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Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
Coffee and Caffeine Genetics Consortium; Cornelis MC, Byrne EM, Esko T, Nalls MA, Ganna A, Paynter N, Monda KL, Amin N, Fischer K, Renstrom F, Ngwa JS, Huikari V, Cavadino A, Nolte IM, Teumer A, Yu K, Marques-Vidal P, Rawal R, Manichaikul A, Wojczynski MK, Vink JM, Zhao JH, Burlutsky G, Lahti J, Mikkilä V, Lemaitre RN, Eriksson J, Musani SK, Tanaka T, Geller F, Luan J, Hui J, Mägi R, Dimitriou M, Garcia ME, Ho WK, Wright MJ, Rose LM, Magnusson PK, Pedersen NL, Couper D, Oostra BA, Hofman A, Ikram MA, Tiemeier HW, Uitterlinden AG, van Rooij FJ, Barroso I, Johansson I, Xue L, Kaakinen M, Milani L, Power C, Snieder H, Stolk RP, Baumeister SE, Biffar R, Gu F, Bastardot F, Kutalik Z, Jacobs DR Jr, Forouhi NG, Mihailov E, Lind L, Lindgren C, Michaëlsson K, Morris A, Jensen M, Khaw KT, Luben RN, Wang JJ, Männistö S, Perälä MM, Kähönen M, Lehtimäki T, Viikari J, Mozaffarian D, Mukamal K, Psaty BM, Döring A, Heath AC, Montgomery GW, Dahmen N, Carithers T, Tucker KL, Ferrucci L, Boyd HA, Melbye M, Treur JL, Mellström D, Hottenga JJ, Prokopenko I, Tönjes A, Deloukas P, Kanoni S, Lorentzon M, Houston DK, Liu Y, Danesh J, Rasheed A, Mason MA, Zonderman AB, Franke L, Kristal BS; Internat… See abstract for full author list ➔ Coffee and Caffeine Genetics Consortium, et al. Among authors: mikkila v. Mol Psychiatry. 2015 May;20(5):647-656. doi: 10.1038/mp.2014.107. Epub 2014 Oct 7. Mol Psychiatry. 2015. PMID: 25288136 Free PMC article. Review.
SNP alleles near GCKR, MLXIPL, BDNF and CYP1A2 that were associated with higher coffee consumption have previously been associated with smoking initiation, higher adiposity and fasting insulin and glucose but lower blood pressure and favorable lipid, inflammatory and liver enzyme …
SNP alleles near GCKR, MLXIPL, BDNF and CYP1A2 that were associated with higher coffee consumption have previously been associated with smok …
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
Jiang X, O'Reilly PF, Aschard H, Hsu YH, Richards JB, Dupuis J, Ingelsson E, Karasik D, Pilz S, Berry D, Kestenbaum B, Zheng J, Luan J, Sofianopoulou E, Streeten EA, Albanes D, Lutsey PL, Yao L, Tang W, Econs MJ, Wallaschofski H, Völzke H, Zhou A, Power C, McCarthy MI, Michos ED, Boerwinkle E, Weinstein SJ, Freedman ND, Huang WY, Van Schoor NM, van der Velde N, Groot LCPGM, Enneman A, Cupples LA, Booth SL, Vasan RS, Liu CT, Zhou Y, Ripatti S, Ohlsson C, Vandenput L, Lorentzon M, Eriksson JG, Shea MK, Houston DK, Kritchevsky SB, Liu Y, Lohman KK, Ferrucci L, Peacock M, Gieger C, Beekman M, Slagboom E, Deelen J, Heemst DV, Kleber ME, März W, de Boer IH, Wood AC, Rotter JI, Rich SS, Robinson-Cohen C, den Heijer M, Jarvelin MR, Cavadino A, Joshi PK, Wilson JF, Hayward C, Lind L, Michaëlsson K, Trompet S, Zillikens MC, Uitterlinden AG, Rivadeneira F, Broer L, Zgaga L, Campbell H, Theodoratou E, Farrington SM, Timofeeva M, Dunlop MG, Valdes AM, Tikkanen E, Lehtimäki T, Lyytikäinen LP, Kähönen M, Raitakari OT, Mikkilä V, Ikram MA, Sattar N, Jukema JW, Wareham NJ, Langenberg C, Forouhi NG, Gundersen TE, Khaw KT, Butterworth AS, Danesh J, Spector T, Wang TJ, Hyppönen E, Kraft P, Kie… See abstract for full author list ➔ Jiang X, et al. Among authors: mikkila v. Nat Commun. 2018 Jan 17;9(1):260. doi: 10.1038/s41467-017-02662-2. Nat Commun. 2018. PMID: 29343764 Free PMC article.
This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.710(-9) at rs8018720 in SEC23A, and P = 1.910(-14) at rs10745742 in AMDHD1). The overall estimate of heritability of 25-hydroxyvitamin D serum concentrations attributable t …
This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.710(-9) at rs8018720 in SEC23A, and …
Top-quality embryo transfer is associated with lower odds of ectopic pregnancy.
Anzhel S, Mäkinen S, Tinkanen H, Mikkilä T, Haltia A, Perheentupa A, Tomás C, Martikainen H, Tiitinen A, Tapanainen JS, Veleva Z. Anzhel S, et al. Among authors: mikkila t. Acta Obstet Gynecol Scand. 2022 Jul;101(7):779-786. doi: 10.1111/aogs.14375. Epub 2022 May 11. Acta Obstet Gynecol Scand. 2022. PMID: 35546786 Free PMC article.
There was no significant difference in ectopic pregnancy rate after fresh embryo transfer and frozen embryo transfer (2.2% vs 2.4%, p = 0.3). The ectopic pregnancy rate was lower in cycles with top-quality embryo transfer (1.9%) than of those where only non-top quality emb …
There was no significant difference in ectopic pregnancy rate after fresh embryo transfer and frozen embryo transfer (2.2% vs 2.4%, p …
FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals.
Qi Q, Kilpeläinen TO, Downer MK, Tanaka T, Smith CE, Sluijs I, Sonestedt E, Chu AY, Renström F, Lin X, Ängquist LH, Huang J, Liu Z, Li Y, Asif Ali M, Xu M, Ahluwalia TS, Boer JM, Chen P, Daimon M, Eriksson J, Perola M, Friedlander Y, Gao YT, Heppe DH, Holloway JW, Houston DK, Kanoni S, Kim YM, Laaksonen MA, Jääskeläinen T, Lee NR, Lehtimäki T, Lemaitre RN, Lu W, Luben RN, Manichaikul A, Männistö S, Marques-Vidal P, Monda KL, Ngwa JS, Perusse L, van Rooij FJ, Xiang YB, Wen W, Wojczynski MK, Zhu J, Borecki IB, Bouchard C, Cai Q, Cooper C, Dedoussis GV, Deloukas P, Ferrucci L, Forouhi NG, Hansen T, Christiansen L, Hofman A, Johansson I, Jørgensen T, Karasawa S, Khaw KT, Kim MK, Kristiansson K, Li H, Lin X, Liu Y, Lohman KK, Long J, Mikkilä V, Mozaffarian D, North K, Pedersen O, Raitakari O, Rissanen H, Tuomilehto J, van der Schouw YT, Uitterlinden AG, Zillikens MC, Franco OH, Shyong Tai E, Ou Shu X, Siscovick DS, Toft U, Verschuren WM, Vollenweider P, Wareham NJ, Witteman JC, Zheng W, Ridker PM, Kang JH, Liang L, Jensen MK, Curhan GC, Pasquale LR, Hunter DJ, Mohlke KL, Uusitupa M, Cupples LA, Rankinen T, Orho-Melander M, Wang T, Chasman DI, Franks PW, Sørensen TI, Hu FB, Loos … See abstract for full author list ➔ Qi Q, et al. Among authors: mikkila v. Hum Mol Genet. 2014 Dec 20;23(25):6961-72. doi: 10.1093/hmg/ddu411. Epub 2014 Aug 7. Hum Mol Genet. 2014. PMID: 25104851 Free PMC article.
The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] %, P = 2.4 10(-16)), and relative weak associations with lower total energy intake (-6.4 [-10.1, -2.6] kcal/day, P …
The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [ …
Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits.
Dashti HS, Follis JL, Smith CE, Tanaka T, Garaulet M, Gottlieb DJ, Hruby A, Jacques PF, Kiefte-de Jong JC, Lamon-Fava S, Scheer FA, Bartz TM, Kovanen L, Wojczynski MK, Frazier-Wood AC, Ahluwalia TS, Perälä MM, Jonsson A, Muka T, Kalafati IP, Mikkilä V, Ordovás JM; CHARGE Nutrition Study Group. Dashti HS, et al. Among authors: mikkila v. Diabetes Care. 2015 Aug;38(8):1456-66. doi: 10.2337/dc14-2709. Epub 2015 Jun 17. Diabetes Care. 2015. PMID: 26084345 Free PMC article.

However, we observed nominally significant interactions (all P < 0.01) between carbohydrate intake and MTNR1B-rs1387153 for FG with a 0.003 mmol/L higher FG with each additional 1% carbohydrate intake in the presence of the T allele, between sleep duration and CRY2-rs11

…

However, we observed nominally significant interactions (all P < 0.01) between carbohydrate intake and MTNR1B-rs1387153 for FG wit

…
Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent.
Smith CE, Follis JL, Dashti HS, Tanaka T, Graff M, Fretts AM, Kilpeläinen TO, Wojczynski MK, Richardson K, Nalls MA, Schulz CA, Liu Y, Frazier-Wood AC, van Eekelen E, Wang C, de Vries PS, Mikkilä V, Rohde R, Psaty BM, Hansen T, Feitosa MF, Lai CQ, Houston DK, Ferruci L, Ericson U, Wang Z, de Mutsert R, Oddy WH, de Jonge EAL, Seppälä I, Justice AE, Lemaitre RN, Sørensen TIA, Province MA, Parnell LD, Garcia ME, Bandinelli S, Orho-Melander M, Rich SS, Rosendaal FR, Pennell CE, Kiefte-de Jong JC, Kähönen M, Young KL, Pedersen O, Aslibekyan S, Rotter JI, Mook-Kanamori DO, Zillikens MC, Raitakari OT, North KE, Overvad K, Arnett DK, Hofman A, Lehtimäki T, Tjønneland A, Uitterlinden AG, Rivadeneira F, Franco OH, German JB, Siscovick DS, Cupples LA, Ordovás JM. Smith CE, et al. Among authors: mikkila v. Mol Nutr Food Res. 2018 Feb;62(3):10.1002/mnfr.201700347. doi: 10.1002/mnfr.201700347. Epub 2017 Dec 11. Mol Nutr Food Res. 2018. PMID: 28941034 Free PMC article.
Twenty-six genetic variants reached the selected significance threshold (p-interaction <10(-7)) , and six independent variants (LINC01512-rs7751666, PALM2/AKAP2-rs914359, ACTA2-rs1388, PPP1R12A-rs7961195, LINC00333-rs9635058, AC098847.1-rs1791355) were evaluated meta-an …
Twenty-six genetic variants reached the selected significance threshold (p-interaction <10(-7)) , and six independent variants (LI …
Pesticide Residue Fast Screening Using Thermal Desorption Multi-Scheme Chemical Ionization Mass Spectrometry (TD-MION MS) with Selective Chemical Ionization.
Partovi F, Mikkilä J, Iyer S, Mikkilä J, Kontro J, Ojanperä S, Juuti P, Kangasluoma J, Shcherbinin A, Rissanen M. Partovi F, et al. Among authors: mikkila j. ACS Omega. 2023 Jul 15;8(29):25749-25757. doi: 10.1021/acsomega.3c00385. eCollection 2023 Jul 25. ACS Omega. 2023. PMID: 37521638 Free PMC article.
Potential of phosphorus recovery from sewage sludge and manure ash by thermochemical treatment.
Havukainen J, Nguyen MT, Hermann L, Horttanainen M, Mikkilä M, Deviatkin I, Linnanen L. Havukainen J, et al. Among authors: mikkila m. Waste Manag. 2016 Mar;49:221-229. doi: 10.1016/j.wasman.2016.01.020. Epub 2016 Jan 22. Waste Manag. 2016. PMID: 26810030
All life forms require phosphorus (P), which has no substitute in food production. The risk of phosphorus loss from soil and limited P rock reserves has led to the development of recycling P from industrial residues. ...An ASH DEC plant could receive 46-76 kt …
All life forms require phosphorus (P), which has no substitute in food production. The risk of phosphorus loss from soil and limited …
Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts.
Würtz P, Havulinna AS, Soininen P, Tynkkynen T, Prieto-Merino D, Tillin T, Ghorbani A, Artati A, Wang Q, Tiainen M, Kangas AJ, Kettunen J, Kaikkonen J, Mikkilä V, Jula A, Kähönen M, Lehtimäki T, Lawlor DA, Gaunt TR, Hughes AD, Sattar N, Illig T, Adamski J, Wang TJ, Perola M, Ripatti S, Vasan RS, Raitakari OT, Gerszten RE, Casas JP, Chaturvedi N, Ala-Korpela M, Salomaa V. Würtz P, et al. Among authors: mikkila v. Circulation. 2015 Mar 3;131(9):774-85. doi: 10.1161/CIRCULATIONAHA.114.013116. Epub 2015 Jan 8. Circulation. 2015. PMID: 25573147 Free PMC article.
In targeted analyses of 68 lipids and metabolites, 33 measures were associated with incident cardiovascular events at P<0.0007 after adjusting for age, sex, blood pressure, smoking, diabetes mellitus, and medication. When further adjusting for routine lipids, 4 metaboli …
In targeted analyses of 68 lipids and metabolites, 33 measures were associated with incident cardiovascular events at P<0.0007 aft …
74 results