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1973 2
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1989 3
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1991 3
1992 1
1993 2
1994 4
1995 4
1996 1
1997 3
1998 3
1999 3
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2002 7
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2004 3
2005 6
2006 5
2007 6
2008 4
2009 3
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106 results

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Page 1
Direct binding to sterols accelerates endoplasmic reticulum-associated degradation of HMG CoA reductase.
Faulkner RA, Yang Y, Tsien J, Qin T, DeBose-Boyd RA. Faulkner RA, et al. Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2318822121. doi: 10.1073/pnas.2318822121. Epub 2024 Feb 6. Proc Natl Acad Sci U S A. 2024. PMID: 38319967 Free PMC article.
Two integral membrane proteins, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and Scap, are key targets of a complex feedback regulatory system that operates to ensure cholesterol homeostasis. ...
Two integral membrane proteins, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and Scap, are key targets of a complex feedba …
Sitosterolemia.
Salen G, Shefer S, Nguyen L, Ness GC, Tint GS, Shore V. Salen G, et al. J Lipid Res. 1992 Jul;33(7):945-55. J Lipid Res. 1992. PMID: 1431587 Free article. Review.
Very low cholesterol synthesis due to a deficiency of HMG-CoA reductase associated with increased intestinal plant sterol absorption and slow hepatic sterol removal are major biochemical features. ...
Very low cholesterol synthesis due to a deficiency of HMG-CoA reductase associated with increased intestinal plant ster …
Sitosterolemia.
Salen G, Shefer S, Nguyen L, Ness GC, Tint GS, Batta AK. Salen G, et al. Subcell Biochem. 1997;28:453-76. doi: 10.1007/978-1-4615-5901-6_15. Subcell Biochem. 1997. PMID: 9090303 Review. No abstract available.
Herbs and atherosclerosis.
Heber D. Heber D. Curr Atheroscler Rep. 2001 Jan;3(1):93-6. doi: 10.1007/s11883-001-0016-9. Curr Atheroscler Rep. 2001. PMID: 11123854 Review.
Many herbs have antioxidant activity and can reduce low-density lipoprotein oxidation. Some phytosterols found in botanicals can inhibit cholesterol absorption. After a brief review of herbs being promoted for achieving and maintaining healthy cholesterol levels, the evide …
Many herbs have antioxidant activity and can reduce low-density lipoprotein oxidation. Some phytosterols found in botanicals can inhi …
Monascus rice products.
Wang TH, Lin TF. Wang TH, et al. Adv Food Nutr Res. 2007;53:123-59. doi: 10.1016/S1043-4526(07)53004-4. Adv Food Nutr Res. 2007. PMID: 17900498 Review.
The most important bioactive compound isolated from Monascus is monacolin K, which is identical to the potent cholesterol-lowering, antiatherosclerotic drug lovastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Several species of …
The most important bioactive compound isolated from Monascus is monacolin K, which is identical to the potent cholesterol-lowering, antiathe …
Enhanced seed phytosterol accumulation through expression of a modified HMG-CoA reductase.
Hey SJ, Powers SJ, Beale MH, Hawkins ND, Ward JL, Halford NG. Hey SJ, et al. Plant Biotechnol J. 2006 Mar;4(2):219-29. doi: 10.1111/j.1467-7652.2005.00174.x. Plant Biotechnol J. 2006. PMID: 17177798 Free article.
Mevalonate synthesis via 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) is a key step in phytosterol biosynthesis. HMG-CoA reductase is inactivated by phosphorylation by SNF1-related protein kinase 1 (Sn …
Mevalonate synthesis via 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) is a key step in …
HMG-CoA reductase is not the site of the primary defect in phytosterolemia.
Berger GM, Pegoraro RJ, Patel SB, Naidu P, Rom L, Hidaka H, Marais AD, Jadhav A, Naoumova RP, Thompson GR. Berger GM, et al. J Lipid Res. 1998 May;39(5):1046-54. J Lipid Res. 1998. PMID: 9610772 Free article.
Phytosterolemia is an autosomal recessive disorder characterized by the excessive absorption, reduced excretion, and consequent high tissue and plasma levels of plant sterols, by the presence of tendon xanthomas, and by premature atherosclerosis. Low HMG-CoA redu …
Phytosterolemia is an autosomal recessive disorder characterized by the excessive absorption, reduced excretion, and consequent high tissue …
Cholesterol-lowering nutraceuticals and functional foods.
Chen ZY, Jiao R, Ma KY. Chen ZY, et al. J Agric Food Chem. 2008 Oct 8;56(19):8761-73. doi: 10.1021/jf801566r. Epub 2008 Sep 9. J Agric Food Chem. 2008. PMID: 18778072 Review.
In addition to the use of three main classes of cholesterol-lowering medications, including HMG-CoA reductase inhibitors, anion-exchange resins, and fibrates, a nutritionally balanced diet that reduces saturated fat and cholesterol intake has traditionally be …
In addition to the use of three main classes of cholesterol-lowering medications, including HMG-CoA reductase inhibitor …
106 results