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Year Number of Results
2001 1
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2011 3
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183 results

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Page 1
Assessment of Combination Therapies vs Monotherapy for Erectile Dysfunction: A Systematic Review and Meta-analysis.
Mykoniatis I, Pyrgidis N, Sokolakis I, Ouranidis A, Sountoulides P, Haidich AB, van Renterghem K, Hatzichristodoulou G, Hatzichristou D. Mykoniatis I, et al. JAMA Netw Open. 2021 Feb 1;4(2):e2036337. doi: 10.1001/jamanetworkopen.2020.36337. JAMA Netw Open. 2021. PMID: 33599772 Free PMC article.
IMPORTANCE: Combining 2 first-line treatments for erectile dysfunction (ED) or initiating other modalities in addition to a first-line therapy may produce beneficial outcomes. ...Only comparative human studies, which evaluated the change from baseline of self-report …
IMPORTANCE: Combining 2 first-line treatments for erectile dysfunction (ED) or initiating other modalities in addition to a fi …
Phosphodiesterase type 5 inhibitors combined with traditional Chinese medicine for diabetes mellitus-induced erectile dysfunction: A systematic review and meta-analysis.
Xiang L, Liu A, Tang W, Sun B, Yang Y, Li Y, Chen S, Zhao J, Zhang W, Cai X, Tang X. Xiang L, et al. Medicine (Baltimore). 2025 Jul 11;104(28):e43243. doi: 10.1097/MD.0000000000043243. Medicine (Baltimore). 2025. PMID: 40660517 Free PMC article.
BACKGROUND: Diabetes mellitus-induced erectile dysfunction (DMED) involves complex pathophysiology, leading to suboptimal outcomes with phosphodiesterase type 5 inhibitors (PDE5I) alone. ...METHODS: We conducted a systematic rev …
BACKGROUND: Diabetes mellitus-induced erectile dysfunction (DMED) involves complex pathophysiology, leading to suboptimal outc …
The safety and efficacy of phosphodiesterase type 5 inhibitors in the treatment of diabetic erectile dysfunction: a systematic review and meta-analysis.
Zhu Z, Xu J, Dai B, Lin M, Yang H, Liu S, Bao P, Nan Z. Zhu Z, et al. PeerJ. 2025 Oct 7;13:e20147. doi: 10.7717/peerj.20147. eCollection 2025. PeerJ. 2025. PMID: 41081100 Free PMC article.
BACKGROUND: Previous studies have confirmed the efficacy of phosphodiesterase type 5 inhibitors (PDE-5 inhibitors) in treating diabetic erectile dysfunction (DED), but they still have research value in terms of efficacy comparison and ind …
BACKGROUND: Previous studies have confirmed the efficacy of phosphodiesterase type 5 inhibitors (PDE-5 inhibitor …
Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis.
Gong B, Ma M, Xie W, Yang X, Huang Y, Sun T, Luo Y, Huang J. Gong B, et al. Int Urol Nephrol. 2017 Oct;49(10):1731-1740. doi: 10.1007/s11255-017-1644-5. Epub 2017 Jul 24. Int Urol Nephrol. 2017. PMID: 28741090 Free PMC article.
AIMS: Erectile dysfunction (ED) is a major care problem worldwide. Tadalafil and sildenafil are the two most common phosphodiesterase 5 inhibitors used to treat ED. This systematic review and meta-analysis were conducted to directl …
AIMS: Erectile dysfunction (ED) is a major care problem worldwide. Tadalafil and sildenafil are the two most common phospho …
Nutraceutical interventions for erectile dysfunction: a systematic review and network meta-analysis.
Barbonetti A, Tienforti D, Antolini F, Spagnolo L, Cavallo F, Di Pasquale AB, Maggi M, Corona G. Barbonetti A, et al. J Sex Med. 2024 Oct 31;21(11):1054-1063. doi: 10.1093/jsxmed/qdae123. J Sex Med. 2024. PMID: 39279185
BACKGROUND: Although nutraceutical-based treatments are often offered for erectile dysfunction (ED), their efficacy remains doubtful, and the choice of one substance over the other is challenged by the dearth of head-to-head comparative studies. AIM: We aimed to com …
BACKGROUND: Although nutraceutical-based treatments are often offered for erectile dysfunction (ED), their efficacy remains do …
Systematic Review of Oral Combination Therapy for Erectile Dysfunction When Phosphodiesterase Type 5 Inhibitor Monotherapy Fails.
Munk NE, Knudsen JS, Comerma-Steffensen S, Simonsen U. Munk NE, et al. Sex Med Rev. 2019 Jul;7(3):430-441. doi: 10.1016/j.sxmr.2018.11.007. Epub 2019 Jan 30. Sex Med Rev. 2019. PMID: 30711478
INTRODUCTION: On-demand phosphodiesterase type 5 inhibitor (PDE5i) monotherapy is a first-line treatment for erectile dysfunction (ED), but 30%-40% of patients exhibit little or no response. The success rate of alprostadil therapy is high in these patients, but this …
INTRODUCTION: On-demand phosphodiesterase type 5 inhibitor (PDE5i) monotherapy is a first-line treatment for erectile dysfunction …
Systematic review and meta-analysis of the use of phosphodiesterase type 5 inhibitors for treatment of erectile dysfunction following bilateral nerve-sparing radical prostatectomy.
Wang X, Wang X, Liu T, He Q, Wang Y, Zhang X. Wang X, et al. PLoS One. 2014 Mar 11;9(3):e91327. doi: 10.1371/journal.pone.0091327. eCollection 2014. PLoS One. 2014. PMID: 24618671 Free PMC article.
Radical prostatectomy (RP) is the most effective treatment for a localized tumor but erectile dysfunction (ED) is common complication, even when bilateral nerve-sparing RP (BNSRP) is performed. Clinical trials have shown varied effectiveness of phosphodiesterase …
Radical prostatectomy (RP) is the most effective treatment for a localized tumor but erectile dysfunction (ED) is common compl …
Efficacy and Safety of Phosphodiesterase-5 Inhibitors for Erectile Dysfunction in Schizophrenia: A Systematic Review and Meta-Analysis.
Saito A, Sakuma K, Iwata N, Kishi T. Saito A, et al. Neuropsychiatr Dis Treat. 2025 Sep 4;21:1935-1943. doi: 10.2147/NDT.S548538. eCollection 2025. Neuropsychiatr Dis Treat. 2025. PMID: 40926794 Free PMC article. Review.
BACKGROUND: The benefits of phosphodiesterase-5 inhibitors in the treatment of sexual dysfunction and psychopathology of schizophrenia remain unclear. This systematic review and meta-analysis aimed to address the above clinical question. …
BACKGROUND: The benefits of phosphodiesterase-5 inhibitors in the treatment of sexual dysfunction and psychopath …
Erectile dysfunction.
Khera M, Goldstein I. Khera M, et al. BMJ Clin Evid. 2011 Jun 29;2011:1803. BMJ Clin Evid. 2011. PMID: 21711956 Free PMC article.
METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of phosphodiesterase inhibitors in men with erectile dysfunction of any cause? ...What are the effects of drug treatments …
METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effe …
Effect of different physical activities on erectile dysfunction in adult men not receiving phosphodiesterase-5 inhibitors therapy: A systematic review and meta-analysis.
Chen Z, Wang J, Jia J, Wu C, Song J, Tu J. Chen Z, et al. Andrology. 2024 Nov;12(8):1632-1641. doi: 10.1111/andr.13682. Epub 2024 Jun 27. Andrology. 2024. PMID: 38937909 Free article.
BACKGROUND: Erectile dysfunction (ED) is prevalent not only among older males but also in younger. The physical activity has been considered a potential protective factor against ED. ...OBJECTIVES: This study aimed to assess the effectiveness of the physical activit …
BACKGROUND: Erectile dysfunction (ED) is prevalent not only among older males but also in younger. The physical activity has b …
183 results