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Year Number of Results
2001 1
2003 3
2004 2
2005 1
2006 2
2007 2
2008 3
2009 5
2010 2
2011 4
2012 6
2013 11
2014 6
2015 9
2016 7
2017 12
2018 10
2019 6
2020 9
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94 results
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Page 1
Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity.
Bouzidi A, Magnifico MC, Paiardini A, Macone A, Boumis G, Giardina G, Rinaldo S, Liberati FR, Lauro C, Limatola C, Lanzillotta C, Tramutola A, Perluigi M, Sgarbi G, Solaini G, Baracca A, Paone A, CutruzzolĂ  F. Bouzidi A, et al. Among authors: paiardini a. Cell Death Dis. 2020 Nov 26;11(11):1012. doi: 10.1038/s41419-020-03215-0. Cell Death Dis. 2020. PMID: 33243973
Bacterial Oxidases of the Cytochrome bd Family: Redox Enzymes of Unique Structure, Function, and Utility As Drug Targets.
Borisov VB, Siletsky SA, Paiardini A, Hoogewijs D, Forte E, Giuffrè A, Poole RK. Borisov VB, et al. Among authors: paiardini a. Antioxid Redox Signal. 2020 Nov 9. doi: 10.1089/ars.2020.8039. Online ahead of print. Antioxid Redox Signal. 2020. PMID: 32924537
PyMod 3: a complete suite for structural bioinformatics in PyMOL.
Janson G, Paiardini A. Janson G, et al. Among authors: paiardini a. Bioinformatics. 2020 Oct 3:btaa849. doi: 10.1093/bioinformatics/btaa849. Online ahead of print. Bioinformatics. 2020. PMID: 33010156
A novel CDKN2A in-frame deletion associated with pancreatic cancer-melanoma syndrome.
Bottillo I, Valiante M, Menale L, Paiardini A, Papi L, Janson G, Sestini R, Iorio A, De Simone P, Frascione P, Grammatico P. Bottillo I, et al. Among authors: paiardini a. Dermatol Online J. 2020 Aug 15;26(8):13030/qt5t22m5gk. Dermatol Online J. 2020. PMID: 32941720 Free article.
SMaRT lncRNA controls translation of a G-quadruplex-containing mRNA antagonizing the DHX36 helicase.
Martone J, Mariani D, Santini T, Setti A, Shamloo S, Colantoni A, Capparelli F, Paiardini A, Dimartino D, Morlando M, Bozzoni I. Martone J, et al. Among authors: paiardini a. EMBO Rep. 2020 Jun 4;21(6):e49942. doi: 10.15252/embr.201949942. Epub 2020 Apr 26. EMBO Rep. 2020. PMID: 32337838 Free PMC article.
Insights into PPARÎł Phosphorylation and Its Inhibition Mechanism.
Montanari R, Capelli D, Yamamoto K, Awaishima H, Nishikata K, Barendregt A, Heck AJR, Loiodice F, Altieri F, Paiardini A, Grottesi A, Pirone L, Pedone E, Peiretti F, Brunel JM, Itoh T, Pochetti G. Montanari R, et al. Among authors: paiardini a. J Med Chem. 2020 May 14;63(9):4811-4823. doi: 10.1021/acs.jmedchem.0c00048. Epub 2020 Apr 15. J Med Chem. 2020. PMID: 32239932
Artemisinin Derivatives with Antimelanoma Activity Show Inhibitory Effect against Human DNA Topoisomerase 1.
Botta L, Filippi S, Zippilli C, Cesarini S, Bizzarri BM, Cirigliano A, Rinaldi T, Paiardini A, Fiorucci D, Saladino R, Negri R, Benedetti P. Botta L, et al. Among authors: paiardini a. ACS Med Chem Lett. 2020 Apr 10;11(5):1035-1040. doi: 10.1021/acsmedchemlett.0c00131. eCollection 2020 May 14. ACS Med Chem Lett. 2020. PMID: 32435422
From PARP1 to TNKS2 Inhibition: A Structure-Based Approach.
Tomassi S, Pfahler J, Mautone N, Rovere A, Esposito C, Passeri D, Pellicciari R, Novellino E, Pannek M, Steegborn C, Paiardini A, Mai A, Rotili D. Tomassi S, et al. Among authors: paiardini a. ACS Med Chem Lett. 2020 Feb 3;11(5):862-868. doi: 10.1021/acsmedchemlett.9b00654. eCollection 2020 May 14. ACS Med Chem Lett. 2020. PMID: 32435397
Revisiting the "satisfaction of spatial restraints" approach of MODELLER for protein homology modeling.
Janson G, Grottesi A, Pietrosanto M, Ausiello G, Guarguaglini G, Paiardini A. Janson G, et al. Among authors: paiardini a. PLoS Comput Biol. 2019 Dec 17;15(12):e1007219. doi: 10.1371/journal.pcbi.1007219. eCollection 2019 Dec. PLoS Comput Biol. 2019. PMID: 31846452 Free PMC article.
Prenatal whole exome sequencing detects a new homozygous fukutin (FKTN) mutation in a fetus with an ultrasound suspicion of familial Dandy-Walker malformation.
Traversa A, Bernardo S, Paiardini A, Giovannetti A, Marchionni E, Genovesi ML, Guadagnolo D, Torres B, Paolacci S, Bernardini L, Mazza T, Carella M, Caputo V, Pizzuti A. Traversa A, et al. Among authors: paiardini a. Mol Genet Genomic Med. 2020 Jan;8(1):e1054. doi: 10.1002/mgg3.1054. Epub 2019 Nov 22. Mol Genet Genomic Med. 2020. PMID: 31756055 Free PMC article.
A novel compound heterozygous genotype associated with aromatic amino acid decarboxylase deficiency: Clinical aspects and biochemical studies.
Montioli R, Battini R, Paiardini A, Tolve M, Bertoldi M, Carducci C, Leuzzi V, Borri Voltattorni C. Montioli R, et al. Among authors: paiardini a. Mol Genet Metab. 2019 Jun;127(2):132-137. doi: 10.1016/j.ymgme.2019.05.004. Epub 2019 May 10. Mol Genet Metab. 2019. PMID: 31104889
The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism.
Guiducci G, Paone A, Tramonti A, Giardina G, Rinaldo S, Bouzidi A, Magnifico MC, Marani M, Menendez JA, Fatica A, Macone A, Armaos A, Tartaglia GG, Contestabile R, Paiardini A, CutruzzolĂ  F. Guiducci G, et al. Among authors: paiardini a. Nucleic Acids Res. 2019 May 7;47(8):4240-4254. doi: 10.1093/nar/gkz129. Nucleic Acids Res. 2019. PMID: 30809670 Free PMC article.
R180T variant of δ-ornithine aminotransferase associated with gyrate atrophy: biochemical, computational, X-ray and NMR studies provide insight into its catalytic features.
Montioli R, Paiardini A, Giardina G, Zanzoni S, Cutruzzola F, Cellini B, Borri Voltattorni C. Montioli R, et al. Among authors: paiardini a. FEBS J. 2019 Jul;286(14):2787-2798. doi: 10.1111/febs.14843. Epub 2019 Apr 15. FEBS J. 2019. PMID: 30957963 Free article.
N6-Methyladenosine (m6A): A Promising New Molecular Target in Acute Myeloid Leukemia.
Ianniello Z, Paiardini A, Fatica A. Ianniello Z, et al. Among authors: paiardini a. Front Oncol. 2019 Apr 9;9:251. doi: 10.3389/fonc.2019.00251. eCollection 2019. Front Oncol. 2019. PMID: 31024852 Free PMC article. Review.
Cysteine 180 Is a Redox Sensor Modulating the Activity of Human Pyridoxal 5'-Phosphate Histidine Decarboxylase.
Rossignoli G, Grottesi A, Bisello G, Montioli R, Borri Voltattorni C, Paiardini A, Bertoldi M. Rossignoli G, et al. Among authors: paiardini a. Biochemistry. 2018 Nov 6;57(44):6336-6348. doi: 10.1021/acs.biochem.8b00625. Epub 2018 Oct 29. Biochemistry. 2018. PMID: 30346159
A novel bacterial l-arginine sensor controlling c-di-GMP levels in Pseudomonas aeruginosa.
Paiardini A, Mantoni F, Giardina G, Paone A, Janson G, Leoni L, Rampioni G, CutruzzolĂ  F, Rinaldo S. Paiardini A, et al. Proteins. 2018 Oct;86(10):1088-1096. doi: 10.1002/prot.25587. Epub 2018 Sep 8. Proteins. 2018. PMID: 30040157
Insights into the GTP-dependent allosteric control of c-di-GMP hydrolysis from the crystal structure of PA0575 protein from Pseudomonas aeruginosa.
Mantoni F, Paiardini A, Brunotti P, D'Angelo C, Cervoni L, Paone A, Cappellacci L, Petrelli R, Ricciutelli M, Leoni L, Rampioni G, Arcovito A, Rinaldo S, CutruzzolĂ  F, Giardina G. Mantoni F, et al. Among authors: paiardini a. FEBS J. 2018 Oct;285(20):3815-3834. doi: 10.1111/febs.14634. Epub 2018 Sep 7. FEBS J. 2018. PMID: 30106221 Free article.
The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.
Giardina G, Paone A, Tramonti A, Lucchi R, Marani M, Magnifico MC, Bouzidi A, Pontecorvi V, Guiducci G, Zamparelli C, Rinaldo S, Paiardini A, Contestabile R, CutruzzolĂ  F. Giardina G, et al. Among authors: paiardini a. FEBS J. 2018 Sep;285(17):3238-3253. doi: 10.1111/febs.14610. Epub 2018 Aug 7. FEBS J. 2018. PMID: 30035852 Free article.
Functional Characterization and Structure-Guided Mutational Analysis of the Transsulfuration Enzyme Cystathionine Îł-Lyase from Toxoplasma gondii.
Maresi E, Janson G, Fruncillo S, Paiardini A, Vallone R, Dominici P, Astegno A. Maresi E, et al. Among authors: paiardini a. Int J Mol Sci. 2018 Jul 20;19(7):2111. doi: 10.3390/ijms19072111. Int J Mol Sci. 2018. PMID: 30036991 Free PMC article.
Familial hypomagnesaemia, Hypercalciuria and Nephrocalcinosis associated with a novel mutation of the highly conserved leucine residue 116 of Claudin 16 in a Chinese patient with a delayed diagnosis: a case report.
Lu J, Zhao X, Paiardini A, Lang Y, Bottillo I, Shao L. Lu J, et al. Among authors: paiardini a. BMC Nephrol. 2018 Jul 13;19(1):181. doi: 10.1186/s12882-018-0979-1. BMC Nephrol. 2018. PMID: 30005619 Free PMC article.
Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes.
Tramonti A, Paiardini A, Paone A, Bouzidi A, Giardina G, Guiducci G, Magnifico MC, Rinaldo S, McDermott L, Menendez JA, Contestabile R, CutruzzolĂ  F. Tramonti A, et al. Among authors: paiardini a. Arch Biochem Biophys. 2018 Sep 1;653:71-79. doi: 10.1016/j.abb.2018.07.001. Epub 2018 Jul 4. Arch Biochem Biophys. 2018. PMID: 29991441
Corrigendum to "Pyridoxine-5'-phosphate oxidase (Pnpo) deficiency: Clinical and biochemical alterations associated with the C.347g>A (P.·Arg116gln) mutation" [Mol. Genet. Metab. 122/1-2 (2017) 135-142].
di Salvo ML, Mastrangelo M, Nogués I, Tolve M, Paiardini A, Carducci C, Mei D, Montomoli M, Tramonti A, Guerrini R, Contestabile R, Leuzzi V. di Salvo ML, et al. Among authors: paiardini a. Mol Genet Metab. 2018 Dec;125(4):359. doi: 10.1016/j.ymgme.2018.02.017. Epub 2018 Mar 14. Mol Genet Metab. 2018. PMID: 29548777 No abstract available.
Heterozygosis in aromatic amino acid decarboxylase deficiency: Evidence for a positive interallelic complementation between R347Q and R358H mutations.
Montioli R, Janson G, Paiardini A, Bertoldi M, Borri Voltattorni C. Montioli R, et al. Among authors: paiardini a. IUBMB Life. 2018 Mar;70(3):215-223. doi: 10.1002/iub.1718. Epub 2018 Jan 22. IUBMB Life. 2018. PMID: 29356298 Free article.
A novel germline mutation in CDK4 codon 24 associated to familial melanoma.
Bottillo I, La Starza R, Radio FC, Molica C, Pedace L, Pierini T, De Bernardo C, Stingeni L, Bargiacchi S, Paiardini A, Janson G, Mecucci C, Grammatico P. Bottillo I, et al. Among authors: paiardini a. Clin Genet. 2018 Apr;93(4):934-935. doi: 10.1111/cge.13129. Epub 2017 Nov 10. Clin Genet. 2018. PMID: 29124743 No abstract available.
Biochemical data from the characterization of a new pathogenic mutation of human pyridoxine-5'-phosphate oxidase (PNPO).
di Salvo ML, Mastrangelo M, Nogués I, Tolve M, Paiardini A, Carducci C, Mei D, Montomoli M, Tramonti A, Guerrini R, Contestabile R, Leuzzi V. di Salvo ML, et al. Among authors: paiardini a. Data Brief. 2017 Oct 28;15:868-875. doi: 10.1016/j.dib.2017.10.032. eCollection 2017 Dec. Data Brief. 2017. PMID: 29379851 Free PMC article.
Structural investigation of nucleophosmin interaction with the tumor suppressor Fbw7Îł.
Di Matteo A, Franceschini M, Paiardini A, Grottesi A, Chiarella S, Rocchio S, Di Natale C, Marasco D, Vitagliano L, Travaglini-Allocatelli C, Federici L. Di Matteo A, et al. Among authors: paiardini a. Oncogenesis. 2017 Sep 18;6(9):e379. doi: 10.1038/oncsis.2017.78. Oncogenesis. 2017. PMID: 28920929 Free PMC article.
Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.
Giardina G, Paiardini A, Montioli R, Cellini B, Voltattorni CB, CutruzzolĂ  F. Giardina G, et al. Among authors: paiardini a. Sci Rep. 2017 Sep 15;7(1):11704. doi: 10.1038/s41598-017-11948-w. Sci Rep. 2017. PMID: 28916765 Free PMC article.
Pyridoxine-5'-phosphate oxidase (Pnpo) deficiency: Clinical and biochemical alterations associated with the C.347g>A (P.·Arg116gln) mutation.
di Salvo ML, Mastrangelo M, Nogués I, Tolve M, Paiardini A, Carducci C, Mei D, Montomoli M, Tramonti A, Guerrini R, Contestabile R, Leuzzi V. di Salvo ML, et al. Among authors: paiardini a. Mol Genet Metab. 2017 Sep;122(1-2):135-142. doi: 10.1016/j.ymgme.2017.08.003. Epub 2017 Aug 12. Mol Genet Metab. 2017. PMID: 28818555
Betulinic acid is a PPARÎł antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis.
Brusotti G, Montanari R, Capelli D, Cattaneo G, Laghezza A, Tortorella P, Loiodice F, Peiretti F, Bonardo B, Paiardini A, Calleri E, Pochetti G. Brusotti G, et al. Among authors: paiardini a. Sci Rep. 2017 Jul 18;7(1):5777. doi: 10.1038/s41598-017-05666-6. Sci Rep. 2017. PMID: 28720829 Free PMC article.
Identification of small molecule inhibitors of the Aurora-A/TPX2 complex.
Asteriti IA, Daidone F, Colotti G, Rinaldo S, Lavia P, Guarguaglini G, Paiardini A. Asteriti IA, et al. Among authors: paiardini a. Oncotarget. 2017 May 9;8(19):32117-32133. doi: 10.18632/oncotarget.16738. Oncotarget. 2017. PMID: 28389630 Free PMC article.
Unique substrate specificity of ornithine aminotransferase from Toxoplasma gondii.
Astegno A, Maresi E, Bertoldi M, La Verde V, Paiardini A, Dominici P. Astegno A, et al. Among authors: paiardini a. Biochem J. 2017 Mar 7;474(6):939-955. doi: 10.1042/BCJ20161021. Biochem J. 2017. PMID: 28126740
Glucose Metabolism in the Progression of Prostate Cancer.
CutruzzolĂ  F, Giardina G, Marani M, Macone A, Paiardini A, Rinaldo S, Paone A. CutruzzolĂ  F, et al. Among authors: paiardini a. Front Physiol. 2017 Feb 21;8:97. doi: 10.3389/fphys.2017.00097. eCollection 2017. Front Physiol. 2017. PMID: 28270771 Free PMC article. Review.
PyMod 2.0: improvements in protein sequence-structure analysis and homology modeling within PyMOL.
Janson G, Zhang C, Prado MG, Paiardini A. Janson G, et al. Among authors: paiardini a. Bioinformatics. 2017 Feb 1;33(3):444-446. doi: 10.1093/bioinformatics/btw638. Bioinformatics. 2017. PMID: 28158668
Discovering Selective Diguanylate Cyclase Inhibitors: From PleD to Discrimination of the Active Site of Cyclic-di-GMP Phosphodiesterases.
Rinaldo S, Giardina G, Mantoni F, Paiardini A, Paone A, CutruzzolĂ  F. Rinaldo S, et al. Among authors: paiardini a. Methods Mol Biol. 2017;1657:431-453. doi: 10.1007/978-1-4939-7240-1_32. Methods Mol Biol. 2017. PMID: 28889312
New Insights Emerging from Recent Investigations on Human Group II Pyridoxal 5'-Phosphate Decarboxylases.
Paiardini A, Giardina G, Rossignoli G, Voltattorni CB, Bertoldi M. Paiardini A, et al. Curr Med Chem. 2017;24(3):226-244. doi: 10.2174/0929867324666161123093339. Curr Med Chem. 2017. PMID: 27881066 Review.
Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming.
Paiardini A, Tramonti A, Schirch D, Guiducci G, di Salvo ML, Fiascarelli A, Giorgi A, Maras B, CutruzzolĂ  F, Contestabile R. Paiardini A, et al. Biochim Biophys Acta. 2016 Nov;1864(11):1506-17. doi: 10.1016/j.bbapap.2016.08.010. Epub 2016 Aug 13. Biochim Biophys Acta. 2016. PMID: 27530298
The novel R347g pathogenic mutation of aromatic amino acid decarboxylase provides additional molecular insights into enzyme catalysis and deficiency.
Montioli R, Paiardini A, Kurian MA, Dindo M, Rossignoli G, Heales SJR, Pope S, Voltattorni CB, Bertoldi M. Montioli R, et al. Among authors: paiardini a. Biochim Biophys Acta. 2016 Jun;1864(6):676-682. doi: 10.1016/j.bbapap.2016.03.011. Epub 2016 Mar 17. Biochim Biophys Acta. 2016. PMID: 26994895
Prediction and visualization data for the interpretation of sarcomeric and non-sarcomeric DNA variants found in patients with hypertrophic cardiomyopathy.
Bottillo I, D'Angelantonio D, Caputo V, Paiardini A, Lipari M, De Bernardo C, Majore S, Castori M, Zachara E, Re F, Grammatico P. Bottillo I, et al. Among authors: paiardini a. Data Brief. 2016 Mar 10;7:607-13. doi: 10.1016/j.dib.2016.03.004. eCollection 2016 Jun. Data Brief. 2016. PMID: 27054166 Free PMC article.
A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells.
Marani M, Paone A, Fiascarelli A, Macone A, Gargano M, Rinaldo S, Giardina G, Pontecorvi V, Koes D, McDermott L, Yang T, Paiardini A, Contestabile R, CutruzzolĂ  F. Marani M, et al. Among authors: paiardini a. Oncotarget. 2016 Jan 26;7(4):4570-83. doi: 10.18632/oncotarget.6726. Oncotarget. 2016. PMID: 26717037 Free PMC article.
Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.
Drinkwater N, Vinh NB, Mistry SN, Bamert RS, Ruggeri C, Holleran JP, Loganathan S, Paiardini A, Charman SA, Powell AK, Avery VM, McGowan S, Scammells PJ. Drinkwater N, et al. Among authors: paiardini a. Eur J Med Chem. 2016 Mar 3;110:43-64. doi: 10.1016/j.ejmech.2016.01.015. Epub 2016 Jan 13. Eur J Med Chem. 2016. PMID: 26807544
Molecular analysis of sarcomeric and non-sarcomeric genes in patients with hypertrophic cardiomyopathy.
Bottillo I, D'Angelantonio D, Caputo V, Paiardini A, Lipari M, De Bernardo C, Giannarelli D, Pizzuti A, Majore S, Castori M, Zachara E, Re F, Grammatico P. Bottillo I, et al. Among authors: paiardini a. Gene. 2016 Feb 15;577(2):227-35. doi: 10.1016/j.gene.2015.11.048. Epub 2015 Dec 2. Gene. 2016. PMID: 26656175
Synthesis of Triazole-Linked Analogues of c-di-GMP and Their Interactions with Diguanylate Cyclase.
Fernicola S, Torquati I, Paiardini A, Giardina G, Rampioni G, Messina M, Leoni L, Del Bello F, Petrelli R, Rinaldo S, Cappellacci L, CutruzzolĂ  F. Fernicola S, et al. Among authors: paiardini a. J Med Chem. 2015 Oct 22;58(20):8269-84. doi: 10.1021/acs.jmedchem.5b01184. Epub 2015 Oct 12. J Med Chem. 2015. PMID: 26426545
In Silico Discovery and In Vitro Validation of Catechol-Containing Sulfonohydrazide Compounds as Potent Inhibitors of the Diguanylate Cyclase PleD.
Fernicola S, Paiardini A, Giardina G, Rampioni G, Leoni L, CutruzzolĂ  F, Rinaldo S. Fernicola S, et al. Among authors: paiardini a. J Bacteriol. 2015 Sep 28;198(1):147-56. doi: 10.1128/JB.00742-15. Print 2016 Jan 1. J Bacteriol. 2015. PMID: 26416830 Free PMC article.
Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening.
Ruggeri C, Drinkwater N, Sivaraman KK, Bamert RS, McGowan S, Paiardini A. Ruggeri C, et al. Among authors: paiardini a. PLoS One. 2015 Sep 25;10(9):e0138957. doi: 10.1371/journal.pone.0138957. eCollection 2015. PLoS One. 2015. PMID: 26406322 Free PMC article.
X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17.
Drinkwater N, Bamert RS, Sivaraman KK, Paiardini A, McGowan S. Drinkwater N, et al. Among authors: paiardini a. Proteins. 2015 Apr;83(4):789-95. doi: 10.1002/prot.24771. Epub 2015 Feb 28. Proteins. 2015. PMID: 25645579
Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18.
Paiardini A, Bamert RS, Kannan-Sivaraman K, Drinkwater N, Mistry SN, Scammells PJ, McGowan S. Paiardini A, et al. PLoS One. 2015 Feb 20;10(2):e0115859. doi: 10.1371/journal.pone.0115859. eCollection 2015. PLoS One. 2015. PMID: 25700165 Free PMC article.
Structural basis of functional diversification of the HD-GYP domain revealed by the Pseudomonas aeruginosa PA4781 protein, which displays an unselective bimetallic binding site.
Rinaldo S, Paiardini A, Stelitano V, Brunotti P, Cervoni L, Fernicola S, Protano C, Vitali M, CutruzzolĂ  F, Giardina G. Rinaldo S, et al. Among authors: paiardini a. J Bacteriol. 2015 Apr;197(8):1525-35. doi: 10.1128/JB.02606-14. Epub 2015 Feb 17. J Bacteriol. 2015. PMID: 25691523 Free PMC article.
How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state.
Giardina G, Brunotti P, Fiascarelli A, Cicalini A, Costa MG, Buckle AM, di Salvo ML, Giorgi A, Marani M, Paone A, Rinaldo S, Paiardini A, Contestabile R, CutruzzolĂ  F. Giardina G, et al. Among authors: paiardini a. FEBS J. 2015 Apr;282(7):1225-41. doi: 10.1111/febs.13211. Epub 2015 Feb 13. FEBS J. 2015. PMID: 25619277 Free article.
Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase.
Paiardini A, Fiascarelli A, Rinaldo S, Daidone F, Giardina G, Koes DR, Parroni A, Montini G, Marani M, Paone A, McDermott LA, Contestabile R, CutruzzolĂ  F. Paiardini A, et al. ChemMedChem. 2015 Mar;10(3):490-7. doi: 10.1002/cmdc.201500028. Epub 2015 Feb 10. ChemMedChem. 2015. PMID: 25677305 Free PMC article.
SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation.
Paone A, Marani M, Fiascarelli A, Rinaldo S, Giardina G, Contestabile R, Paiardini A, CutruzzolĂ  F. Paone A, et al. Among authors: paiardini a. Cell Death Dis. 2014 Nov 20;5(11):e1525. doi: 10.1038/cddis.2014.482. Cell Death Dis. 2014. PMID: 25412303 Free PMC article.
Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors.
Mistry SN, Drinkwater N, Ruggeri C, Sivaraman KK, Loganathan S, Fletcher S, Drag M, Paiardini A, Avery VM, Scammells PJ, McGowan S. Mistry SN, et al. Among authors: paiardini a. J Med Chem. 2014 Nov 13;57(21):9168-83. doi: 10.1021/jm501323a. Epub 2014 Oct 24. J Med Chem. 2014. PMID: 25299353
Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis.
Kass I, Hoke DE, Costa MG, Reboul CF, Porebski BT, Cowieson NP, Leh H, Pennacchietti E, McCoey J, Kleifeld O, Borri Voltattorni C, Langley D, Roome B, Mackay IR, Christ D, Perahia D, Buckle M, Paiardini A, De Biase D, Buckle AM. Kass I, et al. Among authors: paiardini a. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2524-9. doi: 10.1073/pnas.1403182111. Epub 2014 Jun 9. Proc Natl Acad Sci U S A. 2014. PMID: 24927554 Free PMC article.
PLP-dependent enzymes.
Paiardini A, Contestabile R, Buckle AM, Cellini B. Paiardini A, et al. Biomed Res Int. 2014;2014:856076. doi: 10.1155/2014/856076. Epub 2014 Jan 15. Biomed Res Int. 2014. PMID: 24527459 Free PMC article. No abstract available.
The phytotoxin fusicoccin differently regulates 14-3-3 proteins association to mode III targets.
Paiardini A, Aducci P, Cervoni L, CutruzzolĂ  F, Di Lucente C, Janson G, Pascarella S, Rinaldo S, Visconti S, Camoni L. Paiardini A, et al. IUBMB Life. 2014 Jan;66(1):52-62. doi: 10.1002/iub.1239. Epub 2014 Jan 10. IUBMB Life. 2014. PMID: 24408864 Free article.
Investigating the allosteric regulation of YfiN from Pseudomonas aeruginosa: clues from the structure of the catalytic domain.
Giardina G, Paiardini A, Fernicola S, Franceschini S, Rinaldo S, Stelitano V, CutruzzolĂ  F. Giardina G, et al. Among authors: paiardini a. PLoS One. 2013 Nov 22;8(11):e81324. doi: 10.1371/journal.pone.0081324. eCollection 2013. PLoS One. 2013. PMID: 24278422 Free PMC article.
On the catalytic mechanism and stereospecificity of Escherichia coli L-threonine aldolase.
di Salvo ML, Remesh SG, Vivoli M, Ghatge MS, Paiardini A, D'Aguanno S, Safo MK, Contestabile R. di Salvo ML, et al. Among authors: paiardini a. FEBS J. 2014 Jan;281(1):129-45. doi: 10.1111/febs.12581. Epub 2013 Nov 13. FEBS J. 2014. PMID: 24165453 Free PMC article.
Type I pyridoxal 5'-phosphate dependent enzymatic domains embedded within multimodular nonribosomal peptide synthetase and polyketide synthase assembly lines.
Milano T, Paiardini A, Grgurina I, Pascarella S. Milano T, et al. Among authors: paiardini a. BMC Struct Biol. 2013 Oct 23;13:26. doi: 10.1186/1472-6807-13-26. BMC Struct Biol. 2013. PMID: 24148833 Free PMC article.
C-di-GMP hydrolysis by Pseudomonas aeruginosa HD-GYP phosphodiesterases: analysis of the reaction mechanism and novel roles for pGpG.
Stelitano V, Giardina G, Paiardini A, Castiglione N, CutruzzolĂ  F, Rinaldo S. Stelitano V, et al. Among authors: paiardini a. PLoS One. 2013 Sep 16;8(9):e74920. doi: 10.1371/journal.pone.0074920. eCollection 2013. PLoS One. 2013. PMID: 24066157 Free PMC article.