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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1938 1
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1954 8
1956 3
1957 7
1958 4
1959 5
1960 7
1961 8
1962 2
1963 15
1964 15
1965 13
1966 14
1967 22
1968 24
1969 28
1970 35
1971 30
1972 31
1973 35
1974 49
1975 236
1976 276
1977 216
1978 215
1979 273
1980 378
1981 425
1982 412
1983 564
1984 648
1985 699
1986 759
1987 733
1988 804
1989 862
1990 849
1991 872
1992 893
1993 913
1994 989
1995 954
1996 926
1997 956
1998 985
1999 1019
2000 1077
2001 1069
2002 1176
2003 1192
2004 1241
2005 1327
2006 1408
2007 1445
2008 1465
2009 1581
2010 1656
2011 1692
2012 1735
2013 1723
2014 1656
2015 1660
2016 1584
2017 1626
2018 1562
2019 1505
2020 1593
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2023 1396
2024 1395
2025 1378
2026 763

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51,434 results

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Page 1
Analysis of Peptide Hormone Maturation and Processing Specificity Using Isotope-Labeled Peptides.
Brück S, Pfannstiel J, Ingram G, Stintzi A, Schaller A. Brück S, et al. Methods Mol Biol. 2023;2581:323-335. doi: 10.1007/978-1-0716-2784-6_23. Methods Mol Biol. 2023. PMID: 36413328 Free article.
Many peptide hormones and growth factors in plants, particularly the small posttranslationally modified signaling peptides, are synthesized as larger precursor proteins. Proteolytic processing is thus required for peptide maturation, and additional pos …
Many peptide hormones and growth factors in plants, particularly the small posttranslationally modified signaling peptides, ar …
Processing of a plant peptide hormone precursor facilitated by posttranslational tyrosine sulfation.
Royek S, Bayer M, Pfannstiel J, Pleiss J, Ingram G, Stintzi A, Schaller A. Royek S, et al. Proc Natl Acad Sci U S A. 2022 Apr 19;119(16):e2201195119. doi: 10.1073/pnas.2201195119. Epub 2022 Apr 11. Proc Natl Acad Sci U S A. 2022. PMID: 35412898 Free PMC article.
Most peptide hormones and growth factors are matured from larger inactive precursor proteins by proteolytic processing and further posttranslational modification. ...Arginine 302 of SBT1.8 was found to be required for sulfotyrosine binding and for accurate …
Most peptide hormones and growth factors are matured from larger inactive precursor proteins by proteolytic processing …
Golgi/granule processing of peptide hormone and neuropeptide precursors: a minireview.
Steiner DF, Docherty K, Carroll R. Steiner DF, et al. J Cell Biochem. 1984;24(2):121-30. doi: 10.1002/jcb.240240204. J Cell Biochem. 1984. PMID: 6373800 Review.
Proteolytic processing of precursor proteins is a phylogenetically ancient and widely used mechanism for producing biologically active peptides. ...The cosecretion of nonfunctional peptide " leftovers ," such as the proinsulin C-peptide, can serve as useful m …
Proteolytic processing of precursor proteins is a phylogenetically ancient and widely used mechanism for producing biologically activ …
Peptide hormone processing in tumours: biogenetic and diagnostic implications.
Rehfeld JF, Bardram L, Blanke S, Bundgaard JR, Friis-Hansen L, Hilsted L, Johnsen AH, Kofod M, Lüttichau HR, Monstein HJ, et al. Rehfeld JF, et al. Tumour Biol. 1993;14(3):174-83. doi: 10.1159/000217833. Tumour Biol. 1993. PMID: 8210950 Free article. Review.
Insight into the biogenesis of peptide hormones has grown explosively by elucidation of gene, mRNA and prohormone structures. ...An increasing number of common carcinomas also expresses peptide hormone genes. However, the translation and post-translati …
Insight into the biogenesis of peptide hormones has grown explosively by elucidation of gene, mRNA and prohormone structures. …
Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide.
Coassolo L, B Danneskiold-Samsøe N, Nguyen Q, Wiggenhorn A, Zhao M, Wang DC, Toomer D, Lone J, Wei Y, Patel A, Liparulo I, Kavi D, Wat LW, Reghupaty SC, Kim JJ, Asemi T, Bielczyk-Maczynska E, Li VL, Moya-Garzon MD, Krentz NAJ, Stahl A, Chou DH, Luo L, Svensson KJ. Coassolo L, et al. Nature. 2025 May;641(8061):192-201. doi: 10.1038/s41586-025-08683-y. Epub 2025 Mar 5. Nature. 2025. PMID: 40044869 Free PMC article.
Peptide hormones, a class of pharmacologically active molecules, have a critical role in regulating energy homeostasis. Prohormone convertase 1/3 (also known as PCSK1/3) represents a key enzymatic mechanism in peptide processing, as exemplified with th …
Peptide hormones, a class of pharmacologically active molecules, have a critical role in regulating energy homeostasis. Prohor …
Peptide hormone precursor processing: getting sorted?
Canaff L, Bennett HP, Hendy GN. Canaff L, et al. Mol Cell Endocrinol. 1999 Oct 25;156(1-2):1-6. doi: 10.1016/s0303-7207(99)00129-x. Mol Cell Endocrinol. 1999. PMID: 10612417 Review.
Processing of proproteins to biologically active peptides and, in the case of peptide hormones and neuropeptides, their sorting to granules of the regulated secretory pathway, requires the concerted action of a cascade of enzymes and chaperones. ...
Processing of proproteins to biologically active peptides and, in the case of peptide hormones and neuropeptides, their …
Comparative aspects of intracellular proteolytic processing of peptide hormone precursors: studies of proopiomelanocortin processing.
Tanaka S. Tanaka S. Zoolog Sci. 2003 Oct;20(10):1183-98. doi: 10.2108/zsj.20.1183. Zoolog Sci. 2003. PMID: 14569141 Review.
In this review, the mechanisms underlying the intracellular processing of peptide hormone precursors, with a focus on proopiomelanocortin (POMC), were discussed on the basis of recent information. ...Together, secretory granules in endocrine and neuroendocrin …
In this review, the mechanisms underlying the intracellular processing of peptide hormone precursors, with a focus on p …
A famsin-glucagon axis mediates glucose homeostasis.
Long A, Wang Y, Guo Y, Hong J, Ning G, Meng Z, Wang J, Wang Y. Long A, et al. Cell Metab. 2025 Mar 4;37(3):629-639.e6. doi: 10.1016/j.cmet.2024.11.008. Epub 2024 Dec 19. Cell Metab. 2025. PMID: 39706194 Free article.
Here, we unveil that famsin, a gut-secreted hormone, promotes glucagon release and modulates glucose homeostasis. Mechanistically, famsin binds to its receptor OLFR796 in mice (OR10P1 in humans), initiating calcium release in the endoplasmic reticulum of islet alpha cells. …
Here, we unveil that famsin, a gut-secreted hormone, promotes glucagon release and modulates glucose homeostasis. Mechanistically, fa …
Peptide Hormone Regulation of DNA Damage Responses.
Chesnokova V, Melmed S. Chesnokova V, et al. Endocr Rev. 2020 Jul 1;41(4):bnaa009. doi: 10.1210/endrev/bnaa009. Endocr Rev. 2020. PMID: 32270196 Free PMC article. Review.
Recent evidence suggests that polypeptide hormones play a role in modulating DDR and DNA damage repair, while DNA damage accumulation may also affect hormonal status. We review the available reports elucidating involvement of insulin-like growth factor 1 (IGF1), growth …
Recent evidence suggests that polypeptide hormones play a role in modulating DDR and DNA damage repair, while DNA damage accumulation …
Precursor processing for plant peptide hormone maturation by subtilisin-like serine proteinases.
Schardon K, Hohl M, Graff L, Pfannstiel J, Schulze W, Stintzi A, Schaller A. Schardon K, et al. Science. 2016 Dec 23;354(6319):1594-1597. doi: 10.1126/science.aai8550. Epub 2016 Dec 8. Science. 2016. PMID: 27940581
Peptide hormones that regulate plant growth and development are derived from larger precursor proteins by proteolytic processing. Our study addressed the role of subtilisin-like proteinases (SBTs) in this process. Using tissue-specific expression of pr …
Peptide hormones that regulate plant growth and development are derived from larger precursor proteins by proteolytic proce …
51,434 results
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