns surrounding ORT and the absence studies of (S)-ORT, the toxicity and toxicokinetics of (S)-ORT
Oxiracetam (ORT) is known as a derivative of piracetam in the family of nootropics for treating memory impairment and cognition disor
Combined bone marrow stromal cells and oxiracetam treatments ameliorates acute cerebral ischemia/reperfusion injury through TRPC6.
Wang J, Sun R, Li Z, Pan Y. Wang J, et al. Acta Biochim Biophys Sin (Shanghai). 2019 Aug 5;51(8):767-777. doi: 10.1093/abbs/gmz059. Acta Biochim Biophys Sin (Shanghai). 2019. PMID: 31236585
In this study, we investigated the therapeutic effects of combined bone marrow stromal cells (BMSCs) and oxiracetam treatments on acute cerebral ischemia/reperfusion (I/R) injury. ...The increased expression of TRPC6 along with the reduction of neuronal cell death in the O …
In this study, we investigated the therapeutic effects of combined bone marrow stromal cells (BMSCs) and oxiracetam treatments on acu …
Nerve growth factor in combination with Oxiracetam in the treatment of Hypertensive Cerebral Hemorrhage.
Sun Y, Xu B, Zhang Q. Sun Y, et al. Pak J Med Sci. 2018 Jan-Feb;34(1):73-77. doi: 10.12669/pjms.341.13395. Pak J Med Sci. 2018. PMID: 29643882 Free PMC article.
OBJECTIVE: To compare the clinical efficacy of nerve growth factor (NGF) in combination with oxiracetam and single use of oxiracetam in the treatment of hypertensive cerebral hemorrhage. METHODS: One hundred and forty patients with hypertensive cerebral hemorrhage w …
OBJECTIVE: To compare the clinical efficacy of nerve growth factor (NGF) in combination with oxiracetam and single use of oxiracet
Oxiracetam ameliorates cognitive deficits in vascular dementia rats by regulating the expression of neuronal apoptosis/autophagy-related genes associated with the activation of the Akt/mTOR signaling pathway.
Xu J, Qi Q, Lv P, Dong Y, Jiang X, Liu Z. Xu J, et al. Braz J Med Biol Res. 2019 Nov 7;52(11):e8371. doi: 10.1590/1414-431X20198371. eCollection 2019. Braz J Med Biol Res. 2019. PMID: 31721903 Free PMC article.
Oxiracetam (ORC) is a commonly used nootropic drug for improving cognition and memory impairments. ...
Oxiracetam (ORC) is a commonly used nootropic drug for improving cognition and memory impairments. ...
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