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Page 1
Comparative physiological effects of antipsychotic drugs in children and young people: a network meta-analysis.
Rogdaki M, McCutcheon RA, D'Ambrosio E, Mancini V, Watson CJ, Fanshawe JB, Carr R, Telesia L, Martini MG, Philip A, Gilbert BJ, Salazar-de-Pablo G, Kyriakopoulos M, Siskind D, Correll CU, Cipriani A, Efthimiou O, Howes OD, Pillinger T. Rogdaki M, et al. Lancet Child Adolesc Health. 2024 Jul;8(7):510-521. doi: 10.1016/S2352-4642(24)00098-1. Lancet Child Adolesc Health. 2024. PMID: 38897716 Free PMC article.
Primary outcomes were mean change from baseline to end of acute treatment in bodyweight, BMI, fasting glucose, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, prolactin, heart rate, systolic blood pressure (SBP), and QT interval corrected for heart rate …
Primary outcomes were mean change from baseline to end of acute treatment in bodyweight, BMI, fasting glucose, total cholesterol, LDL choles …
Paliperidone Use in Child Psychiatry: Evidence or Diffidence?
Naguy A, Adel T, Almazeedi I. Naguy A, et al. Pharmacology. 2019;104(1-2):67-70. doi: 10.1159/000500629. Epub 2019 May 16. Pharmacology. 2019. PMID: 31096228 Review.
BACKGROUND: Paliperidone is FDA-approved for schizophrenia aged 12-17. However, the pharmacologic portfolio, extrapolation from adult studies, and the long track record of the parent drug, risperidone in child/adolescent psychiatric (CAP) population might expand its therap …
BACKGROUND: Paliperidone is FDA-approved for schizophrenia aged 12-17. However, the pharmacologic portfolio, extrapolation from adult …
Paliperidone: a review of clinical trial data and clinical implications.
Wang SM, Han C, Lee SJ, Patkar AA, Pae CU, Fleischhacker WW. Wang SM, et al. Clin Drug Investig. 2012 Aug 1;32(8):497-512. doi: 10.2165/11634440-000000000-00000. Clin Drug Investig. 2012. PMID: 22747259 Review.
Limited evidence suggests that paliperidone ER can potentially be superior to quetiapine and risperidone. However, few direct head-to-head comparisons between paliperidone ER and other antipsychotics have been conducted to confirm these results. ...The risks for ort …
Limited evidence suggests that paliperidone ER can potentially be superior to quetiapine and risperidone. However, few direct head-to …
First-Degree Atrioventricular Block with Tachycardia from Paliperidone and Mirtazapine Overdose.
Cheung B, Levy C, Shivkumar A. Cheung B, et al. Eur J Case Rep Intern Med. 2020 Sep 29;7(12):001879. doi: 10.12890/2020_001879. eCollection 2020. Eur J Case Rep Intern Med. 2020. PMID: 33312997 Free PMC article.
BACKGROUND: Paliperidone and mirtazapine are psychotropic agents associated with proarrhythmic effects. ...CONCLUSION: Drug-induced first-degree AVB from paliperidone and mirtazapine should be on the differential diagnosis in patients on paliperidone and/or m …
BACKGROUND: Paliperidone and mirtazapine are psychotropic agents associated with proarrhythmic effects. ...CONCLUSION: Drug-induced f …
Risk of cardiovascular morbidity with risperidone or paliperidone treatment: analysis of 64 randomized, double-blind trials.
Gopal S, Hough D, Karcher K, Nuamah I, Palumbo J, Berlin JA, Baseman A, Xu Y, Kent J. Gopal S, et al. J Clin Psychopharmacol. 2013 Apr;33(2):157-61. doi: 10.1097/JCP.0b013e318283983f. J Clin Psychopharmacol. 2013. PMID: 23422378
A post hoc analysis of the risperidone (RIS)/paliperidone (Pali) clinical trials database comprising 64 studies was conducted. Risk of sudden death, cardiovascular (CV), and cerebrovascular events during RIS or Pali treatment was estimated. Treatment emergent CV adverse ev …
A post hoc analysis of the risperidone (RIS)/paliperidone (Pali) clinical trials database comprising 64 studies was conducted. Risk o …
QT and QTc in Male Patients with Psychotic Disorders Treated with Atypical Neuroleptics.
Miniati M, Simoncini M, Vanelli F, Franceschini C, Massimetti G, Carmassi C, Dell'Osso L. Miniati M, et al. ScientificWorldJournal. 2017;2017:1951628. doi: 10.1155/2017/1951628. Epub 2017 Jul 12. ScientificWorldJournal. 2017. PMID: 28785719 Free PMC article.
QT values were significantly different (chi-square = 17.3; df = 5; p = .004). Statistically significant differences between aripiprazole and paliperidone (349.0 28.3 versus 390.5 29.8; p = .002) and between clozapine and paliperidone (361.1 22.43 versus …
QT values were significantly different (chi-square = 17.3; df = 5; p = .004). Statistically significant differences between aripipraz …
Corrected QT changes during antipsychotic treatment of children and adolescents: a systematic review and meta-analysis of clinical trials.
Jensen KG, Juul K, Fink-Jensen A, Correll CU, Pagsberg AK. Jensen KG, et al. J Am Acad Child Adolesc Psychiatry. 2015 Jan;54(1):25-36. doi: 10.1016/j.jaac.2014.10.002. Epub 2014 Oct 16. J Am Acad Child Adolesc Psychiatry. 2015. PMID: 25524787
OBJECTIVE: To evaluate the effect of antipsychotics on the corrected QT (QTc) interval in youth. METHOD: We searched PubMed (http://www.ncbi.nlm.nih.gov/pubmed) for randomized or open clinical trials of antipsychotics in youth <18 years with QTc data, meta-analyzing the …
OBJECTIVE: To evaluate the effect of antipsychotics on the corrected QT (QTc) interval in youth. METHOD: We searched PubMed (http://w …
Need for Bioequivalence Standards that Reflect the Clinical Importance of the Complex Pharmacokinetics of Paliperidone Palmitate Long-Acting Injectable Suspension.
Procyshyn RM, Lamoure JW, Katzman MA, Skinner PL, Sherman SE. Procyshyn RM, et al. J Pharm Pharm Sci. 2019;22(1):548-566. doi: 10.18433/jpps30669. J Pharm Pharm Sci. 2019. PMID: 31730504 Free article.
Paliperidone palmitate dissolves slowly after deep intramuscular injection before being hydrolyzed to paliperidone and absorbed into the systemic circulation. ...Changes to the manufacturing processes can substantially alter the release characteristics of …
Paliperidone palmitate dissolves slowly after deep intramuscular injection before being hydrolyzed to paliperidone and …
Prolongation of cardiac ventricular repolarization under paliperidone: how and how much?
Vigneault P, Kaddar N, Bourgault S, Caillier B, Pilote S, Patoine D, Simard C, Drolet B. Vigneault P, et al. J Cardiovasc Pharmacol. 2011 Jun;57(6):690-5. doi: 10.1097/FJC.0b013e318217d941. J Cardiovasc Pharmacol. 2011. PMID: 21394035
INTRODUCTION: Paliperidone (9-hydroxyrisperidone) is a second-generation antipsychotic. As observed with risperidone, QT interval prolongation was reported with paliperidone. ...CONCLUSIONS: Paliperidone prolongs the QT interval by blocking HERG …
INTRODUCTION: Paliperidone (9-hydroxyrisperidone) is a second-generation antipsychotic. As observed with risperidone, QT inter …
Studies on the acute toxicity, pharmacokinetics and pharmacodynamics of paliperidone derivatives--comparison to paliperidone and risperidone in mice and rats.
Sun F, Su Z, Sui C, Zhang C, Yuan L, Meng Q, Teng L, Li Y. Sun F, et al. Basic Clin Pharmacol Toxicol. 2010 Aug;107(2):656-62. doi: 10.1111/j.1742-7843.2010.00552.x. Basic Clin Pharmacol Toxicol. 2010. PMID: 20662826
The objective of this study was to investigate the acute toxicity, pharmacokinetics and pharmacodynamics of paliperidone derivatives (PDs) compared with paliperidone and risperidone. The i.g. LD(50) and i.v. maximum tolerated doses of PD1, PD5 and PD6 were greater t …
The objective of this study was to investigate the acute toxicity, pharmacokinetics and pharmacodynamics of paliperidone derivatives …
28 results