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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 1
1956 1
1958 2
1960 1
1961 1
1969 1
1970 2
1971 3
1972 1
1973 1
1974 1
1979 1
1981 1
1983 1
1986 2
1988 2
1989 1
1991 2
1992 1
1993 1
1994 3
1995 8
1996 6
1997 4
1998 9
1999 17
2000 21
2001 19
2002 23
2003 13
2004 25
2005 16
2006 16
2007 21
2008 14
2009 16
2010 15
2011 29
2012 28
2013 20
2014 16
2015 31
2016 28
2017 43
2018 25
2019 29
2020 24
2021 23
2022 2
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522 results
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Page 1
The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells.
Muñoz-Guardiola P, Casas J, Megías-Roda E, Solé S, Perez-Montoyo H, Yeste-Velasco M, Erazo T, Diéguez-Martínez N, Espinosa-Gil S, Muñoz-Pinedo C, Yoldi G, Abad JL, Segura MF, Moran T, Romeo M, Bosch-Barrera J, Oaknin A, Alfón J, Domènech C, Fabriàs G, Velasco G, Lizcano JM. Muñoz-Guardiola P, et al. Autophagy. 2021 Jun;17(6):1349-1366. doi: 10.1080/15548627.2020.1761651. Epub 2020 May 25. Autophagy. 2021. PMID: 32397857 Free PMC article.
ABTL0812 is a first-in-class small molecule with anti-cancer activity, which is currently in clinical evaluation in a phase 2 trial in patients with advanced endometrial and squamous non-small cell lung carcinoma (NCT03366480). ...Using a wide range of biochemical and lipi …
ABTL0812 is a first-in-class small molecule with anti-cancer activity, which is currently in clinical evaluation in a phase 2 trial i …
ER stress and autophagy are involved in the apoptosis induced by cisplatin in human lung cancer cells.
Shi S, Tan P, Yan B, Gao R, Zhao J, Wang J, Guo J, Li N, Ma Z. Shi S, et al. Oncol Rep. 2016 May;35(5):2606-14. doi: 10.3892/or.2016.4680. Epub 2016 Mar 16. Oncol Rep. 2016. PMID: 26985651 Free PMC article.
Cisplatin [cis-diamminedichloroplatinum II (CDDP)] is one of the most classical and effective chemotherapeutic drugs for the treatment of cancers including lung cancer. However, the presence of cisplatin resistance in cancer lowers its curative effect and lim …
Cisplatin [cis-diamminedichloroplatinum II (CDDP)] is one of the most classical and effective chemotherapeutic drugs for the treatment of …
Modifying histones to tame cancer: clinical development of sodium phenylbutyrate and other histone deacetylase inhibitors.
Gore SD, Carducci MA. Gore SD, et al. Expert Opin Investig Drugs. 2000 Dec;9(12):2923-34. doi: 10.1517/13543784.9.12.2923. Expert Opin Investig Drugs. 2000. PMID: 11093362 Review.
Although several molecules that inhibit histone deacetylase are undergoing preclinical development, butyric acid derivatives have undergone clinical investigation for several years, initially for non-malignant indications and more recently for the treatment of cancer. Of t …
Although several molecules that inhibit histone deacetylase are undergoing preclinical development, butyric acid derivatives have undergone …
Potential of Phenylbutyrate as Adjuvant Chemotherapy: An Overview of Cellular and Molecular Anticancer Mechanisms.
Al-Keilani MS, Al-Sawalha NA. Al-Keilani MS, et al. Chem Res Toxicol. 2017 Oct 16;30(10):1767-1777. doi: 10.1021/acs.chemrestox.7b00149. Epub 2017 Oct 3. Chem Res Toxicol. 2017. PMID: 28930444 Review.
Moreover, phenylbutyrate administration in vivo provided an oncoprotective effect. ...The present review discusses the proposed mechanisms of antineoplastic effect of phenylbutyrate and the preclinical and clinical evidence suggesting its potential role as anticance …
Moreover, phenylbutyrate administration in vivo provided an oncoprotective effect. ...The present review discusses the proposed mecha …
Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy.
Wang J, Qi Q, Zhou W, Feng Z, Huang B, Chen A, Zhang D, Li W, Zhang Q, Jiang Z, Bjerkvig R, Prestegarden L, Thorsen F, Wang X, Li X, Wang J. Wang J, et al. Autophagy. 2018;14(11):2007-2022. doi: 10.1080/15548627.2018.1501133. Epub 2018 Aug 17. Autophagy. 2018. PMID: 30025493 Free PMC article.
Flavokawain B (FKB), a natural kava chalcone, displays potent antitumor activity in various types of cancer. The mechanism of action, however, remains unclear. Here, we evaluated the efficacy of FKB in the treatment of human glioblastoma multiforme (GBM) as well as the mol …
Flavokawain B (FKB), a natural kava chalcone, displays potent antitumor activity in various types of cancer. The mechanism of action, …
Curcumin induces endoplasmic reticulum stress-associated apoptosis in human papillary thyroid carcinoma BCPAP cells via disruption of intracellular calcium homeostasis.
Zhang L, Cheng X, Xu S, Bao J, Yu H. Zhang L, et al. Medicine (Baltimore). 2018 Jun;97(24):e11095. doi: 10.1097/MD.0000000000011095. Medicine (Baltimore). 2018. PMID: 29901626 Free PMC article. Clinical Trial.
BACKGROUND: Thyroid cancer is the most common endocrine tumor. Our previous studies have demonstrated that curcumin can induce apoptosis in human papillary thyroid carcinoma BCPAP cells. ...Our observations provoked that ER stress activation may be a promising therapeutic …
BACKGROUND: Thyroid cancer is the most common endocrine tumor. Our previous studies have demonstrated that curcumin can induce apopto …
Outline of gelatinase inhibitors as anti-cancer agents: A patent mini-review for 2010-present.
Baidya SK, Amin SA, Jha T. Baidya SK, et al. Eur J Med Chem. 2021 Mar 5;213:113044. doi: 10.1016/j.ejmech.2020.113044. Epub 2020 Nov 24. Eur J Med Chem. 2021. PMID: 33279289 Review.
Gelatinases (MMP-2 and -9) have significant attention as therapeutic targets against cancer. Gelatinase inhibitors have demonstrated their effectiveness in several diseases including cancer. ...
Gelatinases (MMP-2 and -9) have significant attention as therapeutic targets against cancer. Gelatinase inhibitors have demonstrated …
Phenylbutyrate interferes with the Fanconi anemia and BRCA pathway and sensitizes head and neck cancer cells to cisplatin.
Burkitt K, Ljungman M. Burkitt K, et al. Mol Cancer. 2008 Mar 6;7:24. doi: 10.1186/1476-4598-7-24. Mol Cancer. 2008. PMID: 18325101 Free PMC article.
RESULTS: We found that the phenylbutyrate sensitizes head and neck cancer cell lines to cisplatin. ...Furthermore, we found that cancer cells defective in the FA pathway were also sensitized to cisplatin by phenylbutyrate suggesting that phenylbutyr
RESULTS: We found that the phenylbutyrate sensitizes head and neck cancer cell lines to cisplatin. ...Furthermore, we found th …
522 results