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Reverse skin aging signs by red light photobiomodulation.
Couturaud V, Le Fur M, Pelletier M, Granotier F. Couturaud V, et al. Skin Res Technol. 2023 Jul;29(7):e13391. doi: 10.1111/srt.13391. Skin Res Technol. 2023. PMID: 37522497 Free PMC article.
Light emitting diodes (LEDs) photobiomodulation is an increasingly popular therapy for treating skin problems, especially for reversing the signs of skin aging. ...The LED mask used is the Skin Light Dior x Lucibel mask diffusing a cold red light …
Light emitting diodes (LEDs) photobiomodulation is an increasingly popular therapy for treating skin problems, especial …
Brain Photobiomodulation Therapy: a Narrative Review.
Salehpour F, Mahmoudi J, Kamari F, Sadigh-Eteghad S, Rasta SH, Hamblin MR. Salehpour F, et al. Mol Neurobiol. 2018 Aug;55(8):6601-6636. doi: 10.1007/s12035-017-0852-4. Epub 2018 Jan 11. Mol Neurobiol. 2018. PMID: 29327206 Free PMC article. Review.
Brain photobiomodulation (PBM) therapy using red to near-infrared (NIR) light is an innovative treatment for a wide range of neurological and psychological conditions. ...This article reviews the state-of-the-art preclinical and clinical evidence regarding th …
Brain photobiomodulation (PBM) therapy using red to near-infrared (NIR) light is an innovative treatment for a wide ran …
Photobiomodulation CME part I: Overview and mechanism of action.
Maghfour J, Ozog DM, Mineroff J, Jagdeo J, Kohli I, Lim HW. Maghfour J, et al. J Am Acad Dermatol. 2024 Nov;91(5):793-802. doi: 10.1016/j.jaad.2023.10.073. Epub 2024 Feb 1. J Am Acad Dermatol. 2024. PMID: 38309304 Review.
Photobiomodulation (PBM), previously known as low-level laser light therapy, represents a noninvasive form of phototherapy that utilizes wavelengths in the red light (RL, 620-700 nm) portion of the visible light (VL, 400-700 nm) sp …
Photobiomodulation (PBM), previously known as low-level laser light therapy, represents a noninvasive for …
Photobiomodulation: The Clinical Applications of Low-Level Light Therapy.
Glass GE. Glass GE. Aesthet Surg J. 2021 May 18;41(6):723-738. doi: 10.1093/asj/sjab025. Aesthet Surg J. 2021. PMID: 33471046 Review.
BACKGROUND: Low-level light therapy (LLLT) is a recent addition to the pantheon of light-based therapeutic interventions. The absorption of red/near-infrared light energy, a process termed "photobiomodulation," enhances mitochondri …
BACKGROUND: Low-level light therapy (LLLT) is a recent addition to the pantheon of light-based therapeuti …
Photobiomodulation CME part II: Clinical applications in dermatology.
Mineroff J, Maghfour J, Ozog DM, Lim HW, Kohli I, Jagdeo J. Mineroff J, et al. J Am Acad Dermatol. 2024 Nov;91(5):805-815. doi: 10.1016/j.jaad.2023.10.074. Epub 2024 Feb 1. J Am Acad Dermatol. 2024. PMID: 38307144 Review.
PBM is the use of various light sources in the red light (620-700 nm) and near-infrared (700-1440 nm) spectrum as a form of light therapy. PBM is often administered through low-level lasers or light-emitting diodes. Studies show th …
PBM is the use of various light sources in the red light (620-700 nm) and near-infrared (700-1440 nm) spectrum as a form of …
Evidence-based consensus on the clinical application of photobiomodulation.
Maghfour J, Mineroff J, Ozog DM, Jagdeo J, Lim HW, Kohli I, Anderson R, Kelly KM, Mamalis A, Munavalli G, Cleber F, Siegel D, Geneva I, Weiss R, Morita A, Juanita A, Goldman MP, Arany PR, Sliney D, Ibrahimi OA, Chopp M, Esmat S, Tuner J. Maghfour J, et al. J Am Acad Dermatol. 2025 Aug;93(2):429-443. doi: 10.1016/j.jaad.2025.04.031. Epub 2025 Apr 17. J Am Acad Dermatol. 2025. PMID: 40253006 Free article.
BACKGROUND: There is a lack of evidence-based consensus to assist clinicians in using photobiomodulation (PBM). OBJECTIVE: To create a consensus on the safe and effective use of PBM. ...The key findings that informed the consensus developed by the expert panel were as foll …
BACKGROUND: There is a lack of evidence-based consensus to assist clinicians in using photobiomodulation (PBM). OBJECTIVE: To create …
Photobiomodulation: evidence and applications in ophthalmology.
Tan NRX, Chan KE, Lim BXH, Giannaccare G, Najjar RP, Lim CHL. Tan NRX, et al. Curr Opin Ophthalmol. 2025 Sep 1;36(5):345-381. doi: 10.1097/ICU.0000000000001154. Epub 2025 Jun 5. Curr Opin Ophthalmol. 2025. PMID: 40471752 Review.
PURPOSE OF REVIEW: Photobiomodulation (PBM) is a noninvasive therapy utilising low-level light energy to stimulate cellular processes, modulate inflammatory pathways, enhance mitochondrial activity, promote tissue regeneration. ...
PURPOSE OF REVIEW: Photobiomodulation (PBM) is a noninvasive therapy utilising low-level light energy to …
Photobiomodulation: A review of the molecular evidence for low level light therapy.
Glass GE. Glass GE. J Plast Reconstr Aesthet Surg. 2021 May;74(5):1050-1060. doi: 10.1016/j.bjps.2020.12.059. Epub 2020 Dec 27. J Plast Reconstr Aesthet Surg. 2021. PMID: 33436333 Review.
Light energy is harnessed for therapeutic use in a number of ways, most recently by way of photobiomodulation (PBM). ...This article presents a summary of the science of PBM and examines the differences between laser light, on which much of the preclinical ev …
Light energy is harnessed for therapeutic use in a number of ways, most recently by way of photobiomodulation (PBM). ...This a …
Unlocking the Power of Light on the Skin: A Comprehensive Review on Photobiomodulation.
Hernández-Bule ML, Naharro-Rodríguez J, Bacci S, Fernández-Guarino M. Hernández-Bule ML, et al. Int J Mol Sci. 2024 Apr 19;25(8):4483. doi: 10.3390/ijms25084483. Int J Mol Sci. 2024. PMID: 38674067 Free PMC article. Review.
Photobiomodulation (PBM) is a procedure that uses light to modulate cellular functions and biological processes. ...We conducted a narrative review including articles about photobiomodulation, LED light therapy or low-level laser …
Photobiomodulation (PBM) is a procedure that uses light to modulate cellular functions and biological processes. ...We conduct …
Photobiomodulation (low-level light therapy) and dry eye disease.
Markoulli M, Chandramohan N, Papas EB. Markoulli M, et al. Clin Exp Optom. 2021 Jul;104(5):561-566. doi: 10.1080/08164622.2021.1878866. Epub 2021 Feb 27. Clin Exp Optom. 2021. PMID: 33689636
Treatments for meibomian gland dysfunction aim to restore tear film homoeostasis and include warm compress therapy, eyelid hygiene, in-office meibomian gland expression and lipid-containing, artificial tears. A recent introduction to the in-office treatments available for …
Treatments for meibomian gland dysfunction aim to restore tear film homoeostasis and include warm compress therapy, eyelid hygiene, i …
Photobiomodulation for Achilles Tendinopathy.
Atik OS. Atik OS. Photomed Laser Surg. 2018 Jan;36(1):1-2. doi: 10.1089/pho.2017.4361. Epub 2017 Oct 12. Photomed Laser Surg. 2018. PMID: 29023220 Review. No abstract available.
Photobiomodulation: Evolution and Adaptation.
Lipko NB. Lipko NB. Photobiomodul Photomed Laser Surg. 2022 Apr;40(4):213-233. doi: 10.1089/photob.2021.0145. Epub 2022 Mar 29. Photobiomodul Photomed Laser Surg. 2022. PMID: 35353639 Review.
Photobiomodulation (PBM) can be described as the intentional use of low-power laser or light-emitting diode light in the visible and near-infrared light spectra as a medical treatment to living biological tissues. This article describes the evolution o …
Photobiomodulation (PBM) can be described as the intentional use of low-power laser or light-emitting diode light in th …
Photobiomodulation therapy assisted orthodontic tooth movement: potential implications, challenges, and new perspectives.
Yong J, Gröger S, VON Bremen J, Martins Marques M, Braun A, Chen X, Ruf S, Chen Q. Yong J, et al. J Zhejiang Univ Sci B. 2023 Sep 27;24(11):957-973. doi: 10.1631/jzus.B2200706. J Zhejiang Univ Sci B. 2023. PMID: 37961799 Free PMC article. Review.
Over the past decade, dramatic progress has been made in dental research areas involving laser therapy. The photobiomodulatory effect of laser light regulates the behavior of periodontal tissues and promotes damaged tissues to heal faster. Additionally, photobiom …
Over the past decade, dramatic progress has been made in dental research areas involving laser therapy. The photobiomodulatory effect …
Could photobiomodulation be used for treatment of rosacea?
Boaretto Netto JC, Cardoso Borges AJ, Gomes Farias T, de Souza da Fonseca A. Boaretto Netto JC, et al. Lasers Med Sci. 2025 May 29;40(1):250. doi: 10.1007/s10103-025-04503-x. Lasers Med Sci. 2025. PMID: 40439755 Review.
The data analysis allowed to list the conditions for applying photobiomodulation that could lead to therapeutic effects, safety, and efficacy in treating the rosacea. ...However, due to few studies available on the application of photobiomodulation in the treatment …
The data analysis allowed to list the conditions for applying photobiomodulation that could lead to therapeutic effects, safety, and …
Photobiomodulation therapy for acute radiodermatitis.
Robijns J, Lodewijckx J, Mebis J. Robijns J, et al. Curr Opin Oncol. 2019 Jul;31(4):291-298. doi: 10.1097/CCO.0000000000000511. Curr Opin Oncol. 2019. PMID: 31170115 Review.
PURPOSE OF REVIEW: The number of clinical trials on the use of photobiomodulation therapy (PBMT) for the management of cancer therapy-related complications is growing steadily. ...
PURPOSE OF REVIEW: The number of clinical trials on the use of photobiomodulation therapy (PBMT) for the management of cancer …
Photobiomodulation for diabetes and its complications: a review of general presentation, mechanisms and efficacy.
Wang K, Zhao H, Zhao X, Zhang X, Zhang W, Cheng Y, Ge J. Wang K, et al. Ann Med. 2024 Dec;56(1):2433684. doi: 10.1080/07853890.2024.2433684. Epub 2024 Nov 28. Ann Med. 2024. PMID: 39607829 Free PMC article. Review.
Traditional treatments for diabetes and its complications still suffer from limited clinical efficacy and high therapeutic side effects. Photobiomodulation (PBM), which utilizes low levels of red or near-infrared laser to irradiate cells and tissues, has been shown to be e …
Traditional treatments for diabetes and its complications still suffer from limited clinical efficacy and high therapeutic side effects. …
Photobiomodulation: shining a light on depression.
Wang L, Mao L, Huang Z, Switzer JA, Hess DC, Zhang Q. Wang L, et al. Theranostics. 2025 Jan 1;15(2):362-383. doi: 10.7150/thno.104502. eCollection 2025. Theranostics. 2025. PMID: 39744683 Free PMC article. Review.
Depression is a prevalent public health issue, characterized by persistent low mood, impaired concentration, and diminished motivation. Photobiomodulation (PBM), which involves the application of red or near-infrared light, modulates physiological processes by enhan …
Depression is a prevalent public health issue, characterized by persistent low mood, impaired concentration, and diminished motivation. P …
Review of light parameters and photobiomodulation efficacy: dive into complexity.
Zein R, Selting W, Hamblin MR. Zein R, et al. J Biomed Opt. 2018 Dec;23(12):1-17. doi: 10.1117/1.JBO.23.12.120901. J Biomed Opt. 2018. PMID: 30550048 Free PMC article.
Photobiomodulation (PBM) therapy, previously known as low-level laser therapy, was discovered more than 50 years ago, yet there is still no agreement on the parameters and protocols for its clinical application. ...Although the results showed a …
Photobiomodulation (PBM) therapy, previously known as low-level laser therapy, was discovered more than 5 …
Photobiomodulation in Temporomandibular Disorders.
Tunér J, Hosseinpour S, Fekrazad R. Tunér J, et al. Photobiomodul Photomed Laser Surg. 2019 Dec;37(12):826-836. doi: 10.1089/photob.2019.4705. Epub 2019 Nov 26. Photobiomodul Photomed Laser Surg. 2019. PMID: 31770071
Objective: This systematic review aimed to comprehensively review all available documents regarding photobiomodulation therapy (PBMT) application in temporomandibular disorder (TMD) patients and to suggest an evidence-based protocol for therapeutic PBM administratio …
Objective: This systematic review aimed to comprehensively review all available documents regarding photobiomodulation therapy …
Photobiomodulation for Tendinopathy: A Review of Preclinical Studies.
Alzyoud JAM, Omoush SA, Al-Qtaitat A. Alzyoud JAM, et al. Photobiomodul Photomed Laser Surg. 2022 Jun;40(6):370-377. doi: 10.1089/photob.2021.0192. Epub 2022 May 27. Photobiomodul Photomed Laser Surg. 2022. PMID: 35639100 Review.
Mechanical outcomes were reported in four, and two studies demonstrate significant effects. Photobiomodulation has the potential to enhance tendon structure and function, however, inevitable embedded heterogeneity related to study design and quality of methods, light …
Mechanical outcomes were reported in four, and two studies demonstrate significant effects. Photobiomodulation has the potential to e …
Photobiomodulation on trigeminal neuralgia: systematic review.
Ibarra AMC, Biasotto-Gonzalez DA, Kohatsu EYI, de Oliveira SSI, Bussadori SK, Tanganeli JPC. Ibarra AMC, et al. Lasers Med Sci. 2021 Jun;36(4):715-722. doi: 10.1007/s10103-020-03198-6. Epub 2020 Nov 20. Lasers Med Sci. 2021. PMID: 33219445
The available treatments are pharmacotherapy or surgery; however, both are susceptible to develop side effects. Photobiomodulation could be a promising alternative therapy for trigeminal neuralgia. A systematic review of literature was carried out using the PRISMA p …
The available treatments are pharmacotherapy or surgery; however, both are susceptible to develop side effects. Photobiomodulation co …
Photobiomodulation therapy in age-related macular degeneration.
Muste JC, Kalur A, Iyer A, Valentim CCS, Singh RP. Muste JC, et al. Curr Opin Ophthalmol. 2021 May 1;32(3):225-232. doi: 10.1097/ICU.0000000000000742. Curr Opin Ophthalmol. 2021. PMID: 33606405 Review.
PURPOSE OF REVIEW: To review the available data supporting the use of photobiomodulation therapy (PBT) in the treatment of age-related macular degeneration (AMD). ...
PURPOSE OF REVIEW: To review the available data supporting the use of photobiomodulation therapy (PBT) in the treatment of age …
Vascular Photobiomodulation.
Fernandes KPS, Ferrari RM, Bussadori SK, Franca CM. Fernandes KPS, et al. Photobiomodul Photomed Laser Surg. 2021 Mar;39(3):143-144. doi: 10.1089/photob.2020.4965. Epub 2021 Feb 12. Photobiomodul Photomed Laser Surg. 2021. PMID: 33577376 No abstract available.
Photobiomodulation for the management of hair loss.
Torres AE, Lim HW. Torres AE, et al. Photodermatol Photoimmunol Photomed. 2021 Mar;37(2):91-98. doi: 10.1111/phpp.12649. Epub 2021 Jan 13. Photodermatol Photoimmunol Photomed. 2021. PMID: 33377535 Review.
Photobiomodulation, otherwise known as low-level laser (or light) therapy, is an emerging modality for the management of hair loss. ...These devices come in many forms including wearable caps or helmets that afford hands-free and discreet use. M …
Photobiomodulation, otherwise known as low-level laser (or light) therapy, is an emerging modality for th …
Tailoring photobiomodulation to enhance tissue regeneration.
Selestin Raja I, Kim C, Oh N, Park JH, Hong SW, Kang MS, Mao C, Han DW. Selestin Raja I, et al. Biomaterials. 2024 Sep;309:122623. doi: 10.1016/j.biomaterials.2024.122623. Epub 2024 May 23. Biomaterials. 2024. PMID: 38797121 Review.
Photobiomodulation (PBM), the use of biocompatible tissue-penetrating light to interact with intracellular chromophores to modulate the fates of cells and tissues, has emerged as a promising non-invasive approach to enhancing tissue regeneration. ...With its non-har …
Photobiomodulation (PBM), the use of biocompatible tissue-penetrating light to interact with intracellular chromophores to mod …
Brain photobiomodulation therapy on neurological and psychological diseases.
Chamkouri H, Liu Q, Zhang Y, Chen C, Chen L. Chamkouri H, et al. J Biophotonics. 2024 Jan;17(1):e202300145. doi: 10.1002/jbio.202300145. Epub 2023 Oct 1. J Biophotonics. 2024. PMID: 37403428 Review.
Photobiomodulation (PBM) therapy is an innovative treatment for neurological and psychological conditions. Complex IV of the mitochondrial respiratory chain can be stimulated by red light, which increases ATP synthesis. In addition, the ion channels' light …
Photobiomodulation (PBM) therapy is an innovative treatment for neurological and psychological conditions. Complex IV of the m …
Photobiomodulation for Chemotherapy-Induced Oral Mucositis in Pediatric Patients.
Hafner D, Hrast P, Tomaževič T, Jazbec J, Kavčič M. Hafner D, et al. Biomolecules. 2023 Feb 23;13(3):418. doi: 10.3390/biom13030418. Biomolecules. 2023. PMID: 36979353 Free PMC article. Review.
It has been associated with a significant reduction in life quality since it leads to pain, an inadequate intake of nutrients, an increased risk of opportunistic infections, and interruptions of CT. Photobiomodulation (PMB) with low-level laser therapy …
It has been associated with a significant reduction in life quality since it leads to pain, an inadequate intake of nutrients, an increased …
Photobiomodulation and Lasers.
Chiari S. Chiari S. Front Oral Biol. 2016;18:118-23. doi: 10.1159/000351906. Epub 2015 Nov 24. Front Oral Biol. 2016. PMID: 26599125 Review.
The stimulatory effect of low-level laser therapy is well known and includes enhancement in tissue growth and tissue regeneration, resolvement of inflammation and pain. ...The effect of laser regarding the reduction of the postadjustment pain could be proved, …
The stimulatory effect of low-level laser therapy is well known and includes enhancement in tissue growth and tissue re …
Photobiomodulation therapy in mood disorders: a systematic review.
Montazeri K, Farhadi M, Fekrazad R, Chaibakhsh S, Mahmoudian S. Montazeri K, et al. Lasers Med Sci. 2022 Dec;37(9):3343-3351. doi: 10.1007/s10103-022-03641-w. Epub 2022 Nov 21. Lasers Med Sci. 2022. PMID: 36404359
Side effects and resistance to psychiatric drugs justify finding new treatment methods. Photobiomodulation therapy (PBMT) uses photons of light to repair, modulate and improve the function of target tissue. ...
Side effects and resistance to psychiatric drugs justify finding new treatment methods. Photobiomodulation therapy (PBMT) uses …
Photobiomodulation for Degenerative Diseases: An Overview and Perspectives.
Lizarelli RFZ, Salgado ASI, Cardoso FDS, Souza KJO, Bello LT, Assis L, Cordon R, Bagnato VS. Lizarelli RFZ, et al. Photobiomodul Photomed Laser Surg. 2025 Sep;43(9):383-393. doi: 10.1177/15578550251363061. Epub 2025 Jul 30. Photobiomodul Photomed Laser Surg. 2025. PMID: 40735780 Review.
Background: Photobiomodulation (PBM) is a well-established, noninvasive therapeutic modality supported by a robust scientific foundation and extensive case studies. Objectives: However, in recent years, researchers have reported that low-intensity light could also h …
Background: Photobiomodulation (PBM) is a well-established, noninvasive therapeutic modality supported by a robust scientific foundat …
Photobiomodulation and Cancer: What Is the Truth?
Hamblin MR, Nelson ST, Strahan JR. Hamblin MR, et al. Photomed Laser Surg. 2018 May;36(5):241-245. doi: 10.1089/pho.2017.4401. Epub 2018 Feb 21. Photomed Laser Surg. 2018. PMID: 29466089 Free PMC article. Review.
BACKGROUND: Photobiomodulation (PBM) therapy is a rapidly growing approach to stimulate healing, reduce pain, increase athletic performance, and improve general wellness. OBJECTIVE: Applying PBM therapy over the site of a tumor has been considered to be a con …
BACKGROUND: Photobiomodulation (PBM) therapy is a rapidly growing approach to stimulate healing, reduce pain, increase athleti …
Photobiomodulation (Therapeutic Lasers): An Update and Review of Current Literature.
Bunch J. Bunch J. Vet Clin North Am Small Anim Pract. 2023 Jul;53(4):783-799. doi: 10.1016/j.cvsm.2023.02.010. Epub 2023 Mar 22. Vet Clin North Am Small Anim Pract. 2023. PMID: 36964028 Review.
Photobiomodulation therapy, also commonly known as laser therapy, continues to grow in popularity in veterinary medicine. It is the use of red and near-infrared light to simulate healing, relieve pain, and reduce inflammation. The potential variety of …
Photobiomodulation therapy, also commonly known as laser therapy, continues to grow in popularity in veterinary medicin …
Photobiomodulation in Periodontology and Implant Dentistry: Part 2.
Gholami L, Asefi S, Hooshyarfard A, Sculean A, Romanos GE, Aoki A, Fekrazad R. Gholami L, et al. Photobiomodul Photomed Laser Surg. 2019 Dec;37(12):766-783. doi: 10.1089/photob.2019.4731. Epub 2019 Nov 25. Photobiomodul Photomed Laser Surg. 2019. PMID: 31765274 Review.
Objective: Finding evidence-based treatment strategies for low-level light therapy and the correct incorporation of these treatment methods in the clinical practice of periodontics. ...Conclusions: Based on our search results, an obvious positive effec …
Objective: Finding evidence-based treatment strategies for low-level light therapy and the correct incorporation …
Photobiomodulation in Periodontology and Implant Dentistry: Part 1.
Gholami L, Asefi S, Hooshyarfard A, Sculean A, Romanos GE, Aoki A, Fekrazad R. Gholami L, et al. Photobiomodul Photomed Laser Surg. 2019 Dec;37(12):739-765. doi: 10.1089/photob.2019.4710. Epub 2019 Nov 21. Photobiomodul Photomed Laser Surg. 2019. PMID: 31750783 Review.
Objective: Finding evidence-based treatment strategies for low-level light therapy (LLLT) and the correct incorporation of these treatment methods in the clinical practice of periodontics. ...Methods: In this review we have addressed some clinical ques …
Objective: Finding evidence-based treatment strategies for low-level light therapy (LLLT) and the correct incorp …
Advances in photobiomodulation for cognitive improvement by near-infrared derived multiple strategies.
Pan WT, Liu PM, Ma D, Yang JJ. Pan WT, et al. J Transl Med. 2023 Feb 22;21(1):135. doi: 10.1186/s12967-023-03988-w. J Transl Med. 2023. PMID: 36814278 Free PMC article. Review.
Cognitive function is an important ability of the brain, but cognitive dysfunction can easily develop once the brain is injured in various neuropathological conditions or diseases. Photobiomodulation therapy is a type of noninvasive physical therapy that is g …
Cognitive function is an important ability of the brain, but cognitive dysfunction can easily develop once the brain is injured in various n …
Photobiomodulation in dental extraction therapy: Postsurgical pain reduction and wound healing.
Sourvanos D, Lander B, Sarmiento H, Carroll J, Hall RD, Zhu TC, Fiorellini JP. Sourvanos D, et al. J Am Dent Assoc. 2023 Jul;154(7):567-579. doi: 10.1016/j.adaj.2023.03.004. Epub 2023 May 18. J Am Dent Assoc. 2023. PMID: 37204376 Free PMC article. Review.
BACKGROUND: This scoping review and analysis were designed to assess the amount of time spent delivering photobiomodulation (PBM) light therapy after dental extraction to improve postoperative pain and wound healing. ...Further investigation is needed to tran …
BACKGROUND: This scoping review and analysis were designed to assess the amount of time spent delivering photobiomodulation (PBM) …
Photobiomodulation and pain.
Keim RG. Keim RG. J Clin Orthod. 2020 Feb;54(2):69. J Clin Orthod. 2020. PMID: 32554914 No abstract available.
Photobiomodulation in Acute Traumatic Brain Injury: A Systematic Review and Meta-Analysis.
Stevens AR, Hadis M, Milward M, Ahmed Z, Belli A, Palin W, Davies DJ. Stevens AR, et al. J Neurotrauma. 2023 Feb;40(3-4):210-227. doi: 10.1089/neu.2022.0140. Epub 2022 Aug 30. J Neurotrauma. 2023. PMID: 35698294
Photobiomodulation (PBM) is a therapeutic modality that has gained increasing interest in neuroscience applications, including acute traumatic brain injury (TBI). ...
Photobiomodulation (PBM) is a therapeutic modality that has gained increasing interest in neuroscience applications, including acute …
Violet photobiomodulation: biological effects and health implications.
Cidral FJ, Hewitson A, Donatello N, Piovezan AP. Cidral FJ, et al. Lasers Med Sci. 2025 Jun 20;40(1):292. doi: 10.1007/s10103-025-04550-4. Lasers Med Sci. 2025. PMID: 40537562
Photobiomodulation (PBM), presents a viable therapeutic modality for a range of medical conditions, leveraging specific wavelengths to target various clinical outcomes. ...This review aims to consolidate current findings on the effects of Violet light PBM, to inform …
Photobiomodulation (PBM), presents a viable therapeutic modality for a range of medical conditions, leveraging specific wavelengths t …
Immunomodulatory effects of photobiomodulation: a comprehensive review.
Al Balah OF, Rafie M, Osama AR. Al Balah OF, et al. Lasers Med Sci. 2025 Apr 11;40(1):187. doi: 10.1007/s10103-025-04417-8. Lasers Med Sci. 2025. PMID: 40214677 Free PMC article. Review.
Photobiomodulation, also known as low-level light therapy (LLLT), has emerged as a promising non-invasive treatment modality with significant immunomodulatory effects. ...We explore the cellular and molecular pathways affected by photobiomodu …
Photobiomodulation, also known as low-level light therapy (LLLT), has emerged as a promising non-invasive …
Quantitative and Integrative Photobiomodulation.
Guo ZL, Liu TC. Guo ZL, et al. Photobiomodul Photomed Laser Surg. 2022 Oct;40(10):659-660. doi: 10.1089/photob.2022.0053. Epub 2022 Oct 7. Photobiomodul Photomed Laser Surg. 2022. PMID: 36206020 No abstract available.
Acute Delirium and Transcranial Photobiomodulation.
Leditschke IA, Laakso EL. Leditschke IA, et al. Photobiomodul Photomed Laser Surg. 2023 Dec;41(12):661-662. doi: 10.1089/photob.2023.0143. Epub 2023 Nov 28. Photobiomodul Photomed Laser Surg. 2023. PMID: 38016154 No abstract available.
Photobiomodulation Therapy in Veterinary Medicine: A Review.
Hochman L. Hochman L. Top Companion Anim Med. 2018 Sep;33(3):83-88. doi: 10.1053/j.tcam.2018.06.004. Epub 2018 Jul 5. Top Companion Anim Med. 2018. PMID: 30243364 Review.
Laser therapy, or photobiomodulation, has rapidly grown in popularity in human and veterinary medicine. With a number of proposed indications and broad, sometimes anecdotal, use in practice, research interest has expanded aimed at providing scientific support. Recen …
Laser therapy, or photobiomodulation, has rapidly grown in popularity in human and veterinary medicine. With a number of propo …
Photobiomodulation therapy as a high potential treatment modality for COVID-19.
Soheilifar S, Fathi H, Naghdi N. Soheilifar S, et al. Lasers Med Sci. 2021 Jul;36(5):935-938. doi: 10.1007/s10103-020-03206-9. Epub 2020 Nov 25. Lasers Med Sci. 2021. PMID: 33241526 Free PMC article. Review.
In severe cases, however, immune system impairment causes cytokine release syndrome which eventually leads to acute respiratory distress syndrome (ARDS). In recent years, photobiomodulation (PBM) has shown promising results in reducing acute pulmonary inflammation. ...
In severe cases, however, immune system impairment causes cytokine release syndrome which eventually leads to acute respiratory distress syn …
Photobiomodulation Therapy With Different Wavebands for Hair Loss: A Systematic Review and Meta-Analysis.
Zhang Y, Su J, Ma K, Fu X, Zhang C. Zhang Y, et al. Dermatol Surg. 2022 Jul 1;48(7):737-740. doi: 10.1097/DSS.0000000000003472. Epub 2022 Apr 25. Dermatol Surg. 2022. PMID: 35510860
BACKGROUND: Photobiomodulation is a promising therapy for hair loss with negligible side effects. However, the reported effects of photobiomodulation therapy for hair loss are inconsistent. ...CONCLUSION: The meta-analyses strongly suggested that ph …
BACKGROUND: Photobiomodulation is a promising therapy for hair loss with negligible side effects. However, the reported effect …
Photobiomodulation Regulation as One Promising Therapeutic Approach for Myocardial Infarction.
Gao X, Zhang W, Yang F, Ma W, Cai B. Gao X, et al. Oxid Med Cell Longev. 2021 Jul 17;2021:9962922. doi: 10.1155/2021/9962922. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 34336126 Free PMC article. Review.
Therefore, this article introduces the progress of research on phototherapy as a new therapeutic strategy in the treatment of myocardial infarction. The wavelength of photobiomodulation in the treatment of myocardial infarction is specific, and the influence of light …
Therefore, this article introduces the progress of research on phototherapy as a new therapeutic strategy in the treatment of myocardial inf …
Photobiomodulation for oral mucositis management in pediatric patients: a systematic review.
Calarga CC, Cotomácio CC, Simões A. Calarga CC, et al. Lasers Med Sci. 2024 Nov 10;39(1):272. doi: 10.1007/s10103-024-04221-w. Lasers Med Sci. 2024. PMID: 39523254
This review aimed to determine whether photobiomodulation therapy (PBMT) is a safe and effective alternative for treating and preventing OM in children. ...
This review aimed to determine whether photobiomodulation therapy (PBMT) is a safe and effective alternative for treating and …
Photobiomodulation Therapy on the Treatment of Insulin Resistance: A Narrative Review.
Magalhães FC, Ferraresi C. Magalhães FC, et al. Photobiomodul Photomed Laser Surg. 2022 Sep;40(9):597-603. doi: 10.1089/photob.2022.0031. Epub 2022 Aug 30. Photobiomodul Photomed Laser Surg. 2022. PMID: 36040371 Review.
Noninvasive and nonpharmacological therapies, such as exercise and diet are effective in treating IR and DM2; however, adherence to them generally is low and diminishes positive effects in the long term. Photobiomodulation therapy (PBMT) is another noninvasive and n …
Noninvasive and nonpharmacological therapies, such as exercise and diet are effective in treating IR and DM2; however, adherence to them gen …
Photobiomodulation Therapy for Dementia: A Systematic Review of Pre-Clinical and Clinical Studies.
Salehpour F, Khademi M, Hamblin MR. Salehpour F, et al. J Alzheimers Dis. 2021;83(4):1431-1452. doi: 10.3233/JAD-210029. J Alzheimers Dis. 2021. PMID: 33935090
BACKGROUND: Photobiomodulation (PBM) involves the use of red and/or near-infrared light from lasers or LEDs to improve a wide range of medical disorders. ...METHODS: Literature was searched between 1967 and 2020 using a range of keywords relevant to PBM and dementia …
BACKGROUND: Photobiomodulation (PBM) involves the use of red and/or near-infrared light from lasers or LEDs to improve a wide …
Photobiomodulation on shoulder and neck pain and disability: A comprehensive review.
Cidral-Filho F, Donatello NN, Lugtu C, Hewitson A. Cidral-Filho F, et al. Lasers Med Sci. 2024 Oct 25;39(1):263. doi: 10.1007/s10103-024-04212-x. Lasers Med Sci. 2024. PMID: 39453527 Review.
The keywords used were "Low-level laser therapy", "photobiomodulation", "LASER", combined with "shoulder" or "neck". ...The review included 36 studies applying PBM therapy to alleviate pain or disability in patients with shoulder and neck condit …
The keywords used were "Low-level laser therapy", "photobiomodulation", "LASER", combined with "shoulder" or "ne …
Personalizing Photobiomodulation Therapy.
Laakso EL. Laakso EL. Photomed Laser Surg. 2017 Jan;35(1):1-2. doi: 10.1089/pho.2016.4218. Photomed Laser Surg. 2017. PMID: 28055687 No abstract available.
Role of Polarized Light in Photobiomodulation.
Hamblin MR. Hamblin MR. Photobiomodul Photomed Laser Surg. 2022 Dec;40(12):775-776. doi: 10.1089/photob.2022.0110. Photobiomodul Photomed Laser Surg. 2022. PMID: 36507767 No abstract available.
Photobiomodulation Therapy in Clinical Dentistry.
Fekrazad R, Arany P. Fekrazad R, et al. Photobiomodul Photomed Laser Surg. 2019 Dec;37(12):737-738. doi: 10.1089/photob.2019.4756. Epub 2019 Nov 21. Photobiomodul Photomed Laser Surg. 2019. PMID: 31750781 No abstract available.
Photobiomodulation in stroke prevention and treatment: neuroprotective mechanisms and therapeutic challenges.
Li Y, Zhang L, Lin J, Yang L, Duan R. Li Y, et al. Brain Res. 2025 Dec 1;1868:149981. doi: 10.1016/j.brainres.2025.149981. Epub 2025 Oct 9. Brain Res. 2025. PMID: 41067675 Review.
While acute treatments have been a primary focus, there is increasing interest in the potential of photobiomodulation (PBM) therapy for both stroke prevention and rehabilitation. PBM harnesses specific wavelengths of light to stimulate biological processes th …
While acute treatments have been a primary focus, there is increasing interest in the potential of photobiomodulation (PBM) therap …
Could Photobiomodulation Therapy Be Helpful in Epilepsy?
Hamblin MR. Hamblin MR. Photobiomodul Photomed Laser Surg. 2023 Feb;41(2):35-36. doi: 10.1089/photob.2023.0003. Epub 2023 Jan 24. Photobiomodul Photomed Laser Surg. 2023. PMID: 36695664 No abstract available.
Photobiomodulation in acceleration of orthodontic tooth movement: A systematic review and meta analysis.
AlShahrani I, Togoo RA, Hosmani J, Alhaizaey A. AlShahrani I, et al. Complement Ther Med. 2019 Dec;47:102220. doi: 10.1016/j.ctim.2019.102220. Epub 2019 Oct 16. Complement Ther Med. 2019. PMID: 31780019
BACKGROUND: Photobiomodulation therapy, a non invasive method with no adverse effects, has been used to accelerate tooth movement in orthodontia. ...OBJECTIVES: We decided to undertake a systematic review to eliminate this inconsistency by quantifying the literature …
BACKGROUND: Photobiomodulation therapy, a non invasive method with no adverse effects, has been used to accelerate tooth movem …
Therapeutic Potential of Photobiomodulation in Diabetic Complications.
Hadebe L, Houreld NN. Hadebe L, et al. Discov Med. 2024 Oct;36(189):1987-1997. doi: 10.24976/Discov.Med.202436189.183. Discov Med. 2024. PMID: 39463219 Free article. Review.
Existing treatments often yield unsatisfactory clinical outcomes, underscoring the need for innovative approaches to mitigate debilitating effects on patients' health-related quality of life. Photobiomodulation (PBM) is a non-invasive treatment that utilizes specific wavel …
Existing treatments often yield unsatisfactory clinical outcomes, underscoring the need for innovative approaches to mitigate debilitating e …
Is Photobiomodulation Therapy Cost Effective?
Tunér J. Tunér J. Photobiomodul Photomed Laser Surg. 2020 Apr;38(4):193-194. doi: 10.1089/photob.2020.4805. Photobiomodul Photomed Laser Surg. 2020. PMID: 32301672 No abstract available.
Cutaneous effects of photobiomodulation with 1072 nm light.
Mineroff J, Austin E, Jagdeo J. Mineroff J, et al. Arch Dermatol Res. 2023 Aug;315(6):1481-1486. doi: 10.1007/s00403-022-02480-7. Epub 2022 Dec 10. Arch Dermatol Res. 2023. PMID: 36495337 Review.
Photobiomodulation, also known as low-level light therapy, has gained popularity in treating a variety of dermatologic and non-dermatologic conditions. ...To date, clinical research regarding the application of 1072 NIR is limited to treatments …
Photobiomodulation, also known as low-level light therapy, has gained popularity in treating a variety of …
Is photobiomodulation effective during maxillary expansion? A systematic review and meta-analysis.
Chaves IC, de Paula DS, Mota MRL, Sousa FB, de Barros Silva PG, Nunes Alves APN. Chaves IC, et al. Orthod Craniofac Res. 2023 Feb;26(1):13-26. doi: 10.1111/ocr.12590. Epub 2022 May 25. Orthod Craniofac Res. 2023. PMID: 35545921
We performed a systematic review on literature associated with meta-analyses to elucidate whether (I) low-level laser therapy (C) compared to placebo accelerates (O) bone neoformation in the region of the midpalatal suture in (P) patients undergoing transvers …
We performed a systematic review on literature associated with meta-analyses to elucidate whether (I) low-level laser thera …
Exploring photobiomodulation in the management of bowel diseases: a concise critical review.
De Souza V, Cruz MDP, Mello DC, Oliveira APL, Martins RÁBL, Longo L, Parizotto NA, Marcos RL. De Souza V, et al. Lasers Med Sci. 2024 Oct 27;39(1):265. doi: 10.1007/s10103-024-04217-6. Lasers Med Sci. 2024. PMID: 39463190 Review.
Conventional therapeutic approaches often involve pharmacological interventions, which may have side effects and limited efficacy. Photobiomodulation (PBM), also known as low-level light therapy, has emerged as a promising therapeutic or adjunct …
Conventional therapeutic approaches often involve pharmacological interventions, which may have side effects and limited efficacy. Photob …
Photobiomodulation in promoting increased Skin Flap Viability: a systematic review of animal studies.
Chang AJBA, de Barros Pinto EAF, Silva DR, David AC, de Matos LP, Marcos RL, Silva Junior JA, Zamuner SR. Chang AJBA, et al. Lasers Med Sci. 2024 Apr 22;39(1):109. doi: 10.1007/s10103-024-04055-6. Lasers Med Sci. 2024. PMID: 38649643
Twenty-five studies were selected from 54 original articles that addressed PBMT with low-level laser (LLL) or light-emitting diode (LED) in agreement with the qualifying requirements. Laser parameters varied markedly across studies. In the selected studies, t …
Twenty-five studies were selected from 54 original articles that addressed PBMT with low-level laser (LLL) or light-emi …
Photobiomodulation in oral medicine: a review.
Pandeshwar P, Roa MD, Das R, Shastry SP, Kaul R, Srinivasreddy MB. Pandeshwar P, et al. J Investig Clin Dent. 2016 May;7(2):114-26. doi: 10.1111/jicd.12148. Epub 2015 Feb 26. J Investig Clin Dent. 2016. PMID: 25720555 Review.
Photobiomodulation (PBM) or low-level laser therapy (LLLT) in dentistry is an evolving science, with an increasing number of controlled clinical studies exploring its potential as a treatment modality. ...
Photobiomodulation (PBM) or low-level laser therapy (LLLT) in dentistry is an evolving science, with an increasi …
The role of photobiomodulation in accelerating bone repair.
Lu P, Peng J, Liu J, Chen L. Lu P, et al. Prog Biophys Mol Biol. 2024 May;188:55-67. doi: 10.1016/j.pbiomolbio.2024.03.002. Epub 2024 Mar 16. Prog Biophys Mol Biol. 2024. PMID: 38493961 Review.
Delayed healing even nonunion could occur in bone defects, influencing the life quality of patients severely. Photobiomodulation (PBM) utilizes different light sources to derive beneficial therapeutic effects with the advantage of being non-invasive and painless, pr …
Delayed healing even nonunion could occur in bone defects, influencing the life quality of patients severely. Photobiomodulation (PBM …
Exploring photobiomodulation as a complementary approach for mental health: an integrative review.
Cidral-Filho FJ, Hewitson A, Vitorino VL, Donatello N. Cidral-Filho FJ, et al. Lasers Med Sci. 2025 Nov 29;40(1):502. doi: 10.1007/s10103-025-04738-8. Lasers Med Sci. 2025. PMID: 41315118 Review.
Mental disorders are a leading cause of disability worldwide, with ongoing challenges in treatment effectiveness. Photobiomodulation (PBM) has emerged as a potential complementary approach for managing mental health conditions. ...
Mental disorders are a leading cause of disability worldwide, with ongoing challenges in treatment effectiveness. Photobiomodulation …
Photobiomodulation for Diabetic Foot Ulcers? Show Me!
Gavish L, Raizman R, Hoffer O, Gertz SD. Gavish L, et al. Photobiomodul Photomed Laser Surg. 2021 Oct;39(10):631-633. doi: 10.1089/photob.2021.0082. Epub 2021 Oct 1. Photobiomodul Photomed Laser Surg. 2021. PMID: 34597193 No abstract available.
Photobiomodulation or low-level laser therapy.
Hamblin MR. Hamblin MR. J Biophotonics. 2016 Dec;9(11-12):1122-1124. doi: 10.1002/jbio.201670113. J Biophotonics. 2016. PMID: 27973730 Free PMC article. No abstract available.
Photobiomodulation Therapy: A Novel Therapeutic Approach to Alzheimer's Disease Made Possible by the Evidence of a Brain-Gut Interconnection.
Blivet G, Roman FJ, Lelouvier B, Ribière C, Touchon J. Blivet G, et al. J Integr Neurosci. 2024 Apr 30;23(5):92. doi: 10.31083/j.jin2305092. J Integr Neurosci. 2024. PMID: 38812393 Free article. Review.
The gut microbiota can be used as a potential therapeutic target in AD. In particular, photobiomodulation (PBM) can affect the interaction between the microbiota and the immune system, providing a potential explanation for its restorative properties in AD-associated dysbio …
The gut microbiota can be used as a potential therapeutic target in AD. In particular, photobiomodulation (PBM) can affect the intera …
From light to healing: photobiomodulation therapy in medical disciplines.
Shivappa P, Basha S, Biswas S, Prabhu V, Prabhu SS, Pai AR, Mahato KK. Shivappa P, et al. J Transl Med. 2025 Dec 29;23(1):1430. doi: 10.1186/s12967-025-07466-3. J Transl Med. 2025. PMID: 41466382 Free PMC article. Review.
BACKGROUND: Photobiomodulation therapy (PBMT) represents a rapidly expanding area of translational research that bridges photophysics, mitochondrial biology, and clinical rehabilitation. It leverages low-level light to modulate cellular bioenerg …
BACKGROUND: Photobiomodulation therapy (PBMT) represents a rapidly expanding area of translational research that bridges photo …
Photobiomodulation: A Systematic Review of the Oncologic Safety of Low-Level Light Therapy for Aesthetic Skin Rejuvenation.
Glass GE. Glass GE. Aesthet Surg J. 2023 Apr 10;43(5):NP357-NP371. doi: 10.1093/asj/sjad018. Aesthet Surg J. 2023. PMID: 36722207 Free PMC article.
Photobiomodulation (PBM) therapy is an increasingly popular modality for aesthetic skin rejuvenation. ...The same light parameters mainly reduce neoplastic cell proliferation and viability or else make no difference. ...
Photobiomodulation (PBM) therapy is an increasingly popular modality for aesthetic skin rejuvenation. ...The same light …
Modulating macrophage polarization by photobiomodulation.
Ferreira VB, Sarmento JB, de Paoli F. Ferreira VB, et al. Lasers Med Sci. 2025 Nov 6;40(1):467. doi: 10.1007/s10103-025-04717-z. Lasers Med Sci. 2025. PMID: 41196409 Review.
Photobiomodulation (PBM), employing low-power lasers and light-emitting diodes (LEDs), has emerged as an innovative therapeutic modality for modulating macrophage polarization. ...This review analyzed studies focusing on macrophage polarization induced by low-power …
Photobiomodulation (PBM), employing low-power lasers and light-emitting diodes (LEDs), has emerged as an innovative therapeuti …
Mechanistic aspects of photobiomodulation therapy in the nervous system.
Ramezani F, Neshasteh-Riz A, Ghadaksaz A, Fazeli SM, Janzadeh A, Hamblin MR. Ramezani F, et al. Lasers Med Sci. 2022 Feb;37(1):11-18. doi: 10.1007/s10103-021-03277-2. Epub 2021 Feb 24. Lasers Med Sci. 2022. PMID: 33624187 Review.
Photobiomodulation therapy (PBMT) previously known as low-level laser therapy (LLLT) has been used for over 30 years, to treat neurological diseases. ...
Photobiomodulation therapy (PBMT) previously known as low-level laser therapy (LLLT) has been used for ov …
Photobiomodulation enhances osteogenesis in oral and adipose-derived mesenchymal stem cells: A systematic review of in vitro evidence.
Hakimiha N, Barzegar Reyhani N, Haddadi A, Aghayan S. Hakimiha N, et al. Photodiagnosis Photodyn Ther. 2025 Dec;56:105238. doi: 10.1016/j.pdpdt.2025.105238. Epub 2025 Oct 4. Photodiagnosis Photodyn Ther. 2025. PMID: 41052564 Free article.
OBJECTIVE: Photobiomodulation (PBM), a non-invasive light-based therapy, has gained attention for enhancing osteogenic differentiation in mesenchymal stem cells (MSCs). ...
OBJECTIVE: Photobiomodulation (PBM), a non-invasive light-based therapy, has gained attention for enhancing osteogenic …
Effect of Laser Photobiomodulation on Postoperative Pain in Endodontics: A Systematic Review.
Kadam AS, Merwade S, Kumar Neelakantappa K, Naik SB, Brigit B, Bhumralkar SS, Naik BH. Kadam AS, et al. Photobiomodul Photomed Laser Surg. 2024 Jan;42(1):11-19. doi: 10.1089/photob.2023.0129. Photobiomodul Photomed Laser Surg. 2024. PMID: 38252493
Objective: Photobiomodulation therapy has proven benefits in various dental treatments. The current systematic review aims to explore the role of laser photobiomodulation in modulating postoperative pain followed by endodontic treatment. Methods: In this syst …
Objective: Photobiomodulation therapy has proven benefits in various dental treatments. The current systematic review aims to …
Photobiomodulation therapy on bothrops snake venom-induced local pathological effects: A systematic review.
Silva LMG, Zamuner LF, David AC, Dos Santos SA, de Carvalho PTC, Zamuner SR. Silva LMG, et al. Toxicon. 2018 Sep 15;152:23-29. doi: 10.1016/j.toxicon.2018.07.006. Epub 2018 Jul 17. Toxicon. 2018. PMID: 30025889
There are evidence that photobiomodulation therapy (PBMT) has emerged as a promising tool to counteract the venom-induced local effects. ...Sixteen studies were selected from 54 original articles targeted PBMT (low-level laser or light emitting …
There are evidence that photobiomodulation therapy (PBMT) has emerged as a promising tool to counteract the venom-induced loca …
Photobiomodulation and sleep quality: systematic review and meta-analysis.
Vital de Azevedo WM, de Souza K, Defante ML, Salgado ASI, Lopes-Martins RÁB, Gomes da Silva S, Gonzalez-Lima F, Cardoso FDS. Vital de Azevedo WM, et al. Lasers Med Sci. 2026 Jun 20;41(1):122. doi: 10.1007/s10103-026-04913-5. Lasers Med Sci. 2026. PMID: 42322437 Free PMC article. Review.
Sleep disturbances are increasingly prevalent and associated with altered brain metabolism and neuroinflammation. Photobiomodulation, a non-invasive technique using red or near-infrared light, can modulate mitochondrial activity, cerebral perfusion, and glial functi …
Sleep disturbances are increasingly prevalent and associated with altered brain metabolism and neuroinflammation. Photobiomodulation, …
Photobiomodulation Reduces Pain-Related Symptoms Without Interfering in the Efficacy of In-Office Tooth Bleaching: A Systematic Review and Meta-Analysis of Placebo-Controlled Clinical Trials.
de Barros Silva PG, Filho ELC, Nigri FMN, Dantas TS, de Miranda Candeiro GT, Neri JR. de Barros Silva PG, et al. Photobiomodul Photomed Laser Surg. 2022 Mar;40(3):163-177. doi: 10.1089/photob.2021.0105. Photobiomodul Photomed Laser Surg. 2022. PMID: 35298283
Objective: This systematic review aimed to determine whether the use of photobiomodulation (PBM) with low-level laser therapy prevents tooth sensitivity induced by in-office tooth bleaching with hydrogen. Methods: Placebo-controlled clinical trials wer …
Objective: This systematic review aimed to determine whether the use of photobiomodulation (PBM) with low-level laser …
New Insights into Photobiomodulation of the Vaginal Microbiome-A Critical Review.
Santos FP, Carvalhos CA, Figueiredo-Dias M. Santos FP, et al. Int J Mol Sci. 2023 Aug 31;24(17):13507. doi: 10.3390/ijms241713507. Int J Mol Sci. 2023. PMID: 37686314 Free PMC article. Review.
To date, the progress in treating or modulating the VMB has lagged far behind research efforts. Photobiomodulation (PBM) uses low levels of light, usually red or near-infrared, to treat a diversity of conditions. ...In this review, we will discuss the potential mech …
To date, the progress in treating or modulating the VMB has lagged far behind research efforts. Photobiomodulation (PBM) uses low lev …
Efficacy of photobiomodulation therapy on Bell's palsy symptoms: a systematic review.
Amiri P, Fekrazad R. Amiri P, et al. Lasers Med Sci. 2024 Dec 4;39(1):288. doi: 10.1007/s10103-024-04240-7. Lasers Med Sci. 2024. PMID: 39627559
Recently, increasing attention has been directed towards photobiomodulation therapy (PBMT) and its prospective contribution to managing various neurological and musculoskeletal conditions, including Bell's palsy. ...Our systematic review indicates that photobiomo …
Recently, increasing attention has been directed towards photobiomodulation therapy (PBMT) and its prospective contribution to …
Photobiomodulation Therapy: The Dawn of Myopia Control.
Gettinger K, Huang Y, Tsubota K, Negishi K, Kurihara T. Gettinger K, et al. Cells. 2026 Mar 16;15(6):526. doi: 10.3390/cells15060526. Cells. 2026. PMID: 41892317 Free PMC article. Review.
This review explores the growing field of photobiomodulation, or the use of light to modulate biological processes, to prevent myopia development. ...Through this review, we see that photobiomodulation offers a potential intervention to control myopia progres …
This review explores the growing field of photobiomodulation, or the use of light to modulate biological processes, to prevent …
[Photobiomodulation in the prevention and the management of side effects of cancer treatments: Bases, results and perspectives].
Lairedj K, Klausner G, Robijns J, Arany PR, Bensadoun RJ. Lairedj K, et al. Bull Cancer. 2024 Mar;111(3):314-326. doi: 10.1016/j.bulcan.2023.08.011. Epub 2023 Oct 17. Bull Cancer. 2024. PMID: 37858427 Review. French.
BACKGROUND: Assess the current and potential indications of photobiomodulation (PBM) therapy and their level of evidence in the prevention or treatment of side effects related to oncology treatments (radiation therapy, and to a minimal extent favored and hema …
BACKGROUND: Assess the current and potential indications of photobiomodulation (PBM) therapy and their level of evidence in th …
Transcranial photobiomodulation (laser) therapy for cognitive impairment: A review of molecular mechanisms and potential application to canine cognitive dysfunction (CCD).
Dewey CW, Brunke MW, Sakovitch K. Dewey CW, et al. Open Vet J. 2022 Mar-Apr;12(2):256-263. doi: 10.5455/OVJ.2022.v12.i2.14. Epub 2022 Apr 17. Open Vet J. 2022. PMID: 35603072 Free PMC article. Review.
CCD is considered a naturally occurring model of human AD. Transcranial photobiomodulation therapy (tPBMT), also known as transcranial laser therapy, entails delivering photons of near infrared to infrared light from the skin surface of the scalp to th …
CCD is considered a naturally occurring model of human AD. Transcranial photobiomodulation therapy (tPBMT), also known as tran …
The effect of photobiomodulation on hearing loss: A systematic review.
Nikookam Y, Zia N, Lotfallah A, Muzaffar J, Davis-Manders J, Kullar P, Smith M, Bale G, Boyle P, Irving R, Jiang D, Bance M. Nikookam Y, et al. Clin Otolaryngol. 2024 Jan;49(1):41-61. doi: 10.1111/coa.14113. Epub 2023 Oct 26. Clin Otolaryngol. 2024. PMID: 37885344
OBJECTIVES: To assess outcomes associated with photobiomodulation therapy (PBMT) for hearing loss in human and animal studies. DESIGN: Systematic review and narrative synthesis in accordance with PRISMA guidelines. ...PBMT enables concentrated, focused delivery of …
OBJECTIVES: To assess outcomes associated with photobiomodulation therapy (PBMT) for hearing loss in human and animal studies. …
Effectiveness of photobiomodulation therapy in radiation dermatitis: A systematic review and meta-analysis.
Aguiar BRL, Guerra ENS, Normando AGC, Martins CC, Reis PEDD, Ferreira EB. Aguiar BRL, et al. Crit Rev Oncol Hematol. 2021 Jun;162:103349. doi: 10.1016/j.critrevonc.2021.103349. Epub 2021 May 11. Crit Rev Oncol Hematol. 2021. PMID: 33989768
PURPOSE: To evaluate the effectiveness of photobiomodulation therapy (PBMT) in the prevention and treatment of radiation dermatitis (RD). ...
PURPOSE: To evaluate the effectiveness of photobiomodulation therapy (PBMT) in the prevention and treatment of radiation derma …
Efficacy of photobiomodulation in the treatment of oral mucositis in patients undergoing antineoplastic therapy: systematic review and meta-analysis.
Cruz AR, Minicucci EM, Betini M, Almeida-Lopes L, Tieghi Neto V, Cataneo AJM. Cruz AR, et al. Support Care Cancer. 2023 Oct 19;31(12):645. doi: 10.1007/s00520-023-08105-7. Support Care Cancer. 2023. PMID: 37853254
A total of 37 studies were chosen for full reading, of which 6 were included in the review, totaling 299 patients. The treatment used was photobiomodulation. The patients were divided into two groups: the laser group used only photobiomodulation or associated with o …
A total of 37 studies were chosen for full reading, of which 6 were included in the review, totaling 299 patients. The treatment used was …
Photobiomodulation therapy for androgenetic alopecia: A clinician's guide to home-use devices cleared by the Federal Drug Administration.
Dodd EM, Winter MA, Hordinsky MK, Sadick NS, Farah RS. Dodd EM, et al. J Cosmet Laser Ther. 2018 Jun;20(3):159-167. doi: 10.1080/14764172.2017.1383613. Epub 2017 Dec 5. J Cosmet Laser Ther. 2018. PMID: 29020478 Review.
Photobiomodulation therapy devices have an excellent safety profile and mounting evidence supporting their efficacy. ...ABBREVIATIONS: AGA, androgenetic alopecia; FDA, Food and Drug Administration; IEC, International Electrotechnical Commission; LED, light-em …
Photobiomodulation therapy devices have an excellent safety profile and mounting evidence supporting their efficacy. ...ABBREV …
How to Write a Good Photobiomodulation Article.
Hamblin MR. Hamblin MR. Photobiomodul Photomed Laser Surg. 2019 Jun;37(6):325-326. doi: 10.1089/photob.2019.4648. Epub 2019 May 17. Photobiomodul Photomed Laser Surg. 2019. PMID: 31099699 No abstract available.
Adjunctive photobiomodulation to Basic Periodontal therapy using different low-power laser application techniques: a systematic review and meta-analysis.
da Silva RCM, da Silva LGC, Martins AA, de Araújo CM, Martins ARLA. da Silva RCM, et al. Lasers Med Sci. 2024 Aug 2;39(1):207. doi: 10.1007/s10103-024-04148-2. Lasers Med Sci. 2024. PMID: 39093490
To review current literature and synthesize clinical outcomes related to different low-level laser techniques as a complement to basic periodontal therapy (BPT). Electronic searches were conducted in PubMed, Cochrane, and Scopus, and clinical trials published …
To review current literature and synthesize clinical outcomes related to different low-level laser techniques as a complement …
Effectiveness of Photobiomodulation Therapy on Human Bone Healing in Dentistry: A Systematic Review.
Lopes CCA, Limirio JPJO, Zanatta LSA, Simamoto VRN, Dechichi P, Limirio APHJO. Lopes CCA, et al. Photobiomodul Photomed Laser Surg. 2022 Jul;40(7):440-453. doi: 10.1089/photob.2021.0092. Epub 2022 May 6. Photobiomodul Photomed Laser Surg. 2022. PMID: 35527692
Background: Despite the association, possible causality, and contradictory results, numerous studies evaluate photobiomodulation (PBM) therapy on the process of human bone healing. It is of paramount importance to review the available literature to elucidate the eff …
Background: Despite the association, possible causality, and contradictory results, numerous studies evaluate photobiomodulation (PBM …
Does photobiomodulation influence ageing?
Mitrofanis J, Jeffery G. Mitrofanis J, et al. Aging (Albany NY). 2018 Sep 15;10(9):2224-2225. doi: 10.18632/aging.101556. Aging (Albany NY). 2018. PMID: 30219804 Free PMC article. No abstract available.
Potential and Challenges of Transcranial Photobiomodulation for the Treatment of Stroke.
Li S, Wong TWL, Ng SSM. Li S, et al. CNS Neurosci Ther. 2024 Dec;30(12):e70142. doi: 10.1111/cns.70142. CNS Neurosci Ther. 2024. PMID: 39692710 Free PMC article. Review.
Photobiomodulation (PBM), also known as low-level laser therapy, employs red or near-infrared light emitted from a laser or light-emitting diode for the treatment of various conditions. ...Furthermore, it proposes new technologies and dir …
Photobiomodulation (PBM), also known as low-level laser therapy, employs red or near-infrared light emitt …
Photobiomodulation and Dentistry: Visualization and Analysis of Knowledge of the Most Cited Articles.
Silva APA, Alexandre da Silva Z, Melo WWP, Lima RR, Souza-Rodrigues RD. Silva APA, et al. Photobiomodul Photomed Laser Surg. 2025 May;43(5):177-189. doi: 10.1089/photob.2025.0004. Epub 2025 Apr 10. Photobiomodul Photomed Laser Surg. 2025. PMID: 40208840 Review.
Objective: The aim of this study was to map and analyze the 20 most cited articles on the use of photobiomodulation (PBM) in different areas of dentistry. Methods: To this end, in June 2024, a search was carried out in the main Web of Science Core Collection for the most c …
Objective: The aim of this study was to map and analyze the 20 most cited articles on the use of photobiomodulation (PBM) in differen …
Photobiomodulation or low-level laser therapy in the management of cancer therapy-induced mucositis, dermatitis and lymphedema.
Bensadoun RJ. Bensadoun RJ. Curr Opin Oncol. 2018 Jul;30(4):226-232. doi: 10.1097/CCO.0000000000000452. Curr Opin Oncol. 2018. PMID: 29794809 Review.
PURPOSE OR REVIEW: There is a large body of evidence supporting the efficacy of low-level laser therapy (LLLT) also known as PhotoBioModulation (PBM) when used for the prevention and/or treatment of oral mucositis in patients undergoing radiotherapy fo …
PURPOSE OR REVIEW: There is a large body of evidence supporting the efficacy of low-level laser therapy (LLLT) also kno …
Photobiomodulation of gut microbiota with low-level laser therapy: a light for treating neuroinflammation.
da Silva LE, Martins DF, de Oliveira MP, Stenier MR, Fernandes BB, Willemann SDS, de Souza G, Vieira WF, Hewitson A, Cidral-Filho FJ, Rezin GT. da Silva LE, et al. Lasers Med Sci. 2025 Feb 4;40(1):64. doi: 10.1007/s10103-025-04319-9. Lasers Med Sci. 2025. PMID: 39903307 Review.
Intestinal dysbiosis can lead to increased peripheral inflammation and, consequently, affect the brain, resulting in neuroinflammation. Photobiomodulation (PBM) has demonstrated positive regulatory effects on the imbalance of certain body functions, including pain, inflamm …
Intestinal dysbiosis can lead to increased peripheral inflammation and, consequently, affect the brain, resulting in neuroinflammation. P …
Efficacy of photobiomodulation therapy in reducing dental injection pain in adults: A systematic review and meta-analysis.
Amrollahi N, Adel SAR, Tarrahi MJ, Kalantari M. Amrollahi N, et al. J Dent. 2025 Nov;162:106003. doi: 10.1016/j.jdent.2025.106003. Epub 2025 Jul 30. J Dent. 2025. PMID: 40750083
OBJECTIVES: This systematic review and meta-analysis aimed to determine the efficacy of photobiomodulation therapy (PBMT), also known as low-level laser therapy (LLLT), in reducing dental injection pain in adults. ...
OBJECTIVES: This systematic review and meta-analysis aimed to determine the efficacy of photobiomodulation therapy (PBMT), als …
Effect of photobiomodulation therapy on pain perception during anesthetic puncture of dental local anesthesia: A systematic review.
Mesquita CM, Oliveira MB, Costa MDMA, Vieira WA, Lima RR, Rode SM, Paranhos LR. Mesquita CM, et al. Clinics (Sao Paulo). 2024 Mar 13;79:100322. doi: 10.1016/j.clinsp.2023.100322. eCollection 2024. Clinics (Sao Paulo). 2024. PMID: 38484582 Free PMC article.
This study aimed to systematically analyze the literature on changes in pain perception during the anesthetic puncture of dental local anesthesia after Photobiomodulation Therapy (PBMT). MATERIAL AND METHODS: An electronic search was performed in eight primary datab …
This study aimed to systematically analyze the literature on changes in pain perception during the anesthetic puncture of dental local anest …
Visible light. Part I: Properties and cutaneous effects of visible light.
Austin E, Geisler AN, Nguyen J, Kohli I, Hamzavi I, Lim HW, Jagdeo J. Austin E, et al. J Am Acad Dermatol. 2021 May;84(5):1219-1231. doi: 10.1016/j.jaad.2021.02.048. Epub 2021 Feb 25. J Am Acad Dermatol. 2021. PMID: 33640508 Free PMC article. Review.
Approximately 50% of the sunlight reaching the Earth's surface is visible light (400-700 nm). Other sources of visible light include lasers, light-emitting diodes, and flash lamps. ...Red and blue light from light-emitting diodes and intense pul …
Approximately 50% of the sunlight reaching the Earth's surface is visible light (400-700 nm). Other sources of visible light i …
Impact of photobiomodulation in alveolar ridge preservation and implant stability after a dental extraction: a systematic review.
Mahintach T, Hascoet E, Cloitre A, Chaux AG. Mahintach T, et al. Lasers Med Sci. 2024 Oct 26;39(1):264. doi: 10.1007/s10103-024-04215-8. Lasers Med Sci. 2024. PMID: 39460822
The aim of the systematic review was to determine if the use of photobiomodulation had an impact on implant stability and on alveolar bone healing, either in quality or in quantity. ...The use of photobiomodulation seemed to inhance the alveolar bone healing after a …
The aim of the systematic review was to determine if the use of photobiomodulation had an impact on implant stability and on alveolar …
Photobiomodulation for Side Effects of Cancer Therapy.
Bensadoun RJ, Nair RG, Robijns J. Bensadoun RJ, et al. Photobiomodul Photomed Laser Surg. 2020 Jun;38(6):323-325. doi: 10.1089/photob.2019.4759. Epub 2020 May 4. Photobiomodul Photomed Laser Surg. 2020. PMID: 32364823 No abstract available.
Photobiomodulation studies on diabetic wound healing: An insight into the inflammatory pathway in diabetic wound healing.
Mgwenya TN, Abrahamse H, Houreld NN. Mgwenya TN, et al. Wound Repair Regen. 2025 Jan-Feb;33(1):e13239. doi: 10.1111/wrr.13239. Epub 2024 Nov 28. Wound Repair Regen. 2025. PMID: 39610015 Free PMC article. Review.
Chronic diabetic ulcers do not follow an orderly progression through the wound healing process and are associated with a persistent inflammatory state characterised by the accumulation of pro-inflammatory macrophages, cytokines and proteases. Photobiomodulation has been su …
Chronic diabetic ulcers do not follow an orderly progression through the wound healing process and are associated with a persistent inflamma …
Mitochondrial Bioenergetic, Photobiomodulation and Trigeminal Branches Nerve Damage, What's the Connection? A Review.
Ravera S, Colombo E, Pasquale C, Benedicenti S, Solimei L, Signore A, Amaroli A. Ravera S, et al. Int J Mol Sci. 2021 Apr 21;22(9):4347. doi: 10.3390/ijms22094347. Int J Mol Sci. 2021. PMID: 33919443 Free PMC article. Review.
A challenge for research is to individuate new therapies able to normalise mitochondrial and energetic metabolism to aid nerve recovery after damage. Photobiomodulation therapy can be an interesting candidate, because it is a technique involving cell manipulation th …
A challenge for research is to individuate new therapies able to normalise mitochondrial and energetic metabolism to aid nerve recovery afte …
The Role of Photobiomodulation on Dental-Derived Stem Cells in Regenerative Dentistry: A Comprehensive Systematic Review.
Firoozi P, Amiri MA, Soghli N, Farshidfar N, Hakimiha N, Fekrazad R. Firoozi P, et al. Curr Stem Cell Res Ther. 2024;19(4):559-586. doi: 10.2174/1574888X17666220810141411. Curr Stem Cell Res Ther. 2024. PMID: 35950251
BACKGROUND: Photobiomodulation therapy involves exposing tissues to light sources, including light-emitting diodes or low-level lasers, which results in cellular function modulation. ...OBJECTIVE: The current systematic review aimed to ev …
BACKGROUND: Photobiomodulation therapy involves exposing tissues to light sources, including light-emitting diod …
Photobiomodulation in major and minor salivary glands in Sjogren's Syndrome.
Reia VCB, de Alencar JCG, Dos Santos Sobrinho O, Buchaim RL, da Silva Santos PS. Reia VCB, et al. J Stomatol Oral Maxillofac Surg. 2025 Oct;126(5S):102437. doi: 10.1016/j.jormas.2025.102437. Epub 2025 Jun 17. J Stomatol Oral Maxillofac Surg. 2025. PMID: 40554095
The Technical Note titled "Photobiomodulation in major and minor salivary glands in Sjogren's Syndrome (SS)" assesses the potential therapeutic application of photobiomodulation in the treatment of major and minor salivary gland dysfunction caused by systemic condit …
The Technical Note titled "Photobiomodulation in major and minor salivary glands in Sjogren's Syndrome (SS)" assesses the potential t …
Effects of photobiomodulation therapy on human sperm function.
Saylan A, Firat T, Yis OM. Saylan A, et al. Rev Int Androl. 2023 Apr-Jun;21(2):100340. doi: 10.1016/j.androl.2022.04.001. Epub 2023 Jan 5. Rev Int Androl. 2023. PMID: 36610824
INTRODUCTION: Sperm motility is a crucial factor in male infertility and it depends on mitochondrial tail movements. Photobiomodulation light therapy allows the cells to produce their energy through activation of the mitochondria. ...RESULTS: Sperm motilities …
INTRODUCTION: Sperm motility is a crucial factor in male infertility and it depends on mitochondrial tail movements. Photobiomodulation …
Photobiomodulation and alopecia: a crowdsourced survey study on patient preferences.
Paiewonsky B, Winter M, Hordinsky M, Griffith M, Farah RS. Paiewonsky B, et al. J Cosmet Laser Ther. 2023 Nov 17;25(5-8):92-94. doi: 10.1080/14764172.2023.2284641. Epub 2023 Nov 27. J Cosmet Laser Ther. 2023. PMID: 38011870
Photobiomodulation is a treatment option for hair loss and is currently FDA cleared for androgenetic alopecia. ...The majority of participants had never used a photobiomodulation device (n = 50; 86.2%). Most respondents (n = 40; 67.8%) felt the efficacy of the devic …
Photobiomodulation is a treatment option for hair loss and is currently FDA cleared for androgenetic alopecia. ...The majority of par …
Photobiomodulation therapy (PBMT) in skeletal muscle regeneration: A comprehensive review of mechanisms, clinical applications, and future directions.
Liu H, Cheema U, Player DJ. Liu H, et al. Photodiagnosis Photodyn Ther. 2025 Jun;53:104634. doi: 10.1016/j.pdpdt.2025.104634. Epub 2025 May 15. Photodiagnosis Photodyn Ther. 2025. PMID: 40381876 Free article. Review.
Photobiomodulation therapy (PBMT) emerged as a significant non-invasive method of stimulating regeneration of the skeletal muscle tissue. ...Future directions for research involve the application of real-time biofeedback devices, the utilization of artificial intell …
Photobiomodulation therapy (PBMT) emerged as a significant non-invasive method of stimulating regeneration of the skeletal mus …
Efficacy of photobiomodulation therapy on healing of ionizing irradiated bone: a systematic review of in vivo animal studies.
de Oliveira SV, Dos Reis T, Amorim J, Rocha FS, Marques MM, Guerra ES, Hanna R, Gallo CB. de Oliveira SV, et al. Lasers Med Sci. 2022 Dec;37(9):3379-3392. doi: 10.1007/s10103-022-03649-2. Epub 2022 Oct 4. Lasers Med Sci. 2022. PMID: 36194304
This systematic review aimed to answer the research focused question: What are the effects of photobiomodulation (PBM) therapy on bone healing after ionizing irradiation in animal models? The EMBASE, LILACS, LIVIVO, PubMed, Scopus, and Web of Science databases, incl …
This systematic review aimed to answer the research focused question: What are the effects of photobiomodulation (PBM) therapy …
The effects of photobiomodulation on the improvement of sperm parameters: A review study.
Parvin A, Erabi G, Saboohi Tasooji MR, Sadeghpour S, Mellatyar H, Rezaei Arablouydareh S, Navapour L, Taheri-Anganeh M, Ghasemnejad-Berenji H. Parvin A, et al. Photochem Photobiol. 2024 Nov-Dec;100(6):1713-1739. doi: 10.1111/php.13941. Epub 2024 Apr 16. Photochem Photobiol. 2024. PMID: 38623963 Review.
The rates of fertilization and subsequent development of embryos are dependent on many parameters associated with the quality and viability of sperm. Photobiomodulation (PBM) is a promising approach with a great potential for translational applications in the treatment of …
The rates of fertilization and subsequent development of embryos are dependent on many parameters associated with the quality and viability …
Photobiomodulation therapy as an additional method for the treatment of temporomandibular disorder patients- a narrative review.
Karic V, Penny C. Karic V, et al. Lasers Med Sci. 2025 Jan 31;40(1):56. doi: 10.1007/s10103-025-04324-y. Lasers Med Sci. 2025. PMID: 39885096 Free PMC article. Review.
The photobiomodulation therapy (PBMT) is promising additional therapy in the treatment of temporomandibular disorder (TMD). ...
The photobiomodulation therapy (PBMT) is promising additional therapy in the treatment of temporomandibular disorder (T …
Photobiomodulation in dentistry.
Ross G. Ross G. Photomed Laser Surg. 2012 Oct;30(10):565-7. doi: 10.1089/pho.2012.9883. Epub 2012 Sep 12. Photomed Laser Surg. 2012. PMID: 22970655 No abstract available.
Photobiomodulation in cardiovascular diseases: molecular mechanisms and pharmacological approaches to enhance the therapeutics effects of light.
Oliveira de Moraes LH, Buzinari TC. Oliveira de Moraes LH, et al. Lasers Med Sci. 2025 Nov 3;40(1):464. doi: 10.1007/s10103-025-04708-0. Lasers Med Sci. 2025. PMID: 41177806 Review.
Photobiomodulation (PBM) is an emerging therapeutic strategy that uses light to modulate biological processes. ...
Photobiomodulation (PBM) is an emerging therapeutic strategy that uses light to modulate biological processes. ...
Parameter Reproducibility in Photobiomodulation.
Tunér J, Jenkins PA. Tunér J, et al. Photomed Laser Surg. 2016 Mar;34(3):91-2. doi: 10.1089/pho.2016.4105. Photomed Laser Surg. 2016. PMID: 26953553 Free PMC article. No abstract available.
Photobiomodulation in skeletal muscle repair: Mechanisms, parameters, and therapeutic potential.
Wang X, Zhao C, Yang L. Wang X, et al. Biochem Biophys Res Commun. 2026 Apr 30;811:153562. doi: 10.1016/j.bbrc.2026.153562. Epub 2026 Mar 4. Biochem Biophys Res Commun. 2026. PMID: 41795372 Review.
Therefore, the main objective of this study is to investigate the potential application of laser therapy in skeletal muscle by analyzing the mechanism of laser action on target cells. Interest in laser-based photobiomodulation (PBM) has increased significantly in re …
Therefore, the main objective of this study is to investigate the potential application of laser therapy in skeletal muscle by analyz …
Good, better, best? The effects of polarization on photobiomodulation therapy.
Tripodi N, Feehan J, Husaric M, Kiatos D, Sidiroglou F, Fraser S, Apostolopoulos V. Tripodi N, et al. J Biophotonics. 2020 May;13(5):e201960230. doi: 10.1002/jbio.201960230. Epub 2020 Feb 27. J Biophotonics. 2020. PMID: 32077232 Review.
Photobiomodulation therapy (PBMT) is a widely adopted form of phototherapy used to treat many chronic conditions that effect the population at large. ...These enhanced cellular effects may also be present when the polarized light is applied linear to the tiss …
Photobiomodulation therapy (PBMT) is a widely adopted form of phototherapy used to treat many chronic conditions that effect t …
Effects of photobiomodulation on bone defects grafted with bone substitutes: A systematic review of in vivo animal studies.
Hanna R, Dalvi S, Amaroli A, De Angelis N, Benedicenti S. Hanna R, et al. J Biophotonics. 2021 Jan;14(1):e202000267. doi: 10.1002/jbio.202000267. Epub 2020 Oct 2. J Biophotonics. 2021. PMID: 32857463
A present, photobiomodulation therapy (PBMT) effectiveness in enhancing bone regeneration in bone defects grafted with or without biomaterials is unclear. ...MEDLINE, CCCT, Scopus, Science Direct, Google Scholar, EMBASE, EBSCO were searched, utilizing the following …
A present, photobiomodulation therapy (PBMT) effectiveness in enhancing bone regeneration in bone defects grafted with or with …
Photobiomodulation: Inhibition or Resolution of the Inflammatory Process?
Lopes-Martins RAB, Leonardo PS, Bjordal JM, Marcos RL. Lopes-Martins RAB, et al. Photobiomodul Photomed Laser Surg. 2020 Aug;38(8):453-454. doi: 10.1089/photob.2020.4825. Epub 2020 Jun 29. Photobiomodul Photomed Laser Surg. 2020. PMID: 32609051 No abstract available.
Therapeutic Efficacy of Home-Use Photobiomodulation Devices: A Systematic Literature Review.
Gavish L, Houreld NN. Gavish L, et al. Photobiomodul Photomed Laser Surg. 2019 Jan;37(1):4-16. doi: 10.1089/photob.2018.4512. Photobiomodul Photomed Laser Surg. 2019. PMID: 31050938
Objective: Perform systematic literature review on photobiomodulation (PBM) devices used at home for nonesthetic applications. Background: Home-use PBM devices have been marketed for cosmetic and therapeutic purposes. ...Treatment dosage appropriateness was compared to the …
Objective: Perform systematic literature review on photobiomodulation (PBM) devices used at home for nonesthetic applications. Backgr …
Effects of transcranial photobiomodulation in cerebral circulation and brain neural oscillations: a systematic review.
Montazeri K, Chaibakhsh S, Fekrazad R. Montazeri K, et al. Lasers Med Sci. 2025 Aug 22;40(1):341. doi: 10.1007/s10103-025-04601-w. Lasers Med Sci. 2025. PMID: 40844561
Transcranial photobiomodulation (tPBM) uses the light of lasers or light-emitting diodes to modulate and improve brain function. ..."Google scholar", "Pub Med", "Scopus" and "science direct" online databases were searched based on Preferred Reporting Items fo …
Transcranial photobiomodulation (tPBM) uses the light of lasers or light-emitting diodes to modulate and improve brain …
Photobiomodulation Therapy to Improve Glycemic Control in People with Diabetes Mellitus: A Systematic Review.
da Rocha FC, Espósito LMB, Hamblin MR, Ferraresi C. da Rocha FC, et al. Photobiomodul Photomed Laser Surg. 2026 May;44(5):275-284. doi: 10.1177/25785478261433321. Epub 2026 Mar 20. Photobiomodul Photomed Laser Surg. 2026. PMID: 41858223 Review.
OBJECTIVE: To evaluate the effects of photobiomodulation (PBM) on glycemic control in individuals with type 2 diabetes mellitus (T2DM). ...CONCLUSIONS: PBM shows potential as an adjunctive therapy for glycemic control in T2DM, although further well-designed trials a …
OBJECTIVE: To evaluate the effects of photobiomodulation (PBM) on glycemic control in individuals with type 2 diabetes mellitus (T2DM …
Systematic Review of Photobiomodulation Therapy (PBMT) on the Experimental Calcaneal Tendon Injury in Rats.
Lopes Silva RSD, Pessoa DR, Mariano RR, Castro ABS, de Oliveira RA, Ferraresi C. Lopes Silva RSD, et al. Photochem Photobiol. 2020 Sep;96(5):981-997. doi: 10.1111/php.13262. Epub 2020 May 19. Photochem Photobiol. 2020. PMID: 32191817
This systematic review analyzed the light parameters and the effects of photobiomodulation therapy (PBMT) through low-level laser therapy (LLLT) and/or LED (light-emitting diode) on tendon repair of rats submitted to calcaneal inju …
This systematic review analyzed the light parameters and the effects of photobiomodulation therapy (PBMT) through lo …
Effects of photobiomodulation on experimental models of peripheral nerve injury.
Andreo L, Soldera CB, Ribeiro BG, de Matos PRV, Bussadori SK, Fernandes KPS, Mesquita-Ferrari RA. Andreo L, et al. Lasers Med Sci. 2017 Dec;32(9):2155-2165. doi: 10.1007/s10103-017-2359-7. Epub 2017 Oct 23. Lasers Med Sci. 2017. PMID: 29063472 Review.
Thus, the aim of the present study was to conduct a literature review on the effects of photobiomodulation with the use of low-level laser therapy (LLLT) on the treatment of peripheral nerve injury in experimental models. ...LLLT is a viable photothera …
Thus, the aim of the present study was to conduct a literature review on the effects of photobiomodulation with the use of low …
The supportive use of photobiomodulation on salivary glands: a narrative review and meta-analysis.
Oliveira SV, Batista JVF, Gutierres GG, Silva NP, Lino-Dos-Santos-Franco A, Rodrigues MFSD, Cecatto RB. Oliveira SV, et al. Eur Arch Otorhinolaryngol. 2024 Jun;281(6):2793-2805. doi: 10.1007/s00405-023-08425-8. Epub 2024 Jan 8. Eur Arch Otorhinolaryngol. 2024. PMID: 38189964 Review.
METHODS: This study reviews the use of extra-oral salivary glands photobiomodulation in treating xerostomia and/or hyposalivation after radiotherapy and performs a meta-analysis of this data. ...CONCLUSION: The most promising parameters comprise wavelengths between 630 and …
METHODS: This study reviews the use of extra-oral salivary glands photobiomodulation in treating xerostomia and/or hyposalivation aft …
Transcranial Photobiomodulation in Sports Medicine: Enhancing Athletic Performance and Injury Prevention.
Iravani M, Moghaddam Salimi M, Jahan A, Rastgar-Farajzadeh L, Jamali B, Ebrahimi-Kalan A. Iravani M, et al. Photobiomodul Photomed Laser Surg. 2026 Apr;44(4):216-225. doi: 10.1177/25785478261429308. Epub 2026 Mar 12. Photobiomodul Photomed Laser Surg. 2026. PMID: 41817276 Review.
This narrative review, aligned with PRISMA guidelines, synthesizes evidence from 7 human and animal studies on the effects of transcranial photobiomodulation (tPBM) in sports medicine, focusing on athletic performance. RESULTS: tPBM, which uses red and near-infrared lig …
This narrative review, aligned with PRISMA guidelines, synthesizes evidence from 7 human and animal studies on the effects of transcranial …
Effect of Photobiomodulation on Mesenchymal Stem Cells.
Fekrazad R, Asefi S, Allahdadi M, Kalhori KA. Fekrazad R, et al. Photomed Laser Surg. 2016 Nov;34(11):533-542. doi: 10.1089/pho.2015.4029. Epub 2016 Apr 12. Photomed Laser Surg. 2016. PMID: 27070113 Review.
OBJECTIVE: The purpose of this study was to review available literature about the effect of photobiomodulation (PBM) on mesenchymal stem cells (MSCs). BACKGROUND DATA: The effects of coherent and noncoherent light sources such as low-level lasers and …
OBJECTIVE: The purpose of this study was to review available literature about the effect of photobiomodulation (PBM) on mesenchymal s …
Photobiomodulation and space closure.
Priya P, Mishra S, Madhok S, Nongthombam H. Priya P, et al. Am J Orthod Dentofacial Orthop. 2022 Feb;161(2):e93. doi: 10.1016/j.ajodo.2021.09.013. Am J Orthod Dentofacial Orthop. 2022. PMID: 35094755 No abstract available.
Transcranial Photobiomodulation for Down Syndrome.
Mannu P, Maiello M, Spera V, Cassano P. Mannu P, et al. Photobiomodul Photomed Laser Surg. 2019 Oct;37(10):579-580. doi: 10.1089/photob.2019.4675. Epub 2019 Sep 19. Photobiomodul Photomed Laser Surg. 2019. PMID: 31536469 No abstract available.
The effects of photobiomodulation on human dermal fibroblasts in vitro: A systematic review.
Tripodi N, Corcoran D, Antonello P, Balic N, Caddy D, Knight A, Meehan C, Sidiroglou F, Fraser S, Kiatos D, Husaric M, Apostolopoulos V, Feehan J. Tripodi N, et al. J Photochem Photobiol B. 2021 Jan;214:112100. doi: 10.1016/j.jphotobiol.2020.112100. Epub 2020 Dec 4. J Photochem Photobiol B. 2021. PMID: 33316625
Photobiomodulation (PBM) is reported to impart a range of clinical benefits, from the healing of chronic wounds to athletic performance enhancement. The increasing prevalence of this therapy conflicts with the lack of understanding concerning specific cellular mecha …
Photobiomodulation (PBM) is reported to impart a range of clinical benefits, from the healing of chronic wounds to athletic performan …
Efficacy of photobiomodulation therapy on neurosensory recovery in patients with inferior alveolar nerve injury following oral surgical procedures: a systematic review.
Hakimiha N, Bassir SH, Romanos GE, Shamshiri AR, Moslemi N. Hakimiha N, et al. Quintessence Int. 2021;52(2):140-153. doi: 10.3290/j.qi.a45430. Quintessence Int. 2021. PMID: 33433080
OBJECTIVE: The present systematic review aimed to assess the efficacy of photobiomodulation (PBM) therapy on neurosensory recovery of patients with inferior alveolar nerve injury following third molar surgery or dental implant placement. ...Two out of three RCTs fou …
OBJECTIVE: The present systematic review aimed to assess the efficacy of photobiomodulation (PBM) therapy on neurosensory reco …
Biological effects and medical applications of infrared radiation.
Tsai SR, Hamblin MR. Tsai SR, et al. J Photochem Photobiol B. 2017 May;170:197-207. doi: 10.1016/j.jphotobiol.2017.04.014. Epub 2017 Apr 13. J Photochem Photobiol B. 2017. PMID: 28441605 Free PMC article. Review.
Infrared (IR) radiation is electromagnetic radiation with wavelengths between 760nm and 100,000nm. Low-level light therapy (LLLT) or photobiomodulation (PBM) therapy generally employs light at red and near-infrared wavelengths (600 …
Infrared (IR) radiation is electromagnetic radiation with wavelengths between 760nm and 100,000nm. Low-level light t …
Photobiomodulation and Low-Level Laser Therapy as Complementary Strategies in Diabetes Treatment.
Kurhaluk N, Tomin V, Kołodziejska R, Tkaczenko H. Kurhaluk N, et al. Int J Mol Sci. 2026 Feb 23;27(4):2078. doi: 10.3390/ijms27042078. Int J Mol Sci. 2026. PMID: 41752213 Free PMC article. Review.
This narrative review examines the therapeutic potential of laser-based modalities, particularly low-level laser therapy (LLLT) and photobiomodulation therapy (PBMT), as complementary strategies in diabetes management. ...It emphasises the need …
This narrative review examines the therapeutic potential of laser-based modalities, particularly low-level laser therapy …
Systematic Review of Orthodontic Treatment Management with Photobiomodulation Therapy.
Cronshaw M, Parker S, Anagnostaki E, Lynch E. Cronshaw M, et al. Photobiomodul Photomed Laser Surg. 2019 Dec;37(12):862-868. doi: 10.1089/photob.2019.4702. Epub 2019 Nov 22. Photobiomodul Photomed Laser Surg. 2019. PMID: 31755850
Objective: This systematic review of published research evaluates the parameters and reported outcomes in photobiomodulation therapies (PBMTs) used in management of pain and accelerated tooth movement during orthodontic treatment. ...Materials and methods: Search engines, …
Objective: This systematic review of published research evaluates the parameters and reported outcomes in photobiomodulation therapie …
Therapeutic potential of intranasal photobiomodulation therapy for neurological and neuropsychiatric disorders: a narrative review.
Salehpour F, Gholipour-Khalili S, Farajdokht F, Kamari F, Walski T, Hamblin MR, DiDuro JO, Cassano P. Salehpour F, et al. Rev Neurosci. 2020 Apr 28;31(3):269-286. doi: 10.1515/revneuro-2019-0063. Rev Neurosci. 2020. PMID: 31812948 Free PMC article. Review.
The application of photobiomodulation therapy (PBMT) for neuronal stimulation is studied in different animal models and in humans, and has shown to improve cerebral metabolic activity and blood flow, and provide neuroprotection via anti-inflammatory and antioxidant …
The application of photobiomodulation therapy (PBMT) for neuronal stimulation is studied in different animal models and in hum …
Recent advances in light energy biotherapeutic strategies with photobiomodulation on central nervous system disorders.
Ma H, Du Y, Xie D, Wei ZZ, Pan Y, Zhang Y. Ma H, et al. Brain Res. 2024 Jan 1;1822:148615. doi: 10.1016/j.brainres.2023.148615. Epub 2023 Oct 14. Brain Res. 2024. PMID: 37783261 Review.
Transcranial photobiomodulation refers to irradiation of the brain through the skull using low-intensity red or near-infrared light, which is the most commonly studied method of light energy biotherapy for central nervous system disorders. ...This review main …
Transcranial photobiomodulation refers to irradiation of the brain through the skull using low-intensity red or near-infrared ligh …
Effective Wavelength Range in Photobiomodulation for Tooth Movement Acceleration in Orthodontics: A Systematic Review.
Domínguez Camacho A, Montoya Guzmán D, Velásquez Cujar SA. Domínguez Camacho A, et al. Photobiomodul Photomed Laser Surg. 2020 Oct;38(10):581-590. doi: 10.1089/photob.2020.4814. Epub 2020 Jun 30. Photobiomodul Photomed Laser Surg. 2020. PMID: 32609566
Objective: The present systematic review aims to establish an effective range of low-level laser therapy wavelengths to accelerate tooth movement in orthodontic treatments. ...Further studies are necessary to establish the exact dosimeter in photobiomodula …
Objective: The present systematic review aims to establish an effective range of low-level laser therapy wavelengths to …
A systematic review of the effects of transcranial photobiomodulation on brain activity in humans.
Dole M, Auboiroux V, Langar L, Mitrofanis J. Dole M, et al. Rev Neurosci. 2023 Mar 17;34(6):671-693. doi: 10.1515/revneuro-2023-0003. Print 2023 Aug 28. Rev Neurosci. 2023. PMID: 36927734
In recent years, transcranial photobiomodulation (tPBM) has been developing as a promising method to protect and repair brain tissues against damages. ...Four databases were screened for references containing terms encompassing photobiomodulation, brain activity, br …
In recent years, transcranial photobiomodulation (tPBM) has been developing as a promising method to protect and repair brain tissues …
Photobiomodulation and Wearable Light Therapies: A Bibliometric Analysis of the Scientific Literature (1970-2025).
Grossi A, Campoli F, Messina G, Caminiti G, Vitarelli M, Morganti G, Padua E, Ruscello B. Grossi A, et al. Int J Environ Res Public Health. 2026 May 5;23(5):610. doi: 10.3390/ijerph23050610. Int J Environ Res Public Health. 2026. PMID: 42196703 Free PMC article. Review.
BACKGROUND: This study aims to map the temporal evolution of light-based therapies and identify emerging technological trends in wearable photobiomodulation (PBM) devices. ...The period 2010-2023 represents a central thematic hub in research. During this time, new …
BACKGROUND: This study aims to map the temporal evolution of light-based therapies and identify emerging technological trends in wear …
Green Light Photobiomodulation: A Systematic Review of New Approaches for Treating Bone Repair.
Bao W, Zhuang J, Liu F, Hu J, Chen X, Jiang Y. Bao W, et al. Photobiomodul Photomed Laser Surg. 2025 Dec;43(12):565-584. doi: 10.1177/25785478251381479. Epub 2025 Sep 30. Photobiomodul Photomed Laser Surg. 2025. PMID: 41027665 Free article.
Background: Green light photobiomodulation (GPBM, 500-565 nm) promotes tissue healing, reduces inflammation, and alleviates pain, with emerging potential in bone repair. ...
Background: Green light photobiomodulation (GPBM, 500-565 nm) promotes tissue healing, reduces inflammation, and alleviates pa …
Traumatic Brain Injury Recovery with Photobiomodulation: Cellular Mechanisms, Clinical Evidence, and Future Potential.
Lim L. Lim L. Cells. 2024 Feb 23;13(5):385. doi: 10.3390/cells13050385. Cells. 2024. PMID: 38474349 Free PMC article. Review.
The objective of this study is to analyze transcranial photobiomodulation (PBM), which employs specific red to near-infrared light wavelengths to modulate brain functions, as a promising therapy to address TBI's complex pathophysiology in a single interventio …
The objective of this study is to analyze transcranial photobiomodulation (PBM), which employs specific red to near-infrared light …
Systematic Review of Delivery Parameters Used in Dental Photobiomodulation Therapy.
Parker S, Cronshaw M, Anagnostaki E, Bordin-Aykroyd SR, Lynch E. Parker S, et al. Photobiomodul Photomed Laser Surg. 2019 Dec;37(12):784-797. doi: 10.1089/photob.2019.4694. Epub 2019 Oct 1. Photobiomodul Photomed Laser Surg. 2019. PMID: 31573388
Background: Key to the standardization of randomized clinical trials and associated peer-reviewed articles is the disclosure of all laser and light-emitting diode operating parameters. The current status shows a lack of full parameters and significantly impacts on the abil …
Background: Key to the standardization of randomized clinical trials and associated peer-reviewed articles is the disclosure of all laser an …
Clinical evidence of photobiomodulation therapy (PBMT) on implant stability and success: a systematic review and meta-analysis.
Chen Y, Liu C, Chen X, Mo A. Chen Y, et al. BMC Oral Health. 2019 May 7;19(1):77. doi: 10.1186/s12903-019-0779-4. BMC Oral Health. 2019. PMID: 31064350 Free PMC article.
BACKGROUND: Photobiomodulation therapy (PBMT), a type of light therapy that uses the concept of photobiomodulation, is developed to promote bone healing. ...
BACKGROUND: Photobiomodulation therapy (PBMT), a type of light therapy that uses the concept of photobiomodul …
Photobiomodulation induces murine macrophages polarization toward M2 phenotype.
Reis VP, Paloschi MV, Rego CMA, Tavares MNM, Boeno CN, Lopes JA, Ferreira E Ferreira AA, Soares AM, Zamuner SR, Zuliani JP. Reis VP, et al. Toxicon. 2021 Jul 30;198:171-175. doi: 10.1016/j.toxicon.2021.05.009. Epub 2021 May 21. Toxicon. 2021. PMID: 34029603 Free article.
Photobiomodulation using light-emitting diode (LED) treatment has analgesic and anti-inflammatory effects which can be an effective therapeutic associated with serum therapy for local treatment of snakebites. ...
Photobiomodulation using light-emitting diode (LED) treatment has analgesic and anti-inflammatory effects which can be an effe …
Evidence from systematic reviews on photobiomodulation of human bone and stromal cells: Where do we stand?
Incerti Parenti S, Tschon M, Sartori M, Visani A, Aroni E, Fini M, Alessandri-Bonetti G. Incerti Parenti S, et al. Arch Biochem Biophys. 2020 May 30;685:108333. doi: 10.1016/j.abb.2020.108333. Epub 2020 Mar 16. Arch Biochem Biophys. 2020. PMID: 32194044 Review.
This study summarizes the available evidence from systematic reviews on the in vitro effects of photobiomodulation on the proliferation and differentiation of human bone and stromal cells by appraising their methodological quality. ...These methodological improvements will …
This study summarizes the available evidence from systematic reviews on the in vitro effects of photobiomodulation on the proliferati …
Photobiomodulation therapy with light-emitting diode in stimulating adipose tissue mitochondria.
Modena DAO, Ferro AP, de Oliveira Guirro EC, Cazzo E, Chaim EA. Modena DAO, et al. Lasers Med Sci. 2023 Oct 18;38(1):238. doi: 10.1007/s10103-023-03906-y. Lasers Med Sci. 2023. PMID: 37851070 Clinical Trial.
Low-level laser therapy (LLLT) is known for its ability to induce a photochemical process, primarily targeting mitochondria, a process referred to as photobiomodulation (PBM). ...Thus, the objective of this study was to understand whether mitochondrial …
Low-level laser therapy (LLLT) is known for its ability to induce a photochemical process, primarily targeting mitochon …
The potential of transcranial photobiomodulation therapy for treatment of major depressive disorder.
Salehpour F, Rasta SH. Salehpour F, et al. Rev Neurosci. 2017 May 24;28(4):441-453. doi: 10.1515/revneuro-2016-0087. Rev Neurosci. 2017. PMID: 28231069 Review.
Beneficial effects of transcranial photobiomodulation therapy in the wide range of neurological and psychological disorders have been already shown. In this review, we focus on some issue relating to the application of photobiomodulation therapy for ma …
Beneficial effects of transcranial photobiomodulation therapy in the wide range of neurological and psychological disorders ha …
Transcranial Photobiomodulation in Rett Syndrome: A Mechanistic Review and Therapeutic Hypothesis.
Luchese F, Lohmann C, Ferreras BI, Cassano P. Luchese F, et al. Photobiomodul Photomed Laser Surg. 2026 Mar;44(3):157-167. doi: 10.1177/25785478251415480. Epub 2026 Feb 9. Photobiomodul Photomed Laser Surg. 2026. PMID: 41660724 Review.
OBJECTIVE: To propose a mechanistic framework for the use of transcranial photobiomodulation (tPBM) as an adjunctive treatment in Rett syndrome (RTT). BACKGROUND DATA: RTT is a severe X-linked neurodevelopmental disorder caused mainly by MECP2 variants, with limited diseas …
OBJECTIVE: To propose a mechanistic framework for the use of transcranial photobiomodulation (tPBM) as an adjunctive treatment in Ret …
Photobiomodulation improves acute restraint stress-induced visceral hyperalgesia in rats.
Ishibashi N, Nanjo T, Tao S. Ishibashi N, et al. Lasers Med Sci. 2024 May 28;39(1):143. doi: 10.1007/s10103-024-04091-2. Lasers Med Sci. 2024. PMID: 38806837 Free PMC article.
After a 30-minute acclimatization period, the catheter was inflated to a pressure of 60 mmHg, and the number of abdominal muscle contractions was measured over a 5-minute period. The results showed that photobiomodulation significantly suppressed the number of abdominal mu …
After a 30-minute acclimatization period, the catheter was inflated to a pressure of 60 mmHg, and the number of abdominal muscle contraction …
Photobiomodulation rescues cognitive flexibility in early stressed subjects.
Banqueri M, Martínez JA, Prieto MJ, Cid-Duarte S, Méndez M, Arias JL. Banqueri M, et al. Brain Res. 2019 Oct 1;1720:146300. doi: 10.1016/j.brainres.2019.146300. Epub 2019 Jun 18. Brain Res. 2019. PMID: 31226326
In this study, we performed maternal separation (10 days, 4 h per day) in rats, and in adulthood, we tested their spatial navigation and cognitive flexibility. In addition, we delivered photobiomodulation treatment (Low-level light therapy: 1064 …
In this study, we performed maternal separation (10 days, 4 h per day) in rats, and in adulthood, we tested their spatial navigation and cog …
Effect of photobiomodulation treatment on pain control in patients with temporomandibular dysfunction disorder: systematic review.
da Silveira RB, Ferreira I, Botelho AL, Dos Reis AC. da Silveira RB, et al. Cranio. 2025 Jan;43(1):117-127. doi: 10.1080/08869634.2022.2086599. Epub 2022 Jun 15. Cranio. 2025. PMID: 35703499
OBJECTIVE: To critically evaluate the literature and answer the question, "How effective is photobiomodulation treatment on pain control in patients with TMJ disorder?". METHODS: PRISMA, PubMed, Web of Science, Scopus, and Embase databases were used for the personalized se …
OBJECTIVE: To critically evaluate the literature and answer the question, "How effective is photobiomodulation treatment on pain cont …
Effects of Photobiomodulation Therapy on Oxidative Stress in Muscle Injury Animal Models: A Systematic Review.
Dos Santos SA, Serra AJ, Stancker TG, Simões MCB, Dos Santos Vieira MA, Leal-Junior EC, Prokic M, Vasconsuelo A, Santos SS, de Carvalho PTC. Dos Santos SA, et al. Oxid Med Cell Longev. 2017;2017:5273403. doi: 10.1155/2017/5273403. Epub 2017 Sep 17. Oxid Med Cell Longev. 2017. PMID: 29075364 Free PMC article.
This systematic review was performed to identify the role of photobiomodulation therapy on experimental muscle injury models linked to induce oxidative stress. ...However, there is a nonuniformity in the terminology used to describe the parameters and dose for lo …
This systematic review was performed to identify the role of photobiomodulation therapy on experimental muscle injury models l …
The review of the light parameters and mechanisms of Photobiomodulation on melanoma cells.
Chen Z, Huang S, Liu M. Chen Z, et al. Photodermatol Photoimmunol Photomed. 2022 Jan;38(1):3-11. doi: 10.1111/phpp.12715. Epub 2021 Jul 7. Photodermatol Photoimmunol Photomed. 2022. PMID: 34181781 Review.
Photobiomodulation (PBM) uses low-intensity visible or near-infrared light to produce beneficial effects on cells or tissues, such as brain therapy, wound healing. ...Through further in-depth studies of the underlying potential mechanisms, it can strengthen t …
Photobiomodulation (PBM) uses low-intensity visible or near-infrared light to produce beneficial effects on cells or tissues, …
Effects of photobiomodulation on oral mucositis, oral pain, xerostomia, salivary flow rate, and quality of life in patients with head and neck cancer: a systematic review and meta-analysis.
Pedroso MNM, Rech A, Casagrande N, Pissaia JF, Zardo JS, Borges VL, Bombana SR, Muller CT, Casara P, Brollo J, Júnior CP, Gallon CW, Lopez P. Pedroso MNM, et al. Support Care Cancer. 2026 Mar 25;34(4):364. doi: 10.1007/s00520-026-10575-4. Support Care Cancer. 2026. PMID: 41880047 Free PMC article. Review.
PURPOSE: To systematically review and analyze the effects of photobiomodulation on oral mucositis, xerostomia, salivary flow rates, oral pain, and quality of life in patients with head and neck cancer. ...The benefits were consistent across different photobiomodulation …
PURPOSE: To systematically review and analyze the effects of photobiomodulation on oral mucositis, xerostomia, salivary flow rates, o …
Promises and Pitfalls of Regenerative Therapies for Androgenetic Alopecia: Platelet-Rich Plasma, Photobiomodulation, Stem Cells, and Exosomes.
Gupta AK, Wang T, Welter R, Unger R, Mejia R. Gupta AK, et al. Med Sci (Basel). 2025 Dec 22;14(1):5. doi: 10.3390/medsci14010005. Med Sci (Basel). 2025. PMID: 41562895 Free PMC article. Review.
OBJECTIVE: To critically review recently published evidence (2020-2025) on platelet-rich plasma, photobiomodulation, stem cells, and exosomes for the treatment of androgenetic alopecia. METHODS: A scoping review was conducted using PubMed, Embase (Ovid) and the Cochrane Co …
OBJECTIVE: To critically review recently published evidence (2020-2025) on platelet-rich plasma, photobiomodulation, stem cells, and …
Photobiomodulation therapy for enhanced wound and Scar healing: visual and statistical evaluation.
Shurrab K, Wael Aoida N. Shurrab K, et al. Lasers Med Sci. 2025 Aug 13;40(1):334. doi: 10.1007/s10103-025-04587-5. Lasers Med Sci. 2025. PMID: 40802060 Clinical Trial.
To evaluate the effectiveness and safety of Photobiomodulation Therapy (PBMT), formerly referred to as Low-level laser therapy (LLLT), in promoting enhanced wound and scar healing, and to optimize treatment parameters for various scar types. ...
To evaluate the effectiveness and safety of Photobiomodulation Therapy (PBMT), formerly referred to as Low-level …
Perspective on Broad-Acting Clinical Physiological Effects of Photobiomodulation.
Shanks S, Leisman G. Shanks S, et al. Adv Exp Med Biol. 2018;1096:41-52. doi: 10.1007/5584_2018_188. Adv Exp Med Biol. 2018. PMID: 29572678 Review.
Research into photobiomodulation reveals beneficial effects of light therapy for a rapidly expanding list of medical conditions and illnesses. Although it has become more widely accepted by the mainstream medicine, the effects and mechanisms of action appear …
Research into photobiomodulation reveals beneficial effects of light therapy for a rapidly expanding list of medical co …
Transcranial and systemic photobiomodulation for major depressive disorder: A systematic review of efficacy, tolerability and biological mechanisms.
Caldieraro MA, Cassano P. Caldieraro MA, et al. J Affect Disord. 2019 Jan 15;243:262-273. doi: 10.1016/j.jad.2018.09.048. Epub 2018 Sep 17. J Affect Disord. 2019. PMID: 30248638
BACKGROUND: Photobiomodulation (PBM) with red and near-infrared light (NIR) -also known as Low-Level Light Therapy-is a low risk, inexpensive treatment-based on non-retinal exposure-under study for several neuropsychiatric conditions. ... …
BACKGROUND: Photobiomodulation (PBM) with red and near-infrared light (NIR) -also known as Low-Level Light …
Photobiomodulation and Biological Pathways in Skin Regeneration and Rejuvenation: Light and Biological Activation of Skin Improvement.
Khalifian S, Shisler J. Khalifian S, et al. Facial Plast Surg Clin North Am. 2026 Aug;34(3):471-485. doi: 10.1016/j.fsc.2026.05.002. Epub 2026 Jun 8. Facial Plast Surg Clin North Am. 2026. PMID: 42392660 Review.
Photobiomodulation harnesses visible and near-infrared wavelengths to modulate mitochondrial energetics and transcriptional programs that orchestrate wound repair, immune homeostasis, angiogenesis, and organized extracellular matrix remodeling. ...
Photobiomodulation harnesses visible and near-infrared wavelengths to modulate mitochondrial energetics and transcriptional programs …
Acute and cumulative benefits of Photobiomodulation for xerostomia: A systematic review and meta-analysis.
Galiano-Castillo N, Liu L, Lozano-Lozano M, Tumilty S, Cantarero-Villanueva I, Baxter GD. Galiano-Castillo N, et al. Oral Dis. 2021 Jul;27(5):1115-1126. doi: 10.1111/odi.13648. Epub 2020 Oct 10. Oral Dis. 2021. PMID: 32964596
The objective was to explore the effectiveness of photobiomodulation therapy for treating patients who suffer xerostomia and/or hyposalivation due to the most prevalent clinical diagnoses. ...The present review and meta-analysis suggest that photobiomodulation …
The objective was to explore the effectiveness of photobiomodulation therapy for treating patients who suffer xerostomia and/o …
Transcranial photobiomodulation changes neuronal morphology in the cerebral cortex of rats.
Cardoso FDS, Serra FT, Coimbra NC, Gonzalez-Lima F, Gomes da Silva S. Cardoso FDS, et al. Neurosci Lett. 2022 Jun 11;781:136681. doi: 10.1016/j.neulet.2022.136681. Epub 2022 May 13. Neurosci Lett. 2022. PMID: 35569700
Transcranial photobiomodulation improves cerebral cortex metabolism. We hypothesized that chronic laser treatment may stimulate neuronal growth. ...Taken together, our data indicate that chronic transcranial photobiomodulation induces morphological neuroplasticity i …
Transcranial photobiomodulation improves cerebral cortex metabolism. We hypothesized that chronic laser treatment may stimulate neuro …
Optimal Timing of Photobiomodulation Therapy for Retinal Diseases: Leveraging Circadian Mitochondrial Rhythms.
Siqueira RC. Siqueira RC. Photobiomodul Photomed Laser Surg. 2025 Mar;43(3):81-82. doi: 10.1089/photob.2024.0154. Epub 2025 Jan 29. Photobiomodul Photomed Laser Surg. 2025. PMID: 39876708 Review.
Age-related retinal degeneration is associated with mitochondrial dysfunction. Emerging evidence suggests that photobiomodulation therapy (PBMT) using near-infrared light may improve mitochondrial function and visual performance, but its efficacy is criticall …
Age-related retinal degeneration is associated with mitochondrial dysfunction. Emerging evidence suggests that photobiomodulation …
Inflammation in obsessive-compulsive disorder: A literature review and hypothesis-based potential of transcranial photobiomodulation.
Coelho DRA, Salvi JD, Vieira WF, Cassano P. Coelho DRA, et al. J Neurosci Res. 2024 Mar;102(3):e25317. doi: 10.1002/jnr.25317. J Neurosci Res. 2024. PMID: 38459770 Review.
These findings suggest that inflammation could be a promising target for intervention. Transcranial photobiomodulation (t-PBM) with near-infrared light is a noninvasive neuromodulation technique that has shown potential for several neuropsychiatric disorders. ...
These findings suggest that inflammation could be a promising target for intervention. Transcranial photobiomodulation (t-PBM) with n …
Management of Cancer Therapy-Induced Oral Mucositis Using Photobiomodulation Therapy: An Overview of Systematic Reviews.
Vieira Nascimento M, Costa FWG, de Oliveira Filho OV, Silva PGB, de Freitas Pontes KM. Vieira Nascimento M, et al. Photobiomodul Photomed Laser Surg. 2023 Oct;41(10):513-538. doi: 10.1089/photob.2023.0091. Epub 2023 Oct 3. Photobiomodul Photomed Laser Surg. 2023. PMID: 37788454 Review.
Objective: To systematically summarize the evidence for photobiomodulation therapy (PBMT) in the prevention and treatment of oral mucositis (OM) in patients undergoing cancer treatment. ...
Objective: To systematically summarize the evidence for photobiomodulation therapy (PBMT) in the prevention and treatment of o …
The effect of photobiomodulation on oral microbiota dysbiosis: A literature review.
Pourhajibagher M, Gharibpour F, Nikparto N, Bahrami R, Bahador A. Pourhajibagher M, et al. Photodiagnosis Photodyn Ther. 2025 Apr;52:104525. doi: 10.1016/j.pdpdt.2025.104525. Epub 2025 Feb 15. Photodiagnosis Photodyn Ther. 2025. PMID: 39956443 Free article. Review.
Conventional treatments, such as mechanical debridement, antibiotics, probiotics, and prebiotics, aim to restore the balance of oral microbiota, but they encounter challenges like microbial resistance and patient compliance issues. To address these problems, laser therapy …
Conventional treatments, such as mechanical debridement, antibiotics, probiotics, and prebiotics, aim to restore the balance of oral microbi …
[State of art of photobiomodulation in the management of radiotherapy adverse events: Indications and level of evidence].
Klausner G, Bensadoun RJ, Champion A, Benzaquen D, Canova CH, Claren A, Mancuso V, Suhl J, Balard R, Troussier I. Klausner G, et al. Cancer Radiother. 2021 Oct;25(6-7):584-592. doi: 10.1016/j.canrad.2021.06.025. Epub 2021 Jul 13. Cancer Radiother. 2021. PMID: 34272181 Review. French.
PURPOSE: To evaluate the current and potential indications of photobiomodulation (PBM) and their level of evidence in the prevention or management of radiation therapy-related side effects. MATERIALS AND METHODS: The Embase, Medline/PubMed, Cochrane, EBSCO, Scopus, …
PURPOSE: To evaluate the current and potential indications of photobiomodulation (PBM) and their level of evidence in the prevention …
Craniofacial Wound Healing with Photobiomodulation Therapy: New Insights and Current Challenges.
Arany PR. Arany PR. J Dent Res. 2016 Aug;95(9):977-84. doi: 10.1177/0022034516648939. Epub 2016 May 9. J Dent Res. 2016. PMID: 27161014 Review.
Use of high-dose lasers and light devices in dermatology, ophthalmology, oncology, and dentistry are now popular for specific clinical applications, such as surgery, skin rejuvenation, ocular and soft tissue recontouring, and antitumor and antimicrobial photodynamic the …
Use of high-dose lasers and light devices in dermatology, ophthalmology, oncology, and dentistry are now popular for specific clinica …
Photobiomodulation therapy for treatment olfactory and taste dysfunction COVID-19-related: A case report.
de Souza VB, Ferreira LT, Sene-Fiorese M, Garcia V, Rodrigues TZ, de Aquino Junior AE, Bagnato VS, Panhoca VH. de Souza VB, et al. J Biophotonics. 2022 Aug;15(8):e202200058. doi: 10.1002/jbio.202200058. Epub 2022 May 17. J Biophotonics. 2022. PMID: 35445797
In the present case report, we observed clinical improvement in the symptoms of anosmia and ageusia related to COVID-19 after treatment with photobiomodulation. Due to the inflammatory nature of COVID-19 and the anti-inflammatory effects, photobiomodulation antioxid …
In the present case report, we observed clinical improvement in the symptoms of anosmia and ageusia related to COVID-19 after treatment with …
Effect Of Photobiomodulation (Low-Level Laser Therapy) In Patients With Knee Osteoarthritis: A Randomized Controlled Trial.
Dos Santos Maciel T, Corrêa Lima Chamy N, Dos Santos Maciel M, Pasqual Marques A. Dos Santos Maciel T, et al. Lasers Med Sci. 2025 Jun 23;40(1):293. doi: 10.1007/s10103-025-04542-4. Lasers Med Sci. 2025. PMID: 40545487 Clinical Trial.
This study aimed to evaluate the effects of photobiomodulation (low-level laser therapy) on patients with symptomatic knee osteoarthritis through a double-blind, randomized clinical trial conducted in accordance with the CONSORT guidelines for non-phar …
This study aimed to evaluate the effects of photobiomodulation (low-level laser therapy) on patients with sympto …
Photobiomodulation Activates Microglia/Astrocytes and Relieves Neuropathic Pain in Inferior Alveolar Nerve Injury.
Daigo E, Daigo Y, Idogaki J, Fukuoka H, Fukuoka N, Ishikawa M, Takahashi K. Daigo E, et al. Photobiomodul Photomed Laser Surg. 2023 Dec;41(12):694-702. doi: 10.1089/photob.2023.0078. Photobiomodul Photomed Laser Surg. 2023. PMID: 38085185
Objective: This study aimed to determine microglial/astrocyte changes and their associated analgesic effect in inferior alveolar nerve injury (IANI) model rats treated with photobiomodulation therapy (PBMT) using a 940-nm diode laser. Background: Very few basic stud …
Objective: This study aimed to determine microglial/astrocyte changes and their associated analgesic effect in inferior alveolar nerve injur …
Effects of low-level laser photobiomodulation on the masticatory function and mandibular movements in adults with temporomandibular disorder: a systematic review with meta-analysis.
Máximo CFGP, Coêlho JF, Benevides SD, Alves GÂDS. Máximo CFGP, et al. Codas. 2022 Jan 31;34(3):e20210138. doi: 10.1590/2317-1782/20212021138. eCollection 2022. Codas. 2022. PMID: 35107512 Free PMC article.
PURPOSE: To review the effects of low-level laser photobiomodulation on masticatory function and mandibular movements in adults with temporomandibular disorder. RESEARCH STRATEGIES: Search in PubMed, Web of Science, Scopus, EMBASE, Cochrane, LILACS, ScienceDi …
PURPOSE: To review the effects of low-level laser photobiomodulation on masticatory function and mandibular movements i …
The effect of photobiomodulation on the radiosensitivity of cancer cells: a literature review.
Durães C, Tabosa A, Santos E, Jesus S, Guimarães VH, Queiroz L, Farias L, Guimarães A. Durães C, et al. Lasers Med Sci. 2025 Apr 23;40(1):210. doi: 10.1007/s10103-025-04465-0. Lasers Med Sci. 2025. PMID: 40266395 Review.
This review examines the potential use of photobiomodulation (PBM) as a radiosensitizer for cancer cells to improve the effectiveness and safety of radiotherapy. A literature search was conducted in the MEDLINE/PubMed and Google Scholar databases using keywords like "PBM, …
This review examines the potential use of photobiomodulation (PBM) as a radiosensitizer for cancer cells to improve the effectiveness …
Radiographical impact of photobiomodulation therapy on bone regeneration in clinical studies: a systematic review.
Sadeghian A, Rohani B, Salehi-Marzijarani M, Fekrazad R. Sadeghian A, et al. Lasers Med Sci. 2025 Jan 20;40(1):23. doi: 10.1007/s10103-024-04244-3. Lasers Med Sci. 2025. PMID: 39828883
The search strategy involved using a mix of relevant medical subject headings (MeSH) terms and pertinent keywords such as photobiomodulation therapy, low-level laser therapy, bone, regeneration, PBMT, and LLLT. From an initial search identifying …
The search strategy involved using a mix of relevant medical subject headings (MeSH) terms and pertinent keywords such as photobiomodulat …
The Application of Photobiomodulation on Mesenchymal Stem Cells and its Potential Use for Tenocyte Differentiation.
Roets B, Abrahamse H, Crous A. Roets B, et al. Curr Stem Cell Res Ther. 2025;20(3):232-245. doi: 10.2174/011574888X295488240319111911. Curr Stem Cell Res Ther. 2025. PMID: 38847377 Review.
It is based on the fact that MSCs can be differentiated into tenocytes, the major cell type within tendons, and facilitate tendon repair. Photobiomodulation (PBM) is a non-invasive and potentially promising therapeutic technique that utilizes low-level lig …
It is based on the fact that MSCs can be differentiated into tenocytes, the major cell type within tendons, and facilitate tendon repair. …
Laser oromaxillofacial photobiomodulation therapy: molecular mechanisms, outcomes and considerations.
Fiani B, Jarrah R, Nathani KR. Fiani B, et al. Regen Med. 2022 Sep;17(9):611-615. doi: 10.2217/rme-2022-0091. Epub 2022 Jun 22. Regen Med. 2022. PMID: 35730260
Tweetable abstract Photobiomodulation therapy is largely characterized as a safe therapeutic model that can modulate the activity of inflammatory and immune biomarkers while facilitating a metabolic response that can regenerate damaged tissue....
Tweetable abstract Photobiomodulation therapy is largely characterized as a safe therapeutic model that can modulate the activ …
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