Randomised controlled trial for emphysema with a selective agonist of the γ-type retinoic acid receptor.
Stolk J, Stockley RA, Stoel BC, Cooper BG, Piitulainen E, Seersholm N, Chapman KR, Burdon JG, Decramer M, Abboud RT, Mannes GP, Wouters EF, Garrett JE, Barros-Tizon JC, Russi EW, Lomas DA, MacNee WA, Rames A.
Stolk J, et al.
Eur Respir J. 2012 Aug;40(2):306-12. doi: 10.1183/09031936.00161911. Epub 2012 Jan 26.
Eur Respir J. 2012.
PMID: 22282548
Free article.
Clinical Trial.
Palovarotene is an oral gamma-selective retinoid agonist. In animal emphysema models, palovarotene reduced inflammation, promoted structural repair and functional improvement. ...We randomly assigned 133 and 129 patients to placebo or palovarotene, respective …
Palovarotene is an oral gamma-selective retinoid agonist. In animal emphysema models, palovarotene reduced inflammation, promo …