Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 1
1956 1
1958 2
1960 1
1961 1
1969 1
1970 2
1971 3
1972 1
1973 1
1974 1
1979 1
1981 1
1983 1
1986 2
1988 2
1989 1
1991 2
1992 1
1993 1
1994 3
1995 8
1996 6
1997 4
1998 9
1999 17
2000 21
2001 19
2002 23
2003 13
2004 25
2005 16
2006 16
2007 21
2008 14
2009 16
2010 15
2011 29
2012 28
2013 20
2014 16
2015 31
2016 28
2017 43
2018 25
2019 30
2020 25
2021 25
2022 28
2023 26
2024 14
2025 3

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

587 results

Results by year

Filters applied: . Clear all
Page 1
Modifying histones to tame cancer: clinical development of sodium phenylbutyrate and other histone deacetylase inhibitors.
Gore SD, Carducci MA. Gore SD, et al. Expert Opin Investig Drugs. 2000 Dec;9(12):2923-34. doi: 10.1517/13543784.9.12.2923. Expert Opin Investig Drugs. 2000. PMID: 11093362 Review.
Although several molecules that inhibit histone deacetylase are undergoing preclinical development, butyric acid derivatives have undergone clinical investigation for several years, initially for non-malignant indications and more recently for the treatment of cancer. Of t …
Although several molecules that inhibit histone deacetylase are undergoing preclinical development, butyric acid derivatives have undergone …
Novel nitric oxide donor, nitrated phenylbutyrate, induces cell death of human pancreatic cancer cells and suppresses tumor growth of cancer xenografts.
Beppu T, Nishi K, Imoto S, Araki W, Setoguchi I, Ueda A, Suetsugi N, Ishima Y, Ikeda T, Otagiri M, Yamasaki K. Beppu T, et al. Oncol Rep. 2022 Oct;48(4):178. doi: 10.3892/or.2022.8393. Epub 2022 Aug 25. Oncol Rep. 2022. PMID: 36004467
Pancreatic cancer has a low response rate to chemotherapy due to the low drug transferability caused by the low blood flow around the tumor. In the present study, focusing on nitric oxide (NO) for its vasodilatory and antitumor effects, a novel NO donor, a nitrated form of …
Pancreatic cancer has a low response rate to chemotherapy due to the low drug transferability caused by the low blood flow around the …
Comparison Between Dichloroacetate and Phenylbutyrate Treatment for Pyruvate Dehydrogenase Deficiency.
Karissa P, Simpson T, Dawson SP, Low TY, Tay SH, Nordin FDA, Zain SM, Lee PY, Pung YF. Karissa P, et al. Br J Biomed Sci. 2022 May 19;79:10382. doi: 10.3389/bjbs.2022.10382. eCollection 2022. Br J Biomed Sci. 2022. PMID: 35996497 Free PMC article. Review.
Potential treatments for this disease include dichloroacetate and phenylbutyrate, previously used for other diseases such as cancer and maple syrup urine disease. ...This review analysed the efficacy of dichloroacetate and phenylbutyrate as potential treatmen …
Potential treatments for this disease include dichloroacetate and phenylbutyrate, previously used for other diseases such as cance …
Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy.
Wang J, Qi Q, Zhou W, Feng Z, Huang B, Chen A, Zhang D, Li W, Zhang Q, Jiang Z, Bjerkvig R, Prestegarden L, Thorsen F, Wang X, Li X, Wang J. Wang J, et al. Autophagy. 2018;14(11):2007-2022. doi: 10.1080/15548627.2018.1501133. Epub 2018 Aug 17. Autophagy. 2018. PMID: 30025493 Free PMC article.
Flavokawain B (FKB), a natural kava chalcone, displays potent antitumor activity in various types of cancer. The mechanism of action, however, remains unclear. Here, we evaluated the efficacy of FKB in the treatment of human glioblastoma multiforme (GBM) as well as the mol …
Flavokawain B (FKB), a natural kava chalcone, displays potent antitumor activity in various types of cancer. The mechanism of action, …
Inhibition of USP1 activates ER stress through Ubi-protein aggregation to induce autophagy and apoptosis in HCC.
Wang L, Hu T, Shen Z, Zheng Y, Geng Q, Li L, Sha B, Li M, Sun Y, Guo Y, Xue W, Xuan D, Chen P, Zhao J. Wang L, et al. Cell Death Dis. 2022 Nov 10;13(11):951. doi: 10.1038/s41419-022-05341-3. Cell Death Dis. 2022. PMID: 36357365 Free PMC article.
Moreover, active ER stress induces protective autophagy by increasing AMPK phosphorylation; therefore, we inhibited ER stress using 4-Phenylbutyric acid (4-PBA), which resulted in ER stress reduction, apoptosis, and autophagy in ML-323-treated HCC cells. ...
Moreover, active ER stress induces protective autophagy by increasing AMPK phosphorylation; therefore, we inhibited ER stress using 4-Phe …
Differentiation therapy.
Spira AI, Carducci MA. Spira AI, et al. Curr Opin Pharmacol. 2003 Aug;3(4):338-43. doi: 10.1016/s1471-4892(03)00081-x. Curr Opin Pharmacol. 2003. PMID: 12901941 Review.
Theoretically, the concept of differentiation therapy involves turning a cancer cell "off" biologically and reverting to a more "benign" phenotype. Many agents have been studied over the past few years, with many already either in use clinically or showing future promise.. …
Theoretically, the concept of differentiation therapy involves turning a cancer cell "off" biologically and reverting to a more "beni …
Phenylbutyrate inhibits the invasive properties of prostate and breast cancer cell lines in the sea urchin embryo basement membrane invasion assay.
Dyer ES, Paulsen MT, Markwart SM, Goh M, Livant DL, Ljungman M. Dyer ES, et al. Int J Cancer. 2002 Oct 10;101(5):496-9. doi: 10.1002/ijc.10609. Int J Cancer. 2002. PMID: 12216080 Free article.
Histone deacetylase inhibitors, such as phenylbutyrate, are currently undergoing clinical trials as potential anticancer agents. Phenylbutyrate can induce cell differentiation and apoptosis in a number of cancer cell types and can act in synergy with ionizing …
Histone deacetylase inhibitors, such as phenylbutyrate, are currently undergoing clinical trials as potential anticancer agents. P …
587 results

Searches related to "phenylbutyrate cancer"