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Did you mean pericentromeric satellite dna expression (125 results)?
Satellite double-stranded RNA induces mesenchymal transition in pancreatic cancer by regulating alternative splicing.
Iwata T, Kishikawa T, Seimiya T, Notoya G, Suzuki T, Shibata C, Miyakawa Y, Odawara N, Funato K, Tanaka E, Yamagami M, Sekiba K, Otsuka M, Koike K, Fujishiro M. Iwata T, et al. J Biol Chem. 2024 Mar;300(3):105742. doi: 10.1016/j.jbc.2024.105742. Epub 2024 Feb 10. J Biol Chem. 2024. PMID: 38346537 Free PMC article.
Human satellite II (HSATII), composed of tandem repeats in pericentromeric regions, is aberrantly transcribed in epithelial cancers, particularly pancreatic cancer. ...These findings reveal a novel tumor-promoting function of dsHSATII RNA, inducing EMT-like c …
Human satellite II (HSATII), composed of tandem repeats in pericentromeric regions, is aberrantly transcribed in epithelial ca …
YBX1 Regulates Satellite II RNA Loading into Small Extracellular Vesicles and Promotes the Senescent Phenotype.
Chiba M, Miyata K, Okawa H, Tanaka Y, Ueda K, Seimiya H, Takahashi A. Chiba M, et al. Int J Mol Sci. 2023 Nov 16;24(22):16399. doi: 10.3390/ijms242216399. Int J Mol Sci. 2023. PMID: 38003589 Free PMC article.
Senescent cells secrete inflammatory proteins and small extracellular vesicles (sEVs), collectively termed senescence-associated secretory phenotype (SASP), and promote age-related diseases. Epigenetic alteration in senescent cells induces the expression of satellite …
Senescent cells secrete inflammatory proteins and small extracellular vesicles (sEVs), collectively termed senescence-associated secretory p …
Recruitment of the Histone Variant MacroH2A1 to the Pericentric Region Occurs upon Chromatin Relaxation and Is Responsible for Major Satellite Transcriptional Regulation.
Recoules L, Tanguy Le Gac N, Moutahir F, Bystricky K, Lavigne AC. Recoules L, et al. Cells. 2023 Aug 30;12(17):2175. doi: 10.3390/cells12172175. Cells. 2023. PMID: 37681907 Free PMC article.
Heterochromatin formation plays a pivotal role in regulating chromatin organization and influences nuclear architecture and genome stability and expression. Amongst the locations where heterochromatin is found, the pericentric regions have the capability to attract the his …
Heterochromatin formation plays a pivotal role in regulating chromatin organization and influences nuclear architecture and genome stability …
Satellite RNAs: emerging players in subnuclear architecture and gene regulation.
Ninomiya K, Yamazaki T, Hirose T. Ninomiya K, et al. EMBO J. 2023 Sep 18;42(18):e114331. doi: 10.15252/embj.2023114331. Epub 2023 Aug 1. EMBO J. 2023. PMID: 37526230 Free PMC article. Review.
Satellite DNA is characterized by long, tandemly repeated sequences mainly found in centromeres and pericentromeric chromosomal regions. ...This review discusses the structural features and regulatory roles of satellite RNAs in intracellular architecture and …
Satellite DNA is characterized by long, tandemly repeated sequences mainly found in centromeres and pericentromeric chromosoma …
Chromatin conformational changes at human satellite II contribute to the senescence phenotype in the tumor microenvironment.
Miyata K, Zhou X, Nishio M, Hanyu A, Chiba M, Kawasaki H, Osako T, Takeuchi K, Ohno S, Ueno T, Maruyama R, Takahashi A. Miyata K, et al. Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2305046120. doi: 10.1073/pnas.2305046120. Epub 2023 Jul 31. Proc Natl Acad Sci U S A. 2023. PMID: 37523559 Free PMC article.
Furthermore, we reanalyzed the single-cell assay for transposase-accessible chromatin with sequencing data and found increased SASP-related gene expression in fibroblasts exhibiting hSATII decompaction in breast cancer tissues. These findings suggest that changes in …
Furthermore, we reanalyzed the single-cell assay for transposase-accessible chromatin with sequencing data and found increased SASP-related …
Overexpression of Pericentromeric HSAT2 DNA Increases Expression of EMT Markers in Human Epithelial Cancer Cell Lines.
Ponomartsev N, Zilov D, Gushcha E, Travina A, Sergeev A, Enukashvily N. Ponomartsev N, et al. Int J Mol Sci. 2023 Apr 7;24(8):6918. doi: 10.3390/ijms24086918. Int J Mol Sci. 2023. PMID: 37108080 Free PMC article.
Pericentromeric tandemly repeated DNA of human satellites 1, 2, and 3 (HS1, HS2, and HS3) is actively transcribed in some cells. ...Thus, our study suggests HSAT2 lncRNA transcribed from the pericentromeric tandemly repeated DNA is involved in EMT regulation in canc …
Pericentromeric tandemly repeated DNA of human satellites 1, 2, and 3 (HS1, HS2, and HS3) is actively transcribed in some cells. ...T …
Repetitive elements in aging and neurodegeneration.
Copley KE, Shorter J. Copley KE, et al. Trends Genet. 2023 May;39(5):381-400. doi: 10.1016/j.tig.2023.02.008. Epub 2023 Mar 17. Trends Genet. 2023. PMID: 36935218 Review.
Repetitive elements (REs), such as transposable elements (TEs) and satellites, comprise much of the genome. Here, we review how TEs and (peri)centromeric satellite DNA may contribute to aging and neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). A …
Repetitive elements (REs), such as transposable elements (TEs) and satellites, comprise much of the genome. Here, we review how TEs and (per …
Human Satellite 1A analysis provides evidence of pericentromeric transcription.
Lopes M, Louzada S, Ferreira D, Veríssimo G, Eleutério D, Gama-Carvalho M, Chaves R. Lopes M, et al. BMC Biol. 2023 Feb 8;21(1):28. doi: 10.1186/s12915-023-01521-5. BMC Biol. 2023. PMID: 36755311 Free PMC article.
BACKGROUND: Pericentromeric regions of human chromosomes are composed of tandem-repeated and highly organized sequences named satellite DNAs. ...With the emergence of new human genome assemblies, acrocentric pericentromeres are becoming relevant characters in …
BACKGROUND: Pericentromeric regions of human chromosomes are composed of tandem-repeated and highly organized sequences named sate …
Pericentromeric satellite lncRNAs are induced in cancer-associated fibroblasts and regulate their functions in lung tumorigenesis.
Enukashvily NI, Ponomartsev NV, Ketkar A, Suezov R, Chubar AV, Prjibelski AD, Shafranskaya DD, Elmshäuser S, Keber CU, Stefanova VN, Akopov AL, Klingmüller U, Pfefferle PI, Stiewe T, Lauth M, Brichkina AI. Enukashvily NI, et al. Cell Death Dis. 2023 Jan 12;14(1):19. doi: 10.1038/s41419-023-05553-1. Cell Death Dis. 2023. PMID: 36635266 Free PMC article.
The abnormal tumor microenvironment (TME) often dictates the therapeutic response of cancer to chemo- and immuno-therapy. Aberrant expression of pericentromeric satellite repeats has been reported for epithelial cancers, including lung cancer. ...In vivo, lun …
The abnormal tumor microenvironment (TME) often dictates the therapeutic response of cancer to chemo- and immuno-therapy. Aberrant expres …
HP1 proteins regulate nucleolar structure and function by secluding pericentromeric constitutive heterochromatin.
Ballmer D, Tardat M, Ortiz R, Graff-Meyer A, Ozonov EA, Genoud C, Peters AH, Fanourgakis G. Ballmer D, et al. Nucleic Acids Res. 2023 Jan 11;51(1):117-143. doi: 10.1093/nar/gkac1159. Nucleic Acids Res. 2023. PMID: 36533441 Free PMC article.
In embryonic stem cells (ESCs), nucleoli containing transcriptionally active ribosomal genes are spatially separated from pericentromeric satellite repeat sequences packaged in largely repressed constitutive heterochromatin (PCH). ...Hp1alpha/beta deficiency reduces …
In embryonic stem cells (ESCs), nucleoli containing transcriptionally active ribosomal genes are spatially separated from pericentromeric …
63 results