paiardini a - Search Results

Year	Number of Results
2001	1
2003	3
2004	2
2005	1
2006	2
2007	2
2008	3
2009	5
2010	2
2011	4
2012	6
2013	11
2014	6
2015	9
2016	7
2017	12
2018	10
2019	6
2020	10
2021	8
2022	9
2023	15
2024	10
2025	11
2026	1

1

Correction: An evolutionarily conserved role for separase in the regulation of nuclear lamins.

Cipressa F, Pennarun G, Bosso G, Rosignoli S, Tullo L, Schiralli N, Di Dio C, Borghi C, Paiardini A, Esposito G, Goldberg ML, Bertrand P, Cenci G. Cipressa F, et al. Among authors: paiardini a. Cell Death Discov. 2026 Jan 28;12(1):73. doi: 10.1038/s41420-025-02938-3. Cell Death Discov. 2026. PMID: 41605896 Free PMC article. No abstract available.

2

An evolutionarily conserved role for separase in the regulation of nuclear lamins.

Cipressa F, Pennarun G, Bosso G, Rosignoli S, Tullo L, Schiralli N, Di Dio C, Borghi C, Paiardini A, Esposito G, Goldberg ML, Bertrand P, Cenci G. Cipressa F, et al. Among authors: paiardini a. Cell Death Discov. 2025 Oct 21;11(1):475. doi: 10.1038/s41420-025-02758-5. Cell Death Discov. 2025. PMID: 41120332 Free PMC article.

3

Sensing the Reducing Power to Determine the Cell Fate: Flavin Redox-Switches in Signal Transduction.

Scribani-Rossi C, Angeli S, Paone A, Spizzichino S, Di Fonzo F, Arese M, Cutruzzolà F, Paiardini A, Rinaldo S. Scribani-Rossi C, et al. Among authors: paiardini a. Curr Microbiol. 2025 Oct 21;82(12):563. doi: 10.1007/s00284-025-04562-x. Curr Microbiol. 2025. PMID: 41117962 Free PMC article. Review.

4

NF-κB-mediated cytokine secretion and glutamate metabolic reprogramming converge in breast cancer brain tropism.

Di Russo S, Borsatti GE, Bouzidi A, Liberati FR, Riva A, Tripodi F, Rolfi LR, Spizzichino S, Tramutola A, Perluigi M, Trisciuoglio D, Giardina G, Paiardini A, Coccetti P, Rinaldo S, Cutruzzolà F, Paone A. Di Russo S, et al. Among authors: paiardini a. Cancer Lett. 2025 Oct 10;630:217907. doi: 10.1016/j.canlet.2025.217907. Epub 2025 Jul 8. Cancer Lett. 2025. PMID: 40639610 Free article.

5

Unraveling the Roles of Epigenetic Regulators During the Embryonic Development of Rhipicephalus microplus.

Amarante AM, de Oliveira DM, de Souza MPNC, Fonseca-Oliveira M, Galina A, Rosignoli S, Arcanjo AF, Moraes B, Paiardini A, Rotili D, de Paula Li Yasumura JD, Henaut-Jacobs S, Venancio TM, Uhl M, Nunes-da-Fonseca R, Parizi LF, da Silva Vaz Junior I, Dos Santos Mermelstein C, Rios T, Tirloni L, Logullo C, Fantappié MR. Amarante AM, et al. Among authors: paiardini a. Int J Mol Sci. 2025 Sep 19;26(18):9171. doi: 10.3390/ijms26189171. Int J Mol Sci. 2025. PMID: 41009732 Free PMC article.

6

RNA-mediated inhibition of mitochondrial SHMT2 impairs cancer cell proliferation.

Liberati FR, Spizzichino S, Di Russo S, Borsatti GE, Riva A, Magnifico MC, Bouzidi A, Giardina G, Arese M, Scribani Rossi C, Boi D, Boumis G, Di Fonzo F, Guarguaglini G, Contestabile R, Tramonti A, Macone A, Paiardini A, Rinaldo S, Paone A, Cutruzzolà F. Liberati FR, et al. Among authors: paiardini a. Cell Death Discov. 2025 Aug 6;11(1):369. doi: 10.1038/s41420-025-02646-y. Cell Death Discov. 2025. PMID: 40770176 Free PMC article.

7

Unravelling the role of epigenetic regulators during embryonic development of Rhipicephalus microplus.

Amarante AM, de Oliveira DM, de Souza MPNC, Fonseca-Oliveira M, Galina A, Rosignoli S, Arcanjo AF, Moraes B, Paiardini A, Rotili D, Li Yasumura JDP, Henaut-Jacobs S, Venancio TM, Uhl M, Nunes-da-Fonseca R, Parizi LF, Vaz Junior IDS, Mermelstein CDS, Tirloni L, Logullo C, Fantappié MR. Amarante AM, et al. Among authors: paiardini a. bioRxiv [Preprint]. 2025 Jul 11:2025.07.11.662657. doi: 10.1101/2025.07.11.662657. bioRxiv. 2025. Update in: Int J Mol Sci. 2025 Sep 19;26(18):9171. doi: 10.3390/ijms26189171. PMID: 40672298 Free PMC article. Updated. Preprint.

8

SERTM2: a neuroactive player in the world of micropeptides.

Lisi M, Santini T, D'Andrea T, Salvatori B, Setti A, Paiardini A, Nutarelli S, Nicoletti C, Pellegrini F, Fucile S, Bozzoni I, Martone J. Lisi M, et al. Among authors: paiardini a. EMBO Rep. 2025 Apr;26(8):2044-2076. doi: 10.1038/s44319-025-00404-w. Epub 2025 Mar 19. EMBO Rep. 2025. PMID: 40108405 Free PMC article.

9

Targeting MDM2 affects spastin protein levels and functions: implications for HSP treatment.

Sardina F, Polverino F, Valentini S, Carsetti C, Falvo E, Tisci G, Soddu S, Moretti F, Paiardini A, Rinaldo C. Sardina F, et al. Among authors: paiardini a. Cell Death Discov. 2025 Feb 7;11(1):53. doi: 10.1038/s41420-025-02333-y. Cell Death Discov. 2025. PMID: 39920118 Free PMC article.

10

Unraveling the Engagement of Kinases to CRBN Through a Shared Structural Motif to Optimize PROTACs Efficacy.

Rosignoli S, Giordani S, Pacelli M, Guarguaglini G, Paiardini A. Rosignoli S, et al. Among authors: paiardini a. Biomolecules. 2025 Feb 1;15(2):206. doi: 10.3390/biom15020206. Biomolecules. 2025. PMID: 40001507 Free PMC article. Review.

11

An outlook on structural biology after AlphaFold: tools, limits and perspectives.

Rosignoli S, Pacelli M, Manganiello F, Paiardini A. Rosignoli S, et al. Among authors: paiardini a. FEBS Open Bio. 2025 Feb;15(2):202-222. doi: 10.1002/2211-5463.13902. Epub 2024 Sep 23. FEBS Open Bio. 2025. PMID: 39313455 Free PMC article. Review.

12

Exploring Innovative Approaches to Isolate a One-Component c-di-GMP Transducer: A Pilot Study.

Scribani Rossi C, Parisi G, Paiardini A, Rinaldo S. Scribani Rossi C, et al. Among authors: paiardini a. Adv Exp Med Biol. 2025;1476:9-21. doi: 10.1007/5584_2023_787. Adv Exp Med Biol. 2025. PMID: 37608242

13

Off-Target Inhibition of Human Dihydroorotate Dehydrogenase (hDHODH) Highlights Challenges in the Development of Fat Mass and Obesity-Associated Protein (FTO) Inhibitors.

Tarullo M, Fernandez Rodriguez G, Iaiza A, Venezia S, Macone A, Incocciati A, Masciarelli S, Marchioni M, Giorgis M, Lolli ML, Fornaseri F, Proietti L, Grebien F, Rosignoli S, Paiardini A, Rotili D, Mai A, Bochenkova E, Caflisch A, Fazi F, Fatica A. Tarullo M, et al. Among authors: paiardini a. ACS Pharmacol Transl Sci. 2024 Nov 26;7(12):4096-4111. doi: 10.1021/acsptsci.4c00533. eCollection 2024 Dec 13. ACS Pharmacol Transl Sci. 2024. PMID: 39698280 Free PMC article.

14

An inherited TBX3 alteration in a prenatal case of ulnar-mammary syndrome: Clinical assessment and functional characterization in Drosophila melanogaster.

Bottillo I, D'Alessandro A, Ciccone MP, Cestra G, Di Giacomo G, Silvestri E, Castori M, Brancati F, Lenzi A, Paiardini A, Majore S, Cenci G, Grammatico P. Bottillo I, et al. Among authors: paiardini a. J Cell Physiol. 2024 Dec;239(12):e31440. doi: 10.1002/jcp.31440. Epub 2024 Sep 25. J Cell Physiol. 2024. PMID: 39320041 Free PMC article.

15

The Z isomer of pyridoxilidenerhodanine 5'-phosphate is an efficient inhibitor of human pyridoxine 5'-phosphate oxidase, a crucial enzyme in vitamin B₆ salvage pathway and a potential chemotherapeutic target.

Graziani C, Barile A, Antonelli L, Fiorillo A, Ilari A, Vetica F, di Salvo ML, Paiardini A, Tramonti A, Contestabile R. Graziani C, et al. Among authors: paiardini a. FEBS J. 2024 Nov;291(22):4984-5001. doi: 10.1111/febs.17274. Epub 2024 Sep 17. FEBS J. 2024. PMID: 39288205 Free article.

16

Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1.

Spizzichino S, Di Fonzo F, Marabelli C, Tramonti A, Chaves-Sanjuan A, Parroni A, Boumis G, Liberati FR, Paone A, Montemiglio LC, Ardini M, Jakobi AJ, Bharadwaj A, Swuec P, Tartaglia GG, Paiardini A, Contestabile R, Mai A, Rotili D, Fiorentino F, Macone A, Giorgi A, Tria G, Rinaldo S, Bolognesi M, Giardina G, Cutruzzolà F. Spizzichino S, et al. Among authors: paiardini a. Mol Cell. 2024 Jul 25;84(14):2682-2697.e6. doi: 10.1016/j.molcel.2024.06.016. Epub 2024 Jul 11. Mol Cell. 2024. PMID: 38996576 Free article.

17

AlPaCas: allele-specific CRISPR gene editing through a protospacer-adjacent-motif (PAM) approach.

Rosignoli S, Lustrino E, Conci A, Fabrizi A, Rinaldo S, Latella MC, Enzo E, Prosseda G, De Rosa L, De Luca M, Paiardini A. Rosignoli S, et al. Among authors: paiardini a. Nucleic Acids Res. 2024 Jul 5;52(W1):W29-W38. doi: 10.1093/nar/gkae419. Nucleic Acids Res. 2024. PMID: 38795068 Free PMC article.

18

Targeting staphylococcal enterotoxin B binding to CD28 as a new strategy for dampening superantigen-mediated intestinal epithelial barrier dysfunctions.

Amormino C, Russo E, Tedeschi V, Fiorillo MT, Paiardini A, Spallotta F, Rosanò L, Tuosto L, Kunkl M. Amormino C, et al. Among authors: paiardini a. Front Immunol. 2024 Mar 6;15:1365074. doi: 10.3389/fimmu.2024.1365074. eCollection 2024. Front Immunol. 2024. PMID: 38510259 Free PMC article.

19

Allele-specific CRISPR-Cas9 editing of dominant epidermolysis bullosa simplex in human epidermal stem cells.

Cattaneo C, Enzo E, De Rosa L, Sercia L, Consiglio F, Forcato M, Bicciato S, Paiardini A, Basso G, Tagliafico E, Paganelli A, Fiorentini C, Magnoni C, Latella MC, De Luca M. Cattaneo C, et al. Among authors: paiardini a. Mol Ther. 2024 Feb 7;32(2):372-383. doi: 10.1016/j.ymthe.2023.11.027. Epub 2023 Dec 5. Mol Ther. 2024. PMID: 38053334 Free PMC article.

20

Identification of the pyridoxal 5'-phosphate allosteric site in human pyridox(am)ine 5'-phosphate oxidase.

Barile A, Graziani C, Antonelli L, Parroni A, Fiorillo A, di Salvo ML, Ilari A, Giorgi A, Rosignoli S, Paiardini A, Contestabile R, Tramonti A. Barile A, et al. Among authors: paiardini a. Protein Sci. 2024 Feb;33(2):e4900. doi: 10.1002/pro.4900. Protein Sci. 2024. PMID: 38284493 Free PMC article.

21

Making Use of Averaging Methods in MODELLER for Protein Structure Prediction.

Rosignoli S, Lustrino E, Di Silverio I, Paiardini A. Rosignoli S, et al. Among authors: paiardini a. Int J Mol Sci. 2024 Jan 31;25(3):1731. doi: 10.3390/ijms25031731. Int J Mol Sci. 2024. PMID: 38339009 Free PMC article.

22

Molecular insights into RmcA-mediated c-di-GMP consumption: Linking redox potential to biofilm morphogenesis in Pseudomonas aeruginosa.

Scribani Rossi C, Eckartt K, Scarchilli E, Angeli S, Price-Whelan A, Di Matteo A, Chevreuil M, Raynal B, Arcovito A, Giacon N, Fiorentino F, Rotili D, Mai A, Espinosa-Urgel M, Cutruzzolà F, Dietrich LEP, Paone A, Paiardini A, Rinaldo S. Scribani Rossi C, et al. Among authors: paiardini a. Microbiol Res. 2023 Dec;277:127498. doi: 10.1016/j.micres.2023.127498. Epub 2023 Sep 15. Microbiol Res. 2023. PMID: 37776579 Free article.

23

PyPCN: protein contact networks in PyMOL.

Rosignoli S, di Paola L, Paiardini A. Rosignoli S, et al. Among authors: paiardini a. Bioinformatics. 2023 Nov 1;39(11):btad675. doi: 10.1093/bioinformatics/btad675. Bioinformatics. 2023. PMID: 37941462 Free PMC article.

24

Protein Structure Prediction in Drug Discovery.

Paiardini A. Paiardini A. Biomolecules. 2023 Aug 17;13(8):1258. doi: 10.3390/biom13081258. Biomolecules. 2023. PMID: 37627323 Free PMC article.

25

Corrigendum: Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells.

Kunkl M, Amormino C, Spallotta F, Caristi S, Fiorillo MT, Paiardini A, Kaempfer R, Tuosto L. Kunkl M, et al. Among authors: paiardini a. Front Immunol. 2023 Aug 15;14:1273921. doi: 10.3389/fimmu.2023.1273921. eCollection 2023. Front Immunol. 2023. PMID: 37654481 Free PMC article.

26

Diffusible signal factors (DSFs) bind and repress VirF, the leading virulence activator of Shigella flexneri.

Trirocco R, Pasqua M, Tramonti A, Colonna B, Paiardini A, Prosseda G. Trirocco R, et al. Among authors: paiardini a. Sci Rep. 2023 Aug 14;13(1):13170. doi: 10.1038/s41598-023-40023-w. Sci Rep. 2023. PMID: 37580399 Free PMC article.

27

Fatty Acids Abolish Shigella Virulence by Inhibiting Its Master Regulator, VirF.

Trirocco R, Pasqua M, Tramonti A, Grossi M, Colonna B, Paiardini A, Prosseda G. Trirocco R, et al. Among authors: paiardini a. Microbiol Spectr. 2023 Jun 15;11(3):e0077823. doi: 10.1128/spectrum.00778-23. Epub 2023 May 4. Microbiol Spectr. 2023. PMID: 37140433 Free PMC article.

28

A truncated and catalytically inactive isoform of KDM5B histone demethylase accumulates in breast cancer cells and regulates H3K4 tri-methylation and gene expression.

Di Nisio E, Licursi V, Mannironi C, Buglioni V, Paiardini A, Robusti G, Noberini R, Bonaldi T, Negri R. Di Nisio E, et al. Among authors: paiardini a. Cancer Gene Ther. 2023 Jun;30(6):822-832. doi: 10.1038/s41417-022-00584-w. Epub 2023 Jan 26. Cancer Gene Ther. 2023. PMID: 36697763 Free PMC article.

29

First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8.

Fiorentino F, Sementilli S, Menna M, Turrisi F, Tomassi S, Pellegrini FR, Iuzzolino A, D'Acunzo F, Feoli A, Wapenaar H, Taraglio S, Fraschetti C, Del Bufalo D, Sbardella G, Dekker FJ, Paiardini A, Trisciuoglio D, Mai A, Rotili D. Fiorentino F, et al. Among authors: paiardini a. J Med Chem. 2023 May 25;66(10):6591-6616. doi: 10.1021/acs.jmedchem.2c01937. Epub 2023 May 8. J Med Chem. 2023. PMID: 37155735 Free PMC article.

30

Centaurea triumfetii essential oil chemical composition, comparative analysis, and antimicrobial activity of selected compounds.

Carev I, Gelemanović A, Glumac M, Tutek K, Dželalija M, Paiardini A, Prosseda G. Carev I, et al. Among authors: paiardini a. Sci Rep. 2023 May 8;13(1):7475. doi: 10.1038/s41598-023-34058-2. Sci Rep. 2023. PMID: 37156785 Free PMC article.

31

Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells.

Kunkl M, Amormino C, Spallotta F, Caristi S, Fiorillo MT, Paiardini A, Kaempfer R, Tuosto L. Kunkl M, et al. Among authors: paiardini a. Front Immunol. 2023 May 3;14:1170821. doi: 10.3389/fimmu.2023.1170821. eCollection 2023. Front Immunol. 2023. PMID: 37207220 Free PMC article.

32

AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation.

Asteriti IA, Polverino F, Stagni V, Sterbini V, Ascanelli C, Naso FD, Mastrangelo A, Rosa A, Paiardini A, Lindon C, Guarguaglini G. Asteriti IA, et al. Among authors: paiardini a. Life Sci Alliance. 2023 Feb 16;6(5):e202201726. doi: 10.26508/lsa.202201726. Print 2023 May. Life Sci Alliance. 2023. PMID: 36797043 Free PMC article.

33

When Just One Phosphate Is One Too Many: The Multifaceted Interplay between Myc and Kinases.

Boi D, Rubini E, Breccia S, Guarguaglini G, Paiardini A. Boi D, et al. Among authors: paiardini a. Int J Mol Sci. 2023 Mar 1;24(5):4746. doi: 10.3390/ijms24054746. Int J Mol Sci. 2023. PMID: 36902175 Free PMC article. Review.

34

Revisiting degron motifs in human AURKA required for its targeting by APC/C^FZR1.

Abdelbaki A, Ascanelli C, Okoye CN, Akman HB, Janson G, Min M, Marcozzi C, Hagting A, Grant R, De Luca M, Asteriti IA, Guarguaglini G, Paiardini A, Lindon C. Abdelbaki A, et al. Among authors: paiardini a. Life Sci Alliance. 2022 Nov 30;6(2):e202201372. doi: 10.26508/lsa.202201372. Print 2023 Feb. Life Sci Alliance. 2022. PMID: 36450448 Free PMC article.

35

The phosphodiesterase RmcA contributes to the adaptation of Pseudomonas putida to l-arginine.

Scribani-Rossi C, Molina-Henares MA, Angeli S, Cutruzzolà F, Paiardini A, Espinosa-Urgel M, Rinaldo S. Scribani-Rossi C, et al. Among authors: paiardini a. FEMS Microbiol Lett. 2023 Jan 17;370:fnad077. doi: 10.1093/femsle/fnad077. FEMS Microbiol Lett. 2023. PMID: 37550221 Free PMC article.

36

Boosting the Full Potential of PyMOL with Structural Biology Plugins.

Rosignoli S, Paiardini A. Rosignoli S, et al. Among authors: paiardini a. Biomolecules. 2022 Nov 27;12(12):1764. doi: 10.3390/biom12121764. Biomolecules. 2022. PMID: 36551192 Free PMC article. Review.

37

DockingPie: a consensus docking plugin for PyMOL.

Rosignoli S, Paiardini A. Rosignoli S, et al. Among authors: paiardini a. Bioinformatics. 2022 Sep 2;38(17):4233-4234. doi: 10.1093/bioinformatics/btac452. Bioinformatics. 2022. PMID: 35792827

38

SARS-CoV-2 Spike Does Not Possess Intrinsic Superantigen-like Inflammatory Activity.

Amormino C, Tedeschi V, Paldino G, Arcieri S, Fiorillo MT, Paiardini A, Tuosto L, Kunkl M. Amormino C, et al. Among authors: paiardini a. Cells. 2022 Aug 15;11(16):2526. doi: 10.3390/cells11162526. Cells. 2022. PMID: 36010602 Free PMC article.

39

A Novel Hypothesis on Choroideremia-Manifesting Female Carriers: Could CHM In-Frame Variants Exert a Dominant Negative Effect? A Case Report.

Di Giosaffatte N, Valiante M, Tricarico S, Parise G, De Negri AM, Ricciotti G, Florean L, Paiardini A, Bottillo I, Grammatico P. Di Giosaffatte N, et al. Among authors: paiardini a. Genes (Basel). 2022 Jul 17;13(7):1268. doi: 10.3390/genes13071268. Genes (Basel). 2022. PMID: 35886051 Free PMC article.

40

A Short ERAP2 That Binds IRAP Is Expressed in Macrophages Independently of Gene Variation.

Mattorre B, Caristi S, Donato S, Volpe E, Faiella M, Paiardini A, Sorrentino R, Paladini F. Mattorre B, et al. Among authors: paiardini a. Int J Mol Sci. 2022 Apr 29;23(9):4961. doi: 10.3390/ijms23094961. Int J Mol Sci. 2022. PMID: 35563348 Free PMC article.

41

Nutrient Sensing and Biofilm Modulation: The Example of L-arginine in Pseudomonas.

Scribani Rossi C, Barrientos-Moreno L, Paone A, Cutruzzolà F, Paiardini A, Espinosa-Urgel M, Rinaldo S. Scribani Rossi C, et al. Among authors: paiardini a. Int J Mol Sci. 2022 Apr 15;23(8):4386. doi: 10.3390/ijms23084386. Int J Mol Sci. 2022. PMID: 35457206 Free PMC article. Review.

42

Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex.

Spizzichino S, Boi D, Boumis G, Lucchi R, Liberati FR, Capelli D, Montanari R, Pochetti G, Piacentini R, Parisi G, Paone A, Rinaldo S, Contestabile R, Tramonti A, Paiardini A, Giardina G, Cutruzzolà F. Spizzichino S, et al. Among authors: paiardini a. FEBS J. 2022 Mar;289(6):1625-1649. doi: 10.1111/febs.16248. Epub 2021 Nov 12. FEBS J. 2022. PMID: 34694685 Free PMC article.

43

Prediction and Modeling of Protein-Protein Interactions Using "Spotted" Peptides with a Template-Based Approach.

Gasbarri C, Rosignoli S, Janson G, Boi D, Paiardini A. Gasbarri C, et al. Among authors: paiardini a. Biomolecules. 2022 Jan 25;12(2):201. doi: 10.3390/biom12020201. Biomolecules. 2022. PMID: 35204702 Free PMC article.

44

PHA-680626 Is an Effective Inhibitor of the Interaction between Aurora-A and N-Myc.

Boi D, Souvalidou F, Capelli D, Polverino F, Marini G, Montanari R, Pochetti G, Tramonti A, Contestabile R, Trisciuoglio D, Carpinelli P, Ascanelli C, Lindon C, De Leo A, Saviano M, Di Santo R, Costi R, Guarguaglini G, Paiardini A. Boi D, et al. Among authors: paiardini a. Int J Mol Sci. 2021 Dec 4;22(23):13122. doi: 10.3390/ijms222313122. Int J Mol Sci. 2021. PMID: 34884931 Free PMC article.

45

PyMod 3: a complete suite for structural bioinformatics in PyMOL.

Janson G, Paiardini A. Janson G, et al. Among authors: paiardini a. Bioinformatics. 2021 Jun 16;37(10):1471-1472. doi: 10.1093/bioinformatics/btaa849. Bioinformatics. 2021. PMID: 33010156

46

Nuclear localisation of Aurora-A: its regulation and significance for Aurora-A functions in cancer.

Naso FD, Boi D, Ascanelli C, Pamfil G, Lindon C, Paiardini A, Guarguaglini G. Naso FD, et al. Among authors: paiardini a. Oncogene. 2021 Jun;40(23):3917-3928. doi: 10.1038/s41388-021-01766-w. Epub 2021 May 13. Oncogene. 2021. PMID: 33981003 Free PMC article. Review.

47

Bacterial Oxidases of the Cytochrome bd Family: Redox Enzymes of Unique Structure, Function, and Utility As Drug Targets.

Borisov VB, Siletsky SA, Paiardini A, Hoogewijs D, Forte E, Giuffrè A, Poole RK. Borisov VB, et al. Among authors: paiardini a. Antioxid Redox Signal. 2021 Jun 1;34(16):1280-1318. doi: 10.1089/ars.2020.8039. Epub 2020 Nov 9. Antioxid Redox Signal. 2021. PMID: 32924537 Free PMC article. Review.

48

Phosphorylation, Mg-ADP, and Inhibitors Differentially Shape the Conformational Dynamics of the A-Loop of Aurora-A.

Musavizadeh Z, Grottesi A, Guarguaglini G, Paiardini A. Musavizadeh Z, et al. Among authors: paiardini a. Biomolecules. 2021 Apr 12;11(4):567. doi: 10.3390/biom11040567. Biomolecules. 2021. PMID: 33921540 Free PMC article.

49

The Archaeal Elongation Factor EF-2 Induces the Release of aIF6 From 50S Ribosomal Subunit.

Lo Gullo G, De Santis ML, Paiardini A, Rosignoli S, Romagnoli A, La Teana A, Londei P, Benelli D. Lo Gullo G, et al. Among authors: paiardini a. Front Microbiol. 2021 Mar 24;12:631297. doi: 10.3389/fmicb.2021.631297. eCollection 2021. Front Microbiol. 2021. PMID: 33841359 Free PMC article.

50

Studying GGDEF Domain in the Act: Minimize Conformational Frustration to Prevent Artefacts.

Mantoni F, Scribani Rossi C, Paiardini A, Di Matteo A, Cappellacci L, Petrelli R, Ricciutelli M, Paone A, Cutruzzolà F, Giardina G, Rinaldo S. Mantoni F, et al. Among authors: paiardini a. Life (Basel). 2021 Jan 6;11(1):31. doi: 10.3390/life11010031. Life (Basel). 2021. PMID: 33418960 Free PMC article.

51

Intronic Determinants Coordinate Charme lncRNA Nuclear Activity through the Interaction with MATR3 and PTBP1.

Desideri F, Cipriano A, Petrezselyova S, Buonaiuto G, Santini T, Kasparek P, Prochazka J, Janson G, Paiardini A, Calicchio A, Colantoni A, Sedlacek R, Bozzoni I, Ballarino M. Desideri F, et al. Among authors: paiardini a. Cell Rep. 2020 Dec 22;33(12):108548. doi: 10.1016/j.celrep.2020.108548. Cell Rep. 2020. PMID: 33357424 Free PMC article.

52

A Single Center Retrospective Review of Patients from Central Italy Tested for Melanoma Predisposition Genes.

De Simone P, Bottillo I, Valiante M, Iorio A, De Bernardo C, Majore S, D'Angelantonio D, Valentini T, Sperduti I, Piemonte P, Eibenschutz L, Ferrari A, Carbone A, Buccini P, Paiardini A, Silipo V, Frascione P, Grammatico P. De Simone P, et al. Among authors: paiardini a. Int J Mol Sci. 2020 Dec 11;21(24):9432. doi: 10.3390/ijms21249432. Int J Mol Sci. 2020. PMID: 33322357 Free PMC article.

53

Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity.

Bouzidi A, Magnifico MC, Paiardini A, Macone A, Boumis G, Giardina G, Rinaldo S, Liberati FR, Lauro C, Limatola C, Lanzillotta C, Tramutola A, Perluigi M, Sgarbi G, Solaini G, Baracca A, Paone A, Cutruzzolà F. Bouzidi A, et al. Among authors: paiardini a. Cell Death Dis. 2020 Nov 26;11(11):1012. doi: 10.1038/s41419-020-03215-0. Cell Death Dis. 2020. PMID: 33243973 Free PMC article.

54

A novel CDKN2A in-frame deletion associated with pancreatic cancer-melanoma syndrome.

Bottillo I, Valiante M, Menale L, Paiardini A, Papi L, Janson G, Sestini R, Iorio A, De Simone P, Frascione P, Grammatico P. Bottillo I, et al. Among authors: paiardini a. Dermatol Online J. 2020 Aug 15;26(8):13030/qt5t22m5gk. Dermatol Online J. 2020. PMID: 32941720 Free article.

55

SMaRT lncRNA controls translation of a G-quadruplex-containing mRNA antagonizing the DHX36 helicase.

Martone J, Mariani D, Santini T, Setti A, Shamloo S, Colantoni A, Capparelli F, Paiardini A, Dimartino D, Morlando M, Bozzoni I. Martone J, et al. Among authors: paiardini a. EMBO Rep. 2020 Jun 4;21(6):e49942. doi: 10.15252/embr.201949942. Epub 2020 Apr 26. EMBO Rep. 2020. PMID: 32337838 Free PMC article.

56

Artemisinin Derivatives with Antimelanoma Activity Show Inhibitory Effect against Human DNA Topoisomerase 1.

Botta L, Filippi S, Zippilli C, Cesarini S, Bizzarri BM, Cirigliano A, Rinaldi T, Paiardini A, Fiorucci D, Saladino R, Negri R, Benedetti P. Botta L, et al. Among authors: paiardini a. ACS Med Chem Lett. 2020 Apr 10;11(5):1035-1040. doi: 10.1021/acsmedchemlett.0c00131. eCollection 2020 May 14. ACS Med Chem Lett. 2020. PMID: 32435422 Free PMC article.

57

From PARP1 to TNKS2 Inhibition: A Structure-Based Approach.

Tomassi S, Pfahler J, Mautone N, Rovere A, Esposito C, Passeri D, Pellicciari R, Novellino E, Pannek M, Steegborn C, Paiardini A, Mai A, Rotili D. Tomassi S, et al. Among authors: paiardini a. ACS Med Chem Lett. 2020 Feb 3;11(5):862-868. doi: 10.1021/acsmedchemlett.9b00654. eCollection 2020 May 14. ACS Med Chem Lett. 2020. PMID: 32435397 Free PMC article.

58

Insights into PPARγ Phosphorylation and Its Inhibition Mechanism.

Montanari R, Capelli D, Yamamoto K, Awaishima H, Nishikata K, Barendregt A, Heck AJR, Loiodice F, Altieri F, Paiardini A, Grottesi A, Pirone L, Pedone E, Peiretti F, Brunel JM, Itoh T, Pochetti G. Montanari R, et al. Among authors: paiardini a. J Med Chem. 2020 May 14;63(9):4811-4823. doi: 10.1021/acs.jmedchem.0c00048. Epub 2020 Apr 15. J Med Chem. 2020. PMID: 32239932 Free article.

59

Prenatal whole exome sequencing detects a new homozygous fukutin (FKTN) mutation in a fetus with an ultrasound suspicion of familial Dandy-Walker malformation.

Traversa A, Bernardo S, Paiardini A, Giovannetti A, Marchionni E, Genovesi ML, Guadagnolo D, Torres B, Paolacci S, Bernardini L, Mazza T, Carella M, Caputo V, Pizzuti A. Traversa A, et al. Among authors: paiardini a. Mol Genet Genomic Med. 2020 Jan;8(1):e1054. doi: 10.1002/mgg3.1054. Epub 2019 Nov 22. Mol Genet Genomic Med. 2020. PMID: 31756055 Free PMC article.

60

Revisiting the "satisfaction of spatial restraints" approach of MODELLER for protein homology modeling.

Janson G, Grottesi A, Pietrosanto M, Ausiello G, Guarguaglini G, Paiardini A. Janson G, et al. Among authors: paiardini a. PLoS Comput Biol. 2019 Dec 17;15(12):e1007219. doi: 10.1371/journal.pcbi.1007219. eCollection 2019 Dec. PLoS Comput Biol. 2019. PMID: 31846452 Free PMC article.

61

R180T variant of δ-ornithine aminotransferase associated with gyrate atrophy: biochemical, computational, X-ray and NMR studies provide insight into its catalytic features.

Montioli R, Paiardini A, Giardina G, Zanzoni S, Cutruzzola F, Cellini B, Borri Voltattorni C. Montioli R, et al. Among authors: paiardini a. FEBS J. 2019 Jul;286(14):2787-2798. doi: 10.1111/febs.14843. Epub 2019 Apr 15. FEBS J. 2019. PMID: 30957963 Free article.

62

A novel compound heterozygous genotype associated with aromatic amino acid decarboxylase deficiency: Clinical aspects and biochemical studies.

Montioli R, Battini R, Paiardini A, Tolve M, Bertoldi M, Carducci C, Leuzzi V, Borri Voltattorni C. Montioli R, et al. Among authors: paiardini a. Mol Genet Metab. 2019 Jun;127(2):132-137. doi: 10.1016/j.ymgme.2019.05.004. Epub 2019 May 10. Mol Genet Metab. 2019. PMID: 31104889

63

The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism.

Guiducci G, Paone A, Tramonti A, Giardina G, Rinaldo S, Bouzidi A, Magnifico MC, Marani M, Menendez JA, Fatica A, Macone A, Armaos A, Tartaglia GG, Contestabile R, Paiardini A, Cutruzzolà F. Guiducci G, et al. Among authors: paiardini a. Nucleic Acids Res. 2019 May 7;47(8):4240-4254. doi: 10.1093/nar/gkz129. Nucleic Acids Res. 2019. PMID: 30809670 Free PMC article.

64

N⁶-Methyladenosine (m⁶A): A Promising New Molecular Target in Acute Myeloid Leukemia.

Ianniello Z, Paiardini A, Fatica A. Ianniello Z, et al. Among authors: paiardini a. Front Oncol. 2019 Apr 9;9:251. doi: 10.3389/fonc.2019.00251. eCollection 2019. Front Oncol. 2019. PMID: 31024852 Free PMC article. Review.

65

Corrigendum to "Pyridoxine-5'-phosphate oxidase (Pnpo) deficiency: Clinical and biochemical alterations associated with the C.347g>A (P.·Arg116gln) mutation" [Mol. Genet. Metab. 122/1-2 (2017) 135-142].

di Salvo ML, Mastrangelo M, Nogués I, Tolve M, Paiardini A, Carducci C, Mei D, Montomoli M, Tramonti A, Guerrini R, Contestabile R, Leuzzi V. di Salvo ML, et al. Among authors: paiardini a. Mol Genet Metab. 2018 Dec;125(4):359. doi: 10.1016/j.ymgme.2018.02.017. Epub 2018 Mar 14. Mol Genet Metab. 2018. PMID: 29548777 No abstract available.

66

Cysteine 180 Is a Redox Sensor Modulating the Activity of Human Pyridoxal 5'-Phosphate Histidine Decarboxylase.

Rossignoli G, Grottesi A, Bisello G, Montioli R, Borri Voltattorni C, Paiardini A, Bertoldi M. Rossignoli G, et al. Among authors: paiardini a. Biochemistry. 2018 Nov 6;57(44):6336-6348. doi: 10.1021/acs.biochem.8b00625. Epub 2018 Oct 29. Biochemistry. 2018. PMID: 30346159

67

Insights into the GTP-dependent allosteric control of c-di-GMP hydrolysis from the crystal structure of PA0575 protein from Pseudomonas aeruginosa.

Mantoni F, Paiardini A, Brunotti P, D'Angelo C, Cervoni L, Paone A, Cappellacci L, Petrelli R, Ricciutelli M, Leoni L, Rampioni G, Arcovito A, Rinaldo S, Cutruzzolà F, Giardina G. Mantoni F, et al. Among authors: paiardini a. FEBS J. 2018 Oct;285(20):3815-3834. doi: 10.1111/febs.14634. Epub 2018 Sep 7. FEBS J. 2018. PMID: 30106221 Free article.

68

A novel bacterial l-arginine sensor controlling c-di-GMP levels in Pseudomonas aeruginosa.

Paiardini A, Mantoni F, Giardina G, Paone A, Janson G, Leoni L, Rampioni G, Cutruzzolà F, Rinaldo S. Paiardini A, et al. Proteins. 2018 Oct;86(10):1088-1096. doi: 10.1002/prot.25587. Epub 2018 Sep 8. Proteins. 2018. PMID: 30040157

69

The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.

Giardina G, Paone A, Tramonti A, Lucchi R, Marani M, Magnifico MC, Bouzidi A, Pontecorvi V, Guiducci G, Zamparelli C, Rinaldo S, Paiardini A, Contestabile R, Cutruzzolà F. Giardina G, et al. Among authors: paiardini a. FEBS J. 2018 Sep;285(17):3238-3253. doi: 10.1111/febs.14610. Epub 2018 Aug 7. FEBS J. 2018. PMID: 30035852 Free article.

70

Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes.

Tramonti A, Paiardini A, Paone A, Bouzidi A, Giardina G, Guiducci G, Magnifico MC, Rinaldo S, McDermott L, Menendez JA, Contestabile R, Cutruzzolà F. Tramonti A, et al. Among authors: paiardini a. Arch Biochem Biophys. 2018 Sep 1;653:71-79. doi: 10.1016/j.abb.2018.07.001. Epub 2018 Jul 4. Arch Biochem Biophys. 2018. PMID: 29991441

71

Functional Characterization and Structure-Guided Mutational Analysis of the Transsulfuration Enzyme Cystathionine γ-Lyase from Toxoplasma gondii.

Maresi E, Janson G, Fruncillo S, Paiardini A, Vallone R, Dominici P, Astegno A. Maresi E, et al. Among authors: paiardini a. Int J Mol Sci. 2018 Jul 20;19(7):2111. doi: 10.3390/ijms19072111. Int J Mol Sci. 2018. PMID: 30036991 Free PMC article.

72

Familial hypomagnesaemia, Hypercalciuria and Nephrocalcinosis associated with a novel mutation of the highly conserved leucine residue 116 of Claudin 16 in a Chinese patient with a delayed diagnosis: a case report.

Lu J, Zhao X, Paiardini A, Lang Y, Bottillo I, Shao L. Lu J, et al. Among authors: paiardini a. BMC Nephrol. 2018 Jul 13;19(1):181. doi: 10.1186/s12882-018-0979-1. BMC Nephrol. 2018. PMID: 30005619 Free PMC article.

73

A novel germline mutation in CDK4 codon 24 associated to familial melanoma.

Bottillo I, La Starza R, Radio FC, Molica C, Pedace L, Pierini T, De Bernardo C, Stingeni L, Bargiacchi S, Paiardini A, Janson G, Mecucci C, Grammatico P. Bottillo I, et al. Among authors: paiardini a. Clin Genet. 2018 Apr;93(4):934-935. doi: 10.1111/cge.13129. Epub 2017 Nov 10. Clin Genet. 2018. PMID: 29124743 No abstract available.

74

Heterozygosis in aromatic amino acid decarboxylase deficiency: Evidence for a positive interallelic complementation between R347Q and R358H mutations.

Montioli R, Janson G, Paiardini A, Bertoldi M, Borri Voltattorni C. Montioli R, et al. Among authors: paiardini a. IUBMB Life. 2018 Mar;70(3):215-223. doi: 10.1002/iub.1718. Epub 2018 Jan 22. IUBMB Life. 2018. PMID: 29356298 Free article.

75

Biochemical data from the characterization of a new pathogenic mutation of human pyridoxine-5'-phosphate oxidase (PNPO).

di Salvo ML, Mastrangelo M, Nogués I, Tolve M, Paiardini A, Carducci C, Mei D, Montomoli M, Tramonti A, Guerrini R, Contestabile R, Leuzzi V. di Salvo ML, et al. Among authors: paiardini a. Data Brief. 2017 Oct 28;15:868-875. doi: 10.1016/j.dib.2017.10.032. eCollection 2017 Dec. Data Brief. 2017. PMID: 29379851 Free PMC article.

76

Structural investigation of nucleophosmin interaction with the tumor suppressor Fbw7γ.

Di Matteo A, Franceschini M, Paiardini A, Grottesi A, Chiarella S, Rocchio S, Di Natale C, Marasco D, Vitagliano L, Travaglini-Allocatelli C, Federici L. Di Matteo A, et al. Among authors: paiardini a. Oncogenesis. 2017 Sep 18;6(9):e379. doi: 10.1038/oncsis.2017.78. Oncogenesis. 2017. PMID: 28920929 Free PMC article.

77

Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.

Giardina G, Paiardini A, Montioli R, Cellini B, Voltattorni CB, Cutruzzolà F. Giardina G, et al. Among authors: paiardini a. Sci Rep. 2017 Sep 15;7(1):11704. doi: 10.1038/s41598-017-11948-w. Sci Rep. 2017. PMID: 28916765 Free PMC article.

78

Pyridoxine-5'-phosphate oxidase (Pnpo) deficiency: Clinical and biochemical alterations associated with the C.347g>A (P.·Arg116gln) mutation.

di Salvo ML, Mastrangelo M, Nogués I, Tolve M, Paiardini A, Carducci C, Mei D, Montomoli M, Tramonti A, Guerrini R, Contestabile R, Leuzzi V. di Salvo ML, et al. Among authors: paiardini a. Mol Genet Metab. 2017 Sep;122(1-2):135-142. doi: 10.1016/j.ymgme.2017.08.003. Epub 2017 Aug 12. Mol Genet Metab. 2017. PMID: 28818555

79

Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis.

Brusotti G, Montanari R, Capelli D, Cattaneo G, Laghezza A, Tortorella P, Loiodice F, Peiretti F, Bonardo B, Paiardini A, Calleri E, Pochetti G. Brusotti G, et al. Among authors: paiardini a. Sci Rep. 2017 Jul 18;7(1):5777. doi: 10.1038/s41598-017-05666-6. Sci Rep. 2017. PMID: 28720829 Free PMC article.

80

Identification of small molecule inhibitors of the Aurora-A/TPX2 complex.

Asteriti IA, Daidone F, Colotti G, Rinaldo S, Lavia P, Guarguaglini G, Paiardini A. Asteriti IA, et al. Among authors: paiardini a. Oncotarget. 2017 May 9;8(19):32117-32133. doi: 10.18632/oncotarget.16738. Oncotarget. 2017. PMID: 28389630 Free PMC article.

81

Unique substrate specificity of ornithine aminotransferase from Toxoplasma gondii.

Astegno A, Maresi E, Bertoldi M, La Verde V, Paiardini A, Dominici P. Astegno A, et al. Among authors: paiardini a. Biochem J. 2017 Mar 7;474(6):939-955. doi: 10.1042/BCJ20161021. Biochem J. 2017. PMID: 28126740

82

Glucose Metabolism in the Progression of Prostate Cancer.

Cutruzzolà F, Giardina G, Marani M, Macone A, Paiardini A, Rinaldo S, Paone A. Cutruzzolà F, et al. Among authors: paiardini a. Front Physiol. 2017 Feb 21;8:97. doi: 10.3389/fphys.2017.00097. eCollection 2017. Front Physiol. 2017. PMID: 28270771 Free PMC article. Review.

83

PyMod 2.0: improvements in protein sequence-structure analysis and homology modeling within PyMOL.

Janson G, Zhang C, Prado MG, Paiardini A. Janson G, et al. Among authors: paiardini a. Bioinformatics. 2017 Feb 1;33(3):444-446. doi: 10.1093/bioinformatics/btw638. Bioinformatics. 2017. PMID: 28158668

84

Discovering Selective Diguanylate Cyclase Inhibitors: From PleD to Discrimination of the Active Site of Cyclic-di-GMP Phosphodiesterases.

Rinaldo S, Giardina G, Mantoni F, Paiardini A, Paone A, Cutruzzolà F. Rinaldo S, et al. Among authors: paiardini a. Methods Mol Biol. 2017;1657:431-453. doi: 10.1007/978-1-4939-7240-1_32. Methods Mol Biol. 2017. PMID: 28889312

85

New Insights Emerging from Recent Investigations on Human Group II Pyridoxal 5'-Phosphate Decarboxylases.

Paiardini A, Giardina G, Rossignoli G, Voltattorni CB, Bertoldi M. Paiardini A, et al. Curr Med Chem. 2017;24(3):226-244. doi: 10.2174/0929867324666161123093339. Curr Med Chem. 2017. PMID: 27881066 Review.

86

Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming.

Paiardini A, Tramonti A, Schirch D, Guiducci G, di Salvo ML, Fiascarelli A, Giorgi A, Maras B, Cutruzzolà F, Contestabile R. Paiardini A, et al. Biochim Biophys Acta. 2016 Nov;1864(11):1506-17. doi: 10.1016/j.bbapap.2016.08.010. Epub 2016 Aug 13. Biochim Biophys Acta. 2016. PMID: 27530298

87

Prediction and visualization data for the interpretation of sarcomeric and non-sarcomeric DNA variants found in patients with hypertrophic cardiomyopathy.

Bottillo I, D'Angelantonio D, Caputo V, Paiardini A, Lipari M, De Bernardo C, Majore S, Castori M, Zachara E, Re F, Grammatico P. Bottillo I, et al. Among authors: paiardini a. Data Brief. 2016 Mar 10;7:607-13. doi: 10.1016/j.dib.2016.03.004. eCollection 2016 Jun. Data Brief. 2016. PMID: 27054166 Free PMC article.

88

The novel R347g pathogenic mutation of aromatic amino acid decarboxylase provides additional molecular insights into enzyme catalysis and deficiency.

Montioli R, Paiardini A, Kurian MA, Dindo M, Rossignoli G, Heales SJR, Pope S, Voltattorni CB, Bertoldi M. Montioli R, et al. Among authors: paiardini a. Biochim Biophys Acta. 2016 Jun;1864(6):676-682. doi: 10.1016/j.bbapap.2016.03.011. Epub 2016 Mar 17. Biochim Biophys Acta. 2016. PMID: 26994895

89

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.

Drinkwater N, Vinh NB, Mistry SN, Bamert RS, Ruggeri C, Holleran JP, Loganathan S, Paiardini A, Charman SA, Powell AK, Avery VM, McGowan S, Scammells PJ. Drinkwater N, et al. Among authors: paiardini a. Eur J Med Chem. 2016 Mar 3;110:43-64. doi: 10.1016/j.ejmech.2016.01.015. Epub 2016 Jan 13. Eur J Med Chem. 2016. PMID: 26807544

90

Molecular analysis of sarcomeric and non-sarcomeric genes in patients with hypertrophic cardiomyopathy.

Bottillo I, D'Angelantonio D, Caputo V, Paiardini A, Lipari M, De Bernardo C, Giannarelli D, Pizzuti A, Majore S, Castori M, Zachara E, Re F, Grammatico P. Bottillo I, et al. Among authors: paiardini a. Gene. 2016 Feb 15;577(2):227-35. doi: 10.1016/j.gene.2015.11.048. Epub 2015 Dec 2. Gene. 2016. PMID: 26656175

91

A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells.

Marani M, Paone A, Fiascarelli A, Macone A, Gargano M, Rinaldo S, Giardina G, Pontecorvi V, Koes D, McDermott L, Yang T, Paiardini A, Contestabile R, Cutruzzolà F. Marani M, et al. Among authors: paiardini a. Oncotarget. 2016 Jan 26;7(4):4570-83. doi: 10.18632/oncotarget.6726. Oncotarget. 2016. PMID: 26717037 Free PMC article.

92

In Silico Discovery and In Vitro Validation of Catechol-Containing Sulfonohydrazide Compounds as Potent Inhibitors of the Diguanylate Cyclase PleD.

Fernicola S, Paiardini A, Giardina G, Rampioni G, Leoni L, Cutruzzolà F, Rinaldo S. Fernicola S, et al. Among authors: paiardini a. J Bacteriol. 2015 Sep 28;198(1):147-56. doi: 10.1128/JB.00742-15. Print 2016 Jan 1. J Bacteriol. 2015. PMID: 26416830 Free PMC article.

93

Synthesis of Triazole-Linked Analogues of c-di-GMP and Their Interactions with Diguanylate Cyclase.

Fernicola S, Torquati I, Paiardini A, Giardina G, Rampioni G, Messina M, Leoni L, Del Bello F, Petrelli R, Rinaldo S, Cappellacci L, Cutruzzolà F. Fernicola S, et al. Among authors: paiardini a. J Med Chem. 2015 Oct 22;58(20):8269-84. doi: 10.1021/acs.jmedchem.5b01184. Epub 2015 Oct 12. J Med Chem. 2015. PMID: 26426545

94

Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening.

Ruggeri C, Drinkwater N, Sivaraman KK, Bamert RS, McGowan S, Paiardini A. Ruggeri C, et al. Among authors: paiardini a. PLoS One. 2015 Sep 25;10(9):e0138957. doi: 10.1371/journal.pone.0138957. eCollection 2015. PLoS One. 2015. PMID: 26406322 Free PMC article.

95

Structural basis of functional diversification of the HD-GYP domain revealed by the Pseudomonas aeruginosa PA4781 protein, which displays an unselective bimetallic binding site.

Rinaldo S, Paiardini A, Stelitano V, Brunotti P, Cervoni L, Fernicola S, Protano C, Vitali M, Cutruzzolà F, Giardina G. Rinaldo S, et al. Among authors: paiardini a. J Bacteriol. 2015 Apr;197(8):1525-35. doi: 10.1128/JB.02606-14. Epub 2015 Feb 17. J Bacteriol. 2015. PMID: 25691523 Free PMC article.

96

X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17.

Drinkwater N, Bamert RS, Sivaraman KK, Paiardini A, McGowan S. Drinkwater N, et al. Among authors: paiardini a. Proteins. 2015 Apr;83(4):789-95. doi: 10.1002/prot.24771. Epub 2015 Feb 28. Proteins. 2015. PMID: 25645579

97

How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state.

Giardina G, Brunotti P, Fiascarelli A, Cicalini A, Costa MG, Buckle AM, di Salvo ML, Giorgi A, Marani M, Paone A, Rinaldo S, Paiardini A, Contestabile R, Cutruzzolà F. Giardina G, et al. Among authors: paiardini a. FEBS J. 2015 Apr;282(7):1225-41. doi: 10.1111/febs.13211. Epub 2015 Feb 13. FEBS J. 2015. PMID: 25619277 Free article.

98

Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase.

Paiardini A, Fiascarelli A, Rinaldo S, Daidone F, Giardina G, Koes DR, Parroni A, Montini G, Marani M, Paone A, McDermott LA, Contestabile R, Cutruzzolà F. Paiardini A, et al. ChemMedChem. 2015 Mar;10(3):490-7. doi: 10.1002/cmdc.201500028. Epub 2015 Feb 10. ChemMedChem. 2015. PMID: 25677305 Free PMC article.

99

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18.

Paiardini A, Bamert RS, Kannan-Sivaraman K, Drinkwater N, Mistry SN, Scammells PJ, McGowan S. Paiardini A, et al. PLoS One. 2015 Feb 20;10(2):e0115859. doi: 10.1371/journal.pone.0115859. eCollection 2015. PLoS One. 2015. PMID: 25700165 Free PMC article.

100

SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation.

Paone A, Marani M, Fiascarelli A, Rinaldo S, Giardina G, Contestabile R, Paiardini A, Cutruzzolà F. Paone A, et al. Among authors: paiardini a. Cell Death Dis. 2014 Nov 20;5(11):e1525. doi: 10.1038/cddis.2014.482. Cell Death Dis. 2014. PMID: 25412303 Free PMC article.

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