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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2005 1
2007 1
2010 1
2011 1
2012 3
2013 3
2014 2
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2017 1
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2022 1
2024 0

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Page 1
p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases.
Kumar S, Boehm J, Lee JC. Kumar S, et al. Nat Rev Drug Discov. 2003 Sep;2(9):717-26. doi: 10.1038/nrd1177. Nat Rev Drug Discov. 2003. PMID: 12951578 Review.
The p38 MAP kinases are a family of serine/threonine protein kinases that play important roles in cellular responses to external stress signals. ...Several promising compounds have also progressed to clinical trials. In this review, we provide a …
The p38 MAP kinases are a family of serine/threonine protein kinases that play important roles in cellular respo …
A Novel Phytochemical, DIM, Inhibits Proliferation, Migration, Invasion and TNF-alpha Induced Inflammatory Cytokine Production of Synovial Fibroblasts From Rheumatoid Arthritis Patients by Targeting MAPK and AKT/mTOR Signal Pathway.
Du H, Zhang X, Zeng Y, Huang X, Chen H, Wang S, Wu J, Li Q, Zhu W, Li H, Liu T, Yu Q, Wu Y, Jie L. Du H, et al. Front Immunol. 2019 Jul 23;10:1620. doi: 10.3389/fimmu.2019.01620. eCollection 2019. Front Immunol. 2019. PMID: 31396207 Free PMC article.
The effects of DIM on Matrix metalloproteinases (MMPs) and some inflammatory factors mRNA and key molecules such as some inflammatory factors and those involved in aberrantly-activated signaling pathway in response to tumor necrosis factor alpha …
The effects of DIM on Matrix metalloproteinases (MMPs) and some inflammatory factors mRNA and key molecules such as som …
ASK1 inhibition: a therapeutic strategy with multi-system benefits.
Ogier JM, Nayagam BA, Lockhart PJ. Ogier JM, et al. J Mol Med (Berl). 2020 Mar;98(3):335-348. doi: 10.1007/s00109-020-01878-y. Epub 2020 Feb 14. J Mol Med (Berl). 2020. PMID: 32060587 Free PMC article. Review.
Attempts to prevent P38- and JNK-mediated disease using small molecule inhibitors of P38 or JNK have generally been unsuccessful. However, apoptosis signal-regulating kinase 1 (ASK1), an upstream regulator of P38 and JNK, has emerg …
Attempts to prevent P38- and JNK-mediated disease using small molecule inhibitors of P38 or JNK have generally b …
p38 pathway kinases as anti-inflammatory drug targets.
Schindler JF, Monahan JB, Smith WG. Schindler JF, et al. J Dent Res. 2007 Sep;86(9):800-11. doi: 10.1177/154405910708600902. J Dent Res. 2007. PMID: 17720847 Review.
Mitogen-activated protein kinases (MAPK) are intracellular signaling molecules involved in cytokine synthesis. Several classes of mammalian MAPK have been identified, including extracellular signal-regulated kinase, c-jun N-terminal kinase …
Mitogen-activated protein kinases (MAPK) are intracellular signaling molecules involved in cytokine synthesis. Several …
Therapeutic potential of targeting mixed lineage kinases in cancer and inflammation.
Gallo KA, Ellsworth E, Stoub H, Conrad SE. Gallo KA, et al. Pharmacol Ther. 2020 Mar;207:107457. doi: 10.1016/j.pharmthera.2019.107457. Epub 2019 Dec 18. Pharmacol Ther. 2020. PMID: 31863814 Review.
Dysregulation of intracellular signaling pathways is a key attribute of diseases associated with chronic inflammation, including cancer. ...Mixed lineage kinases (MLKs) are mitogen-activated protein kinase kinase kinases (MAP3Ks) t …
Dysregulation of intracellular signaling pathways is a key attribute of diseases associated with chronic inflammation, …
MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation.
Romero-Becerra R, Mora A, Manieri E, Nikolic I, Santamans AM, Montalvo-Romeral V, Cruz FM, Rodríguez E, León M, Leiva-Vega L, Sanz L, Bondía V, Filgueiras-Rama D, Jiménez-Borreguero LJ, Jalife J, Gonzalez-Teran B, Sabio G. Romero-Becerra R, et al. Elife. 2022 Aug 16;11:e75250. doi: 10.7554/eLife.75250. Elife. 2022. PMID: 35971771 Free PMC article.
Therefore, they have been identified as potential targets for novel therapeutic strategies. There are four p38 family members (p38alpha, p38beta, p38gamma, and p38delta) that are activated by MKK3 and MKK6. ...There are different types of p38 enzyme wh …
Therefore, they have been identified as potential targets for novel therapeutic strategies. There are four p38 family m …
Therapeutic potential of p38 MAP kinase inhibition in the management of cardiovascular disease.
Fisk M, Gajendragadkar PR, Mäki-Petäjä KM, Wilkinson IB, Cheriyan J. Fisk M, et al. Am J Cardiovasc Drugs. 2014 Jun;14(3):155-65. doi: 10.1007/s40256-014-0063-6. Am J Cardiovasc Drugs. 2014. PMID: 24504769 Review.
p38 mitogen-activated protein kinases (p38 MAPKs) are key signalling molecules that regulate cellular behavior in response to environmental stresses. ...This review aims to provide succinct background information regarding the p38 …
p38 mitogen-activated protein kinases (p38 MAPKs) are key signalling molecules that regulate cellu …
Transforming growth factor-beta and Smad signalling in kidney diseases.
Wang W, Koka V, Lan HY. Wang W, et al. Nephrology (Carlton). 2005 Feb;10(1):48-56. doi: 10.1111/j.1440-1797.2005.00334.x. Nephrology (Carlton). 2005. PMID: 15705182 Review.
Results from these studies indicate that Smad signalling is a key and final common pathway of renal fibrosis. In addition, TGF-beta has anti-inflammatory and immune-regulatory properties. ...Thus, targeting Smad signalling by overexpression of S …
Results from these studies indicate that Smad signalling is a key and final common pathway of renal fibrosis. In addition, TGF …
Interleukin-1 drives cerebrovascular inflammation via MAP kinase-independent pathways.
Thornton P, McColl BW, Cooper L, Rothwell NJ, Allan SM. Thornton P, et al. Curr Neurovasc Res. 2010 Nov;7(4):330-40. doi: 10.2174/156720210793180800. Curr Neurovasc Res. 2010. PMID: 20854249
Cerebrovascular inflammation is triggered by diverse central nervous system (CNS) insults and contributes to disease pathogenesis. The pro-inflammatory cytokine interleukin (IL)-1 is central to this cerebrovascular inflammatory response and understanding the …
Cerebrovascular inflammation is triggered by diverse central nervous system (CNS) insults and contributes to disease pathogenesis. Th …
Comparison of PPAR Ligands as Modulators of Resolution of Inflammation, via Their Influence on Cytokines and Oxylipins Release in Astrocytes.
Chistyakov DV, Astakhova AA, Goriainov SV, Sergeeva MG. Chistyakov DV, et al. Int J Mol Sci. 2020 Dec 16;21(24):9577. doi: 10.3390/ijms21249577. Int J Mol Sci. 2020. PMID: 33339154 Free PMC article.
Neuroinflammation is a key process of many neurodegenerative diseases and other brain disturbances, and astrocytes play an essential role in neuroinflammation. Therefore, the regulation of astrocyte responses for inflammatory stimuli, using small molecules …
Neuroinflammation is a key process of many neurodegenerative diseases and other brain disturbances, and astrocytes play an ess …
18 results