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Page 1
Role of K364 next to the active site cysteine in voltage-dependent phosphatase activity of Ci-VSP.
Paixao IC, Mizutani N, Matsuda M, Andriani RT, Kawai T, Nakagawa A, Okochi Y, Okamura Y. Paixao IC, et al. Biophys J. 2023 Jun 6;122(11):2267-2284. doi: 10.1016/j.bpj.2023.01.022. Epub 2023 Jan 20. Biophys J. 2023. PMID: 36680342 Free PMC article.
All mutants retained both 5-phosphatase and 3-phosphatase activity, indicating that lysine at this site is dispensable for 3-phosphatase activity, unlike PTEN. Notably, K364M mutant showed increased activity both of 5-phosphatase a …
All mutants retained both 5-phosphatase and 3-phosphatase activity, indicating that lysine at this site is dispensable …
Analysis of Smad Phosphatase Activity In Vitro.
Shen T, Qin L, Lin X. Shen T, et al. Methods Mol Biol. 2016;1344:111-9. doi: 10.1007/978-1-4939-2966-5_6. Methods Mol Biol. 2016. PMID: 26520120
Bacterially purified recombinant PPM1H possesses phosphatase activity toward artificial substrate para-nitrophenyl phosphate (pNPP). Recombinant PPM1H also dephosphorylates immuno-purified phosphorylated Smad1 in test tubes. These direct in vitro phosphatase …
Bacterially purified recombinant PPM1H possesses phosphatase activity toward artificial substrate para-nitrophenyl phosphate ( …
In Vitro Assays for Measuring Protein Histidine Phosphatase Activity.
McCullough BS, Barrios AM. McCullough BS, et al. Methods Mol Biol. 2020;2077:109-120. doi: 10.1007/978-1-4939-9884-5_8. Methods Mol Biol. 2020. PMID: 31707655
Here we present a brief overview of the techniques available to monitor histidine phosphatase activity and provide protocols for measuring the activity and inhibition of PHPT1 in vitro using the fluorescent probe 6,8-difluoro-4-methylumbelliferyl phosphate (D …
Here we present a brief overview of the techniques available to monitor histidine phosphatase activity and provide protocols f …
Phosphatase regulation of macrophage activation.
Kozicky LK, Sly LM. Kozicky LK, et al. Semin Immunol. 2015 Aug;27(4):276-85. doi: 10.1016/j.smim.2015.07.001. Epub 2015 Jul 26. Semin Immunol. 2015. PMID: 26216598 Review.
Downstream of these cell surface receptors, cell signalling cascades are activated and deactivated by reversible and competing activities of lipid and protein kinases and phosphatases. While kinases drive the activation of cell signalling pathways crit …
Downstream of these cell surface receptors, cell signalling cascades are activated and deactivated by reversible and competing act …
The yeast phosphatase system.
Vogel K, Hinnen A. Vogel K, et al. Mol Microbiol. 1990 Dec;4(12):2013-7. doi: 10.1111/j.1365-2958.1990.tb00560.x. Mol Microbiol. 1990. PMID: 1965216 Review.
Yeast cells produce a set of enzymes which are involved in the metabolism of phosphate, and include acid and alkaline phosphatases as well as permeases. Most of these enzymes are synthesized in response to the presence or absence of inorganic phosphate. In the past few yea …
Yeast cells produce a set of enzymes which are involved in the metabolism of phosphate, and include acid and alkaline phosphatases as …
The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways.
Wang Z, Jiang H, Chen S, Du F, Wang X. Wang Z, et al. Cell. 2012 Jan 20;148(1-2):228-43. doi: 10.1016/j.cell.2011.11.030. Cell. 2012. PMID: 22265414 Free article.
One component of these complexes is the mitochondrial protein phosphatase PGAM5, which presents as two splice variants, PGAM5L (long form) and PGAM5S (short form). ...Upon necrosis induction, PGAM5S recruited the mitochondrial fission factor Drp1 and activated its G …
One component of these complexes is the mitochondrial protein phosphatase PGAM5, which presents as two splice variants, PGAM5L (long …
Structure-Activity Studies on Bis-Sulfonamide SHIP1 Activators.
Meyer ST, Fernandes S, Anderson RE, Pacherille A, Toms B, Kerr WG, Chisholm JD. Meyer ST, et al. Molecules. 2023 Dec 12;28(24):8048. doi: 10.3390/molecules28248048. Molecules. 2023. PMID: 38138538 Free PMC article.
The SH2-containing inositol polyphosphate 5-phosphatase 1 (SHIP1) enzyme opposes the activity of PI3K and therefore is of interest in the treatment of inflammatory disorders. ...A series of similar SHIP1 activators have been synthesized and evaluated to deter …
The SH2-containing inositol polyphosphate 5-phosphatase 1 (SHIP1) enzyme opposes the activity of PI3K and therefore is of inte …
Carbonic anhydrase III: the phosphatase activity is extrinsic.
Kim G, Selengut J, Levine RL. Kim G, et al. Arch Biochem Biophys. 2000 May 15;377(2):334-40. doi: 10.1006/abbi.2000.1793. Arch Biochem Biophys. 2000. PMID: 10845711
We attempted to identify an activator of the phosphatase in rat liver and found a protein of approximately 14 kDa, the amount of which correlated with the phosphatase activity of the carbonic anhydrase III fractions. It was identified as liver fatty ac …
We attempted to identify an activator of the phosphatase in rat liver and found a protein of approximately 14 kDa, the amount …
Phosphatase activity of the voltage-sensing phosphatase, VSP, shows graded dependence on the extent of activation of the voltage sensor.
Sakata S, Okamura Y. Sakata S, et al. J Physiol. 2014 Mar 1;592(5):899-914. doi: 10.1113/jphysiol.2013.263640. Epub 2013 Nov 25. J Physiol. 2014. PMID: 24277865 Free PMC article.
The voltage-sensing phosphatase (VSP) consists of a voltage sensor and a cytoplasmic phosphatase region, and the movement of the voltage sensor is coupled to the phosphatase activity. However, its coupling mechanisms still remain unclear. One possible …
The voltage-sensing phosphatase (VSP) consists of a voltage sensor and a cytoplasmic phosphatase region, and the movement of t …
Molecular insight into 2-phosphoglycolate activation of the phosphatase activity of bisphosphoglycerate mutase.
Aljahdali AS, Musayev FN, Burgner JW 2nd, Ghatge MS, Shekar V, Zhang Y, Omar AM, Safo MK. Aljahdali AS, et al. Acta Crystallogr D Struct Biol. 2022 Apr 1;78(Pt 4):472-482. doi: 10.1107/S2059798322001802. Epub 2022 Mar 11. Acta Crystallogr D Struct Biol. 2022. PMID: 35362470 Free PMC article.
Bisphosphoglycerate mutase (BPGM) is an erythrocyte-specific multifunctional enzyme that is responsible for the regulation of 2,3-bisphosphoglycerate (2,3-BPG) in red blood cells through its synthase and phosphatase activities; the latter enzymatic function is stimu …
Bisphosphoglycerate mutase (BPGM) is an erythrocyte-specific multifunctional enzyme that is responsible for the regulation of 2,3-bisphospho …
148,362 results
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