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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1962 2
1967 2
1968 4
1969 2
1970 7
1971 1
1972 1
1973 4
1974 2
1975 13
1976 6
1977 5
1978 3
1979 8
1980 3
1981 2
1982 6
1983 5
1984 5
1985 4
1986 5
1987 2
1988 4
1989 7
1990 10
1991 7
1992 8
1993 5
1994 12
1995 14
1996 21
1997 10
1998 18
1999 23
2000 37
2001 44
2002 38
2003 52
2004 44
2005 70
2006 75
2007 90
2008 83
2009 79
2010 102
2011 114
2012 150
2013 138
2014 140
2015 199
2016 176
2017 200
2018 216
2019 234
2020 265
2021 288
2022 317
2023 90
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3,026 results
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P-Coumaric Acid Reverses Depression-Like Behavior and Memory Deficit Via Inhibiting AGE-RAGE-Mediated Neuroinflammation.
Yu XD, Zhang D, Xiao CL, Zhou Y, Li X, Wang L, He Z, Reilly J, Xiao ZY, Shu X. Yu XD, et al. Cells. 2022 May 10;11(10):1594. doi: 10.3390/cells11101594. Cells. 2022. PMID: 35626632 Free PMC article.
Depression, a mood disorder, affects one in fifteen adults, has multiple risk factors and is associated with complicated underlying pathological mechanisms. P-coumaric acid (p-CA), a phenolic acid, is widely distributed in vegetables, fruits and …
Depression, a mood disorder, affects one in fifteen adults, has multiple risk factors and is associated with complicated underlying patholog …
p-Coumaric acid and its conjugates: dietary sources, pharmacokinetic properties and biological activities.
Pei K, Ou J, Huang J, Ou S. Pei K, et al. J Sci Food Agric. 2016 Jul;96(9):2952-62. doi: 10.1002/jsfa.7578. Epub 2016 Jan 25. J Sci Food Agric. 2016. PMID: 26692250 Review.
p-Coumaric acid (4-hydroxycinnamic acid) is a phenolic acid that has low toxicity in mice (LD50 = 2850 mg kg(-1) body weight), serves as a precursor of other phenolic compounds, and exists either in free or conjugated form in plants. Conjugates …
p-Coumaric acid (4-hydroxycinnamic acid) is a phenolic acid that has low toxicity in mice (LD50 = 2850 mg …
p-Coumaric acid attenuates high-fat diet-induced oxidative stress and nephropathy in diabetic rats.
Mani A, Kushwaha K, Khurana N, Gupta J. Mani A, et al. J Anim Physiol Anim Nutr (Berl). 2022 Jul;106(4):872-880. doi: 10.1111/jpn.13645. Epub 2021 Oct 1. J Anim Physiol Anim Nutr (Berl). 2022. PMID: 34596925
The aim of this study is to analyse the protective effects of p-coumaric acid against diabetes-induced oxidative stress and nephropathy in high-fat diet-induced diabetic rats. The oral feeding of p-coumaric acid (20 mg/kg for 12 weeks) wa …
The aim of this study is to analyse the protective effects of p-coumaric acid against diabetes-induced oxidative stress …
p-Coumaric acid alleviates cisplatin-induced ovarian toxicity in rats.
Ayazoglu Demir E, Mentese A, Kucuk H, Turkmen Alemdar N, Demir S. Ayazoglu Demir E, et al. J Obstet Gynaecol Res. 2022 Feb;48(2):411-419. doi: 10.1111/jog.15119. Epub 2021 Dec 7. J Obstet Gynaecol Res. 2022. PMID: 34877753
The effect of natural phenolic acids in the prevention of many diseases related to oxidative stress has been reported. Here, the ability of p-coumaric (pCA) acid, a member of phenolic acids, to protect rat ovary tissue against CDDP-induced oxidative stress wa …
The effect of natural phenolic acids in the prevention of many diseases related to oxidative stress has been reported. Here, the ability of …
Intensification of p-coumaric acid heterologous production using extractive biphasic fermentation.
Combes J, Imatoukene N, Couvreur J, Godon B, Brunissen F, Fojcik C, Allais F, Lopez M. Combes J, et al. Bioresour Technol. 2021 Oct;337:125436. doi: 10.1016/j.biortech.2021.125436. Epub 2021 Jun 19. Bioresour Technol. 2021. PMID: 34182346
p-coumaric acid (p-CA) can be produced from D-glucose by an engineered S. cerevisiae strain. p-CA has antimicrobial properties and retro-inhibition activity. Moreover, p-CA is a hydrophobic compound, limiting its accumulation in fermentat …
p-coumaric acid (p-CA) can be produced from D-glucose by an engineered S. cerevisiae strain. p-CA has ant …
p-Coumaric acid mitigates lipopolysaccharide induced brain damage via alleviating oxidative stress, inflammation and apoptosis.
Daroi PA, Dhage SN, Juvekar AR. Daroi PA, et al. J Pharm Pharmacol. 2022 Apr 20;74(4):556-564. doi: 10.1093/jpp/rgab077. J Pharm Pharmacol. 2022. PMID: 34190326
OBJECTIVES: Systemic administration of lipopolysaccharide induces neuroinflammation leading to cognitive deficit and memory impairment. Herein, we investigated the effects of p-Coumaric acid (PCA) in LPS induced neuroinflammation in mice. ...METHODS: Mice rec …
OBJECTIVES: Systemic administration of lipopolysaccharide induces neuroinflammation leading to cognitive deficit and memory impairment. Here …
Identification of p-Coumaric Acid and Ethyl p-Coumarate as the Main Phenolic Components of Hemp (Cannabis sativa L.) Roots.
Oh CM, Choi JY, Bae IA, Kim HT, Hong SS, Noah JK, Boo YC. Oh CM, et al. Molecules. 2022 Apr 27;27(9):2781. doi: 10.3390/molecules27092781. Molecules. 2022. PMID: 35566134 Free PMC article.
For comparative purposes, ethyl p-coumarate was also chemically synthesized by the esterification reaction of p-coumaric acid. The content of p-coumaric acid and ethyl p-coumarate in the total extract of hemp root was estima …
For comparative purposes, ethyl p-coumarate was also chemically synthesized by the esterification reaction of p-coumaric …
P-coumaric acid ameliorates fipronil induced liver injury in mice through attenuation of structural changes, oxidative stress and inflammation.
Bal SS, Leishangthem GD, Sethi RS, Singh A. Bal SS, et al. Pestic Biochem Physiol. 2022 Jan;180:104997. doi: 10.1016/j.pestbp.2021.104997. Epub 2021 Nov 22. Pestic Biochem Physiol. 2022. PMID: 34955181
Due to its widespread use and bioaccumulation in the environment, it possesses significant threat to human and animals. P-coumaric acid is a natural dietary polyphenolic compound that has anti-oxidant and anti-inflammatory property. ...Thus p-coumar …
Due to its widespread use and bioaccumulation in the environment, it possesses significant threat to human and animals. P-coumaric …
p-Coumaric acid regulates macrophage polarization in myocardial ischemia/reperfusion by promoting the expression of indoleamine 2, 3-dioxygenase.
Li N, Guo X, Li R, Zhou J, Yu F, Yan X. Li N, et al. Bioengineered. 2021 Dec;12(2):10971-10981. doi: 10.1080/21655979.2021.2001924. Bioengineered. 2021. PMID: 34738873 Free PMC article.
Macrophage infiltration is a hallmark pathological change observed in early stage myocardial ischemia/reperfusion (MI/R) injury and one of the main causes of myocardial damage. Here, we investigated the effects of p-Coumaric acid (p-CA) on macrophage p …
Macrophage infiltration is a hallmark pathological change observed in early stage myocardial ischemia/reperfusion (MI/R) injury and one of t …
Protective effects of p-coumaric acid against gentamicin-induced nephrotoxicity in rats.
Hakyemez IN, Cevizci MN, Aksoz E, Yilmaz K, Uysal S, Altun E. Hakyemez IN, et al. Drug Chem Toxicol. 2022 Nov;45(6):2825-2832. doi: 10.1080/01480545.2021.1993703. Epub 2021 Oct 26. Drug Chem Toxicol. 2022. PMID: 34702126
The most important side effect of gentamicin (GM) is nephrotoxicity. p-Coumaric acid (PCA) is a phenolic compound that scavenges free radicals, reduces fibrosis, and tissue damage. ...
The most important side effect of gentamicin (GM) is nephrotoxicity. p-Coumaric acid (PCA) is a phenolic compound that …
3,026 results