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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 1
1989 1
1990 1
1991 2
1992 6
1993 4
1994 4
1995 4
1996 4
1997 7
1998 8
1999 4
2000 5
2001 9
2002 12
2003 12
2004 13
2005 18
2006 16
2007 19
2008 23
2009 23
2010 22
2011 25
2012 33
2013 23
2014 26
2015 27
2016 27
2017 28
2018 23
2019 20
2020 26
2021 33
2022 7
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446 results
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Page 1
Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders.
Islam MT. Islam MT. Neurol Res. 2017 Jan;39(1):73-82. doi: 10.1080/01616412.2016.1251711. Epub 2016 Nov 3. Neurol Res. 2017. PMID: 27809706 Review.
Moreover, the effects of reactive species on mitochondria and their metabolic processes eventually cause a rise in ROS/RNS levels, leading to oxidation of mitochondrial proteins, lipids, and DNA. Oxidative stress has been considered to be linked to the etiology of many dis …
Moreover, the effects of reactive species on mitochondria and their metabolic processes eventually cause a rise in ROS/RNS levels, le …
Ferroptosis and its potential as a therapeutic target.
Yuan H, Pratte J, Giardina C. Yuan H, et al. Biochem Pharmacol. 2021 Apr;186:114486. doi: 10.1016/j.bcp.2021.114486. Epub 2021 Feb 23. Biochem Pharmacol. 2021. PMID: 33631189 Review.
It is an iron-dependent programmed cell death and the accumulation of lipid hydroperoxides to lethal levels make ferroptosis distinct. Ferroptosis can be effectively regulated by a number of cellular variables including iron content, amino acid uptake, polyunsaturated fatt …
It is an iron-dependent programmed cell death and the accumulation of lipid hydroperoxides to lethal levels make ferroptosis distinct …
Application of Glutathione as Anti-Oxidative and Anti-Aging Drugs.
Homma T, Fujii J. Homma T, et al. Curr Drug Metab. 2015;16(7):560-71. doi: 10.2174/1389200216666151015114515. Curr Drug Metab. 2015. PMID: 26467067 Review.
GSH is now entering a new era of therapeutic applications. Decreased GSH levels are associated with the common features of aging as well as of a wide range of pathological conditions, including neurodegenerative disorders. Notably, GSH depletion and/or alterations i …
GSH is now entering a new era of therapeutic applications. Decreased GSH levels are associated with the common features of aging as w …
Riboflavin in Neurological Diseases: A Narrative Review.
Plantone D, Pardini M, Rinaldi G. Plantone D, et al. Clin Drug Investig. 2021 Jun;41(6):513-527. doi: 10.1007/s40261-021-01038-1. Epub 2021 Apr 22. Clin Drug Investig. 2021. PMID: 33886098 Review.
Several successful trials testing riboflavin for migraine prevention were performed, and this drug is currently classified as a Level B medication for migraine according to the American Academy of Neurology evidence-based rating, with evidence supporting its efficacy. ...T …
Several successful trials testing riboflavin for migraine prevention were performed, and this drug is currently classified as a Level …
Ferroptosis and NRF2: an emerging battlefield in the neurodegeneration of Alzheimer's disease.
Lane DJR, Metselaar B, Greenough M, Bush AI, Ayton SJ. Lane DJR, et al. Essays Biochem. 2021 Dec 22;65(7):925-940. doi: 10.1042/EBC20210017. Essays Biochem. 2021. PMID: 34623415 Review.
Ferroptosis is an iron- and lipid peroxidation-dependent cell death modality and emerging evidence indicates that ferroptosis has great explanatory potential for neuronal loss and associated CNS dysfunction in a range of neurodegenerative diseases (e.g., Alzheimer's, Pa …
Ferroptosis is an iron- and lipid peroxidation-dependent cell death modality and emerging evidence indicates that ferroptosis has great expl …
Neuroprotective effects of Danshensu on rotenone-induced Parkinson's disease models in vitro and in vivo.
Wang T, Li C, Han B, Wang Z, Meng X, Zhang L, He J, Fu F. Wang T, et al. BMC Complement Med Ther. 2020 Jan 23;20(1):20. doi: 10.1186/s12906-019-2738-7. BMC Complement Med Ther. 2020. PMID: 32020857 Free PMC article.
Rotenone inhibits complex I of the mitochondrial electron transport chain in dopaminergic neurons leading to glutathione (GSH) level reduction and oxidative stress. The aim of this study is to investigate neuroprotective effects of Danshensu on rotenone-induced P …
Rotenone inhibits complex I of the mitochondrial electron transport chain in dopaminergic neurons leading to glutathione (GSH) lev …
Altered mitochondrial function, iron metabolism and glutathione levels in Parkinson's disease.
Jenner P. Jenner P. Acta Neurol Scand Suppl. 1993;146:6-13. Acta Neurol Scand Suppl. 1993. PMID: 8333254 Review.
Indeed, in postmortem tissues from patients dying with Parkinson's disease there is evidence for inhibition of complex I of the mitochondrial respiratory chain, altered iron metabolism and decreased levels of reduced glutathione. ...However, the …
Indeed, in postmortem tissues from patients dying with Parkinson's disease there is evidence for inhibition of complex …
α-Lipoic acid alleviates ferroptosis in the MPP+ -induced PC12 cells via activating the PI3K/Akt/Nrf2 pathway.
Liu L, Yang S, Wang H. Liu L, et al. Cell Biol Int. 2021 Feb;45(2):422-431. doi: 10.1002/cbin.11505. Epub 2020 Dec 8. Cell Biol Int. 2021. PMID: 33241887
Parkinson's disease (PD) is a typical neurodegenerative disease. alpha-Lipoic acid (alpha-LA) can reduce the incidence of neuropathy. ...Malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), iron, reactive xygen species (ROS), and glutathione (GSH) c …
Parkinson's disease (PD) is a typical neurodegenerative disease. alpha-Lipoic acid (alpha-LA) can reduce the inc …
6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway.
Urano Y, Mori C, Fuji A, Konno K, Yamamoto T, Yashirogi S, Ando M, Saito Y, Noguchi N. Urano Y, et al. Autophagy. 2018;14(11):1943-1958. doi: 10.1080/15548627.2018.1493043. Epub 2018 Aug 16. Autophagy. 2018. PMID: 30112966 Free PMC article.
PARK7/DJ-1 is a Parkinson disease- and cancer-associated protein that functions as a multifunctional protein involved in gene transcription regulation and anti-oxidative defense. ...We moreover observed that 6-OHDA-derived electrophilic quinone induced oxidative str …
PARK7/DJ-1 is a Parkinson disease- and cancer-associated protein that functions as a multifunctional protein involved in gene …
[Correlations of Melatonin and Glutathione Levels with Oxidative Stress Mechanism in Parkinson's Disease].
Wei HJ, DU M, Bai HY. Wei HJ, et al. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2019 Apr 28;41(2):183-187. doi: 10.3881/j.issn.1000-503X.10775. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2019. PMID: 31060672 Chinese.
Objective To investigate the changes of serum melatonin(MLT)and glutathione(GSH)levels in patients with Parkinson's disease(PD)and explore their relationships with disease severity,cognitive dysfunction,and sleep disorders. ...Conc …
Objective To investigate the changes of serum melatonin(MLT)and glutathione(GSH)levels in patients with Parkinson's …
446 results