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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
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1994 3
1995 6
1997 2
1998 2
1999 8
2000 5
2001 1
2002 6
2003 1
2004 7
2005 6
2006 2
2007 7
2008 10
2009 11
2010 7
2011 11
2012 12
2013 15
2014 8
2015 8
2016 12
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271 results

Results by year

Filters applied: Randomized Controlled Trial. Clear all
Page 1
The comparison effects of intra-articular injection of Platelet Rich Plasma (PRP), Plasma Rich in Growth Factor (PRGF), Hyaluronic Acid (HA), and ozone in knee osteoarthritis; a one year randomized clinical trial.
Raeissadat SA, Ghazi Hosseini P, Bahrami MH, Salman Roghani R, Fathi M, Gharooee Ahangar A, Darvish M. Raeissadat SA, et al. BMC Musculoskelet Disord. 2021 Feb 3;22(1):134. doi: 10.1186/s12891-021-04017-x. BMC Musculoskelet Disord. 2021. PMID: 33536010 Free PMC article. Clinical Trial.

At the end of the 12th month, only PRGF and PRP groups had better results versus HA and ozone groups in all scores (P < 0.05). Despite the fact that ozone showed better early results, its effects begin to wear off earlier than other products and ultimately disapp

…

At the end of the 12th month, only PRGF and PRP groups had better results versus HA and ozone groups in all scores (P < 0.05). Des

…
Topical ozone therapy restores microbiome diversity in atopic dermatitis.
Zeng J, Dou J, Gao L, Xiang Y, Huang J, Ding S, Chen J, Zeng Q, Luo Z, Tan W, Lu J. Zeng J, et al. Int Immunopharmacol. 2020 Mar;80:106191. doi: 10.1016/j.intimp.2020.106191. Epub 2020 Jan 24. Int Immunopharmacol. 2020. PMID: 31986325 Free article. Clinical Trial.
Randomized split sides were performed. One side was treated with ozone hydrotherapy followed by ozonated oil; while the contralateral side with tap water and basal oil. ...The proportion of S. aureus in AD lesions was positively correlated with the severity of AD (r …
Randomized split sides were performed. One side was treated with ozone hydrotherapy followed by ozonated oil; while the contra …
The effects of ozone therapy on periodontal therapy: A randomized placebo-controlled clinical trial.
Tasdemir Z, Oskaybas MN, Alkan AB, Cakmak O. Tasdemir Z, et al. Oral Dis. 2019 May;25(4):1195-1202. doi: 10.1111/odi.13060. Epub 2019 Mar 3. Oral Dis. 2019. PMID: 30739369 Clinical Trial.
OBJECTIVES: The aim of this randomized split-mouth clinical trial was to evaluate the effects of ozone therapy on clinical and biochemical parameters of moderate to severe generalized periodontitis patients after non-surgical periodontal therapy. ...Only the …
OBJECTIVES: The aim of this randomized split-mouth clinical trial was to evaluate the effects of ozone therapy on clinical and …
Comparison of intracanal ozone and low-level laser therapy on postoperative pain in vital teeth with symptomatic apical periodontitis:placebo-controlled randomize trial.
Sağlam H, Aladağ H. Sağlam H, et al. Lasers Med Sci. 2023 Sep 30;38(1):227. doi: 10.1007/s10103-023-03881-4. Lasers Med Sci. 2023. PMID: 37776342 Clinical Trial.
The aim of this study was to compare the effect of ozone and low-level-laser therapy (LLLT) on postoperative pain after root canal treatment in symptomatic apical periodontitis on vital teeth. Eighty patients were divided into four groups using a web program as foll …
The aim of this study was to compare the effect of ozone and low-level-laser therapy (LLLT) on postoperative pain after root c …
Effectiveness of ultrasonography-guided periforaminal oxygen-ozone therapy in chronic low back pain.
Ülgen Kiratlioğlu E, Tezel K, Gürçay E. Ülgen Kiratlioğlu E, et al. Turk J Med Sci. 2025 Apr 24;55(3):676-686. doi: 10.55730/1300-0144.6015. eCollection 2025. Turk J Med Sci. 2025. PMID: 40686713 Free PMC article. Clinical Trial.
The aim of this study, which was planned based on the idea that periforaminal oxygen-ozone (O2-O3) gas application with ultrasonography (USG) could be an alternative treatment option, was to compare the therapeutic efficacy of USG-guided periforaminal ozone infiltra …
The aim of this study, which was planned based on the idea that periforaminal oxygen-ozone (O2-O3) gas application with ultrasonograp …
Comparing the efficacy of combining ozone therapy with hyaluronic acid versus using hyaluronic acid alone for pain relief in patients with knee osteoarthritis: A randomized clinical trial.
Akhavanakbari G, Asayeshi M, Noktehsanj R, Aslani MR. Akhavanakbari G, et al. Complement Ther Med. 2025 Oct;93:103238. doi: 10.1016/j.ctim.2025.103238. Epub 2025 Aug 25. Complement Ther Med. 2025. PMID: 40865738 Free article. Clinical Trial.
BACKGROUND: There is growing interest in the therapeutic application of ozone (OZ) and hyaluronic acid (HA) for individuals suffering from osteoarthritis. This randomized trial aimed to assess the effectiveness of HA versus a mixture of OZ and HA in alleviating pain for pa …
BACKGROUND: There is growing interest in the therapeutic application of ozone (OZ) and hyaluronic acid (HA) for individuals suffering …
Ozone Therapy versus Hyaluronic Acid Injections for Pain Relief in Patients with Knee Osteoarthritis: Preliminary Findings on Molecular and Clinical Outcomes from a Randomized Controlled Trial.
Sconza C, Di Matteo B, Queirazza P, Dina A, Amenta R, Respizzi S, Massazza G, Ammendolia A, Kon E, de Sire A. Sconza C, et al. Int J Mol Sci. 2023 May 15;24(10):8788. doi: 10.3390/ijms24108788. Int J Mol Sci. 2023. PMID: 37240135 Free PMC article. Clinical Trial.
Ozone therapy (OT) is used for the treatment of multiple musculoskeletal disorders. In recent years, there has been a growing interest in its use for the treatment of osteoarthritis (OA). ...Due to its anti-inflammatory and analgesic effects, ozone might be c …
Ozone therapy (OT) is used for the treatment of multiple musculoskeletal disorders. In recent years, there has been a growing …
Ozone therapy versus surgery for lumbar disc herniation: A randomized double-blind controlled trial.
Clavo B, Robaina F, Urrutia G, Bisshopp S, Ramallo Y, Szolna A, Caramés MA, Fiuza MD, Linertová R. Clavo B, et al. Complement Ther Med. 2021 Jun;59:102724. doi: 10.1016/j.ctim.2021.102724. Epub 2021 May 5. Complement Ther Med. 2021. PMID: 33964405 Free article. Clinical Trial.
Several studies have suggested the potential utility of intradiscal ozone infiltration in this pathology. The aim of this trial was to compare intradiscal ozone infiltration vs. oxygen infiltration vs. surgery. ...There were three treatment groups: surgery; intradis …
Several studies have suggested the potential utility of intradiscal ozone infiltration in this pathology. The aim of this trial was t …
The Gaseous Ozone Therapy as a Promising Antiseptic Adjuvant of Periodontal Treatment: A Randomized Controlled Clinical Trial.
Rapone B, Ferrara E, Santacroce L, Topi S, Gnoni A, Dipalma G, Mancini A, Di Domenico M, Tartaglia GM, Scarano A, Inchingolo F. Rapone B, et al. Int J Environ Res Public Health. 2022 Jan 16;19(2):985. doi: 10.3390/ijerph19020985. Int J Environ Res Public Health. 2022. PMID: 35055807 Free PMC article. Clinical Trial.
Then, we hypothesized that the adjunct of gaseous ozone therapy to standard periodontal treatment may be leveraged to promote the tissue healing response. ...Forty-five patients were randomized to receive scaling and root-planning (SRP) used as conventional non-surg …
Then, we hypothesized that the adjunct of gaseous ozone therapy to standard periodontal treatment may be leveraged to promote …
Effect of ozone therapy on post-operative pain following mandibular third molar surgical extraction: a split-mouth randomized clinical trial.
Guaschino L, Vanzanelli A, Babando P, Ricotti A, Ramieri GA, Roccuzzo A, Appendino P. Guaschino L, et al. Clin Oral Investig. 2025 Dec 9;30(1):2. doi: 10.1007/s00784-025-06681-y. Clin Oral Investig. 2025. PMID: 41361069 Free PMC article. Clinical Trial.
OBJECTIVES: To evaluate the efficacy of ozone therapy on pain reduction, trisma and number of analgesic tablets taken following surgical removal of impacted mandibular third molar. ...Test sites were treated with adjunctive ozone therapy to the surgica …
OBJECTIVES: To evaluate the efficacy of ozone therapy on pain reduction, trisma and number of analgesic tablets taken followin …
271 results