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Page 1
EULAR recommendations for the management of Sjögren's syndrome with topical and systemic therapies.
Ramos-Casals M, Brito-Zerón P, Bombardieri S, Bootsma H, De Vita S, Dörner T, Fisher BA, Gottenberg JE, Hernandez-Molina G, Kocher A, Kostov B, Kruize AA, Mandl T, Ng WF, Retamozo S, Seror R, Shoenfeld Y, Sisó-Almirall A, Tzioufas AG, Vitali C, Bowman S, Mariette X; EULAR-Sjögren Syndrome Task Force Group. Ramos-Casals M, et al. Ann Rheum Dis. 2020 Jan;79(1):3-18. doi: 10.1136/annrheumdis-2019-216114. Epub 2019 Oct 31. Ann Rheum Dis. 2020. PMID: 31672775 Free article.
The recommendations address the use of topical oral (saliva substitutes) and ocular (artificial tear drops, topical non-steroidal anti-inflammatory drugs, topical corticosteroids, topical CyA, serum tear drops) therapies, oral muscarinic agonists (pilocarpine, cevimelin …
The recommendations address the use of topical oral (saliva substitutes) and ocular (artificial tear drops, topical non-steroidal anti-infla …
Medication-Induced Xerostomia and Hyposalivation in the Elderly: Culprits, Complications, and Management.
Barbe AG. Barbe AG. Drugs Aging. 2018 Oct;35(10):877-885. doi: 10.1007/s40266-018-0588-5. Drugs Aging. 2018. PMID: 30187289 Review.
All healthcare professionals are encouraged to investigate dry mouth symptoms among their patients, since diagnosis can easily be performed within daily clinical practice. ...The most commonly prescribed pharmaceutical treatment options for dry mouth a …
All healthcare professionals are encouraged to investigate dry mouth symptoms among their patients, since diagnosis can easily …
Pilocarpine for Medication-induced Dry Mouth and Dry Eyes: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines.
Li KX, Loshak H. Li KX, et al. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2019 Dec 11. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2019 Dec 11. PMID: 32129966 Free Books & Documents. Review.
Xerostomia is defined as dry mouth due to reduced salivary flow. As a result of this, patients may have decreased efficiency in chewing and swallowing and an increased risk of dental disease, such as dental caries (i.e., dental decay). ...The purpose of this …
Xerostomia is defined as dry mouth due to reduced salivary flow. As a result of this, patients may have decreased effic …
Pilocarpine for Sjogren's Syndrome-Induced Dry Mouth and Dry Eyes: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines.
Freige C, Ford C. Freige C, et al. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2020 Jan 21. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2020 Jan 21. PMID: 33048480 Free Books & Documents. Review.
Both dry eyes and dry mouth can be managed with a variety of non-pharmacological and non-prescription therapies. Pharmacological therapy with muscarinic agonists (i.e., pilocarpine, cevimeline) which stimulate exocrine glands, can also be used t …
Both dry eyes and dry mouth can be managed with a variety of non-pharmacological and non-prescription therapies. Pharma …
Cevimeline (Evoxac) for dry mouth.
[No authors listed] [No authors listed] Med Lett Drugs Ther. 2000 Aug 7;42(1084):70. Med Lett Drugs Ther. 2000. PMID: 10932302 No abstract available.
Distinct effects of cevimeline and pilocarpine on salivary mechanisms, cardiovascular response and thirst sensation in rats.
Ono K, Inagaki T, Iida T, Wakasugi-Sato N, Hosokawa R, Inenaga K. Ono K, et al. Arch Oral Biol. 2012 Apr;57(4):421-8. doi: 10.1016/j.archoralbio.2011.09.013. Epub 2011 Nov 17. Arch Oral Biol. 2012. PMID: 22099058
OBJECTIVE: Cevimeline and pilocarpine (muscarinic receptor agonists) are used as sialogogues in xerostomia treatment. ...In parotid cells, cevimeline increased the intracellular Ca(2+) concentration in a similar manner to pilocarpine, but at a h …
OBJECTIVE: Cevimeline and pilocarpine (muscarinic receptor agonists) are used as sialogogues in xerostomia treatment. . …
Salivary enhancement therapies.
Fox PC. Fox PC. Caries Res. 2004 May-Jun;38(3):241-6. doi: 10.1159/000077761. Caries Res. 2004. PMID: 15153695 Review.
A large number of systemic agents have also been proposed as secretagogues, but only a few have shown consistent salivary enhancing properties in well-designed, controlled trials. Pilocarpine has been shown to improve symptoms of oral dryness and to increase salivary outpu …
A large number of systemic agents have also been proposed as secretagogues, but only a few have shown consistent salivary enhancing properti …
Buccal drug delivery technologies for patient-centred treatment of radiation-induced xerostomia (dry mouth).
Malallah OS, Garcia CMA, Proctor GB, Forbes B, Royall PG. Malallah OS, et al. Int J Pharm. 2018 Apr 25;541(1-2):157-166. doi: 10.1016/j.ijpharm.2018.02.004. Epub 2018 Feb 6. Int J Pharm. 2018. PMID: 29425763 Free article. Review.
Radiotherapy is a life-saving treatment for head and neck cancers, but almost 100% of patients develop dry mouth (xerostomia) because of radiation-induced damage to their salivary glands. ...The current management of xerostomia is the application of sa …
Radiotherapy is a life-saving treatment for head and neck cancers, but almost 100% of patients develop dry mouth (xerostomi …
Salivary Gland Hypofunction and/or Xerostomia Induced by Nonsurgical Cancer Therapies: ISOO/MASCC/ASCO Guideline.
Mercadante V, Jensen SB, Smith DK, Bohlke K, Bauman J, Brennan MT, Coppes RP, Jessen N, Malhotra NK, Murphy B, Rosenthal DI, Vissink A, Wu J, Saunders DP, Peterson DE. Mercadante V, et al. J Clin Oncol. 2021 Sep 1;39(25):2825-2843. doi: 10.1200/JCO.21.01208. Epub 2021 Jul 20. J Clin Oncol. 2021. PMID: 34283635
For the prevention of salivary gland hypofunction and/or xerostomia in patients with head and neck cancer, there is high-quality evidence for tissue-sparing radiation modalities. ...For patients with head and neck cancer, oral pilocarpine and oral cevimeline, …
For the prevention of salivary gland hypofunction and/or xerostomia in patients with head and neck cancer, there is high-quality evid …
Treatment of xerostomia in Sjogren's syndrome - what effect does it have on the oral microbiome?
Muszyński D, Kucharski R, Marek-Trzonkowska N, Kalinowska M, Brzóska A, Bolcewicz M, Kalinowski L, Kaźmierczak-Siedlecka K. Muszyński D, et al. Front Cell Infect Microbiol. 2025 Apr 14;15:1484951. doi: 10.3389/fcimb.2025.1484951. eCollection 2025. Front Cell Infect Microbiol. 2025. PMID: 40297612 Free PMC article. Review.
The disease results in dryness of the eyeball or mouth, which often occur simultaneously. Agents used to treat Sjogren's syndrome may improve oral hydration and the patient's quality of life. There are several pharmacological and non-pharmacological agents used to treat si …
The disease results in dryness of the eyeball or mouth, which often occur simultaneously. Agents used to treat Sjogren's syndrome may …
77 results