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Total Synthesis of Pargamicin A.
Elbatrawi YM, Gerrein T, Anwar A, Makwana KM, Degen D, Ebright RH, Del Valle JR. Elbatrawi YM, et al. Org Lett. 2022 Dec 23;24(50):9285-9289. doi: 10.1021/acs.orglett.2c03861. Epub 2022 Dec 14. Org Lett. 2022. PMID: 36516292 Free PMC article.
We report the total synthesis and configurational assignment of pargamicin A, a highly oxidized nonribosomal peptide that potently inhibits the growth of drug-resistant bacteria. Our synthetic approach relies on late-stage piperazine ring formation and careful selection of …
We report the total synthesis and configurational assignment of pargamicin A, a highly oxidized nonribosomal peptide that potently in …
Concise Total Synthesis and Biological Evaluation of Pargamicin A and its Diastereomer, Piperazic Acid-containing Cyclopeptides.
Yoshida M, Inaba T, Shibuya Y, Igarashi M, Kigoshi H. Yoshida M, et al. Chempluschem. 2023 Aug;88(8):e202300339. doi: 10.1002/cplu.202300339. Chempluschem. 2023. PMID: 37492977
T3P-promoted macrolactamization under high-dilution conditions, followed by the removal of the benzyl protecting group was used to furnish two putative structures of pargamicin A. Comparison of the (1) H and (13) C NMR spectra and the antibacterial activity of the natural …
T3P-promoted macrolactamization under high-dilution conditions, followed by the removal of the benzyl protecting group was used to furnish t …
Pargamicin A, a novel cyclic peptide antibiotic from Amycolatopsis sp.
Igarashi M, Sawa R, Kinoshita N, Hashizume H, Nakagawa N, Homma Y, Nishimura Y, Akamatsu Y. Igarashi M, et al. J Antibiot (Tokyo). 2008 Jun;61(6):387-93. doi: 10.1038/ja.2008.54. J Antibiot (Tokyo). 2008. PMID: 18667787
Pargamicin A was identified as a novel cyclic hexapeptide antibiotic containing piperazic acid by various spectroscopic analyses. Pargamicin A showed potent antibacterial activity against Staphylococcus aureus strains including MRSA and Enterococcus faecalis/faecium …
Pargamicin A was identified as a novel cyclic hexapeptide antibiotic containing piperazic acid by various spectroscopic analyses. …
[Studies for the development of novel anti-MRSA/VRE drugs].
Hashizume H. Hashizume H. Yakugaku Zasshi. 2012;132(1):59-67. doi: 10.1248/yakushi.132.59. Yakugaku Zasshi. 2012. PMID: 22214581 Free article. Review. Japanese.
In the course of screening for active compounds against the above drug-resistant bacteria from microbial metabolites, we discovered three kinds of novel compounds designated tripropeptins, pargamicin, and amycolamicin. Tripropeptin C (TPPC), major component of tripropeptin …
In the course of screening for active compounds against the above drug-resistant bacteria from microbial metabolites, we discovered three ki …
Biological activities of pargamicin A, a novel cyclic peptide antibiotic from Amycolatopsis sp.
Hashizume H, Adachi H, Igarashi M, Nishimura Y, Akamatsu Y. Hashizume H, et al. J Antibiot (Tokyo). 2010 Jun;63(6):279-83. doi: 10.1038/ja.2010.29. Epub 2010 Mar 26. J Antibiot (Tokyo). 2010. PMID: 20339400
The time-kill studies using pargamicin A against Staphylococcus aureus and Enterococcus faecalis were performed. The effects of the incorporation of radioactive precursors into macromolecules, membrane potential and function using fluorescent dyes were also examined. These …
The time-kill studies using pargamicin A against Staphylococcus aureus and Enterococcus faecalis were performed. The effects of the i …
Valgamicin C, a novel cyclic depsipeptide containing the unusual amino acid cleonine, and related valgamicins A, T and V produced by Amycolatopsis sp. ML1-hF4.
Hashizume H, Iijima K, Yamashita K, Kimura T, Wada SI, Sawa R, Igarashi M. Hashizume H, et al. J Antibiot (Tokyo). 2017 Nov 15. doi: 10.1038/ja.2017.135. Online ahead of print. J Antibiot (Tokyo). 2017. PMID: 29138482
In the course of optimizing pargamicin A production in Amycolatopsis sp. ML1-hF4, we discovered novel cyclic depsipeptide compounds in the broth and designated them valgamicins A, C, T and V. ...
In the course of optimizing pargamicin A production in Amycolatopsis sp. ML1-hF4, we discovered novel cyclic depsipeptide compounds i …