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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 2
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3,147 results

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Skin Biopsy Detection of Phosphorylated alpha-Synuclein in Patients With Synucleinopathies.
Gibbons CH, Levine T, Adler C, Bellaire B, Wang N, Stohl J, Agarwal P, Aldridge GM, Barboi A, Evidente VGH, Galasko D, Geschwind MD, Gonzalez-Duarte A, Gil R, Gudesblatt M, Isaacson SH, Kaufmann H, Khemani P, Kumar R, Lamotte G, Liu AJ, McFarland NR, Miglis M, Reynolds A, Sahagian GA, Saint-Hillaire MH, Schwartzbard JB, Singer W, Soileau MJ, Vernino S, Yerstein O, Freeman R. Gibbons CH, et al. JAMA. 2024 Apr 16;331(15):1298-1306. doi: 10.1001/jama.2024.0792. JAMA. 2024. PMID: 38506839 Free PMC article.
IMPORTANCE: Finding a reliable diagnostic biomarker for the disorders collectively known as synucleinopathies (Parkinson disease [PD], dementia with Lewy bodies [DLB], multiple system atrophy [MSA], and pure autonomic failure [PAF]) is an urgent unmet need. ...All p …
IMPORTANCE: Finding a reliable diagnostic biomarker for the disorders collectively known as synucleinopathies (Parkinson disease [PD] …
A biological definition of neuronal alpha-synuclein disease: towards an integrated staging system for research.
Simuni T, Chahine LM, Poston K, Brumm M, Buracchio T, Campbell M, Chowdhury S, Coffey C, Concha-Marambio L, Dam T, DiBiaso P, Foroud T, Frasier M, Gochanour C, Jennings D, Kieburtz K, Kopil CM, Merchant K, Mollenhauer B, Montine T, Nudelman K, Pagano G, Seibyl J, Sherer T, Singleton A, Stephenson D, Stern M, Soto C, Tanner CM, Tolosa E, Weintraub D, Xiao Y, Siderowf A, Dunn B, Marek K. Simuni T, et al. Lancet Neurol. 2024 Feb;23(2):178-190. doi: 10.1016/S1474-4422(23)00405-2. Lancet Neurol. 2024. PMID: 38267190 Review.
Parkinson's disease and dementia with Lewy bodies are currently defined by their clinical features, with alpha-synuclein pathology as the gold standard to establish the definitive diagnosis. We propose that, given biomarker advances enabling accurate detection of …
Parkinson's disease and dementia with Lewy bodies are currently defined by their clinical features, with alpha-synuclein pathology …
Alpha Synuclein: Neurodegeneration and Inflammation.
Forloni G. Forloni G. Int J Mol Sci. 2023 Mar 21;24(6):5914. doi: 10.3390/ijms24065914. Int J Mol Sci. 2023. PMID: 36982988 Free PMC article. Review.
Alpha-Synuclein (alpha-Syn) is one of the most important molecules involved in the pathogenesis of Parkinson's disease and related disorders, synucleinopathies, but also in several other neurodegenerative disorders with a more elusive role. ...The neur …
Alpha-Synuclein (alpha-Syn) is one of the most important molecules involved in the pathogenesis of Parkinson's disease and related …
Pathological roles of alpha-synuclein in neurological disorders.
Vekrellis K, Xilouri M, Emmanouilidou E, Rideout HJ, Stefanis L. Vekrellis K, et al. Lancet Neurol. 2011 Nov;10(11):1015-25. doi: 10.1016/S1474-4422(11)70213-7. Lancet Neurol. 2011. PMID: 22014436 Review.
Substantial genetic, neuropathological, and biochemical evidence implicates the presynaptic neuronal protein alpha-synuclein in Parkinson's disease and related Lewy body disorders. How dysregulation of alpha-synuclein leads to neurodegeneration is, however, u …
Substantial genetic, neuropathological, and biochemical evidence implicates the presynaptic neuronal protein alpha-synuclein in Parki …
alpha-Synuclein pathology as a target in neurodegenerative diseases.
Park H, Kam TI, Dawson VL, Dawson TM. Park H, et al. Nat Rev Neurol. 2025 Jan;21(1):32-47. doi: 10.1038/s41582-024-01043-w. Epub 2024 Nov 28. Nat Rev Neurol. 2025. PMID: 39609631 Review.
alpha-Synuclein misfolds into pathological forms that lead to various neurodegenerative diseases known collectively as alpha-synucleinopathies. ...We also highlight the existence of disease-specific alpha-synuclein strains and their mechanisms of pa …
alpha-Synuclein misfolds into pathological forms that lead to various neurodegenerative diseases known collectively as …
Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson's disease.
Rocha EM, De Miranda B, Sanders LH. Rocha EM, et al. Neurobiol Dis. 2018 Jan;109(Pt B):249-257. doi: 10.1016/j.nbd.2017.04.004. Epub 2017 Apr 8. Neurobiol Dis. 2018. PMID: 28400134 Review.
Mitochondrial dysfunction is also widely considered to play a major role in the underlying mechanisms contributing to neurodegeneration in PD. This review discusses evidence for the neuropathological role for alpha-synuclein in the dysfunction of dopamine neu …
Mitochondrial dysfunction is also widely considered to play a major role in the underlying mechanisms contributing to neurodegenerati …
Targeting Microglial alpha-Synuclein/TLRs/NF-kappaB/NLRP3 Inflammasome Axis in Parkinson's Disease.
Li Y, Xia Y, Yin S, Wan F, Hu J, Kou L, Sun Y, Wu J, Zhou Q, Huang J, Xiong N, Wang T. Li Y, et al. Front Immunol. 2021 Oct 8;12:719807. doi: 10.3389/fimmu.2021.719807. eCollection 2021. Front Immunol. 2021. PMID: 34691027 Free PMC article. Review.
Activated NLRP3 inflammasome aggravates the pathology and accelerates the progression of neurodegenerative diseases. Abnormal protein aggregation of alpha-synuclein (alpha-syn), a pathologically relevant protein of PD, were reported to activate the NLR …
Activated NLRP3 inflammasome aggravates the pathology and accelerates the progression of neurodegenerative diseases. Abnormal …
Concepts and classification of neurodegenerative diseases.
Kovacs GG. Kovacs GG. Handb Clin Neurol. 2017;145:301-307. doi: 10.1016/B978-0-12-802395-2.00021-3. Handb Clin Neurol. 2017. PMID: 28987178
Molecular classification of neurodegenerative disease is protein-based. This emphasizes the role of protein-processing systems in the pathogenesis. The most frequent proteins involved in the pathogenesis of neurodegenerative diseases are amyloid-beta, prion protein, …
Molecular classification of neurodegenerative disease is protein-based. This emphasizes the role of protein-processing systems in the …
The role of Toll-like receptors and neuroinflammation in Parkinson's disease.
Heidari A, Yazdanpanah N, Rezaei N. Heidari A, et al. J Neuroinflammation. 2022 Jun 6;19(1):135. doi: 10.1186/s12974-022-02496-w. J Neuroinflammation. 2022. PMID: 35668422 Free PMC article. Review.
BACKGROUND: Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, characterized by motor and non-motor symptoms, significantly affecting patients' life. Pathologically, PD is associated with the extensive degeneration of dopaminergic neurons in …
BACKGROUND: Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, characterized by motor and non-motor symptoms, …
The roles of intrinsically disordered proteins in neurodegeneration.
Utami KH, Morimoto S, Mitsukura Y, Okano H. Utami KH, et al. Biochim Biophys Acta Gen Subj. 2025 Apr;1869(4):130772. doi: 10.1016/j.bbagen.2025.130772. Epub 2025 Feb 13. Biochim Biophys Acta Gen Subj. 2025. PMID: 39954969 Free article. Review.
Neurodegenerative diseases such as Amyotrophic Lateral Sclerosis, Alzheimer's disease, Parkinson's disease, and Huntington's disease share a common pathological hallmark: the accumulation of misfolded proteins, particularly involving intrinsically disordered protein …
Neurodegenerative diseases such as Amyotrophic Lateral Sclerosis, Alzheimer's disease, Parkinson's disease, and Huntington's disease …
3,147 results