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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 1
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1976 4
1977 4
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1980 3
1981 2
1982 4
1983 7
1984 4
1985 12
1986 7
1987 4
1988 4
1989 2
1990 6
1991 6
1992 5
1993 3
1994 2
1995 2
1996 7
1997 3
1998 2
1999 3
2000 4
2001 4
2003 3
2004 4
2006 2
2008 1
2009 2
2010 3
2011 1
2012 1
2013 1
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2015 3
2017 1
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2020 1
2022 3
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2026 0

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139 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Trientine tetrahydrochloride versus penicillamine for maintenance therapy in Wilson disease (CHELATE): a randomised, open-label, non-inferiority, phase 3 trial.
Schilsky ML, Czlonkowska A, Zuin M, Cassiman D, Twardowschy C, Poujois A, Gondim FAA, Denk G, Cury RG, Ott P, Moore J, Ala A, D'Inca R, Couchonnal-Bedoya E, D'Hollander K, Dubois N, Kamlin COF, Weiss KH; CHELATE trial investigators. Schilsky ML, et al. Lancet Gastroenterol Hepatol. 2022 Dec;7(12):1092-1102. doi: 10.1016/S2468-1253(22)00270-9. Epub 2022 Sep 30. Lancet Gastroenterol Hepatol. 2022. PMID: 36183738 Clinical Trial.
BACKGROUND: Wilson disease is an inherited disorder of copper transport. Whereas penicillamine is used therapeutically to re-establish copper balance, trientine is indicated for patients with penicillamine intolerance. We aimed to compare penicillamine with t …
BACKGROUND: Wilson disease is an inherited disorder of copper transport. Whereas penicillamine is used therapeutically to re-establis …
Penicillamine in rheumatoid arthritis. A problem of toxicity.
Taylor HG, Samanta A. Taylor HG, et al. Drug Saf. 1992 Jan-Feb;7(1):46-53. doi: 10.2165/00002018-199207010-00006. Drug Saf. 1992. PMID: 1536698 Review.
Penicillamine has proved an effective second line agent in rheumatoid arthritis. Its use, however, is limited by its toxicity. ...Meticulous supervision of penicillamine therapy is required to minimise toxicity....
Penicillamine has proved an effective second line agent in rheumatoid arthritis. Its use, however, is limited by its toxicity. ...Met …
D-penicillamine for primary biliary cirrhosis.
Gong Y, Frederiksen SL, Gluud C. Gong Y, et al. Cochrane Database Syst Rev. 2004 Oct 18;2004(4):CD004789. doi: 10.1002/14651858.CD004789.pub2. Cochrane Database Syst Rev. 2004. PMID: 15495127 Free PMC article.
BACKGROUND: D-penicillamine is used for patients with primary biliary cirrhosis due to its hepatic copper decreasing and immunomodulatory potentials. ...We do not support the use of D-penicillamine for patients with primary biliary cirrhosis....
BACKGROUND: D-penicillamine is used for patients with primary biliary cirrhosis due to its hepatic copper decreasing and immunomodula …
D-Penicillamine for preventing retinopathy of prematurity in preterm infants.
Qureshi MJ, Kumar M. Qureshi MJ, et al. Cochrane Database Syst Rev. 2013 Sep 3;2013(9):CD001073. doi: 10.1002/14651858.CD001073.pub2. Cochrane Database Syst Rev. 2013. PMID: 24002688 Free PMC article.
AUTHORS' CONCLUSIONS: Administration of prophylactic D-penicillamine in preterm infants does not prevent acute or severe ROP, death or neurodevelopmental delay. D-penicillamine cannot be recommended for the prevention of ROP based on the available evidence....
AUTHORS' CONCLUSIONS: Administration of prophylactic D-penicillamine in preterm infants does not prevent acute or severe ROP, death o …
Systematic review and meta-analysis: D-Penicillamine vs. placebo/no intervention in patients with primary biliary cirrhosis--Cochrane Hepato-Biliary Group.
Gong Y, Klingenberg SL, Gluud C. Gong Y, et al. Aliment Pharmacol Ther. 2006 Dec;24(11-12):1535-44. doi: 10.1111/j.1365-2036.2006.03164.x. Aliment Pharmacol Ther. 2006. PMID: 17206942
The results on effects of D--penicillamine in randomized-clinical trials of primary biliary cirrhosis patients are inconsistent. AIM: To systematically evaluate the benefits and harms of D-penicillamine for patients with primary biliary cirrhosis. METHODS: We have p …
The results on effects of D--penicillamine in randomized-clinical trials of primary biliary cirrhosis patients are inconsistent. AIM: …
D-penicillamine treatment improves survival in primary biliary cirrhosis.
Epstein O, Jain S, Lee RG, Cook DG, Boss AM, Scheuer PJ, Sherlock S. Epstein O, et al. Lancet. 1981 Jun 13;1(8233):1275-7. doi: 10.1016/s0140-6736(81)92456-9. Lancet. 1981. PMID: 6112602 Clinical Trial.
In a randomised clinical trail, 55 PBC patients received penicillamine (600 mg daily), and 32 received a placebo. Drug reactions developed in 16 patients on penicillamine. ...Both the copper-chelating and immunological effects of penicillamine are probably im …
In a randomised clinical trail, 55 PBC patients received penicillamine (600 mg daily), and 32 received a placebo. Drug reactions deve …
Penicillamine and hydroxychloroquine in the treatment of severe juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. double-blind placebo-controlled trial.
Brewer EJ, Giannini EH, Kuzmina N, Alekseev L. Brewer EJ, et al. N Engl J Med. 1986 May 15;314(20):1269-76. doi: 10.1056/NEJM198605153142001. N Engl J Med. 1986. PMID: 3517643 Clinical Trial.
One group of subjects received 10 mg of penicillamine per kilogram of body weight per day, another group received 6 mg of hydroxychloroquine per kilogram daily, and a third group received placebo. ...There were no significant differences in efficacy between the penicill …
One group of subjects received 10 mg of penicillamine per kilogram of body weight per day, another group received 6 mg of hydroxychlo …
A prospective trial of D-penicillamine in primary biliary cirrhosis.
Matloff DS, Alpert E, Resnick RH, Kaplan MM. Matloff DS, et al. N Engl J Med. 1982 Feb 11;306(6):319-26. doi: 10.1056/NEJM198202113060602. N Engl J Med. 1982. PMID: 7033789 Clinical Trial.
We evaluated D-penicillamine in the treatment of primary biliary cirrhosis. In a prospective double-blind trial, 26 patients received D-penicillamine (250 mg four times a day), and 26 received an identical placebo. ...Alanine and aspartate aminotransferases were low …
We evaluated D-penicillamine in the treatment of primary biliary cirrhosis. In a prospective double-blind trial, 26 patients received …
Prospective trial of penicillamine in primary sclerosing cholangitis.
LaRusso NF, Wiesner RH, Ludwig J, MacCarty RL, Beaver SJ, Zinsmeister AR. LaRusso NF, et al. Gastroenterology. 1988 Oct;95(4):1036-42. doi: 10.1016/0016-5085(88)90180-1. Gastroenterology. 1988. PMID: 3410217 Clinical Trial.
We evaluated the therapeutic efficacy of penicillamine in primary sclerosing cholangitis. In a randomized, prospective, double-blind trial, 39 patients received penicillamine (250 mg t.i.d.) and 31 received a placebo. ...The development of major side effects led to …
We evaluated the therapeutic efficacy of penicillamine in primary sclerosing cholangitis. In a randomized, prospective, double-blind …
Wilson's disease and pregnancy.
Sternlieb I. Sternlieb I. Hepatology. 2000 Feb;31(2):531-2. doi: 10.1002/hep.510310239. Hepatology. 2000. PMID: 10655282 No abstract available.
139 results