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Page 1
Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer's Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic Neurodegeneration.
Jiang Y, Sachdeva K, Goulbourne CN, Berg MJ, Peddy J, Stavrides PH, Pensalfini A, Pawlik M, Malampati S, Whyte L, Basavarajappa BS, Subbanna S, Bleiwas C, Smiley JF, Mathews PM, Nixon RA. Jiang Y, et al. Among authors: pawlik m. J Neurosci. 2025 Jul 16;45(29):e2331242025. doi: 10.1523/JNEUROSCI.2331-24.2025. J Neurosci. 2025. PMID: 40514243 Free PMC article.
Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer's Disease-related endosomal and synaptic dysfunction with cholinergic neurodegeneration.
Jiang Y, Sachdeva K, Goulbourne CN, Berg MJ, Peddy J, Stavrides PH, Pensalfini A, Pawlik M, Malampati S, Whyte L, Basavarajappa BS, Shivakumar S, Bleiwas C, Smiley JF, Mathews PM, Nixon RA. Jiang Y, et al. Among authors: pawlik m. bioRxiv [Preprint]. 2025 May 8:2024.09.19.613736. doi: 10.1101/2024.09.19.613736. bioRxiv. 2025. Update in: J Neurosci. 2025 Jul 16;45(29):e2331242025. doi: 10.1523/JNEUROSCI.2331-24.2025. PMID: 39345644 Free PMC article. Updated. Preprint.
Cocaine perturbs mitovesicle biology in the brain.
D'Acunzo P, Ungania JM, Kim Y, Barreto BR, DeRosa S, Pawlik M, Canals-Baker S, Erdjument-Bromage H, Hashim A, Goulbourne CN, Neubert TA, Saito M, Sershen H, Levy E. D'Acunzo P, et al. Among authors: pawlik m. J Extracell Vesicles. 2023 Jan;12(1):e12301. doi: 10.1002/jev2.12301. J Extracell Vesicles. 2023. PMID: 36691887 Free PMC article.
Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration.
Jiang Y, Alam JJ, Gomperts SN, Maruff P, Lemstra AW, Germann UA, Stavrides PH, Darji S, Malampati S, Peddy J, Bleiwas C, Pawlik M, Pensalfini A, Yang DS, Subbanna S, Basavarajappa BS, Smiley JF, Gardner A, Blackburn K, Chu HM, Prins ND, Teunissen CE, Harrison JE, Scheltens P, Nixon RA. Jiang Y, et al. Among authors: pawlik m. Nat Commun. 2022 Sep 21;13(1):5308. doi: 10.1038/s41467-022-32944-3. Nat Commun. 2022. PMID: 36130946 Free PMC article. Clinical Trial.
Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques.
Lee JH, Yang DS, Goulbourne CN, Im E, Stavrides P, Pensalfini A, Chan H, Bouchet-Marquis C, Bleiwas C, Berg MJ, Huo C, Peddy J, Pawlik M, Levy E, Rao M, Staufenbiel M, Nixon RA. Lee JH, et al. Among authors: pawlik m. Nat Neurosci. 2022 Jun;25(6):688-701. doi: 10.1038/s41593-022-01084-8. Epub 2022 Jun 2. Nat Neurosci. 2022. PMID: 35654956 Free PMC article.
Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in Down syndrome.
D'Acunzo P, Pérez-González R, Kim Y, Hargash T, Miller C, Alldred MJ, Erdjument-Bromage H, Penikalapati SC, Pawlik M, Saito M, Saito M, Ginsberg SD, Neubert TA, Goulbourne CN, Levy E. D'Acunzo P, et al. Among authors: pawlik m. Sci Adv. 2021 Feb 12;7(7):eabe5085. doi: 10.1126/sciadv.abe5085. Print 2021 Feb. Sci Adv. 2021. PMID: 33579698 Free PMC article.
Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease.
Pensalfini A, Kim S, Subbanna S, Bleiwas C, Goulbourne CN, Stavrides PH, Jiang Y, Lee JH, Darji S, Pawlik M, Huo C, Peddy J, Berg MJ, Smiley JF, Basavarajappa BS, Nixon RA. Pensalfini A, et al. Among authors: pawlik m. Cell Rep. 2020 Nov 24;33(8):108420. doi: 10.1016/j.celrep.2020.108420. Cell Rep. 2020. PMID: 33238112 Free PMC article.
30 results