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81 results

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Page 1
Effect of l-oxiracetam and oxiracetam on memory and cognitive impairment in mild-to-moderate traumatic brain injury patients: Study protocol for a randomized controlled trial.
Liu T, Liu M, Nie M, Zhao Z, Liu X, Qian Y, Yu Y, Sha Z, Wu C, Yuan J, Jiang W, Lv C, Mi L, Tian Y, Zhang J, Jiang R. Liu T, et al. Aging Med (Milton). 2024 Jun 14;7(3):341-349. doi: 10.1002/agm2.12335. eCollection 2024 Jun. Aging Med (Milton). 2024. PMID: 38975302 Free PMC article.
OBJECTIVES: Patients with traumatic brain injury (TBI) often suffer memory and cognitive impairments, and oxiracetam-like drugs are considered to have a positive impact on these symptoms potentially. ...DISCUSSION: There is no robust evidence to suggest that l-ox …
OBJECTIVES: Patients with traumatic brain injury (TBI) often suffer memory and cognitive impairments, and oxiracetam-like drug …
Nanodelivery of oxiracetam enhances memory, functional recovery and induces neuroprotection following concussive head injury.
Niu F, Sharma A, Wang Z, Feng L, Muresanu DF, Sahib S, Tian ZR, Lafuente JV, Buzoianu AD, Castellani RJ, Nozari A, Menon PK, Patnaik R, Wiklund L, Sharma HS. Niu F, et al. Prog Brain Res. 2021;265:139-230. doi: 10.1016/bs.pbr.2021.06.004. Epub 2021 Aug 12. Prog Brain Res. 2021. PMID: 34560921
This was observed using Rota Rod treadmill, memory improvement assessed by the time spent in finding hidden platform under water. The motor function improvement is seen in oxiracetam treated CHI group by placing forepaw on an inclined mesh walking and foot print ana …
This was observed using Rota Rod treadmill, memory improvement assessed by the time spent in finding hidden platform under water. The …
Double-blind placebo-controlled, neuropsychological and neurophysiological investigations with oxiracetam (CGP 21690E) in memory-impaired patients with epilepsy.
Aldenkamp AP, van Wieringen A, Alpherts WC, van Emde Boas W, Haverkort HA, de Vries J, Meinardi H. Aldenkamp AP, et al. Neuropsychobiology. 1990-1991;24(2):90-101. doi: 10.1159/000119467. Neuropsychobiology. 1990. PMID: 2134116 Clinical Trial.
A double-blind placebo-controlled between-patient study was carried out to assess the effects of oxiracetam (CGP 21690E) on memory function in patients with epilepsy. During a 12-week period, either oxiracetam (800 mg t.i.d.) or placebo was given to 30 patien …
A double-blind placebo-controlled between-patient study was carried out to assess the effects of oxiracetam (CGP 21690E) on memory …
Oxiracetam prevented the scopolamine but not the diazepam induced memory deficits in mice.
Hlinák Z, Krejcí I. Hlinák Z, et al. Behav Brain Res. 2002 Jul 18;133(2):395-9. doi: 10.1016/s0166-4328(02)00028-1. Behav Brain Res. 2002. PMID: 12110475
Thus, oxiracetam forestalled the impairment of retrieval of memory trace: the animals were able to remember the spatial configuration of the plus-maze. On the contrary, oxiracetam was not effective in the diazepam treated mice. We suggest that beneficial effe …
Thus, oxiracetam forestalled the impairment of retrieval of memory trace: the animals were able to remember the spatial config …
Oxiracetam antagonizes the disruptive effects of scopolamine on memory in the radial maze.
Magnani M, Pozzi O, Biagetti R, Banfi S, Dorigotti L. Magnani M, et al. Psychopharmacology (Berl). 1992;106(2):175-8. doi: 10.1007/BF02801969. Psychopharmacology (Berl). 1992. PMID: 1549645
The effects of this dose of scopolamine on efficiency and running time were not antagonized by pretreatment with 100 mg/kg oxiracetam. Oxiracetam alone (30 or 100 mg/kg IP) did not modify the performance of previously trained rats. The present results suggest that …
The effects of this dose of scopolamine on efficiency and running time were not antagonized by pretreatment with 100 mg/kg oxiracetam …
Oxiracetam and Zinc Ameliorates Autism-Like Symptoms in Propionic Acid Model of Rats.
Paudel R, Raj K, Gupta YK, Singh S. Paudel R, et al. Neurotox Res. 2020 Apr;37(4):815-826. doi: 10.1007/s12640-020-00169-1. Epub 2020 Feb 5. Neurotox Res. 2020. PMID: 32026359
Rats were administered with propionic acid (250 mg/kg p.o.) for 3 days and immediately on next day treatment were given with oxiracetam (25, 50 mg/kg i.p), zinc (4 mg/kg) as well as oxiracetam (25 mg/kg i.p) in combination with zinc (4 mg/kg p.o). ...The propionic a …
Rats were administered with propionic acid (250 mg/kg p.o.) for 3 days and immediately on next day treatment were given with oxiracetam …
Effects of oxiracetam on learning and memory in animals: comparison with piracetam.
Mondadori C, Classen W, Borkowski J, Ducret T, Buerki H, Schadé A. Mondadori C, et al. Clin Neuropharmacol. 1986;9 Suppl 3:S27-38. Clin Neuropharmacol. 1986. PMID: 3594453
The effects of oxiracetam and piracetam were compared in learning and memory tests in rats and mice. In the dose range examined, the two nootropics were equally active in reducing the amnesia induced by cerebral electroshock in the mouse. Step-down retention perform …
The effects of oxiracetam and piracetam were compared in learning and memory tests in rats and mice. In the dose range examine …
A decrease in brain catecholamines prevents oxiracetam antagonism of the effects of scopolamine on memory and brain acetylcholine.
Giovannini MG, Spignoli G, Carlà V, Pepeu G. Giovannini MG, et al. Pharmacol Res. 1991 Dec;24(4):395-405. doi: 10.1016/1043-6618(91)90044-x. Pharmacol Res. 1991. PMID: 1805193
The effect of oxiracetam on passive avoidance conditioned response and acetylcholine (ACh) levels in rats with selective lesions of the central monoaminergic pathways was investigated. ...In the rats with degeneration of dopaminergic and noradrenergic but not serotoninergi …
The effect of oxiracetam on passive avoidance conditioned response and acetylcholine (ACh) levels in rats with selective lesions of t …
(S)-Oxiracetam is the Active Ingredient in Oxiracetam that Alleviates the Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats.
Li W, Liu H, Jiang H, Wang C, Guo Y, Sun Y, Zhao X, Xiong X, Zhang X, Zhang K, Nie Z, Pu X. Li W, et al. Sci Rep. 2017 Aug 30;7(1):10052. doi: 10.1038/s41598-017-10283-4. Sci Rep. 2017. PMID: 28855592 Free PMC article.
However, oxiracetam is currently used as a racemic mixture whose effective ingredient has not been identified to date. In this study, we first identified that (S)-oxiracetam, but not (R)-oxiracetam, was the effective ingredient that alleviated the impairments …
However, oxiracetam is currently used as a racemic mixture whose effective ingredient has not been identified to date. In this study, …
Effect of alaptide, its analogues and oxiracetam on memory for an elevated plus-maze in mice.
Hlinák Z, Vinsová J, Kasafírek E. Hlinák Z, et al. Eur J Pharmacol. 1996 Oct 24;314(1-2):1-7. doi: 10.1016/s0014-2999(96)00485-2. Eur J Pharmacol. 1996. PMID: 8957212
Thus, a 10-day inter-session interval was chosen for testing drugs which were expected to enhance memory. In Experiment 2, in the retest performed on day 10, both alaptide (cyclo(L-alanyl-1-amino-1- cyclopentanecarbonyl)) and oxiracetam, given immediately after the …
Thus, a 10-day inter-session interval was chosen for testing drugs which were expected to enhance memory. In Experiment 2, in the ret …
81 results