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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 2
1953 1
1954 3
1955 4
1956 11
1957 3
1958 6
1959 9
1960 12
1961 16
1962 21
1963 23
1964 34
1965 65
1966 140
1967 201
1968 246
1969 268
1970 358
1971 340
1972 400
1973 434
1974 407
1975 468
1976 354
1977 381
1978 323
1979 371
1980 320
1981 293
1982 337
1983 310
1984 363
1985 371
1986 387
1987 325
1988 345
1989 368
1990 430
1991 387
1992 379
1993 347
1994 378
1995 427
1996 458
1997 447
1998 578
1999 576
2000 658
2001 799
2002 902
2003 1040
2004 1158
2005 1316
2006 1365
2007 1588
2008 1608
2009 1783
2010 2034
2011 2105
2012 2340
2013 2707
2014 2818
2015 2913
2016 3133
2017 3258
2018 3458
2019 3702
2020 3973
2021 3880
2022 3123
2023 2931
2024 3760
2025 4503
2026 1463

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69,285 results

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Page 1
Cellular adaptation to hypoxia through hypoxia inducible factors and beyond.
Lee P, Chandel NS, Simon MC. Lee P, et al. Nat Rev Mol Cell Biol. 2020 May;21(5):268-283. doi: 10.1038/s41580-020-0227-y. Epub 2020 Mar 6. Nat Rev Mol Cell Biol. 2020. PMID: 32144406 Free PMC article. Review.
Systemically, these adaptations include increased ventilation, cardiac output, blood vessel growth and circulating red blood cell numbers. On a cellular level, ATP-consuming reactions are suppressed, and metabolism is altered until oxygen homeostasis is restored. .. …
Systemically, these adaptations include increased ventilation, cardiac output, blood vessel growth and circulating red blood cell num …
Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism.
Jain IH, Calvo SE, Markhard AL, Skinner OS, To TL, Ast T, Mootha VK. Jain IH, et al. Cell. 2020 Apr 30;181(3):716-727.e11. doi: 10.1016/j.cell.2020.03.029. Epub 2020 Apr 6. Cell. 2020. PMID: 32259488 Free PMC article.
Knockouts of many mitochondrial pathways thought to be essential, including complex I and enzymes in Fe-S biosynthesis, grow relatively well at low oxygen and thus are buffered by hypoxia. In contrast, in certain cell types, knockout of lipid biosynthetic and peroxi …
Knockouts of many mitochondrial pathways thought to be essential, including complex I and enzymes in Fe-S biosynthesis, grow relatively well …
Kidney physiology and susceptibility to acute kidney injury: implications for renoprotection.
Scholz H, Boivin FJ, Schmidt-Ott KM, Bachmann S, Eckardt KU, Scholl UI, Persson PB. Scholz H, et al. Nat Rev Nephrol. 2021 May;17(5):335-349. doi: 10.1038/s41581-021-00394-7. Epub 2021 Feb 5. Nat Rev Nephrol. 2021. PMID: 33547418 Review.
AKI is often linked to defects in kidney oxygen supply, and some nephron segments might not be able to shift to anaerobic metabolism under low oxygen conditions or might have remarkably low basal oxygen levels, which enhances their vulnerability to damage. .. …
AKI is often linked to defects in kidney oxygen supply, and some nephron segments might not be able to shift to anaerobic metabolism …
High-throughput method for Oxygen Consumption Rate measurement (OCR) in plant mitochondria.
Fuchs H, Malecka A, Budzinska A, Jarmuszkiewicz W, Ciszewska L, Staszak AM, Kijowska-Oberc J, Ratajczak E. Fuchs H, et al. BMC Plant Biol. 2023 Oct 17;23(1):496. doi: 10.1186/s12870-023-04516-0. BMC Plant Biol. 2023. PMID: 37845628 Free PMC article.
Moreover, commercially available kits for high-throughput methods are usually optimized for animal cells and mitochondria. Here, we present a novel method to measure the oxygen consumption rate using a high-throughput assay in isolated mitochondria of Europea …
Moreover, commercially available kits for high-throughput methods are usually optimized for animal cells and mitochondria. Here, we p …
The dependence of brain mitochondria reactive oxygen species production on oxygen level is linear, except when inhibited by antimycin A.
Stepanova A, Konrad C, Manfredi G, Springett R, Ten V, Galkin A. Stepanova A, et al. J Neurochem. 2019 Mar;148(6):731-745. doi: 10.1111/jnc.14654. Epub 2019 Jan 24. J Neurochem. 2019. PMID: 30582748 Free PMC article.
The mitochondrial respiratory chain is considered a major source of ROS; however, there is little agreement on how ROS release depends on oxygen concentration. The rate of H(2) O(2) release by intact brain mitochondria was measured with an Amplex UltraRed assay usin …
The mitochondrial respiratory chain is considered a major source of ROS; however, there is little agreement on how ROS release depends on …
Mitochondria control acute and chronic responses to hypoxia.
McElroy GS, Chandel NS. McElroy GS, et al. Exp Cell Res. 2017 Jul 15;356(2):217-222. doi: 10.1016/j.yexcr.2017.03.034. Epub 2017 Mar 19. Exp Cell Res. 2017. PMID: 28327410 Free PMC article. Review.
Mitochondria account for the majority of oxygen consumption in the cell and have recently been appreciated to serve as signaling organelles required for the initiation or propagation of numerous homeostatic mechanisms. Mitochondria can influence cel …
Mitochondria account for the majority of oxygen consumption in the cell and have recently been appreciated to serve as …
Hypoxic adaptation of mitochondria and its impact on tumor cell function.
Benej M, Papandreou I, Denko NC. Benej M, et al. Semin Cancer Biol. 2024 May;100:28-38. doi: 10.1016/j.semcancer.2024.03.004. Epub 2024 Mar 30. Semin Cancer Biol. 2024. PMID: 38556040 Free PMC article. Review.
Mitochondria are the major sink for oxygen in the cell, consuming it during ATP production. ...This coordinated response delivers physiological flexibility and increased tumor cell robustness during the environmental stress of low oxygen....
Mitochondria are the major sink for oxygen in the cell, consuming it during ATP production. ...This coordinated respons …
Environmental and behavioral regulation of HIF-mitochondria crosstalk.
Burtscher J, Hohenauer E, Burtscher M, Millet GP, Egg M. Burtscher J, et al. Free Radic Biol Med. 2023 Sep;206:63-73. doi: 10.1016/j.freeradbiomed.2023.06.015. Epub 2023 Jun 28. Free Radic Biol Med. 2023. PMID: 37385566 Free article. Review.
Reduced oxygen availability (hypoxia) can lead to cell and organ damage. Therefore, aerobic species depend on efficient mechanisms to counteract detrimental consequences of hypoxia. ...This leads to reduced dependence on oxygen, improved oxygen supply, …
Reduced oxygen availability (hypoxia) can lead to cell and organ damage. Therefore, aerobic species depend on efficient mechan …
Revisiting reactive oxygen species production in hypoxia.
Alva R, Wiebe JE, Stuart JA. Alva R, et al. Pflugers Arch. 2024 Sep;476(9):1423-1444. doi: 10.1007/s00424-024-02986-1. Epub 2024 Jul 3. Pflugers Arch. 2024. PMID: 38955833 Review.
We analyze the different outcomes reported in isolated mitochondria, versus intact cells or whole organisms, and evaluate the reliability of various ROS-detecting tools. Finally, we examine the cell-type and context specificity of oxygen's various effe …
We analyze the different outcomes reported in isolated mitochondria, versus intact cells or whole organisms, and evaluate the reliabi …
Oxygen: the poison is in the dose.
Winslow RM. Winslow RM. Transfusion. 2013 Feb;53(2):424-37. doi: 10.1111/j.1537-2995.2012.03774.x. Epub 2012 Jul 15. Transfusion. 2013. PMID: 22804568 Review.
Cell-free hemoglobin (Hb) has been blamed for a spectrum of problems, including vasoconstriction pancreatitis, myocardial infarction, and pulmonary hypertension in hemolytic anemia, malaria, and sickle cell anemia, and from Hb-based oxygen carriers (HBOCs). . …
Cell-free hemoglobin (Hb) has been blamed for a spectrum of problems, including vasoconstriction pancreatitis, myocardial infarction, …
69,285 results
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