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Year Number of Results
2007 1
2008 5
2009 3
2010 7
2011 4
2012 8
2013 17
2014 11
2015 11
2016 18
2017 26
2018 25
2019 20
2020 24
2021 41
2022 29
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Advances in the understanding and treatment of sepsis-induced immunosuppression.
Venet F, Monneret G. Venet F, et al. Nat Rev Nephrol. 2018 Feb;14(2):121-137. doi: 10.1038/nrneph.2017.165. Epub 2017 Dec 11. Nat Rev Nephrol. 2018. PMID: 29225343 Review.
Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. ...Trials assessing the therapeutic benefit of IL-7, granulocyte-macrophage colony-stimulating factor (GM-CSF) and antibodies against programmed cell deat
Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. ...Trials asse
Upregulated PD-L1 delays human neutrophil apoptosis and promotes lung injury in an experimental mouse model of sepsis.
Wang JF, Wang YP, Xie J, Zhao ZZ, Gupta S, Guo Y, Jia SH, Parodo J, Marshall JC, Deng XM. Wang JF, et al. Blood. 2021 Sep 2;138(9):806-810. doi: 10.1182/blood.2020009417. Blood. 2021. PMID: 34473230 Free article.
PD-L1 is a ligand for PD-1, and its expression has been shown to be upregulated in neutrophils harvested from septic patients. However, the effect of PD-L1 on neutrophil survival and sepsis-induced lung injury remains largely unknown. In this study, PD-L1 expression correl …
PD-L1 is a ligand for PD-1, and its expression has been shown to be upregulated in neutrophils harvested from septic patients. However, the …
PD-1 signaling pathway in sepsis: Does it have a future?
Chen R, Zhou L. Chen R, et al. Clin Immunol. 2021 Aug;229:108742. doi: 10.1016/j.clim.2021.108742. Epub 2021 Apr 24. Clin Immunol. 2021. PMID: 33905818 Review.
Recently, the role of the PD-1 signaling pathway in sepsis has been widely studied. Studies showed that the PD-1 signaling pathways are closely related to the mortality and prognosis of sepsis patients. ...Finally, the application of the PD-1 signaling pathway in …
Recently, the role of the PD-1 signaling pathway in sepsis has been widely studied. Studies showed that the PD-1 signaling pathways a …
Survival and Pulmonary Injury After Neonatal Sepsis: PD1/PDL1's Contributions to Mouse and Human Immunopathology.
Fallon EA, Chung CS, Heffernan DS, Chen Y, De Paepe ME, Ayala A. Fallon EA, et al. Front Immunol. 2021 Mar 3;12:634529. doi: 10.3389/fimmu.2021.634529. eCollection 2021. Front Immunol. 2021. PMID: 33746973 Free PMC article.
Morbidity and mortality associated with neonatal sepsis remains a healthcare crisis. PD1(-/-) neonatal mice endured experimental sepsis, in the form of cecal slurry (CS), and showed improved rates of survival compared to wildtype (WT) counterparts. End-organ …
Morbidity and mortality associated with neonatal sepsis remains a healthcare crisis. PD1(-/-) neonatal mice endured experiment …
The Diverse Function of PD-1/PD-L Pathway Beyond Cancer.
Qin W, Hu L, Zhang X, Jiang S, Li J, Zhang Z, Wang X. Qin W, et al. Front Immunol. 2019 Oct 4;10:2298. doi: 10.3389/fimmu.2019.02298. eCollection 2019. Front Immunol. 2019. PMID: 31636634 Free PMC article. Review.
However, signaling regulated by the PD-1/PD-L pathway is also associated with substantial inflammatory effects that can resemble those in autoimmune responses, chronic infection, and sepsis, consistent with the role of this pathway in balancing protective immunity and immu …
However, signaling regulated by the PD-1/PD-L pathway is also associated with substantial inflammatory effects that can resemble those in au …
Recurrent Sepsis Exacerbates CD4+ T Cell Exhaustion and Decreases Antiviral Immune Responses.
He W, Xiao K, Xu J, Guan W, Xie S, Wang K, Yan P, Fang M, Xie L. He W, et al. Front Immunol. 2021 Feb 25;12:627435. doi: 10.3389/fimmu.2021.627435. eCollection 2021. Front Immunol. 2021. PMID: 33717146 Free PMC article.
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to an infection. ...However, there remains a gap in the understanding of immunological characteristics and underlying mechanisms of recurrent sepsis. In this study, we used mouse m
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to an infection. ...However, there remains a ga
Immune Checkpoints: Novel Therapeutic Targets to Attenuate Sepsis-Induced Immunosuppression.
McBride MA, Patil TK, Bohannon JK, Hernandez A, Sherwood ER, Patil NK. McBride MA, et al. Front Immunol. 2021 Feb 3;11:624272. doi: 10.3389/fimmu.2020.624272. eCollection 2020. Front Immunol. 2021. PMID: 33613563 Free PMC article. Review.
Sepsis is a leading cause of death in intensive care units and survivors develop prolonged immunosuppression and a high incidence of recurrent infections. No definitive therapy exists to treat sepsis and physicians rely on supportive care including antibiotics, intr
Sepsis is a leading cause of death in intensive care units and survivors develop prolonged immunosuppression and a high incidence of
PD-1 blockade improves Kupffer cell bacterial clearance in acute liver injury.
Triantafyllou E, Gudd CL, Mawhin MA, Husbyn HC, Trovato FM, Siggins MK, O'Connor T, Kudo H, Mukherjee SK, Wendon JA, Bernsmeier C, Goldin RD, Botto M, Khamri W, McPhail MJ, Possamai LA, Woollard KJ, Antoniades CG, Thursz MR. Triantafyllou E, et al. J Clin Invest. 2021 Feb 15;131(4):e140196. doi: 10.1172/JCI140196. J Clin Invest. 2021. PMID: 33320839 Free PMC article.
Programmed cell death 1 (PD-1) expression by macrophages has been associated with immune suppression during sepsis and cancer. We therefore examined the role of the programmed cell death 1/programmed death ligand 1 (PD-1/PD-L1) pathway in regulating Kupffer cell (KC) infla …
Programmed cell death 1 (PD-1) expression by macrophages has been associated with immune suppression during sepsis and cancer. We the …
Pembrolizumab alone or combined with chemotherapy versus chemotherapy as first-line therapy for advanced urothelial carcinoma (KEYNOTE-361): a randomised, open-label, phase 3 trial.
Powles T, Csőszi T, Özgüroğlu M, Matsubara N, Géczi L, Cheng SY, Fradet Y, Oudard S, Vulsteke C, Morales Barrera R, Fléchon A, Gunduz S, Loriot Y, Rodriguez-Vida A, Mamtani R, Yu EY, Nam K, Imai K, Homet Moreno B, Alva A; KEYNOTE-361 Investigators. Powles T, et al. Lancet Oncol. 2021 Jul;22(7):931-945. doi: 10.1016/S1470-2045(21)00152-2. Epub 2021 May 26. Lancet Oncol. 2021. PMID: 34051178 Clinical Trial.
Six (1%) of 1010 patients died due to an adverse event attributed to study treatment; two patients in each treatment group. One each occurred due to cardiac arrest and device-related sepsis in the pembrolizumab plus chemotherapy group, one each due to cardiac failure and m …
Six (1%) of 1010 patients died due to an adverse event attributed to study treatment; two patients in each treatment group. One each occurre …
Splenectomy provides protective effects against CLP-induced sepsis by reducing TRegs and PD-1/PD-L1 expression.
Chen H, Huang N, Tian H, Li J, Li B, Sun J, Zhang S, Zhang C, Zhao Y, Kong G, Li Z. Chen H, et al. Int J Biochem Cell Biol. 2021 Jul;136:105970. doi: 10.1016/j.biocel.2021.105970. Epub 2021 Mar 24. Int J Biochem Cell Biol. 2021. PMID: 33774183
The role of the spleen in sepsis is still controversial. Therefore, we investigated the effect of the spleen on sepsis-induced immune dysfunction in C57BL/6 mice subjected to caecal ligation and puncture (CLP). ...The spleen is an important regulator of the occurren …
The role of the spleen in sepsis is still controversial. Therefore, we investigated the effect of the spleen on sepsis-induced …
224 results