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N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health.
Hofer DC, Zirkovits G, Pelzmann HJ, Huber K, Pessentheiner AR, Xia W, Uno K, Miyazaki T, Kon K, Tsuneki H, Pendl T, Zoughbi WA, Madreiter-Sokolowski CT, Trausinger G, Abdellatif M, Schoiswohl G, Schreiber R, Eisenberg T, Magnes C, Sedej S, Eckhardt M, Sasahara M, Sasaoka T, Nitta A, Hoefler G, Graier WF, Kratky D, Auwerx J, Bogner-Strauss JG. Hofer DC, et al. FASEB J. 2019 Dec;33(12):13808-13824. doi: 10.1096/fj.201801323R. Epub 2019 Nov 1. FASEB J. 2019. PMID: 31638418 Free PMC article.
Mechanistically, our data point to a possible role of NAA as modulator of pancreatic insulin secretion and suggest NAA as a critical energy metabolite for adipocyte and whole-body energy homeostasis.-Hofer, D. C., Zirkovits, G., Pelzmann, H. J., Huber, K., Pessenthe …
Mechanistically, our data point to a possible role of NAA as modulator of pancreatic insulin secretion and suggest NAA as a critical energy …
APMAP interacts with lysyl oxidase-like proteins, and disruption of Apmap leads to beneficial visceral adipose tissue expansion.
Pessentheiner AR, Huber K, Pelzmann HJ, Prokesch A, Radner FPW, Wolinski H, Lindroos-Christensen J, Hoefler G, Rülicke T, Birner-Gruenberger R, Bilban M, Bogner-Strauss JG. Pessentheiner AR, et al. FASEB J. 2017 Sep;31(9):4088-4103. doi: 10.1096/fj.201601337R. Epub 2017 May 30. FASEB J. 2017. PMID: 28559441 Free PMC article.
Together, our data suggest that APMAP is a novel regulator of extracellular matrix components, and establish that APMAP is a potential target to mitigate obesity-associated insulin resistance.-Pessentheiner, A. R., Huber, K., Pelzmann, H. J., Prokesch, A., Radner, F …
Together, our data suggest that APMAP is a novel regulator of extracellular matrix components, and establish that APMAP is a potential targe …
Critical role of the peroxisomal protein PEX16 in white adipocyte development and lipid homeostasis.
Hofer DC, Pessentheiner AR, Pelzmann HJ, Schlager S, Madreiter-Sokolowski CT, Kolb D, Eichmann TO, Rechberger G, Bilban M, Graier WF, Kratky D, Bogner-Strauss JG. Hofer DC, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Mar;1862(3):358-368. doi: 10.1016/j.bbalip.2016.12.009. Epub 2016 Dec 23. Biochim Biophys Acta Mol Cell Biol Lipids. 2017. PMID: 28017862 Free PMC article.
N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes.
Huber K, Hofer DC, Trefely S, Pelzmann HJ, Madreiter-Sokolowski C, Duta-Mare M, Schlager S, Trausinger G, Stryeck S, Graier WF, Kolb D, Magnes C, Snyder NW, Prokesch A, Kratky D, Madl T, Wellen KE, Bogner-Strauss JG. Huber K, et al. Biochim Biophys Acta Mol Cell Res. 2019 Mar;1866(3):337-348. doi: 10.1016/j.bbamcr.2018.08.017. Epub 2018 Aug 31. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 30595160 Free PMC article.