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Page 1
P-MAPA, a Fungi-Derived Immunomodulatory Compound, Induces a Proinflammatory Response in a Human Whole Blood Model.
Gonçalves MT, Squaiella-Baptistão CC, Pidde G, Lopes PH, da Silva Nunes I, Tambourgi DV. Gonçalves MT, et al. Mediators Inflamm. 2020 Nov 24;2020:8831389. doi: 10.1155/2020/8831389. eCollection 2020. Mediators Inflamm. 2020. PMID: 33299378 Free PMC article.
P-MAPA induced complement activation in human blood, detected by increased levels of C3a, C5a, and SC5b-9 in plasma. ...Complement inhibition with compstatin showed that P-MAPA-induced complement activation drives modulation of C5aR, but not of CD11b, …
P-MAPA induced complement activation in human blood, detected by increased levels of C3a, C5a, and SC5b-9 in plasma. ...Comple …
P-MAPA activates TLR2 and TLR4 signaling while its combination with IL-12 stimulates CD4+ and CD8+ effector T cells in ovarian cancer.
Silveira HS, Lupi LA, Romagnoli GG, Kaneno R, da Silva Nunes I, Fávaro WJ, de Almeida Chuffa LG. Silveira HS, et al. Life Sci. 2020 Aug 1;254:117786. doi: 10.1016/j.lfs.2020.117786. Epub 2020 May 18. Life Sci. 2020. PMID: 32433918 Free article.
MAIN METHODS: OCs were induced with 7,12-dimethylbenz(a)anthracene into the ovarian bursa, and the animals were given P-MAPA (5 mg/kg bw., i.p., twice a week), or IL-12 (300 ng/kg bw., i.p., one a week) for 60 days, or both P-MAPA and IL-12. ...Regardi …
MAIN METHODS: OCs were induced with 7,12-dimethylbenz(a)anthracene into the ovarian bursa, and the animals were given P-MAPA ( …
The P-MAPA Immunomodulator Partially Prevents Apoptosis Induced by Zika Virus Infection in THP-1 Cells.
Lima MC, Azevedo EAN, de Morais CNL, de Sousa LIO, Carvalho BM, da Silva IN, Franca RFO. Lima MC, et al. Curr Pharm Biotechnol. 2021;22(4):514-522. doi: 10.2174/1389201021666200602140005. Curr Pharm Biotechnol. 2021. PMID: 32484769
Despite the magnitude of recent outbreaks, there is no specific therapy to prevent or to alleviate disease pathology. OBJECTIVE: To investigate the role of P-MAPA immunomodulator in Zika-infected THP-1 cells. METHODS: THP-1 cells were subjected to Zika virus infecti …
Despite the magnitude of recent outbreaks, there is no specific therapy to prevent or to alleviate disease pathology. OBJECTIVE: To investig …
P-MAPA and IL-12 Differentially Regulate Proteins Associated with Ovarian Cancer Progression: A Proteomic Study.
Júnior LAL, Cucielo MS, Domeniconi RF, Dos Santos LD, Silveira HS, da Silva Nunes I, Martinez M, Martinez FE, Fávaro WJ, Chuffa LGA. Júnior LAL, et al. ACS Omega. 2019 Dec 11;4(26):21761-21777. doi: 10.1021/acsomega.9b02512. eCollection 2019 Dec 24. ACS Omega. 2019. PMID: 31891054 Free PMC article.
Herein, the effects of the protein aggregate magnesium-ammonium phospholinoleate-palmitoleate anhydride, known as P-MAPA, and the human recombinant interleukin-12 (hrIL-12) were tested alone or in combination in human SKOV-3 cells. ...These findings suggest that …
Herein, the effects of the protein aggregate magnesium-ammonium phospholinoleate-palmitoleate anhydride, known as P-MAPA, and …
P-MAPA and Interleukin-12 Reduce Cell Migration/Invasion and Attenuate the Toll-Like Receptor-Mediated Inflammatory Response in Ovarian Cancer SKOV-3 Cells: A Preliminary Study.
Lupi LA, Delella FK, Cucielo MS, Romagnoli GG, Kaneno R, Nunes IDS, Domeniconi RF, Martinez M, Martinez FE, Fávaro WJ, Chuffa LGA. Lupi LA, et al. Molecules. 2019 Dec 18;25(1):5. doi: 10.3390/molecules25010005. Molecules. 2019. PMID: 31861351 Free PMC article.
P-MAPA and IL-12 showed cancer cell toxicity under low doses after 48 h. Although apoptosis/necrosis and the cell cycle were unchanged by the treatments, P-MAPA enhanced the sensitivity to paclitaxel (PTX) and P-MAPA associated with IL-12 …
P-MAPA and IL-12 showed cancer cell toxicity under low doses after 48 h. Although apoptosis/necrosis and the cell cycle were u …
P-mapa, a promisor immunomodulator against tumor cells of colonic tissues: An investigation of the action mechanism over the TLR4 signaling pathway.
Socca EAR, Reis SK, Genaro SC, Leite SK, Reis IB, Bockëlmann PK, Durán N, Fávaro WJ. Socca EAR, et al. Life Sci. 2020 Feb 1;242:117185. doi: 10.1016/j.lfs.2019.117185. Epub 2019 Dec 18. Life Sci. 2020. PMID: 31862453 Free article.
The present results show the immunomodulatory properties of P-mapa in chemically induced CRC model. P-mapa induced a significant increase in Type-I IFNs synthesis and subsequently immune cell recruitment, resulting in an increase of IFNgamma concentrat …
The present results show the immunomodulatory properties of P-mapa in chemically induced CRC model. P-mapa induc …
P-MAPA immunotherapy potentiates the effect of cisplatin on serous ovarian carcinoma through targeting TLR4 signaling.
de Almeida Chuffa LG, de Moura Ferreira G, Lupi LA, da Silva Nunes I, Fávaro WJ. de Almeida Chuffa LG, et al. J Ovarian Res. 2018 Jan 17;11(1):8. doi: 10.1186/s13048-018-0380-5. J Ovarian Res. 2018. PMID: 29343281 Free PMC article.
RESULTS: Although CIS therapy was more effective than P-MAPA in reducing the tumor size, P-MAPA immunotherapy significantly increased the expressions of TLR2 and TLR4. More importantly, the combination of P-MAPA with CIS showed a greater …
RESULTS: Although CIS therapy was more effective than P-MAPA in reducing the tumor size, P-MAPA immunotherapy si …
In vitro and in vivo effects of P-MAPA immunomodulator on schistosomiasis.
Silva JCS, Lins CRB, Lacerda SS, Ramos REM, Araújo HDA, Melo-Junior MR, Alves LC, Brayner FA, Nunes IS, Melo FL, Carvalho BM. Silva JCS, et al. Acta Trop. 2021 Jun;218:105909. doi: 10.1016/j.actatropica.2021.105909. Epub 2021 Mar 28. Acta Trop. 2021. PMID: 33789153
In vitro, P-MAPA (5, 50, and 100 g/mL) damaged the Schistosoma mansoni tegument, causing thorn losses and tuber destruction in male worms and peeling and erosion in females after 24-h incubation. In vivo, P-MAPA (5 and 100 mg/kg, alone and combined wit …
In vitro, P-MAPA (5, 50, and 100 g/mL) damaged the Schistosoma mansoni tegument, causing thorn losses and tuber destruction in …
Effects of P-MAPA Immunomodulator on Toll-Like Receptors and p53: Potential Therapeutic Strategies for Infectious Diseases and Cancer.
Fávaro WJ, Nunes OS, Seiva FR, Nunes IS, Woolhiser LK, Durán N, Lenaerts AJ. Fávaro WJ, et al. Infect Agent Cancer. 2012 Jun 18;7(1):14. doi: 10.1186/1750-9378-7-14. Infect Agent Cancer. 2012. PMID: 22709446 Free PMC article.
RESULTS: The results showed that P-MAPA, administered alone or in combination with MXF, induced significant responses in vivo against TB. In contrast, the compound did not show antimicrobial activity in vitro. P-MAPA showed a significant stimulatory ef …
RESULTS: The results showed that P-MAPA, administered alone or in combination with MXF, induced significant responses in vivo …
Effects of P-MAPA immunomodulator on Toll-like receptor 2, ROS, nitric oxide, MAPKp38 and IKK in PBMC and macrophages from dogs with visceral leishmaniasis.
Melo LM, Perosso J, Almeida BF, Silva KL, Somenzari MA, de Lima VM. Melo LM, et al. Int Immunopharmacol. 2014 Feb;18(2):373-8. doi: 10.1016/j.intimp.2013.12.012. Epub 2013 Dec 24. Int Immunopharmacol. 2014. PMID: 24374021
-infected dogs compared with healthy dogs and P-MAPA improved ROS production. NO production was increased in culture supernatant from macrophages stimulated by P-MAPA in both healthy and Leishmania spp. infected dogs. ...These findings suggest that …
-infected dogs compared with healthy dogs and P-MAPA improved ROS production. NO production was increased in culture supernata …
17 results