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2017 3
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12 results

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Page 1
Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression.
Born E, Lipskaia L, Breau M, Houssaini A, Beaulieu D, Marcos E, Pierre R, Do Cruzeiro M, Lefevre M, Derumeaux G, Bulavin DV, Delcroix M, Quarck R, Reen V, Gil J, Bernard D, Flaman JM, Adnot S, Abid S. Born E, et al. Circulation. 2023 Feb 21;147(8):650-666. doi: 10.1161/CIRCULATIONAHA.122.058794. Epub 2022 Dec 14. Circulation. 2023. PMID: 36515093
SC clearance was obtained by a suicide gene (p16 promoter-driven killer gene construct in p16-ATTAC mice), senolytic drugs (ABT263 and cell-permeable FOXO4-p53 interfering peptide [FOXO4-DRI]), and p16 inactivation in p16(LUC/LUC) mice. We investigated pulmon …
SC clearance was obtained by a suicide gene (p16 promoter-driven killer gene construct in p16-ATTAC mice), senolytic drugs (ABT263 and cell- …
Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes.
Huang Y, He Y, Makarcyzk MJ, Lin H. Huang Y, et al. Front Bioeng Biotechnol. 2021 Apr 29;9:677576. doi: 10.3389/fbioe.2021.677576. eCollection 2021. Front Bioeng Biotechnol. 2021. PMID: 33996787 Free PMC article.
In vitro expansion of chondrocytes, a necessary step in ACI, results in the generation of senescent cells that adversely affect the quality and quantity of newly formed cartilage. Recently, a senolytic peptide, fork head box O transcription factor 4-D-Retro-Inverso (FOX …
In vitro expansion of chondrocytes, a necessary step in ACI, results in the generation of senescent cells that adversely affect the quality …
The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI.
Bourgeois B, Spreitzer E, Platero-Rochart D, Paar M, Zhou Q, Usluer S, de Keizer PLJ, Burgering BMT, Sánchez-Murcia PA, Madl T. Bourgeois B, et al. Nat Commun. 2025 Jul 1;16(1):5672. doi: 10.1038/s41467-025-60844-9. Nat Commun. 2025. PMID: 40593617 Free PMC article.
We recently identified the FOXO4 - p53 axis as pivotal in maintaining the viability of senescent cells, and that senescent cells can be targeted selectively with the senolytic peptide FOXO4-DRI. Here, we solve the solution NMR structural models of the p53 tra …
We recently identified the FOXO4 - p53 axis as pivotal in maintaining the viability of senescent cells, and that senescent cells can be targ …
FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway.
Hu Z, Li F, Hu C, Shan Q, Tang Z, Jiang M, Yi X, Chen X, Jin L, Wang X, Wang Y. Hu Z, et al. Front Bioeng Biotechnol. 2026 Jan 15;13:1729166. doi: 10.3389/fbioe.2025.1729166. eCollection 2025. Front Bioeng Biotechnol. 2026. PMID: 41625068 Free PMC article.
To assess the impact of FOXO4-DRI on endothelial cell senescence, the senescent endothelial cells were treated with FOXO4-DRI, followed by immunofluorescence and Western blotting experiments. ...Additionally, we found that FOXO4-DRI allev …
To assess the impact of FOXO4-DRI on endothelial cell senescence, the senescent endothelial cells were treated with FOXO4 …
FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation.
Kong YX, Li ZS, Liu YB, Pan B, Fu X, Xiao R, Yan L. Kong YX, et al. Commun Biol. 2025 Feb 24;8(1):299. doi: 10.1038/s42003-025-07738-0. Commun Biol. 2025. PMID: 39994346 Free PMC article.
We further demonstrate that a senolytic FOXO4-D-retro-inverso-isoform peptide (FOXO4-DRI) promotes apoptosis and decreases G0/G1 phase cells in pro-senescence models of keloid organ cultures and fibroblasts, accompanied with p53-pS15 nuclear exclusion. Our st …
We further demonstrate that a senolytic FOXO4-D-retro-inverso-isoform peptide (FOXO4-DRI) promotes apoptosis and decrea …
FOXO4 peptide targets myofibroblast ameliorates bleomycin-induced pulmonary fibrosis in mice through ECM-receptor interaction pathway.
Han X, Yuan T, Zhang J, Shi Y, Li D, Dong Y, Fan S. Han X, et al. J Cell Mol Med. 2022 Jun;26(11):3269-3280. doi: 10.1111/jcmm.17333. Epub 2022 May 5. J Cell Mol Med. 2022. PMID: 35510614 Free PMC article.
However, it remains unknown if FOXO4-DRI could clear senescent cells in PF and reverse this disease. In this study, we explored the effect of FOXO4-DRI on bleomycin (BLM)-induced PF mouse model. ...Above all, FOXO4-DRI ameliorates BLM-ind …
However, it remains unknown if FOXO4-DRI could clear senescent cells in PF and reverse this disease. In this study, we explore …
Targeting the FOXO4-p53 axis by retro-inverso peptide senolytic agents: a pharmacological strategy to mitigate brain aging and cognitive decline.
Alameen AAM, Al-Kuraishy HM, Fawzy MN, Batiha GE. Alameen AAM, et al. Naunyn Schmiedebergs Arch Pharmacol. 2026 Jul;399(10):14659-14676. doi: 10.1007/s00210-026-05309-6. Epub 2026 Apr 23. Naunyn Schmiedebergs Arch Pharmacol. 2026. PMID: 42024235 Review.
Cellular senescence, driven by the interaction between FOXO4 and p53, is increasingly recognized as a crucial mechanism in brain aging and the development of neurodegenerative disorders. The senolytic peptide FOXO4-DRI, which has been thoughtfully designed, s …
Cellular senescence, driven by the interaction between FOXO4 and p53, is increasingly recognized as a crucial mechanism in brain aging and t …
FOXO4-D-Retro-Inverso targets extracellular matrix production in fibroblasts and ameliorates bleomycin-induced pulmonary fibrosis in mice.
Liu Y, Hou Q, Wang R, Liu Y, Cheng Z. Liu Y, et al. Naunyn Schmiedebergs Arch Pharmacol. 2023 Oct;396(10):2393-2403. doi: 10.1007/s00210-023-02452-2. Epub 2023 Apr 19. Naunyn Schmiedebergs Arch Pharmacol. 2023. PMID: 37074394
In this research, we explored the effect of FOXO4-DRI on bleomycin (BLM)-induced PF mouse model and activated fibroblasts model. The animal group of FOXO4-DRI therapeutic administration shows a milder pathologic change and less collagen deposition comp …
In this research, we explored the effect of FOXO4-DRI on bleomycin (BLM)-induced PF mouse model and activated fibroblasts mode …
Cellular senescence in the aging and diseased kidney.
Valentijn FA, Falke LL, Nguyen TQ, Goldschmeding R. Valentijn FA, et al. J Cell Commun Signal. 2018 Mar;12(1):69-82. doi: 10.1007/s12079-017-0434-2. Epub 2017 Dec 19. J Cell Commun Signal. 2018. PMID: 29260442 Free PMC article. Review.
Recent groundbreaking studies demonstrate that senescent cell depletion through INK-ATTAC transgene-mediated or cell-penetrating FOXO4-DRI peptide induced forced apoptosis, reduced age-associated damage and dysfunction in multiple organs, in particular the ki …
Recent groundbreaking studies demonstrate that senescent cell depletion through INK-ATTAC transgene-mediated or cell-penetrating FOXO4 …
Rejuvenation by Therapeutic Elimination of Senescent Cells.
Krimpenfort P, Berns A. Krimpenfort P, et al. Cell. 2017 Mar 23;169(1):3-5. doi: 10.1016/j.cell.2017.03.014. Cell. 2017. PMID: 28340347 Free article.
Disrupting this interaction with an all-D amino acid peptide (FOXO4-DRI) restores p53's apoptotic role and ameliorates the consequences of senescence-associated loss of tissue homeostasis....
Disrupting this interaction with an all-D amino acid peptide (FOXO4-DRI) restores p53's apoptotic role and ameliorates …
12 results