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p63 and p73 transcriptionally regulate genes involved in DNA repair.
Lin YL, Sengupta S, Gurdziel K, Bell GW, Jacks T, Flores ER. Lin YL, et al. PLoS Genet. 2009 Oct;5(10):e1000680. doi: 10.1371/journal.pgen.1000680. Epub 2009 Oct 9. PLoS Genet. 2009. PMID: 19816568 Free PMC article.
Therefore, we performed a genome-wide analysis using cells lacking the p53 family members after treatment with DNA damage. We identified over 100 genes involved in multiple pathways that were uniquely regulated by p63 or p73, and not p53. …
Therefore, we performed a genome-wide analysis using cells lacking the p53 family members after treatment with DNA damage. We identif …
p73 protein regulates DNA damage repair.
Zaika E, Wei J, Yin D, Andl C, Moll U, El-Rifai W, Zaika AI. Zaika E, et al. FASEB J. 2011 Dec;25(12):4406-14. doi: 10.1096/fj.11-192815. Epub 2011 Sep 2. FASEB J. 2011. PMID: 21891782 Free PMC article.
The activated p73 protein induces DNA damage repair. Using a human DNA repair PCR array, we identified multiple DNA repair genes affected by p73. Two glycosylases involved in base excision repair, SMUG1 …
The activated p73 protein induces DNA damage repair. Using a human DNA repair PCR array, we identified mu …
TAp63gamma enhances nucleotide excision repair through transcriptional regulation of DNA repair genes.
Liu J, Lin M, Zhang C, Wang D, Feng Z, Hu W. Liu J, et al. DNA Repair (Amst). 2012 Feb 1;11(2):167-76. doi: 10.1016/j.dnarep.2011.10.016. Epub 2011 Nov 6. DNA Repair (Amst). 2012. PMID: 22056305 Free PMC article.
Transactivation (TA) isoforms of p63 and p73 have high similarity with p53 and often have biological functions similar to p53. p53 plays an important role in nucleotide excision repair (NER) through transcriptional regulation of target genes
Transactivation (TA) isoforms of p63 and p73 have high similarity with p53 and often have biological functions similar to p53. …
Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family.
Greiss S, Schumacher B, Grandien K, Rothblatt J, Gartner A. Greiss S, et al. BMC Genomics. 2008 Jul 15;9:334. doi: 10.1186/1471-2164-9-334. BMC Genomics. 2008. PMID: 18627611 Free PMC article.
BACKGROUND: In contrast to the three mammalian p53 family members, p53, which is generally involved in DNA damage responses, and p63 and p73 which are primarily needed for developmental regulation, cep-1 encodes for the single C. elegans p53-lik …
BACKGROUND: In contrast to the three mammalian p53 family members, p53, which is generally involved in DNA damage responses, a …
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