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63 results

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Page 1
Optimal Thyroid Hormone Replacement.
Jonklaas J. Jonklaas J. Endocr Rev. 2022 Mar 9;43(2):366-404. doi: 10.1210/endrev/bnab031. Endocr Rev. 2022. PMID: 34543420 Free PMC article.
Despite the basic tenets of initiating and adjusting levothyroxine being agreed on, there are many nuances and complexities to consistently maintaining euthyroidism. Understanding the impact of patient weight and residual thyroid function on initial levothyroxine do …
Despite the basic tenets of initiating and adjusting levothyroxine being agreed on, there are many nuances and complexities to consistently …
Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Huwiler VV, Maissen-Abgottspon S, Stanga Z, Mühlebach S, Trepp R, Bally L, Bano A. Huwiler VV, et al. Thyroid. 2024 Mar;34(3):295-313. doi: 10.1089/thy.2023.0556. Epub 2024 Feb 16. Thyroid. 2024. PMID: 38243784 Free PMC article.
Methods: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the effect of selenium supplementation on thyroid function (thyrotropin [TSH], free and total thyroxine [fT4, T4], free and total triiodothyronine [fT3, T3]), …
Methods: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the effect of selenium supple …
Efficacy and Safety of TransCon PTH in Adults With Hypoparathyroidism: 52-Week Results From the Phase 3 PaTHway Trial.
Clarke BL, Khan AA, Rubin MR, Schwarz P, Vokes T, Shoback DM, Gagnon C, Palermo A, Abbott LG, Hofbauer LC, Kohlmeier L, Cetani F, Pihl S, An X, Smith AR, Lai B, Ukena J, Sibley CT, Shu AD, Rejnmark L. Clarke BL, et al. J Clin Endocrinol Metab. 2025 Mar 17;110(4):951-960. doi: 10.1210/clinem/dgae693. J Clin Endocrinol Metab. 2025. PMID: 39376010 Free PMC article. Clinical Trial.
Other efficacy endpoints included patient-reported outcomes and bone mineral density. Safety was assessed by 24-hour urine calcium and treatment-emergent adverse events. RESULTS: At week 52, 81% (63/78) met the multicomponent efficacy endpoint, 95% (74/78) ac …
Other efficacy endpoints included patient-reported outcomes and bone mineral density. Safety was assessed by 24-hour ur …
Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document.
Jonklaas J, Bianco AC, Cappola AR, Celi FS, Fliers E, Heuer H, McAninch EA, Moeller LC, Nygaard B, Sawka AM, Watt T, Dayan CM. Jonklaas J, et al. Thyroid. 2021 Feb;31(2):156-182. doi: 10.1089/thy.2020.0720. Thyroid. 2021. PMID: 33276704 Free PMC article. Review.
Those with 100% agreement included studies being powered to study the effect of deiodinase and thyroid hormone transporter polymorphisms on study outcomes, inclusion of patients dissatisfied with their current therapy and requiring at least 1.2 mug/kg of LT4 …
Those with 100% agreement included studies being powered to study the effect of deiodinase and thyroid hormone transporter pol …
Patient-Reported Satisfaction with Thyroid Hormone Replacement Therapy for Subclinical Hypothyroidism in Older Adults: A Pooled Analysis of Individual Participant Data from Two Randomized Controlled Trials.
Ravensberg J, Poortvliet RKE, Du Puy R, Rodondi N, Blum M, Kearney P, McCarthy VJC, Quinn T, Dekkers O, Jukema W, Mooijaart S, Gussekloo J. Ravensberg J, et al. Thyroid. 2024 Jun;34(6):702-712. doi: 10.1089/thy.2023.0624. Epub 2024 May 3. Thyroid. 2024. PMID: 38661527 Free article. Clinical Trial.
Patient-reported outcomes in palopegteriparatide-treated adults with hypoparathyroidism: PaTH Forward trial extension.
Rubin M, Palermo A, Vokes T, Khan AA, Schwarz P, Cetani F, Pagotto U, Tsourdi E, Sikjaer T, Pfeiffer KM, Brod M, McLeod LD, Zhao C, Noori W, Shu AD, Smith AR. Rubin M, et al. J Clin Endocrinol Metab. 2026 Mar 17;111(4):945-952. doi: 10.1210/clinem/dgaf653. J Clin Endocrinol Metab. 2026. PMID: 41365829 Free PMC article. Clinical Trial.
OBJECTIVE: This analysis investigated the long-term impact of parathyroid hormone (PTH) replacement therapy with palopegteriparatide (YORVIPATH ) on symptoms, daily functioning, and well-being in adults with chronic hypoparathyroidism. Associations between patien …
OBJECTIVE: This analysis investigated the long-term impact of parathyroid hormone (PTH) replacement therapy with palopegteripa …
Hypothyroidism: playing the cardiometabolic risk concerto.
Kahaly GJ, Liu Y, Persani L. Kahaly GJ, et al. Thyroid Res. 2025 May 20;18(1):20. doi: 10.1186/s13044-025-00233-y. Thyroid Res. 2025. PMID: 40390147 Free PMC article. Review.
This is especially so as in hypothyroidism, cardiometabolic risk factors and cardiovascular disease are highly prevalent conditions and will often coexist in an individual patient. Accordingly, we have reviewed the cardiometabolic consequences of hypothyroidism and interve …
This is especially so as in hypothyroidism, cardiometabolic risk factors and cardiovascular disease are highly prevalent conditions and will …
Personalized Approaches to Hypothyroidism: The Role of Triiodothyronine (T3) in Thyroid Hormone Replacement.
Mazza AD. Mazza AD. Cureus. 2025 Aug 21;17(8):e90685. doi: 10.7759/cureus.90685. eCollection 2025 Aug. Cureus. 2025. PMID: 40851876 Free PMC article. Review.
Nonetheless, a growing movement toward personalized medicine, including genetic profiling, patient-reported outcomes, and individualized dosing, may pave the way for more nuanced treatment strategies. This review underscores the need for a balanced, patien …
Nonetheless, a growing movement toward personalized medicine, including genetic profiling, patient-reported outcomes, a …
Evaluating health outcomes in the treatment of hypothyroidism.
Ettleson MD, Papaleontiou M. Ettleson MD, et al. Front Endocrinol (Lausanne). 2022 Oct 18;13:1026262. doi: 10.3389/fendo.2022.1026262. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36329885 Free PMC article. Review.
Clinical hypothyroidism is defined by the inadequate production of thyroid hormone from the thyroid gland to maintain normal organ system functions. For nearly all patients with clinical hypothyroidism, lifelong treatment with thyroid hormone …
Clinical hypothyroidism is defined by the inadequate production of thyroid hormone from the thyroid gland to maintain n …
Shared Decisionmaking in the Treatment of Hypothyroidism.
Bianco AC. Bianco AC. Clin Endocrinol (Oxf). 2025 Jul;103(1):106-112. doi: 10.1111/cen.15228. Epub 2025 Mar 12. Clin Endocrinol (Oxf). 2025. PMID: 40077932 Review.
This persistence of symptoms may stem from misdiagnosis, inadequate dosing, or incomplete normalization of thyroid hormone signaling. NEW FINDINGS: Research suggests that LT4 monotherapy may not fully restore T3 levels, leading to suboptimal symptom control. ...Alth …
This persistence of symptoms may stem from misdiagnosis, inadequate dosing, or incomplete normalization of thyroid hormone sig …
63 results