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Year Number of Results
1987 1
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2007 456
2008 411
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10,373 results

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Page 1
Structural basis of phosphatidylinositol 3-kinase C2alpha function.
Lo WT, Zhang Y, Vadas O, Roske Y, Gulluni F, De Santis MC, Zagar AV, Stephanowitz H, Hirsch E, Liu F, Daumke O, Kudryashev M, Haucke V. Lo WT, et al. Nat Struct Mol Biol. 2022 Mar;29(3):218-228. doi: 10.1038/s41594-022-00730-w. Epub 2022 Mar 7. Nat Struct Mol Biol. 2022. PMID: 35256802 Free PMC article.
Phosphatidylinositol 3-kinase type 2alpha (PI3KC2alpha) is an essential member of the structurally unresolved class II PI3K family with crucial functions in lipid signaling, endocytosis, angiogenesis, viral replication, platelet formation and a role in mitosi …
Phosphatidylinositol 3-kinase type 2alpha (PI3KC2alpha) is an essential member of the structurally unresolved class II …
The role of the PI3K/AKT signalling pathway in the corneal epithelium: recent updates.
Chen K, Li Y, Zhang X, Ullah R, Tong J, Shen Y. Chen K, et al. Cell Death Dis. 2022 May 31;13(5):513. doi: 10.1038/s41419-022-04963-x. Cell Death Dis. 2022. PMID: 35641491 Free PMC article. Review.
Phosphatidylinositol 3 kinase (PI3K)/AKT (also called protein kinase B, PKB) signalling regulates various cellular processes, such as apoptosis, cell proliferation, the cell cycle, protein synthesis, glucose metabolism, and telomere activity. ...Various growt …
Phosphatidylinositol 3 kinase (PI3K)/AKT (also called protein kinase B, PKB) signalling regulates various cellular proc …
Risk1, a Phosphatidylinositol 3-Kinase Effector, Promotes Rickettsia typhi Intracellular Survival.
Voss OH, Gillespie JJ, Lehman SS, Rennoll SA, Beier-Sexton M, Rahman MS, Azad AF. Voss OH, et al. mBio. 2020 Jun 16;11(3):e00820-20. doi: 10.1128/mBio.00820-20. mBio. 2020. PMID: 32546622 Free PMC article.
Here, we characterize a new molecule, Risk1, as a phosphatidylinositol 3-kinase (PI3K) secreted effector and the first bacterial secretory kinase with both class I and III PI3K activities. ...Here, we characterize a new effector, Risk1, as a secreted phosp …
Here, we characterize a new molecule, Risk1, as a phosphatidylinositol 3-kinase (PI3K) secreted effector and the first …
Development of selective inhibitors of phosphatidylinositol 3-kinase C2alpha.
Lo WT, Belabed H, Kücükdisli M, Metag J, Roske Y, Prokofeva P, Ohashi Y, Horatscheck A, Cirillo D, Krauss M, Schmied C, Neuenschwander M, von Kries JP, Médard G, Kuster B, Perisic O, Williams RL, Daumke O, Payrastre B, Severin S, Nazaré M, Haucke V. Lo WT, et al. Nat Chem Biol. 2023 Jan;19(1):18-27. doi: 10.1038/s41589-022-01118-z. Epub 2022 Sep 15. Nat Chem Biol. 2023. PMID: 36109648 Free PMC article.
Phosphatidylinositol 3-kinase type 2alpha (PI3KC2alpha) and related class II PI3K isoforms are of increasing biomedical interest because of their crucial roles in endocytic membrane dynamics, cell division and signaling, angiogenesis, and platelet morphology …
Phosphatidylinositol 3-kinase type 2alpha (PI3KC2alpha) and related class II PI3K isoforms are of increasing biomedical …
Lipid signalling enforces functional specialization of Treg cells in tumours.
Lim SA, Wei J, Nguyen TM, Shi H, Su W, Palacios G, Dhungana Y, Chapman NM, Long L, Saravia J, Vogel P, Chi H. Lim SA, et al. Nature. 2021 Mar;591(7849):306-311. doi: 10.1038/s41586-021-03235-6. Epub 2021 Feb 24. Nature. 2021. PMID: 33627871 Free PMC article.
Here we show that inhibiting lipid synthesis and metabolic signalling that are dependent on sterol-regulatory-element-binding proteins (SREBPs) in T(reg) cells unleashes effective antitumour immune responses without autoimmune toxicity. ...Blocking PD-1 or SREBP signalling …
Here we show that inhibiting lipid synthesis and metabolic signalling that are dependent on sterol-regulatory-element-binding protein …
Architecture and activation of phosphatidylinositol 3-kinase related kinases.
Imseng S, Aylett CH, Maier T. Imseng S, et al. Curr Opin Struct Biol. 2018 Apr;49:177-189. doi: 10.1016/j.sbi.2018.03.010. Epub 2018 Apr 3. Curr Opin Struct Biol. 2018. PMID: 29625383 Free article. Review.
The phosphatidylinositol 3-kinase related protein kinases (PIKKs) are key to the regulation of a variety of eukaryotic cellular processes including DNA repair and growth regulation. ...
The phosphatidylinositol 3-kinase related protein kinases (PIKKs) are key to the regulation of a variety of eukaryotic …
Insulin-Responsive Transcription Factors.
Thiel G, Guethlein LA, Rössler OG. Thiel G, et al. Biomolecules. 2021 Dec 15;11(12):1886. doi: 10.3390/biom11121886. Biomolecules. 2021. PMID: 34944530 Free PMC article. Review.
The hormone insulin executes its function via binding and activating of the insulin receptor, a receptor tyrosine kinase that is mainly expressed in skeletal muscle, adipocytes, liver, pancreatic beta-cells, and in some areas of the central nervous system. Stimulation of t …
The hormone insulin executes its function via binding and activating of the insulin receptor, a receptor tyrosine kinase that is main …
Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression.
Abrahamsen H, Stenmark H, Platta HW. Abrahamsen H, et al. FEBS Lett. 2012 Jun 4;586(11):1584-91. doi: 10.1016/j.febslet.2012.04.046. Epub 2012 May 3. FEBS Lett. 2012. PMID: 22673570 Review.
The class III phosphatidylinositol 3-kinase (PI3K-III) complex and its phosphorylated lipid product phosphatidylinositol 3-phosphate (PtdIns3P) control the three topologically related membrane-involution processes autophagy, endocytosis, and cytokinesi …
The class III phosphatidylinositol 3-kinase (PI3K-III) complex and its phosphorylated lipid product phosphatidylinos …
G3BP1 and SLU7 Jointly Promote Immune Evasion by Downregulating MHC-I via PI3K/Akt Activation in Bladder Cancer.
Zheng X, Chen J, Deng M, Ning K, Peng Y, Liu Z, Li X, Zhou Z, Tang H, Li Y, Kang T, Liu Z. Zheng X, et al. Adv Sci (Weinh). 2024 Feb;11(7):e2305922. doi: 10.1002/advs.202305922. Epub 2023 Dec 12. Adv Sci (Weinh). 2024. PMID: 38084438 Free PMC article.
This study conduct a Cox regression analysis to screen mRNA-binding proteins and reveals an association between Ras GTPase-activating protein-binding protein 1 (G3BP1) and diminished effectiveness of ICI therapy in patients with advanced BLCA. Subsequent investigati …
This study conduct a Cox regression analysis to screen mRNA-binding proteins and reveals an association between Ras GTPase-activating …
10,373 results
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