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63 results

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Page 1
A scaffold for quinone channeling between membrane and soluble bacterial oxidoreductases.
Broc M, Cherrier MV, Uzel A, Arias-Cartin R, Arnoux P, Brasseur G, Seduk F, Guigliarelli B, Legrand P, Pierrel F, Schoehn G, Maté MJ, Martin L, Grimaldi S, Nicolet Y, Magalon A, Walburger A. Broc M, et al. Among authors: pierrel f. Nat Struct Mol Biol. 2025 Nov;32(11):2196-2202. doi: 10.1038/s41594-025-01607-4. Epub 2025 Aug 25. Nat Struct Mol Biol. 2025. PMID: 40855134
A novel quinone biosynthetic pathway illuminates the evolution of aerobic metabolism.
Elling FJ, Pierrel F, Chobert SC, Abby SS, Evans TW, Reveillard A, Pelosi L, Schnoebelen J, Hemingway JD, Boumendjel A, Becker KW, Blom P, Cordes J, Nathan V, Baymann F, Lücker S, Spieck E, Leadbetter JR, Hinrichs KU, Summons RE, Pearson A. Elling FJ, et al. Among authors: pierrel f. Proc Natl Acad Sci U S A. 2025 Feb 25;122(8):e2421994122. doi: 10.1073/pnas.2421994122. Epub 2025 Feb 20. Proc Natl Acad Sci U S A. 2025. PMID: 39977315 Free PMC article.
An organic O donor for biological hydroxylation reactions.
Ferizhendi KK, Simon P, Pelosi L, Séchet E, Arulanandam R, Chehade MH, Rey M, Onal D, Flandrin L, Chreim R, Faivre B, Vo SC, Arias-Cartin R, Barras F, Fontecave M, Bouveret E, Lombard M, Pierrel F. Ferizhendi KK, et al. Among authors: pierrel f. Proc Natl Acad Sci U S A. 2024 Mar 26;121(13):e2321242121. doi: 10.1073/pnas.2321242121. Epub 2024 Mar 20. Proc Natl Acad Sci U S A. 2024. PMID: 38507448 Free PMC article.
The acyl-CoA synthetase TgACS1 allows neutral lipid metabolism and extracellular motility in Toxoplasma gondii through relocation via its peroxisomal targeting sequence (PTS) under low nutrient conditions.
Charital S, Shunmugam S, Dass S, Alazzi AM, Arnold C-S, Katris NJ, Duley S, Quansah NA, Pierrel F, Govin J, Yamaryo-Botté Y, Botté CY. Charital S, et al. Among authors: pierrel f. mBio. 2024 Apr 10;15(4):e0042724. doi: 10.1128/mbio.00427-24. Epub 2024 Mar 19. mBio. 2024. PMID: 38501871 Free PMC article.
COQ4 is required for the oxidative decarboxylation of the C1 carbon of coenzyme Q in eukaryotic cells.
Pelosi L, Morbiato L, Burgardt A, Tonello F, Bartlett AK, Guerra RM, Ferizhendi KK, Desbats MA, Rascalou B, Marchi M, Vázquez-Fonseca L, Agosto C, Zanotti G, Roger-Margueritat M, Alcázar-Fabra M, García-Corzo L, Sánchez-Cuesta A, Navas P, Brea-Calvo G, Trevisson E, Wendisch VF, Pagliarini DJ, Salviati L, Pierrel F. Pelosi L, et al. Among authors: pierrel f. Mol Cell. 2024 Mar 7;84(5):981-989.e7. doi: 10.1016/j.molcel.2024.01.003. Epub 2024 Jan 30. Mol Cell. 2024. PMID: 38295803 Free PMC article.
COQ4 is required for the oxidative decarboxylation of the C1 carbon of Coenzyme Q in eukaryotic cells.
Pelosi L, Morbiato L, Burgardt A, Tonello F, Bartlett AK, Guerra RM, Ferizhendi KK, Desbats MA, Rascalou B, Marchi M, Vázquez-Fonseca L, Agosto C, Zanotti G, Roger-Margueritat M, Alcázar-Fabra M, García-Corzo L, Sánchez-Cuesta A, Navas P, Brea-Calvo G, Trevisson E, Wendisch VF, Pagliarini DJ, Salviati L, Pierrel F. Pelosi L, et al. Among authors: pierrel f. bioRxiv [Preprint]. 2023 Nov 13:2023.11.13.566839. doi: 10.1101/2023.11.13.566839. bioRxiv. 2023. Update in: Mol Cell. 2024 Mar 7;84(5):981-989.e7. doi: 10.1016/j.molcel.2024.01.003. PMID: 38014142 Free PMC article. Updated. Preprint.
Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2.
Schulz V, Basu S, Freibert SA, Webert H, Boss L, Mühlenhoff U, Pierrel F, Essen LO, Warui DM, Booker SJ, Stehling O, Lill R. Schulz V, et al. Among authors: pierrel f. Nat Chem Biol. 2023 Feb;19(2):206-217. doi: 10.1038/s41589-022-01159-4. Epub 2022 Oct 24. Nat Chem Biol. 2023. PMID: 36280795 Free PMC article.
Manganese-driven CoQ deficiency.
Diessl J, Berndtsson J, Broeskamp F, Habernig L, Kohler V, Vazquez-Calvo C, Nandy A, Peselj C, Drobysheva S, Pelosi L, Vögtle FN, Pierrel F, Ott M, Büttner S. Diessl J, et al. Among authors: pierrel f. Nat Commun. 2022 Oct 13;13(1):6061. doi: 10.1038/s41467-022-33641-x. Nat Commun. 2022. PMID: 36229432 Free PMC article.
Advances in bacterial pathways for the biosynthesis of ubiquinone.
Abby SS, Kazemzadeh K, Vragniau C, Pelosi L, Pierrel F. Abby SS, et al. Among authors: pierrel f. Biochim Biophys Acta Bioenerg. 2020 Nov 1;1861(11):148259. doi: 10.1016/j.bbabio.2020.148259. Epub 2020 Jul 12. Biochim Biophys Acta Bioenerg. 2020. PMID: 32663475 Free article. Review.
Vanillic Acid Restores Coenzyme Q Biosynthesis and ATP Production in Human Cells Lacking COQ6.
Acosta Lopez MJ, Trevisson E, Canton M, Vazquez-Fonseca L, Morbidoni V, Baschiera E, Frasson C, Pelosi L, Rascalou B, Desbats MA, Alcázar-Fabra M, Ríos JJ, Sánchez-García A, Basso G, Navas P, Pierrel F, Brea-Calvo G, Salviati L. Acosta Lopez MJ, et al. Among authors: pierrel f. Oxid Med Cell Longev. 2019 Jul 10;2019:3904905. doi: 10.1155/2019/3904905. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 31379988 Free PMC article.
A Soluble Metabolon Synthesizes the Isoprenoid Lipid Ubiquinone.
Hajj Chehade M, Pelosi L, Fyfe CD, Loiseau L, Rascalou B, Brugière S, Kazemzadeh K, Vo CD, Ciccone L, Aussel L, Couté Y, Fontecave M, Barras F, Lombard M, Pierrel F. Hajj Chehade M, et al. Among authors: pierrel f. Cell Chem Biol. 2019 Apr 18;26(4):482-492.e7. doi: 10.1016/j.chembiol.2018.12.001. Epub 2019 Jan 24. Cell Chem Biol. 2019. PMID: 30686758 Free article.
The UbiK protein is an accessory factor necessary for bacterial ubiquinone (UQ) biosynthesis and forms a complex with the UQ biogenesis factor UbiJ.
Loiseau L, Fyfe C, Aussel L, Hajj Chehade M, Hernández SB, Faivre B, Hamdane D, Mellot-Draznieks C, Rascalou B, Pelosi L, Velours C, Cornu D, Lombard M, Casadesús J, Pierrel F, Fontecave M, Barras F. Loiseau L, et al. Among authors: pierrel f. J Biol Chem. 2017 Jul 14;292(28):11937-11950. doi: 10.1074/jbc.M117.789164. Epub 2017 May 30. J Biol Chem. 2017. PMID: 28559279 Free PMC article.
Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity.
Stefely JA, Licitra F, Laredj L, Reidenbach AG, Kemmerer ZA, Grangeray A, Jaeg-Ehret T, Minogue CE, Ulbrich A, Hutchins PD, Wilkerson EM, Ruan Z, Aydin D, Hebert AS, Guo X, Freiberger EC, Reutenauer L, Jochem A, Chergova M, Johnson IE, Lohman DC, Rush MJP, Kwiecien NW, Singh PK, Schlagowski AI, Floyd BJ, Forsman U, Sindelar PJ, Westphall MS, Pierrel F, Zoll J, Dal Peraro M, Kannan N, Bingman CA, Coon JJ, Isope P, Puccio H, Pagliarini DJ. Stefely JA, et al. Among authors: pierrel f. Mol Cell. 2016 Aug 18;63(4):608-620. doi: 10.1016/j.molcel.2016.06.030. Epub 2016 Aug 4. Mol Cell. 2016. PMID: 27499294 Free PMC article.
The COQ2 genotype predicts the severity of coenzyme Q10 deficiency.
Desbats MA, Morbidoni V, Silic-Benussi M, Doimo M, Ciminale V, Cassina M, Sacconi S, Hirano M, Basso G, Pierrel F, Navas P, Salviati L, Trevisson E. Desbats MA, et al. Among authors: pierrel f. Hum Mol Genet. 2016 Oct 1;25(19):4256-4265. doi: 10.1093/hmg/ddw257. Epub 2016 Aug 4. Hum Mol Genet. 2016. PMID: 27493029
Demethylmenaquinol is a substrate of Escherichia coli nitrate reductase A (NarGHI) and forms a stable semiquinone intermediate at the NarGHI quinol oxidation site.
Rendon J, Pilet E, Fahs Z, Seduk F, Sylvi L, Hajj Chehade M, Pierrel F, Guigliarelli B, Magalon A, Grimaldi S. Rendon J, et al. Among authors: pierrel f. Biochim Biophys Acta. 2015 Aug;1847(8):739-47. doi: 10.1016/j.bbabio.2015.05.001. Epub 2015 May 12. Biochim Biophys Acta. 2015. PMID: 25976528 Free article.
Biosynthesis and physiology of coenzyme Q in bacteria.
Aussel L, Pierrel F, Loiseau L, Lombard M, Fontecave M, Barras F. Aussel L, et al. Among authors: pierrel f. Biochim Biophys Acta. 2014 Jul;1837(7):1004-11. doi: 10.1016/j.bbabio.2014.01.015. Epub 2014 Jan 28. Biochim Biophys Acta. 2014. PMID: 24480387 Free article. Review.
ubiI, a new gene in Escherichia coli coenzyme Q biosynthesis, is involved in aerobic C5-hydroxylation.
Hajj Chehade M, Loiseau L, Lombard M, Pecqueur L, Ismail A, Smadja M, Golinelli-Pimpaneau B, Mellot-Draznieks C, Hamelin O, Aussel L, Kieffer-Jaquinod S, Labessan N, Barras F, Fontecave M, Pierrel F. Hajj Chehade M, et al. Among authors: pierrel f. J Biol Chem. 2013 Jul 5;288(27):20085-92. doi: 10.1074/jbc.M113.480368. Epub 2013 May 24. J Biol Chem. 2013. PMID: 23709220 Free PMC article.
63 results