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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1975 1
1977 1
1978 1
1979 1
1981 1
1983 2
1984 5
1985 4
1986 1
1987 3
1988 2
1989 4
1990 4
1991 2
1992 9
1993 10
1994 6
1995 7
1996 6
1997 10
1998 16
1999 17
2000 18
2001 30
2002 60
2003 73
2004 75
2005 103
2006 106
2007 122
2008 132
2009 169
2010 187
2011 181
2012 155
2013 179
2014 185
2015 181
2016 150
2017 155
2018 156
2019 169
2020 192
2021 152
2022 149
2023 162
2024 178
2025 148
2026 72

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3,307 results

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Page 1
Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures.
Ding Y, Zuo Y, Zhang B, Fan Y, Xu G, Cheng Z, Ma S, Fang S, Tian A, Gao D, Xu X, Wang Q, Jing Y, Jiang M, Xiong M, Li J, Han Z, Sun S, Wang S, He F, Yang J, Qu J, Zhang W, Liu GH. Ding Y, et al. Cell. 2025 Oct 2;188(20):5763-5784.e26. doi: 10.1016/j.cell.2025.06.047. Epub 2025 Jul 25. Cell. 2025. PMID: 40713952
Temporal analysis revealed an aging inflection around age 50, with blood vessels being a tissue that ages early and is markedly susceptible to aging. We further defined a plasma proteomic signature of aging that matches its tissue origins and identified candi …
Temporal analysis revealed an aging inflection around age 50, with blood vessels being a tissue that ages early and is markedly susce …
Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Victorelli S, et al. Nature. 2023 Oct;622(7983):627-636. doi: 10.1038/s41586-023-06621-4. Epub 2023 Oct 11. Nature. 2023. PMID: 37821702 Free PMC article.
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.
Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM. Baker DJ, et al. Nature. 2011 Nov 2;479(7372):232-6. doi: 10.1038/nature10600. Nature. 2011. PMID: 22048312 Free PMC article.
Advanced age is the main risk factor for most chronic diseases and functional deficits in humans, but the fundamental mechanisms that drive ageing remain largely unknown, impeding the development of interventions that might delay or prevent age-related disorders and maximi …
Advanced age is the main risk factor for most chronic diseases and functional deficits in humans, but the fundamental mechanisms that drive …
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan.
Widjaja AA, Lim WW, Viswanathan S, Chothani S, Corden B, Dasan CM, Goh JWT, Lim R, Singh BK, Tan J, Pua CJ, Lim SY, Adami E, Schafer S, George BL, Sweeney M, Xie C, Tripathi M, Sims NA, Hübner N, Petretto E, Withers DJ, Ho L, Gil J, Carling D, Cook SA. Widjaja AA, et al. Nature. 2024 Aug;632(8023):157-165. doi: 10.1038/s41586-024-07701-9. Epub 2024 Jul 17. Nature. 2024. PMID: 39020175 Free PMC article.
Administration of anti-IL-11 to 75-week-old mice for 25 weeks improves metabolism and muscle function, and reduces ageing biomarkers and frailty across sexes. In lifespan studies, genetic deletion of Il11 extended the lives of mice of both sexes, by 24.9% on average. ...We …
Administration of anti-IL-11 to 75-week-old mice for 25 weeks improves metabolism and muscle function, and reduces ageing biomarkers …
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.
Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, Saltness RA, Jeganathan KB, Verzosa GC, Pezeshki A, Khazaie K, Miller JD, van Deursen JM. Baker DJ, et al. Nature. 2016 Feb 11;530(7589):184-9. doi: 10.1038/nature16932. Epub 2016 Feb 3. Nature. 2016. PMID: 26840489 Free PMC article.
Senescent cells accumulate in various tissues and organs over time, and have been speculated to have a role in ageing. To explore the physiological relevance and consequences of naturally occurring senescent cells, here we use a previously established transgene, INK-ATTAC, …
Senescent cells accumulate in various tissues and organs over time, and have been speculated to have a role in ageing. To explore the …
Mitochondrial stress and mitokines in aging.
Burtscher J, Soltany A, Visavadiya NP, Burtscher M, Millet GP, Khoramipour K, Khamoui AV. Burtscher J, et al. Aging Cell. 2023 Feb;22(2):e13770. doi: 10.1111/acel.13770. Epub 2023 Jan 15. Aging Cell. 2023. PMID: 36642986 Free PMC article. Review.
Among those molecules are FGF21, GDF15 (both expressed in the nucleus) and several mitochondrial-derived peptides, including humanin. Their responsiveness to mitochondrial stress induces mitokine-signaling in response for example to exercise, following mitochondrial challe …
Among those molecules are FGF21, GDF15 (both expressed in the nucleus) and several mitochondrial-derived peptides, including humanin. …
Ageing-associated changes in transcriptional elongation influence longevity.
Debès C, Papadakis A, Grönke S, Karalay Ö, Tain LS, Mizi A, Nakamura S, Hahn O, Weigelt C, Josipovic N, Zirkel A, Brusius I, Sofiadis K, Lamprousi M, Lu YX, Huang W, Esmaillie R, Kubacki T, Späth MR, Schermer B, Benzing T, Müller RU, Antebi A, Partridge L, Papantonis A, Beyer A. Debès C, et al. Nature. 2023 Apr;616(7958):814-821. doi: 10.1038/s41586-023-05922-y. Epub 2023 Apr 12. Nature. 2023. PMID: 37046086 Free PMC article.
Physiological homeostasis becomes compromised during ageing, as a result of impairment of cellular processes, including transcription and RNA splicing(1-4). ...Our findings uncover fundamental molecular mechanisms underlying animal ageing and lifespan-extending inte …
Physiological homeostasis becomes compromised during ageing, as a result of impairment of cellular processes, including transcription …
Suppression of aging in mice by the hormone Klotho.
Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M. Kurosu H, et al. Science. 2005 Sep 16;309(5742):1829-33. doi: 10.1126/science.1112766. Epub 2005 Aug 25. Science. 2005. PMID: 16123266 Free PMC article.
Klotho protein functions as a circulating hormone that binds to a cell-surface receptor and represses intracellular signals of insulin and insulin-like growth factor 1 (IGF1), an evolutionarily conserved mechanism for extending life span. Alleviation of aging-like phenotyp …
Klotho protein functions as a circulating hormone that binds to a cell-surface receptor and represses intracellular signals of insulin and i …
Autophagy activator AA-20 improves proteostasis and extends Caenorhabditis elegans lifespan.
Tan EP, Lyang N, Doroodian S, Sanz-Martinez P, Xu J, Zaretski S, Nieto-Torres JL, Ebata H, Lim SHY, Hou WC, Clay KJ, Yoon L, Massey LA, Rhoades D, Garza D, Johnson KA, To A, Ambaye L, Bentley EP, Petrascheck M, Stolz A, Kelly JW, Hansen M. Tan EP, et al. Proc Natl Acad Sci U S A. 2025 Aug 12;122(32):e2423455122. doi: 10.1073/pnas.2423455122. Epub 2025 Aug 4. Proc Natl Acad Sci U S A. 2025. PMID: 40758884 Free PMC article.
The degradation of cellular components through autophagy is essential for longevity and healthy aging. However, autophagy function decreases with aging, contributing to age-related diseases. ...Collectively, our results identify an autophagy activator AA-20, …
The degradation of cellular components through autophagy is essential for longevity and healthy aging. However, autophagy func …
REST and stress resistance in ageing and Alzheimer's disease.
Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM, Drake D, Liu XS, Bennett DA, Colaiácovo MP, Yankner BA. Lu T, et al. Nature. 2014 Mar 27;507(7493):448-54. doi: 10.1038/nature13163. Epub 2014 Mar 19. Nature. 2014. PMID: 24670762 Free PMC article.
Human neurons are functional over an entire lifetime, yet the mechanisms that preserve function and protect against neurodegeneration during ageing are unknown. Here we show that induction of the repressor element 1-silencing transcription factor (REST; also known as neuro …
Human neurons are functional over an entire lifetime, yet the mechanisms that preserve function and protect against neurodegeneration during …
3,307 results