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Your search for palmitic acid mediates hyopthalamic insulin resistance retrieved no results
Palmitic acid control of ciliogenesis modulates insulin signaling in hypothalamic neurons through an autophagy-dependent mechanism.
Ávalos Y, Hernández-Cáceres MP, Lagos P, Pinto-Nuñez D, Rivera P, Burgos P, Díaz-Castro F, Joy-Immediato M, Venegas-Zamora L, Lopez-Gallardo E, Kretschmar C, Batista-Gonzalez A, Cifuentes-Araneda F, Toledo-Valenzuela L, Rodriguez-Peña M, Espinoza-Caicedo J, Perez-Leighton C, Bertocchi C, Cerda M, Troncoso R, Parra V, Budini M, Burgos PV, Criollo A, Morselli E. Ávalos Y, et al. Cell Death Dis. 2022 Jul 28;13(7):659. doi: 10.1038/s41419-022-05109-9. Cell Death Dis. 2022. PMID: 35902579 Free PMC article.
Palmitic acid (PA) is significantly increased in the hypothalamus of mice, when fed chronically with a high-fat diet (HFD). PA impairs insulin signaling in hypothalamic neurons, by a mechanism dependent on autophagy, a process of lysosomal-me
Palmitic acid (PA) is significantly increased in the hypothalamus of mice, when fed chronically with a high-fat diet (H
Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents.
Benoit SC, Kemp CJ, Elias CF, Abplanalp W, Herman JP, Migrenne S, Lefevre AL, Cruciani-Guglielmacci C, Magnan C, Yu F, Niswender K, Irani BG, Holland WL, Clegg DJ. Benoit SC, et al. J Clin Invest. 2009 Sep;119(9):2577-89. doi: 10.1172/JCI36714. Epub 2009 Aug 10. J Clin Invest. 2009. PMID: 19726875 Free PMC article.
Here, we assessed whether one specific isoform, PKC-theta, was expressed in critical CNS regions that regulate energy balance and whether it mediated the deleterious effects of diets high in fat, specifically palmitic acid, on hypothalamic insulin
Here, we assessed whether one specific isoform, PKC-theta, was expressed in critical CNS regions that regulate energy balance and whether it …
Palmitic acid triggers inflammatory responses in N42 cultured hypothalamic cells partially via ceramide synthesis but not via TLR4.
Sergi D, Morris AC, Kahn DE, McLean FH, Hay EA, Kubitz P, MacKenzie A, Martinoli MG, Drew JE, Williams LM. Sergi D, et al. Nutr Neurosci. 2020 Apr;23(4):321-334. doi: 10.1080/1028415X.2018.1501533. Epub 2018 Jul 21. Nutr Neurosci. 2020. PMID: 30032721
A high-fat diet induces hypothalamic inflammation in rodents which, in turn, contributes to the development of obesity by eliciting both insulin and leptin resistance. ...To elucidate this mechanism, the effect of fatty acids on the expression of the pro-infl …
A high-fat diet induces hypothalamic inflammation in rodents which, in turn, contributes to the development of obesity by eliciting b …
Palmitic Acid Reduces the Autophagic Flux and Insulin Sensitivity Through the Activation of the Free Fatty Acid Receptor 1 (FFAR1) in the Hypothalamic Neuronal Cell Line N43/5.
Hernández-Cáceres MP, Toledo-Valenzuela L, Díaz-Castro F, Ávalos Y, Burgos P, Narro C, Peña-Oyarzun D, Espinoza-Caicedo J, Cifuentes-Araneda F, Navarro-Aguad F, Riquelme C, Troncoso R, Criollo A, Morselli E. Hernández-Cáceres MP, et al. Front Endocrinol (Lausanne). 2019 Mar 26;10:176. doi: 10.3389/fendo.2019.00176. eCollection 2019. Front Endocrinol (Lausanne). 2019. PMID: 30972025 Free PMC article.
Whether malfunction of autophagy specifically in hypothalamic neurons decreases insulin sensitivity remains unknown. PA does activate the Free Fatty Acid Receptor 1 (FFAR1), also known as G protein-coupled receptor 40 (GPR40); however, whether FFAR1 mediat
Whether malfunction of autophagy specifically in hypothalamic neurons decreases insulin sensitivity remains unknown. PA does a …
Jinkui Shenqi pills ameliorate diabetes by regulating hypothalamic insulin resistance and POMC/AgRP expression and activity.
Zhang S, Zhang Y, Wen Z, Yang Y, Bu T, Wei R, Chen Y, Ni Q. Zhang S, et al. Phytomedicine. 2024 Feb 2;126:155297. doi: 10.1016/j.phymed.2023.155297. Online ahead of print. Phytomedicine. 2024. PMID: 38342019
Additionally, primary hypothalamic neurons were exposed to high glucose and palmitic acid levels to induce insulin resistance, and the influence of JSP on POMC/AgRP protein expression and activation was evaluated by PI3K protein inhibition using …
Additionally, primary hypothalamic neurons were exposed to high glucose and palmitic acid levels to induce insulin
Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 5' monophosphate-activated protein kinase activation.
Mayer CM, Belsham DD. Mayer CM, et al. Endocrinology. 2010 Feb;151(2):576-85. doi: 10.1210/en.2009-1122. Epub 2009 Dec 1. Endocrinology. 2010. PMID: 19952270
Hypothalamic insulin signaling is essential to the maintenance of glucose and energy homeostasis. During pathological states, such as obesity and type 2 diabetes mellitus, insulin signaling is impaired. One key mechanism involved in the development of insu
Hypothalamic insulin signaling is essential to the maintenance of glucose and energy homeostasis. During pathological states,
Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism.
Brown WH, Gillum MP, Lee HY, Camporez JP, Zhang XM, Jeong JK, Alves TC, Erion DM, Guigni BA, Kahn M, Samuel VT, Cravatt BF, Diano S, Shulman GI. Brown WH, et al. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14966-71. doi: 10.1073/pnas.1212887109. Epub 2012 Aug 21. Proc Natl Acad Sci U S A. 2012. PMID: 22912404 Free PMC article.
Infusion of NAEs (anandamide and palmitoylethanolamide) recapitulated increases in PPARgamma-mediated decreases in EE. FAAH(-/-) mice were also prone to diet-induced hepatic insulin resistance, which could be attributed to increased hepatic diacylglycerol con …
Infusion of NAEs (anandamide and palmitoylethanolamide) recapitulated increases in PPARgamma-mediated decreases in EE. FAAH(-/-) mice …
Acute effects of fatty acids on autophagy in NPY neurones.
Reginato A, Siqueira BP, Miyamoto JÉ, Portovedo M, Costa SO, de Fante T, Rodrigues HG, Ignácio-Souza LM, Torsoni MA, Torsoni AS, Le Stunff H, Belsham DD, Milanski M. Reginato A, et al. J Neuroendocrinol. 2020 Oct;32(10):e12900. doi: 10.1111/jne.12900. J Neuroendocrinol. 2020. PMID: 33040385
High-fat diet (HFD) feeding is deleterious to hypothalamic tissue, leading to inflammation and lipotoxicity, as well as contributing to central insulin resistance. ...Taken together, these findings provide evidence that saturated and unsaturated fatty acids c …
High-fat diet (HFD) feeding is deleterious to hypothalamic tissue, leading to inflammation and lipotoxicity, as well as contributing …
Ginsenosides Rc, as a novel SIRT6 activator, protects mice against high fat diet induced NAFLD.
Yang Z, Yu Y, Sun N, Zhou L, Zhang D, Chen H, Miao W, Gao W, Zhang C, Liu C, Yang X, Wu X, Gao Y. Yang Z, et al. J Ginseng Res. 2023 May;47(3):376-384. doi: 10.1016/j.jgr.2020.07.005. Epub 2020 Aug 4. J Ginseng Res. 2023. PMID: 37252281 Free PMC article.
METHODS: Mice primary hepatocytes (MPHs) challenged with oleic acid & palmitic acid were used to test the effects of ginsenosides Rc on intracellular lipid metabolism. ...Ginsenosides Rc (20mg/kg) injection improved glucose intolerance, insulin
METHODS: Mice primary hepatocytes (MPHs) challenged with oleic acid & palmitic acid were used to test the effects o …
Dapagliflozin ameliorates ovulation disorders via attenuating activated microglia-mediated hypothalamic inflammation in HFD-fed mice.
Chen X, Xiao Z, Liu Q, Luo D, Cai Y, Fan M. Chen X, et al. Neuroendocrinology. 2023 Dec 26. doi: 10.1159/000535420. Online ahead of print. Neuroendocrinology. 2023. PMID: 38147832
We also examined the effects of dapagliflozin on glucose metabolism and the release of inflammatory factor in palmitic acid (PA)-treated HMC3 cells. RESULTS: As expected, dapagliflozin improved HFD-induced metabolic disturbances, peripheral versus central insulin
We also examined the effects of dapagliflozin on glucose metabolism and the release of inflammatory factor in palmitic acid (P …