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1972 5
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1974 21
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1980 34
1981 32
1982 33
1983 54
1984 54
1985 66
1986 61
1987 51
1988 53
1989 70
1990 71
1991 59
1992 33
1993 49
1994 22
1995 45
1996 44
1997 44
1998 33
1999 39
2000 70
2001 63
2002 78
2003 121
2004 104
2005 118
2006 143
2007 182
2008 192
2009 182
2010 189
2011 194
2012 189
2013 188
2014 182
2015 210
2016 221
2017 185
2018 92
2019 39
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2023 41
2024 10

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Development of new nanofibrous nerve conduits by PCL-Chitosan-Hyaluronic acid containing Piracetam-Vitamin B12 for sciatic nerve: A rat model.
Jafarisavari Z, Ai J, Abbas Mirzaei S, Soleimannejad M, Asadpour S. Jafarisavari Z, et al. Int J Pharm. 2024 Mar 7;655:123978. doi: 10.1016/j.ijpharm.2024.123978. Online ahead of print. Int J Pharm. 2024. PMID: 38458406
Here, we developed new nanofibrous NGCs using polycaprolactone (PCL) and chitosan (CH) containing piracetam (PIR)/vitamin B12(VITB12) with an electrospinning method. ...
Here, we developed new nanofibrous NGCs using polycaprolactone (PCL) and chitosan (CH) containing piracetam (PIR)/vitamin B12(VITB12) …
Insights into the management of Lewy body dementia: a scoping review.
Khan SA, Khan S, Kausar H, Shah R, Luitel A, Gautam S, Parajuli SB, Rauniyar VK, Khan MAB. Khan SA, et al. Ann Med Surg (Lond). 2024 Jan 3;86(2):930-942. doi: 10.1097/MS9.0000000000001664. eCollection 2024 Feb. Ann Med Surg (Lond). 2024. PMID: 38333295 Free PMC article. Review.
Together with that, levodopa, antipsychotics, armodafinil, piracetam, and traditional medications like yokukansan were also used, when indicated. ...
Together with that, levodopa, antipsychotics, armodafinil, piracetam, and traditional medications like yokukansan were also used, whe …
The neuroprotective effects of Piracetam on cisplatin-induced cognitive decline.
Elbeltagy M, Khraisat B, AlZoubi L, Hmoud L, AlJeady A, Yousef M, Salman A. Elbeltagy M, et al. Int J Neurosci. 2023 Dec 28:1-8. doi: 10.1080/00207454.2023.2300733. Online ahead of print. Int J Neurosci. 2023. PMID: 38153438
It also investigates the potential neuroprotective effects of Piracetam, which is a nootropic drug recognized for improving cognitive ability. ...Future research will be needed to study Piracetam's effect on mice with brain cancer after Cisplatin treatment in order …
It also investigates the potential neuroprotective effects of Piracetam, which is a nootropic drug recognized for improving cognitive …
Hexahydrocurcumin Attenuates Neuronal Injury and Modulates Synaptic Plasticity in Chronic Cerebral Hypoperfusion in Rats.
Jearjaroen P, Thangwong P, Tocharus C, Lungkaphin A, Chaichompoo W, Srijun J, Suksamrarn A, Tocharus J. Jearjaroen P, et al. Mol Neurobiol. 2023 Dec 12. doi: 10.1007/s12035-023-03821-x. Online ahead of print. Mol Neurobiol. 2023. PMID: 38087168
The aim of study was to explore the mechanism by which hexahydrocurcumin (HHC) attenuates oxidative stress, amyloidogenesis, phosphorylated Tau (pTau) expression, neuron synaptic function, and cognitive impairment and also the potential mechanisms involved in induced permanent oc …
The aim of study was to explore the mechanism by which hexahydrocurcumin (HHC) attenuates oxidative stress, amyloidogenesis, phosphorylated …
Effect of organic acids on the solid-state polymorphic phase transformation of piracetam.
Fan F, Xu S, Guo M, Cai T. Fan F, et al. Int J Pharm. 2023 Nov 25;647:123532. doi: 10.1016/j.ijpharm.2023.123532. Epub 2023 Oct 21. Int J Pharm. 2023. PMID: 37871868
Here, we report that low-content organic acids can exhibit distinct effects on the solid-state polymorphic phase transformation of piracetam (PCM), a nootropic drug used for memory enhancement. The addition of 1 mol% citric acid (CA) and tricarballylic acid (TA) can signif …
Here, we report that low-content organic acids can exhibit distinct effects on the solid-state polymorphic phase transformation of pirace
Formulating treatment of major psychiatric disorders: algorithm targets the dominantly affected brain cell-types.
Fessel J. Fessel J. Discov Ment Health. 2023 Jan 5;3(1):3. doi: 10.1007/s44192-022-00029-8. Discov Ment Health. 2023. PMID: 37861813 Free PMC article. Review.
The algorithm performs because functions of some or all the affected cell-types benefit from several available drugs: clemastine, dantrolene, erythropoietin, fingolimod, fluoxetine, lithium, memantine, minocycline, pioglitazone, piracetam, and riluzole PROCEDURES/FINDINGS: …
The algorithm performs because functions of some or all the affected cell-types benefit from several available drugs: clemastine, dantrolene …
Hepatic encephalopathy complications are diminished by piracetam via the interaction between mitochondrial function, oxidative stress, inflammatory response, and locomotor activity.
Niknahad H, Mobasheri A, Arjmand A, Rafiei E, Alidaee S, Razavi H, Bagheri S, Rezaei H, Sabouri S, Najibi A, Khodaei F, Kashani SMA, Ommati MM, Heidari R. Niknahad H, et al. Heliyon. 2023 Sep 29;9(10):e20557. doi: 10.1016/j.heliyon.2023.e20557. eCollection 2023 Oct. Heliyon. 2023. PMID: 37810869 Free PMC article.
Piracetam could significantly diminish oxidative stress and improve brain mitochondrial function. ...These data suggest piracetam as a neuroprotective agent which could be repurposed for the management of HE....
Piracetam could significantly diminish oxidative stress and improve brain mitochondrial function. ...These data suggest piracetam
Neuroprotective effects of riluzole in Alzheimer's disease: A comprehensive review.
Golmohammadi M, Mahmoudian M, Hasan EK, Alshahrani SH, Romero-Parra RM, Malviya J, Hjazi A, Najm MAA, Almulla AF, Zamanian MY, Kadkhodaei M, Mousavi N. Golmohammadi M, et al. Fundam Clin Pharmacol. 2024 Apr;38(2):225-237. doi: 10.1111/fcp.12955. Epub 2023 Sep 27. Fundam Clin Pharmacol. 2024. PMID: 37753585 Review.
According to previous studies, eight drugs, namely, dantrolene, erythropoietin, lithium, memantine, minocycline, piracetam, riluzole, and silymarin, have been found to target multiple pathways that are involved in the development of AD. ...
According to previous studies, eight drugs, namely, dantrolene, erythropoietin, lithium, memantine, minocycline, piracetam, riluzole, …
Pyrolae herba alleviates cognitive impairment via hippocampal TREM2 signaling modulating neuroinflammation and neurogenesis in lipopolysaccharide-treated mice.
Sun Y, Zhang H, Liu R, Huang R, Zhang X, Zhou S, Wu L, Zhu B, Wu H. Sun Y, et al. J Ethnopharmacol. 2024 Jan 30;319(Pt 2):117214. doi: 10.1016/j.jep.2023.117214. Epub 2023 Sep 21. J Ethnopharmacol. 2024. PMID: 37739108
RESULTS: The results revealed that LPS contributed to CI, and PH or piracetam treatment significantly ameliorated CI in MWM test. LPS contributed to increasing expressions of TNF-alpha and IL-1beta in serum and hippocampus, which both reversed by PH or piracetam. .. …
RESULTS: The results revealed that LPS contributed to CI, and PH or piracetam treatment significantly ameliorated CI in MWM test. LPS …
Docosahexaenoic Acid Plus Piracetam Versus Piracetam Alone for Treatment of Breath-Holding Spells in Children: A Randomized Clinical Trial.
Salamah A, Darwish AH. Salamah A, et al. Pediatr Neurol. 2023 Nov;148:32-36. doi: 10.1016/j.pediatrneurol.2023.08.003. Epub 2023 Aug 9. Pediatr Neurol. 2023. PMID: 37651975 Clinical Trial.
This study aimed to compare the efficacy of docosahexaenoic acid (DHA) plus piracetam with piracetam alone in reducing the frequency and severity of BHS in infants and preschool children. ...CONCLUSION: DHA plus piracetam is more effective than piracetam
This study aimed to compare the efficacy of docosahexaenoic acid (DHA) plus piracetam with piracetam alone in reducing the fre …
Treatment Efficacy of Pharmacotherapies for Frontotemporal Dementia: A Network Meta-Analysis of Randomized Controlled Trials.
Huang MH, Zeng BS, Tseng PT, Hsu CW, Wu YC, Tu YK, Stubbs B, Carvalho AF, Liang CS, Chen TY, Chen YW, Su KP. Huang MH, et al. Am J Geriatr Psychiatry. 2023 Dec;31(12):1062-1073. doi: 10.1016/j.jagp.2023.06.013. Epub 2023 Jul 6. Am J Geriatr Psychiatry. 2023. PMID: 37633762
Compared with placebo, high-dose oxytocin (72 international units) was associated with the greatest improvement in patients' neuropsychiatric symptoms (SMD = -1.17, 95% CIs = -2.25 to -0.08, z = -2.10, p = 0.035). Piracetam significantly worsened neuropsychiatric symptoms …
Compared with placebo, high-dose oxytocin (72 international units) was associated with the greatest improvement in patients' neuropsychiatri …
Investigation of Cognitive Impairment in the Course of Post-COVID Syndrome.
Dimitrova M, Marinova Y, Dilkov D. Dimitrova M, et al. Diagnostics (Basel). 2023 Aug 18;13(16):2703. doi: 10.3390/diagnostics13162703. Diagnostics (Basel). 2023. PMID: 37627961 Free PMC article.
Deviations from the norm on the MMSE, as well as on the Boston Naming Test, were found in the group of patients with cortical atrophy (mild to moderate aphasia). Neuroprotective agents such as Citicoline, Piracetam and Memantine were prescribed to the patients with evident …
Deviations from the norm on the MMSE, as well as on the Boston Naming Test, were found in the group of patients with cortical atrophy (mild …
Environmentally sustainable DRS-FTIR probe assisted by chemometric tools for quality control analysis of cinnarizine and piracetam having diverged concentration ranges: Validation, greenness, and whiteness studies.
Attia KAM, El-Olemy A, Serag A, Abbas AEF, Eid SM. Attia KAM, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2023 Dec 5;302:123161. doi: 10.1016/j.saa.2023.123161. Epub 2023 Jul 16. Spectrochim Acta A Mol Biomol Spectrosc. 2023. PMID: 37478754
A novel diffuse reflectance fourier transform infrared spectroscopic method accompanied by chemometrics was optimized to fulfill the white analytical chemistry and green analytical chemistry principles for the quantification of cinnarizine and piracetam for the first time …
A novel diffuse reflectance fourier transform infrared spectroscopic method accompanied by chemometrics was optimized to fulfill the white a …
The Outcome of Antipsychotics-induced Tardive Syndromes: A Ten-year Follow-up Study.
Chou PC, Lee Y, Chang YY, Lin PY, Wang LJ. Chou PC, et al. Clin Psychopharmacol Neurosci. 2023 Aug 31;21(3):488-498. doi: 10.9758/cpn.22.1000. Clin Psychopharmacol Neurosci. 2023. PMID: 37424417 Free PMC article.
During the 10-year follow-up period, the remission rate of TS was 74.3%. The use of antioxidants including vitamin B6 and piracetam was related to the remission of TS. Patients with tardive dystonia had a higher remission rate (87.5%) compared to TD (70%). ...
During the 10-year follow-up period, the remission rate of TS was 74.3%. The use of antioxidants including vitamin B6 and piracetam w …
Novel pharmacotherapy targeting the positive symptoms of schizophrenia.
Capuzzi E, Caldiroli A, Quitadamo C, Butturini F, Surace T, Clerici M, Buoli M. Capuzzi E, et al. Expert Opin Pharmacother. 2023 Sep-Dec;24(14):1623-1648. doi: 10.1080/14656566.2023.2231346. Epub 2023 Jul 10. Expert Opin Pharmacother. 2023. PMID: 37401388 Review.
EXPERT OPINION: The most promising compounds include: lamotrigine, pro-cognitive-compounds (donepezil - in the short term, idazoxan and piracetam) and drugs acting partially or totally outside the Central Nervous System (CNS) (anti-inflammatory drugs: celecoxib, methotrexa …
EXPERT OPINION: The most promising compounds include: lamotrigine, pro-cognitive-compounds (donepezil - in the short term, idazoxan and p
Efficacy of acupuncture and pharmacological therapies for vascular cognitive impairment with no dementia: a network meta-analysis.
Li R, Xu C, Zhong P, Wang K, Luo Y, Xiao L, Dai X, Han J, Zhang X. Li R, et al. Front Aging Neurosci. 2023 Jun 15;15:1181160. doi: 10.3389/fnagi.2023.1181160. eCollection 2023. Front Aging Neurosci. 2023. PMID: 37396654 Free PMC article.
In terms of the primary outcome, manual acupuncture plus herbal decoction was considered to be the most effective intervention (P = 91.41%), followed by electroacupuncture (P = 60.77%) and manual acupuncture plus piracetam (P = 42.58%), whereas donepezil hydrochloride rank …
In terms of the primary outcome, manual acupuncture plus herbal decoction was considered to be the most effective intervention (P = 91.41%), …
Unauthorized ingredients in "nootropic" dietary supplements: A review of the history, pharmacology, prevalence, international regulations, and potential as doping agents.
Jędrejko K, Catlin O, Stewart T, Anderson A, Muszyńska B, Catlin DH. Jędrejko K, et al. Drug Test Anal. 2023 Aug;15(8):803-839. doi: 10.1002/dta.3529. Epub 2023 Jun 25. Drug Test Anal. 2023. PMID: 37357012 Review.
Many popular nootropics are unauthorized food or DS ingredients according to the European Commission including huperzine A, yohimbine, and dimethylaminoethanol; unapproved pharmaceuticals like phenibut or emoxypine (mexidol); previously registered drugs like meclofenoxate or rese …
Many popular nootropics are unauthorized food or DS ingredients according to the European Commission including huperzine A, yohimbine, and d …
Therapeutic enhancing potential of piracetam with diethylstilbestrol in prevention of grand-mal seizures in rats: inhibition of PI3K/Akt/mTOR signaling pathway and IL-1beta, IL-6, TNF-alpha cytokines levels.
Pottoo FH, Salahuddin M, Khan FA, Alsaeed WJ, Albaqshi BT, Rahman JU, Gomaa MS, Salama I, Alomary MN, Beigh S. Pottoo FH, et al. Eur Rev Med Pharmacol Sci. 2023 May;27(10):4735-4751. doi: 10.26355/eurrev_202305_32485. Eur Rev Med Pharmacol Sci. 2023. PMID: 37259757 Free article.
The current study sought to ascertain if the therapeutic interactions between piracetam and diethylstilbestrol may prevent grand-mal seizures in rats. MATERIALS AND METHODS: Piracetam (PIR; 10 and 20 mg/kg) and diethylstilbestrol (DES; 10 and 20 mg/kg) alone as a lo …
The current study sought to ascertain if the therapeutic interactions between piracetam and diethylstilbestrol may prevent grand-mal …
Ameliorative effects of 6‑gingerol in cerebral ischemia are mediated via the activation of antioxidant and anti‑inflammatory pathways.
Kongsui R, Jittiwat J. Kongsui R, et al. Biomed Rep. 2023 Feb 15;18(4):26. doi: 10.3892/br.2023.1608. eCollection 2023 Apr. Biomed Rep. 2023. PMID: 36909941 Free PMC article.
Male Wistar rats, weighing 250-300 g, were divided into the following six groups: i) The control; ii) right middle cerebral artery occlusion (Rt.MCAO) + vehicle; iii) Rt.MCAO + piracetam; iv) Rt.MCAO + 6-gingerol (6-Gin) at 5 mg/kg body weight (BW); v) Rt.MCAO + 6-Gin at 1 …
Male Wistar rats, weighing 250-300 g, were divided into the following six groups: i) The control; ii) right middle cerebral artery occlusion …
Estrogenic and anti-amnesic potential of Millettia griffoniana Baill. (Fabaceae) ethanolic extract on scopolamine-induced memory impairment in ovariectomized Wistar rats.
Rebe RN, Lembe JT, Nyayi SDG, Ngatanko HHA, Wado EK, Ketcha Wanda GJM, Ndinteh DT, Njamen D, Zingue S, Foyet HS. Rebe RN, et al. J Ethnopharmacol. 2023 Jun 12;309:116325. doi: 10.1016/j.jep.2023.116325. Epub 2023 Mar 9. J Ethnopharmacol. 2023. PMID: 36906157
., i.p.) injection four days/week and M. griffoniana extract as well as piracetam (standard) were administered daily for 2 weeks to evaluate the extract's neuroprotective potential. ...
., i.p.) injection four days/week and M. griffoniana extract as well as piracetam (standard) were administered daily for 2 weeks to e …
Cure of Alzheimer's Dementia Requires Addressing All of the Affected Brain Cell Types.
Fessel J. Fessel J. J Clin Med. 2023 Mar 4;12(5):2049. doi: 10.3390/jcm12052049. J Clin Med. 2023. PMID: 36902833 Free PMC article.
The available drugs include clemastine, dantrolene, erythropoietin, fingolimod, fluoxetine, lithium, memantine, minocycline, pioglitazone, piracetam, and riluzole. This article describes the ways by which the individual cell types contribute to AD's pathogenesis and how ea …
The available drugs include clemastine, dantrolene, erythropoietin, fingolimod, fluoxetine, lithium, memantine, minocycline, pioglitazone, …
Antiepileptic Drugs Modulate Alzheimer-Related Tau Aggregation in a Neuronal Activity-Independent Manner.
Ito Y, Takeda S, Moroi S, Nakajima T, Oyama A, Miki K, Sugihara N, Takami Y, Takeya Y, Shimamura M, Rakugi H, Morishita R. Ito Y, et al. Dement Geriatr Cogn Disord. 2023;52(2):108-116. doi: 10.1159/000529915. Epub 2023 Mar 6. Dement Geriatr Cogn Disord. 2023. PMID: 36878194
RESULTS: The assay results revealed that phenobarbital inhibited tau aggregation, whereas sodium valproate, gabapentin, and piracetam promoted tau aggregation. In the cell-free tau aggregation assay using ThT, we confirmed that phenobarbital significantly inhibited tau agg …
RESULTS: The assay results revealed that phenobarbital inhibited tau aggregation, whereas sodium valproate, gabapentin, and piracetam
The protective effect of taurine, piracetam and vinpocetine on etoposide-induced inflammation and brain injury in the serum of female albino rats.
Mohammed AS, Al-Hassani AN, Alrawi RA, Tawfeeq RD. Mohammed AS, et al. Ecancermedicalscience. 2023 Jan 23;17:1499. doi: 10.3332/ecancer.2023.1499. eCollection 2023. Ecancermedicalscience. 2023. PMID: 36816786 Free PMC article.
The current research investigates the protective potential of taurine, piracetam and vinpocetine on serum biomarkers associated with inflammation and brain injury induced by ETP in a rodent model. ...Moreover, ETP treatment resulted in upregulation of glial fibrillary acid …
The current research investigates the protective potential of taurine, piracetam and vinpocetine on serum biomarkers associated with …
Neuroprotective effect of piracetam-loaded magnetic chitosan nanoparticles against thiacloprid-induced neurotoxicity in albino rats.
Abomosallam M, Hendam BM, Abdallah AA, Refaat R, Elshatory A, Gad El Hak HN. Abomosallam M, et al. Inflammopharmacology. 2023 Apr;31(2):943-965. doi: 10.1007/s10787-023-01151-x. Epub 2023 Feb 6. Inflammopharmacology. 2023. PMID: 36745244 Free PMC article.
The purpose of this study was to investigate the relationship between TH exposure and memory dysfunction in rats, as well as the potential protective effect of piracetam and piracetam-loaded magnetic chitosan nanoparticles (PMC NPs). ...However, PMC NPs administrati …
The purpose of this study was to investigate the relationship between TH exposure and memory dysfunction in rats, as well as the potential p …
Experience of Subcutaneous Levetiracetam in Palliative Care.
Gaviria-Carrillo M, Mora-Muñoz L, Diaz-Forero AF, Vargas-Osorio J, Torres-Ballesteros V, Estrada J, Vélez Van Meerbeke A, Rodríguez JH. Gaviria-Carrillo M, et al. Med Princ Pract. 2023;32(1):90-95. doi: 10.1159/000529461. Epub 2023 Feb 2. Med Princ Pract. 2023. PMID: 36731437 Free PMC article.
Compound Danshen Dripping Pills moderate intestinal flora and the TLR4/MyD88/NF-κB signaling pathway in alleviating cognitive dysfunction in type 2 diabetic KK-Ay mice.
Fan X, Zhang Y, Song Y, Zhao Y, Xu Y, Guo F, Shao M, Ma X, Zhang W, Wei F, Qin G. Fan X, et al. Phytomedicine. 2023 Mar;111:154656. doi: 10.1016/j.phymed.2023.154656. Epub 2023 Jan 10. Phytomedicine. 2023. PMID: 36682300
METHODS: For 12 weeks, KK-Ay mice, a spontaneous T2DM model, were intragastrically administered various doses of CDDP solution or an equivalent volume of water, and the nootropic drug piracetam was orally administered as a positive control. At the 12th week, cognition was …
METHODS: For 12 weeks, KK-Ay mice, a spontaneous T2DM model, were intragastrically administered various doses of CDDP solution or an equival …
Effect of date molasses on levetiracetam pharmacokinetics in healthy rats.
Abu Dayyih W, Layth R, Hailat M, Alkhawaja B, Al Tamimi L, Zakaraya Z, Aburumman A, Al Dmour N, Saadh MJ, Al-Matubsi H, Aldalaen SM. Abu Dayyih W, et al. Sci Rep. 2023 Jan 14;13(1):758. doi: 10.1038/s41598-023-28074-5. Sci Rep. 2023. PMID: 36641484 Free PMC article.
Ameliorating Effect of Standardized Extract From Textured Soy Protein (Glycine max L.) on Memory Deficit and Learning Insufficiency in Scopolamine-induced Amnesia.
Mandegary A, Sharififar F, Sheibani V, Nasehi N, Asadi A, Mirtadzadini M, Hassanabadi N. Mandegary A, et al. Basic Clin Neurosci. 2022 Jul-Aug;13(4):501-510. doi: 10.32598/bcn.2021.2446.1. Epub 2022 Jul 1. Basic Clin Neurosci. 2022. PMID: 36561237 Free PMC article.
Learning capacity and spatial memory were evaluated using passive avoidance test (PAT) and Morris water maze (MWM) methods compared to physostigmine and piracetam. RESULTS: The greatest antioxidant and anticholinesterase effect was observed for TSPE, which significantly pr …
Learning capacity and spatial memory were evaluated using passive avoidance test (PAT) and Morris water maze (MWM) methods compared to physo …
Piracetam as a Therapeutic Agent for Doxorubicin-Induced Cognitive Deficits by Enhancing Cholinergic Functions and Reducing Neuronal Inflammation, Apoptosis, and Oxidative Stress in Rats.
Mani V, Rabbani SI, Shariq A, Amirthalingam P, Arfeen M. Mani V, et al. Pharmaceuticals (Basel). 2022 Dec 14;15(12):1563. doi: 10.3390/ph15121563. Pharmaceuticals (Basel). 2022. PMID: 36559014 Free PMC article.
Cancer chemotherapy is known to cause cognitive defects in patients. Our study investigated the effect of piracetam (PIRA; 200 or 400 mg/kg) against doxorubicin (DOX)-induced cognitive deficits in a rat model. ...
Cancer chemotherapy is known to cause cognitive defects in patients. Our study investigated the effect of piracetam (PIRA; 200 or 400 …
Levetiracetam-associated pancytopenia.
Unkun R, Kizilkilic EK, Delil S, Kemerdere R, Ozkara C. Unkun R, et al. Acta Neurol Belg. 2023 Aug;123(4):1625-1626. doi: 10.1007/s13760-022-02138-1. Epub 2022 Nov 7. Acta Neurol Belg. 2023. PMID: 36344882 No abstract available.
Extensive pharmacokinetic variability of Levetiracetam. ¿Are doctors aware?
de Toledo M, de la Fuente E, Ramos C, Ferreiros-Martinez R, Muro I, Vieira Campos A, de Toledo MP, Lagares A, Sobrado M, Ovejero-Benito MC. de Toledo M, et al. Epilepsy Res. 2022 Nov;187:107029. doi: 10.1016/j.eplepsyres.2022.107029. Epub 2022 Sep 29. Epilepsy Res. 2022. PMID: 36272308
Neuroprotective Effects of the Ethanolic Leaf Extract of Crassocephalum crepidioides (Asteracaeae) on Diazepam-Induced Amnesia in Mice.
Galba Jean B, Alice Irène F, Albert Donatien A, Hervé-Hervé NA, Bertrand BM, Nanou Gael AD, Merline NY, Franklik ZG, Bertrand DA, Théophile D. Galba Jean B, et al. Adv Pharmacol Pharm Sci. 2022 Sep 28;2022:1919469. doi: 10.1155/2022/1919469. eCollection 2022. Adv Pharmacol Pharm Sci. 2022. PMID: 36212180 Free PMC article.
The normal control and negative control groups received 2% ethanol per os, the positive control group received piracetam (150 mg/kg, p.o), and three experimental groups were treated with three doses of ethanolic leaf extract of Cc (100, 200, and 400 mg/kg, p.o). ...
The normal control and negative control groups received 2% ethanol per os, the positive control group received piracetam (150 mg/kg, …
Reconsideration of the Benefits of Pharmacological Interventions for the Attenuation of the Cognitive Adverse Effects of Electroconvulsive Therapy.
Andrade C. Andrade C. J Clin Psychiatry. 2022 Oct 3;83(5):22f14668. doi: 10.4088/JCP.22f14668. J Clin Psychiatry. 2022. PMID: 36198062 Free article.
Meta-analysis was not possible for the remaining interventions, including piracetam, melatonin, pemoline, nortriptyline, herbal agents, drugs acting on the cortisol pathway, opioid receptor antagonists, l-tryptophan, vasopressin analogs, calcium channel blockers, and other …
Meta-analysis was not possible for the remaining interventions, including piracetam, melatonin, pemoline, nortriptyline, herbal agent …
Synthesis, Neuroprotective Effect and Physicochemical Studies of Novel Peptide and Nootropic Analogues of Alzheimer Disease Drug.
Chayrov R, Volkova T, Perlovich G, Zeng L, Li Z, Štícha M, Liu R, Stankova I. Chayrov R, et al. Pharmaceuticals (Basel). 2022 Sep 5;15(9):1108. doi: 10.3390/ph15091108. Pharmaceuticals (Basel). 2022. PMID: 36145329 Free PMC article.
In this work, we evaluate the neuroprotective action of four memantine analogues of glycine derivatives, including glycyl-glycine, glycyl-glycyl-glycine, sarcosine, dimethylglycine and three conjugates with nootropics, modafinil, piracetam and picamilon. The new structural …
In this work, we evaluate the neuroprotective action of four memantine analogues of glycine derivatives, including glycyl-glycine, glycyl-gl …
Effect of roll compaction pressure on the properties of high drug-loaded piracetam granules and tablets.
Mohylyuk V. Mohylyuk V. Drug Dev Ind Pharm. 2022 Sep;48(9):425-437. doi: 10.1080/03639045.2022.2123499. Epub 2022 Sep 16. Drug Dev Ind Pharm. 2022. PMID: 36082906
OBJECTIVE: The aim of this study was to use an alternative granulation technique, solventless roll compaction, and to investigate the effect of the roll compaction pressure on the properties of granules and high-drug-loaded (80%, w/w) immediate release piracetam tablets. S …
OBJECTIVE: The aim of this study was to use an alternative granulation technique, solventless roll compaction, and to investigate the effect …
Prospective Evaluation of an Amide-Based Zinc Scaffold as an Anti-Alzheimer Agent: In Vitro, In Vivo, and Computational Studies.
Waseem W, Anwar F, Saleem U, Ahmad B, Zafar R, Anwar A, Saeed Jan M, Rashid U, Sadiq A, Ismail T. Waseem W, et al. ACS Omega. 2022 Jul 19;7(30):26723-26737. doi: 10.1021/acsomega.2c03058. eCollection 2022 Aug 2. ACS Omega. 2022. PMID: 35936440 Free PMC article.
Group I was injected with carboxymethylcellulose (CMC) at 1 mL/100 g dose, group II was injected with Streptozotocin (STZ) at 3 mg/kg dose, group III was injected with Piracetam acting as a standard drug at 200 mg/kg dosage, while groups IV-VII were injected with a zinc sc …
Group I was injected with carboxymethylcellulose (CMC) at 1 mL/100 g dose, group II was injected with Streptozotocin (STZ) at 3 mg/kg dose, …
An aqueous extract of Syzygium cumini protects against kainate-induced status epilepticus and amnesia: evidence for antioxidant and anti-inflammatory intervention.
Kandeda AK, Nodeina S, Mabou ST. Kandeda AK, et al. Metab Brain Dis. 2022 Oct;37(7):2581-2602. doi: 10.1007/s11011-022-01052-y. Epub 2022 Aug 2. Metab Brain Dis. 2022. PMID: 35916986
Mice were divided into 7 groups and treated as follows: normal group or kainate group received po distilled water (10 mL/kg), four test groups received Syzygium cumini (28.8, 72, 144, and 288 mg/kg, po), and the positive control group treated intraperitoneally (ip) with sodium va …
Mice were divided into 7 groups and treated as follows: normal group or kainate group received po distilled water (10 mL/kg), four test grou …
Observation on the clinical efficacy of external ventricular drain combined with intraventricular urokinase injection and intravenous piracetam in the treatment of intraventricular hemorrhage.
Cui J, Ma XL, Tong JZ, Shu M. Cui J, et al. Pak J Med Sci. 2022 May-Jun;38(5):1292-1297. doi: 10.12669/pjms.38.5.4820. Pak J Med Sci. 2022. PMID: 35799762 Free PMC article.
OBJECTIVE: To observe the clinical efficacy of external ventricular drain combined with intraventricular urokinase injection and intravenous piracetam in the treatment of intraventricular hemorrhage. METHODS: A randomized controlled trial was used in this study conducted a …
OBJECTIVE: To observe the clinical efficacy of external ventricular drain combined with intraventricular urokinase injection and intravenous …
Coexistence of SARS-CoV-2 and cerebrovascular diseases: does COVID-19 positivity trigger cerebrovascular pathologies?
Ates O, Yilmaz I, Karaarslan N, Ersoz E, Hacioglu Kasim FB, Dogan M, Ozbek H. Ates O, et al. J Infect Dev Ctries. 2022 Jun 30;16(6):981-992. doi: 10.3855/jidc.15800. J Infect Dev Ctries. 2022. PMID: 35797292 Free article.
During the treatment of cerebrovascular diseases, it was discovered that high doses of enoxaparin sodium anti-Xa are combined with apixaban or acetylsalicylic acid or clopidogrel or piracetam, and mannitol, in addition to SARS-CoV-2 treatment modalities. ...
During the treatment of cerebrovascular diseases, it was discovered that high doses of enoxaparin sodium anti-Xa are combined with apixaban …
Extract of Xylopia aethiopica and its kaurene diterpene, xylopic acid, improve learning and memory in mice.
Koomson AE, Kukuia KKE, Amoateng P, Biney RP, Tagoe TA, Mensah JA, Ameyaw EO, Torbi J, Amponsah SK. Koomson AE, et al. IBRO Neurosci Rep. 2022 Mar 29;12:249-259. doi: 10.1016/j.ibneur.2022.03.006. eCollection 2022 Jun. IBRO Neurosci Rep. 2022. PMID: 35746979 Free PMC article.
Institute of Cancer Research (ICR) mice received oral doses of the extract of Xylopia aethiopica (XAE; 30, 100 and 300 mg/kg), xylopic acid (XA; 30, 100 and mg/kg), citicoline (300 mg/kg), piracetam (300 mg/kg) or ketamine (30 mg/kg) and saline (vehicle). ...It is notewort …
Institute of Cancer Research (ICR) mice received oral doses of the extract of Xylopia aethiopica (XAE; 30, 100 and 300 mg/kg), xylopic acid …
A new green approach for the reduction of consumed solvents and simultaneous quality control analysis of several pharmaceuticals using a fast and economic RP-HPLC method; a case study for a mixture of piracetam, ketoprofen and omeprazole drugs.
Abdelgawad MA, Abdelaleem EA, Gamal M, Abourehab MAS, Abdelhamid NS. Abdelgawad MA, et al. RSC Adv. 2022 Jun 1;12(25):16301-16309. doi: 10.1039/d2ra02395d. eCollection 2022 May 23. RSC Adv. 2022. PMID: 35733689 Free PMC article.
Our novel and green RP-HPLC method is able to separate and quantify a tertiary mixture of piracetam, ketoprofen and omeprazole produced by the same manufacturers. ...
Our novel and green RP-HPLC method is able to separate and quantify a tertiary mixture of piracetam, ketoprofen and omeprazole produc …
Analysis of two mixtures containing racetams in their pharmaceuticals using simple spectrophotometric methodologies.
Mansour NM, El-Sherbiny DT, Ibrahim FA, El-Subbagh HI. Mansour NM, et al. Ann Pharm Fr. 2022 Nov;80(6):885-896. doi: 10.1016/j.pharma.2022.06.001. Epub 2022 Jun 16. Ann Pharm Fr. 2022. PMID: 35718111
BACKGROUND: Green spectrophotometric methods were developed and validated for determination of some CNS active drugs as antiepileptics and brain stimulants. OBJECTIVE: Piracetam (PIR), Levetiracetam (LEV) and Brivaracetam (BRV) were assayed as a ternary mixture using doubl …
BACKGROUND: Green spectrophotometric methods were developed and validated for determination of some CNS active drugs as antiepileptics and b …
Effects of Dangshen Yuanzhi Powder on learning ability and gut microflora in rats with memory disorder.
Ren H, Gao S, Wang S, Wang J, Cheng Y, Wang Y, Wang Y. Ren H, et al. J Ethnopharmacol. 2022 Oct 5;296:115410. doi: 10.1016/j.jep.2022.115410. Epub 2022 May 29. J Ethnopharmacol. 2022. PMID: 35640741
The rats in the positive group were similarly administrated with piracetam (0.5 g/kg). The rats' bodyweight was recorded from the 16th day. ...
The rats in the positive group were similarly administrated with piracetam (0.5 g/kg). The rats' bodyweight was recorded from the 16t …
Superior alternating hemiplegia (Weber's syndrome)- Case report.
Sheikh Hassan M, Osman Sidow N, Adam BA, Adani AA. Sheikh Hassan M, et al. Ann Med Surg (Lond). 2022 Apr 28;77:103674. doi: 10.1016/j.amsu.2022.103674. eCollection 2022 May. Ann Med Surg (Lond). 2022. PMID: 35638077 Free PMC article.
Based on the clinical and radiological findings, a diagnosis of Weber's syndrome was made. The patient was treated with antiplatelet and Piracetam along with strict blood pressure control. There was a massive improvement in the patient's condition on the follow-up visit th …
Based on the clinical and radiological findings, a diagnosis of Weber's syndrome was made. The patient was treated with antiplatelet and …
Piracetam attenuates cyclophosphamide-induced hepatotoxicity in rats: Amelioration of necroptosis, pyroptosis and caspase-dependent apoptosis.
Mostafa RE, Morsi AH, Asaad GF. Mostafa RE, et al. Life Sci. 2022 Aug 15;303:120671. doi: 10.1016/j.lfs.2022.120671. Epub 2022 May 27. Life Sci. 2022. PMID: 35636581
The clinical use of Cyclo is limited by significant hepatotoxicity. Piracetam (Pira) is used to improve cognitive function. Pira possesses diverse physiological functions; however, the exact mechanisms of its activity are still non-elucidated. ...
The clinical use of Cyclo is limited by significant hepatotoxicity. Piracetam (Pira) is used to improve cognitive function. Pira poss …
Non-convulsive Status Epilepticus in SEMA6B-Related Progressive Myoclonic Epilepsy: A Case Report With Literature Review.
Duan J, Chen Y, Hu Z, Ye Y, Zhang T, Li C, Zeng Q, Zhao X, Mai J, Sun Y, Liu C, Zheng W, Xiao Y, Liao J, Chen L. Duan J, et al. Front Pediatr. 2022 Apr 28;10:859183. doi: 10.3389/fped.2022.859183. eCollection 2022. Front Pediatr. 2022. PMID: 35573939 Free PMC article.
At different time points since onset, valproic acid, levetiracetam, piracetam, and clobazam were used to control the intractable seizures. Notably, NCSE was controlled by a combination of piracetam with clobazam and valproic acid instead of intravenous infusion of m …
At different time points since onset, valproic acid, levetiracetam, piracetam, and clobazam were used to control the intractable seiz …
Characterization and Crystal Nucleation Kinetics of a New Metastable Polymorph of Piracetam in Alcoholic Solvents.
Kakkar S, Zeng L, Svärd M, Rasmuson ÅC. Kakkar S, et al. Cryst Growth Des. 2022 May 4;22(5):2964-2973. doi: 10.1021/acs.cgd.1c01421. Epub 2022 Apr 22. Cryst Growth Des. 2022. PMID: 35529064 Free PMC article.
A new polymorph of the drug active pharmaceutical ingredient piracetam (Form VI) has been discovered and characterized by X-ray powder diffraction (PXRD), solid-state Raman, attenuated total reflectance infrared spectroscopy, and differential scanning calorimetry. ...A tot …
A new polymorph of the drug active pharmaceutical ingredient piracetam (Form VI) has been discovered and characterized by X-ray powde …
Crystal structures of cocrystals of 2,7-dihydroxynaphthalene with isoniazid and piracetam.
González-González JS, Valiente Flores ME, Flores-Alamo M, Macías-López E, Martínez-Martínez FJ, García-Ortega H. González-González JS, et al. Acta Crystallogr C Struct Chem. 2022 May 1;78(Pt 5):280-286. doi: 10.1107/S2053229622003734. Epub 2022 Apr 11. Acta Crystallogr C Struct Chem. 2022. PMID: 35510433
Cocrystals of 2,7-dihydroxynaphthalene (DHN, or naphthalene-2,7-diol) with isoniazid (pyridine-4-carbohydrazide) (INH), denoted DHN-INH [C(10)H(8)O(2).C(6)H(7)N(3)O, (I)], and piracetam [2-(2-oxopyrrolidin-1-yl)acetamide] (PIR), denoted DHN-PIR [C(10)H(8)O(2).C(6)H(10)N(2) …
Cocrystals of 2,7-dihydroxynaphthalene (DHN, or naphthalene-2,7-diol) with isoniazid (pyridine-4-carbohydrazide) (INH), denoted DHN-INH [C(1 …
Benefits and Harms of 'Smart Drugs' (Nootropics) in Healthy Individuals.
Schifano F, Catalani V, Sharif S, Napoletano F, Corkery JM, Arillotta D, Fergus S, Vento A, Guirguis A. Schifano F, et al. Drugs. 2022 Apr;82(6):633-647. doi: 10.1007/s40265-022-01701-7. Epub 2022 Apr 2. Drugs. 2022. PMID: 35366192 Review.
This paper aims to provide an overview on the prevalence of use; putative neuroenhancement benefits and possible harms relating to the intake of the most popular CEs (e.g. amphetamine-type stimulants, methylphenidate, donepezil, selegiline, modafinil, piracetam, benzodiaze …
This paper aims to provide an overview on the prevalence of use; putative neuroenhancement benefits and possible harms relating to the intak …
Comparison of the Effects of Citicoline and Piracetam on Hypoxic-ischemic Brain Damage in Neonatal Rabbits.
Ebrahimi S, Ashkani Esfahani S, Ebrahimi A. Ebrahimi S, et al. Iran J Child Neurol. 2022 Winter;16(1):77-84. doi: 10.22037/ijcn.v15i4.29816. Epub 2022 Jan 1. Iran J Child Neurol. 2022. PMID: 35222659 Free PMC article.
OBJECTIVES: Perinatal hypoxic-ischemic brain injuries have been a major cause of mortality and neurodevelopmental morbidities in newborns. Citicoline and Piracetam have been used as nootropic agents in a number of studies. ...CONCLUSION: According to our results and previo …
OBJECTIVES: Perinatal hypoxic-ischemic brain injuries have been a major cause of mortality and neurodevelopmental morbidities in newborns. C …
Melatonin improves cognitive function by suppressing endoplasmic reticulum stress and promoting synaptic plasticity during chronic cerebral hypoperfusion in rats.
Thangwong P, Jearjaroen P, Govitrapong P, Tocharus C, Tocharus J. Thangwong P, et al. Biochem Pharmacol. 2022 Apr;198:114980. doi: 10.1016/j.bcp.2022.114980. Epub 2022 Feb 24. Biochem Pharmacol. 2022. PMID: 35219702
After surgery, rats were treated with melatonin (10 mg/kg) or piracetam (600 mg/kg) by oral gavage once a day for 4 weeks. At the end of the experiment, all rats were assessed for memory impairment by using the Morris water maze test. ...
After surgery, rats were treated with melatonin (10 mg/kg) or piracetam (600 mg/kg) by oral gavage once a day for 4 weeks. At the end …
An aqueous extract of Lantana camara attenuates seizures, memory impairment, and anxiety in kainate-treated mice: Evidence of GABA level, oxidative stress, immune and neuronal loss modulation.
Kandeda AK, Mabou ST, Moutchida C. Kandeda AK, et al. Epilepsy Behav. 2022 Apr;129:108611. doi: 10.1016/j.yebeh.2022.108611. Epub 2022 Feb 19. Epilepsy Behav. 2022. PMID: 35193072
.), two positive control groups either treated with sodium valproate (300 mg/kg, p.o.) or with piracetam (200 mg/kg, p.o.), and three test groups received the extract (230, 460, and 917 mg/kg, p.o.). ...
.), two positive control groups either treated with sodium valproate (300 mg/kg, p.o.) or with piracetam (200 mg/kg, p.o.), and three …
Simple Eco-Friendly RP-LC Method for the Synchronous Separation of Six Widely Used Drugs in the Treatment of Cerebrovascular and Vestibular Disorders: Application for Analysis in Their Single and Combined Drug Products.
El-Houssini OM, Mohammad MA. El-Houssini OM, et al. J AOAC Int. 2022 Jun 29;105(4):957-963. doi: 10.1093/jaoacint/qsac021. J AOAC Int. 2022. PMID: 35167683
OBJECTIVE: The target of this work is to develop an eco-friendly RP-LC method for the synchronous separation of six widely used drugs in the treatment of cerebrovascular and vestibular disorders, namely neurotropic piracetam, antihistamines dimenhydrinate, cinnarizine, and …
OBJECTIVE: The target of this work is to develop an eco-friendly RP-LC method for the synchronous separation of six widely used drugs in the …
The Comparison of Levetiracetam and Piracetam Effectiveness on Breath-Holding Spells in Children: A Randomized Controlled Clinical Trial.
Ghazavi MR, Salehi MM, Nasiri J, Yaghini O, Mansouri V, Hoseini N. Ghazavi MR, et al. Adv Biomed Res. 2021 Dec 25;10:47. doi: 10.4103/abr.abr_234_20. eCollection 2021. Adv Biomed Res. 2021. PMID: 35127574 Free PMC article.
Levetiracetam had significant effects on the average incidence of the loss of consciousness and seizure-like movements in our study, while Piracetam had no significant effect on the loss of consciousness. Our result showed better response in the Levetiracetam group (88.9% …
Levetiracetam had significant effects on the average incidence of the loss of consciousness and seizure-like movements in our study, while …
Adaptogenic potential of ginsenosides against domoic acid-induced toxicity by regulating neuronal stress and kinate receptors: Ex vivo and in silico studies.
Ramya EM, Kumar GP, Chandrasekhar Y, Anilakumar KR. Ramya EM, et al. J Food Biochem. 2022 May;46(5):e14089. doi: 10.1111/jfbc.14089. Epub 2022 Feb 1. J Food Biochem. 2022. PMID: 35102569
Domoic acid was injected to the mice to induce excitotoxicity (DA; 3 mg kg(-1) bwt.(-1) ) and piracetam-injected animals (PIR; 100 mg kg(-1) bwt.(-1) ) were treated as positive control. ...
Domoic acid was injected to the mice to induce excitotoxicity (DA; 3 mg kg(-1) bwt.(-1) ) and piracetam-injected animals (PIR; 100 mg …
Synthetic Approaches toward the Synthesis of Brivaracetam: An Antiepileptic Drug.
Gayke M, Narode H, Eppa G, Bhosale RS, Yadav JS. Gayke M, et al. ACS Omega. 2022 Jan 9;7(3):2486-2503. doi: 10.1021/acsomega.1c05378. eCollection 2022 Jan 25. ACS Omega. 2022. PMID: 35097251 Free PMC article. Review.
This drug emerged as an unusual success of rational drug discovery in clinical development by exhibiting magnificent affinity toward synaptic vesicle glycoprotein as compared to conventional drug levetiracetam and piracetam. Given its efficiency in limiting the progression …
This drug emerged as an unusual success of rational drug discovery in clinical development by exhibiting magnificent affinity toward synapti …
Pharmacological interventions to diminish cognitive side effects of electroconvulsive therapy: A systematic review and meta-analysis.
Verdijk JPAJ, van Kessel MA, Oud M, Kellner CH, Hofmeijer J, Verwijk E, van Waarde JA. Verdijk JPAJ, et al. Acta Psychiatr Scand. 2022 Apr;145(4):343-356. doi: 10.1111/acps.13397. Epub 2022 Feb 8. Acta Psychiatr Scand. 2022. PMID: 35075641 Free PMC article. Review.
Very low-quality evidence shows effect of acetylcholine inhibitors, piracetam and melatonin in some cognitive domains. Evidence of no efficacy was revealed for ketamine (very low-quality), herbal preparations with anti-inflammatory properties (very low to low-quality) and …
Very low-quality evidence shows effect of acetylcholine inhibitors, piracetam and melatonin in some cognitive domains. Evidence of no …
[Comparative chemoreactome analysis of the synergism of vinpocetine, piracetam, and cinnarizine molecules].
Gromova OA, Torshin IY. Gromova OA, et al. Zh Nevrol Psikhiatr Im S S Korsakova. 2021;121(12):69-76. doi: 10.17116/jnevro202112112169. Zh Nevrol Psikhiatr Im S S Korsakova. 2021. PMID: 35041315 Russian.
The data obtained made it possible to quantify the value of the synergism score for the combination "vinpocetine + piracetam" (54 points) compared with the combination "piracetam + cinnarizine" (25 points). CONCLUSIONS: The combination of "vinpocetine + piracetam
The data obtained made it possible to quantify the value of the synergism score for the combination "vinpocetine + piracetam" (54 poi …
Diagnosis and differential diagnosis flow diagram of Chinese post-stroke aphasia types and treatment of post-stroke aphasia.
Wang Y, Du W, Yang X, Yan J, Sun W, Bai J, Zhou J, Zhou A, Niu J, Li C, Wang J. Wang Y, et al. Aging Med (Milton). 2021 Nov 26;4(4):325-336. doi: 10.1002/agm2.12183. eCollection 2021 Dec. Aging Med (Milton). 2021. PMID: 34964014 Free PMC article. Review.
It was beneficial for patients to establish targeted and individualized rehabilitation training plans. This review introduced the use of memantine, piracetam, donepezil, etc. in PSA treatment, evaluated clinical studies conducted in China and abroad, investigated the mecha …
It was beneficial for patients to establish targeted and individualized rehabilitation training plans. This review introduced the use of mem …
Protective effect of co-administration of caffeine and piracetam on scopolamine-induced amnesia in Wistar rats.
Chaturvedi S, Ganeshpurkar A, Shrivastava A, Dubey N. Chaturvedi S, et al. Curr Res Pharmacol Drug Discov. 2021 Sep 8;2:100052. doi: 10.1016/j.crphar.2021.100052. eCollection 2021. Curr Res Pharmacol Drug Discov. 2021. PMID: 34909678 Free PMC article.
Piracetam improves cognitive function without stimulation or sedation. ...The present study aimed to determine the protective effect of co-administering piracetam and caffeine on scopolamine-induced amnesia in rats. Pre-treatment with caffeine and piracetam d
Piracetam improves cognitive function without stimulation or sedation. ...The present study aimed to determine the protective effect
A Revisit to Etiopathogenesis and Therapeutic Strategies in Alzheimer's Disease.
Kumar M, Bansal N. Kumar M, et al. Curr Drug Targets. 2022;23(5):486-512. doi: 10.2174/1389450122666211118125233. Curr Drug Targets. 2022. PMID: 34792002 Review.
., inhibition of acetylcholinesterase, glutamate excitotoxicity (memantine), or nootropics (piracetam), even though AD is a multifaceted neurological disorder. ...
., inhibition of acetylcholinesterase, glutamate excitotoxicity (memantine), or nootropics (piracetam), even though AD is a multiface …
Influence of psychostimulants and opioids on epigenetic modification of class III histone deacetylase (HDAC)-sirtuins in glial cells.
Sivalingam K, Doke M, Khan MA, Samikkannu T. Sivalingam K, et al. Sci Rep. 2021 Oct 29;11(1):21335. doi: 10.1038/s41598-021-00836-z. Sci Rep. 2021. PMID: 34716387 Free PMC article.
The present study examined the effects of psychostimulants, such as cocaine and METH, and opioids, such as morphine, on SIRT family (1-7) [class I, II, III and IV] expression and cellular translocation-mediated dysfunction in astrocytes and microglial cells. The "nootropic" drug …
The present study examined the effects of psychostimulants, such as cocaine and METH, and opioids, such as morphine, on SIRT family (1-7) [c …
Unique Severe HyperEkplexia-Like Apneic Events (SHELAE) Improved by High-Dose Piracetam.
Krishnappa J, Ngoh A, Hong YT, ChunLiang C, Derrick CWS. Krishnappa J, et al. Child Neurol Open. 2021 Oct 23;8:2329048X211046447. doi: 10.1177/2329048X211046447. eCollection 2021 Jan-Dec. Child Neurol Open. 2021. PMID: 34708144 Free PMC article.
It is commonly treated with Clonazepam and other anti-epileptic drugs. Piracetam has been reported to be effective in some anecdotal cases. We describe a case of an infant with frequent hyperekplexia-like breath-holding events who failed to respond adequately to glycopyrro …
It is commonly treated with Clonazepam and other anti-epileptic drugs. Piracetam has been reported to be effective in some anecdotal …
Evaluation of nootropic activity of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice through AMPK pathway and amelioration of hippocampal morphological alterations.
Said ES, Elsayed AM, Rashed LA, Nadwa EH, Alsuhaibani NA, Alfuraih BS, Mahmoud RH. Said ES, et al. Eur J Pharmacol. 2021 Dec 5;912:174511. doi: 10.1016/j.ejphar.2021.174511. Epub 2021 Sep 20. Eur J Pharmacol. 2021. PMID: 34547248
The present study has been designed to evaluate the neuroprotective effect of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice. Piracetam was used as an established nootropic agent. Mice were divided into 8 groups, group1; control group which rec …
The present study has been designed to evaluate the neuroprotective effect of telmisartan and metformin on diazepam-induced cognitive dysfun …
HIV-1 Tat and cocaine impact astrocytic energy reservoir influence on miRNA epigenetic regulation.
Doke M, Kashanchi F, Khan MA, Samikkannu T. Doke M, et al. Genomics. 2021 Nov;113(6):3461-3475. doi: 10.1016/j.ygeno.2021.08.013. Epub 2021 Aug 19. Genomics. 2021. PMID: 34418497 Free PMC article.
In addition, the astrocytes treated with the nootropic drug piracetam protects these miRNAs. These findings provide evidence that the miRNAs in the astrocytes may be a potential biomarker and therapeutic target for HIV and cocaine abuse-induced neurodegeneration....
In addition, the astrocytes treated with the nootropic drug piracetam protects these miRNAs. These findings provide evidence that the …
Evaluation of Medicine Abuse Trends in Community Pharmacies: The Medicine Abuse Observatory (MAO) in a Region of Southern Europe.
Perelló M, Rio-Aige K, Guayta-Escolies R, Gascón P, Rius P, Jambrina AM, Bagaria G, Armelles M, Pérez-Cano FJ, Rabanal M. Perelló M, et al. Int J Environ Res Public Health. 2021 Jul 23;18(15):7818. doi: 10.3390/ijerph18157818. Int J Environ Res Public Health. 2021. PMID: 34360110 Free PMC article.
The main drug class involved were benzodiazepines (31.8%), codeine (19.3%), tramadol (7.5%), methylphenidate (5.8%), gabapentinoids (5.8%), cycloplegic drops (4.4%), z-drugs (2.6%), piracetam (2.2%), dextromethorphan (1.6%) and clomethiazole (1.1%). ...
The main drug class involved were benzodiazepines (31.8%), codeine (19.3%), tramadol (7.5%), methylphenidate (5.8%), gabapentinoids (5.8%), …
Development of Synergy-Based Combination for Learning and Memory Using in vitro, in vivo and TLC-MS-Bioautographic Studies.
Khan MA, Srivastava V, Kabir M, Samal M, Insaf A, Ibrahim M, Zahiruddin S, Ahmad S. Khan MA, et al. Front Pharmacol. 2021 Jul 2;12:678611. doi: 10.3389/fphar.2021.678611. eCollection 2021. Front Pharmacol. 2021. PMID: 34276370 Free PMC article.
The observation of neurocognitive behavior in amnesia induced subjects manifested that both the synergistic combinations showed comparable results to that of standard piracetam, though the synergistic combination containing a higher concentration of WSA showed more appreci …
The observation of neurocognitive behavior in amnesia induced subjects manifested that both the synergistic combinations showed comparable r …
Experience of using subcutaneous levetiracetam in palliative patients.
Más-Sesé G, Martín-Bautista D, Navarro-Catalá A. Más-Sesé G, et al. Neurologia (Engl Ed). 2021 Jul-Aug;36(6):474-475. doi: 10.1016/j.nrleng.2020.06.012. Epub 2021 Apr 17. Neurologia (Engl Ed). 2021. PMID: 34238530 Free article. No abstract available.
Psychostimulants and opioids differentially influence the epigenetic modification of histone acetyltransferase and histone deacetylase in astrocytes.
Doke M, Pendyala G, Samikkannu T. Doke M, et al. PLoS One. 2021 Jun 11;16(6):e0252895. doi: 10.1371/journal.pone.0252895. eCollection 2021. PLoS One. 2021. PMID: 34115777 Free PMC article.
In addition, we have explored the neuroprotective "nootropic" drug piracetam were exposed with or without psychostimulants and opioid in the human primary astrocytes. Results revealed that psychostimulants and opioid upregulated HDAC1, HDAC4 and p300 expression, while HDAC …
In addition, we have explored the neuroprotective "nootropic" drug piracetam were exposed with or without psychostimulants and opioid …
Liver proteome alterations in psychologically distressed rats and a nootropic drug.
González-Fernández R, Grigoruţă M, Chávez-Martínez S, Ruiz-May E, Elizalde-Contreras JM, Valero-Galván J, Martínez-Martínez A. González-Fernández R, et al. PeerJ. 2021 May 19;9:e11483. doi: 10.7717/peerj.11483. eCollection 2021. PeerJ. 2021. PMID: 34055494 Free PMC article.
The use of nootropics, as the cognitive enhancer and antioxidant piracetam, is attractive to repair the oxidative damage. A proteomic approach provides the possibility to obtain an in-depth comprehension of the affected cellular processes and the possible consequences for …
The use of nootropics, as the cognitive enhancer and antioxidant piracetam, is attractive to repair the oxidative damage. A proteomic …
Evaluation of Phytochemical, Antioxidant, and Memory-Enhancing Activity of Garuga pinnata Roxb. Bark and Bryophyllum pinnatum (Lam) Oken. Leaves.
Bhandari R, Gyawali S, Aryal N, Gaire D, Paudyal K, Panta A, Panth P, Joshi DR, Rokaya RK, Aryal P, Pandey J. Bhandari R, et al. ScientificWorldJournal. 2021 Apr 27;2021:6649574. doi: 10.1155/2021/6649574. eCollection 2021. ScientificWorldJournal. 2021. PMID: 33994883 Free PMC article.
The memory-enhancing activity was determined by the elevated plus-maze method in Scopolamine-induced amnesic mice, using Piracetam as allopathic and Shankhpushpi as ayurvedic standard drugs. ...DPPH assay method and the Folin-Ciocalteu method were employed to determine ant …
The memory-enhancing activity was determined by the elevated plus-maze method in Scopolamine-induced amnesic mice, using Piracetam as …
DNAJC6 Parkinson Disease.
Kurian MA, Abela L. Kurian MA, et al. 2021 May 13. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2021 May 13. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 33983693 Free Books & Documents. Review.
Medications (e.g., sodium valproate, clonazepam, levetiracetam, piracetam) as needed for myoclonus. Multidisciplinary management including physical and occupational therapy, speech and language therapy, and special education services as indicated for developmental delay an …
Medications (e.g., sodium valproate, clonazepam, levetiracetam, piracetam) as needed for myoclonus. Multidisciplinary management incl …
An experimental study on phytochemical composition and memory enhancing effect of Ginkgo biloba seed extract.
Tomova T, Doncheva N, Mihaylova A, Kostadinov I, Peychev L, Argirova M. Tomova T, et al. Folia Med (Plovdiv). 2021 Apr 30;63(2):203-212. doi: 10.3897/folmed.63.e53060. Folia Med (Plovdiv). 2021. PMID: 33932010
For the in vivo experiments, male Wistar rats were divided randomly into 5 groups (n=8): saline; piracetam; GBSE 50; 100, and 200 mg/kg b.w. Y-maze, T-maze, step-down passive avoidance and novel object recognition test (NORT) were performed. ...
For the in vivo experiments, male Wistar rats were divided randomly into 5 groups (n=8): saline; piracetam; GBSE 50; 100, and 200 mg/ …
Drotaverine Inhibitor of PDE4: Reverses the Streptozotocin Induced Alzheimer's Disease in Mice.
Nazir S, Anwar F, Saleem U, Ahmad B, Raza Z, Sanawar M, Rehman AU, Ismail T. Nazir S, et al. Neurochem Res. 2021 Jul;46(7):1814-1829. doi: 10.1007/s11064-021-03327-9. Epub 2021 Apr 20. Neurochem Res. 2021. PMID: 33877499
Group 1 control group received carboxy methyl cellulose (CMC 1 mL/kg), group II diseased group treated with streptozotocin (STZ 3 mg/kg) by intracerebroventricular (ICV) route, group III administered standard drug Piracetam 200 mg/kg and groups IV-VII were given drotaverin …
Group 1 control group received carboxy methyl cellulose (CMC 1 mL/kg), group II diseased group treated with streptozotocin (STZ 3 mg/kg) by …
Therapeutic effect of piracetam with nimodipine on vascular dementia after cerebral infarction.
Zongfang Z, Wenjing L, Zhaomin C, Lei Z. Zongfang Z, et al. Pak J Pharm Sci. 2020 Sep;33(5(Special)):2405-2411. Pak J Pharm Sci. 2020. PMID: 33832882
This article investigated the clinical effects of piracetam with nimodipine in the treatment of vascular dementia (VD) after cerebral infarction. 98 patients with vascular dementia after cerebral infarction were selected and divided into the control group and the study gro …
This article investigated the clinical effects of piracetam with nimodipine in the treatment of vascular dementia (VD) after cerebral …
The Use and Impact of Cognitive Enhancers among University Students: A Systematic Review.
Sharif S, Guirguis A, Fergus S, Schifano F. Sharif S, et al. Brain Sci. 2021 Mar 10;11(3):355. doi: 10.3390/brainsci11030355. Brain Sci. 2021. PMID: 33802176 Free PMC article. Review.
., prescription CEs including amphetamine salt mixtures, methylphenidate, modafinil and piracetam; and non-prescription CEs including caffeine, cobalamin (vitamin B12), guarana, pyridoxine (vitamin B6) and vinpocetine) that have emerged as being misused. ...
., prescription CEs including amphetamine salt mixtures, methylphenidate, modafinil and piracetam; and non-prescription CEs including …
Evaluation of Nootropic Activity of Limonia acidissima Against Scopolamine-induced Amnesia in Rats.
Mali KK, Sutar GV, Dias RJ, Devade OA. Mali KK, et al. Turk J Pharm Sci. 2021 Feb 25;18(1):3-9. doi: 10.4274/tjps.galenos.2019.30316. Turk J Pharm Sci. 2021. PMID: 33631923 Free PMC article.
MATERIALS AND METHODS: Methanolic extract of Limonia acidissima was used to evaluate nootropic activity, piracetam (200 mg/kg, i.p.) was used as a standard, and scopolamine (1 mg/kg, i.p.) was used to induce amnesia. ...
MATERIALS AND METHODS: Methanolic extract of Limonia acidissima was used to evaluate nootropic activity, piracetam (200 mg/kg, i.p.) …
Effects of ethyl acetate extract from Coreopsis tinctoria on learning and memory impairment in d-galactose-induced aging mice and the underlying molecular mechanism.
Li H , Xu G , Wu D , Li J , Cui J , Liu J . Li H , et al. Food Funct. 2021 Mar 21;12(6):2531-2542. doi: 10.1039/d0fo03293j. Epub 2021 Feb 23. Food Funct. 2021. PMID: 33621295
A mouse aging model was established by subcutaneous injection of d-galactose in mice, and EACC and piracetam were given to the model mice by gavage to observe their behavioral changes and changes in their SOD and GSH-Px activities in MDA contents in their peripheral blood …
A mouse aging model was established by subcutaneous injection of d-galactose in mice, and EACC and piracetam were given to the model …
[Effects of Moringa flavone on cognitive function and neuropathological indexes in diabetic encephalopathy rats].
Zhu J, Zhao C, Qiao Y, Liu Y, Sui Y. Zhu J, et al. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2020 Dec;32(12):1491-1495. doi: 10.3760/cma.j.cn121430-20200330-00459. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2020. PMID: 33541503 Chinese.
After successful model establishment, the rats in the Moringa low and high dose groups were given 4.0 g/kg and 8.0 g/kg Moringa extract (Moringa flavone) by gavage everyday, the rats in the positive drug group were given piracetam 0.48 g/kg, and the rats in the model group …
After successful model establishment, the rats in the Moringa low and high dose groups were given 4.0 g/kg and 8.0 g/kg Moringa extract (Mor …
The effect of piracetam on behavioral reactions of adult rats and morphological changes in the brain after whole body fractionated gamma irradiation: an exploratory study.
Severyukhin YS, Lalkovičová M, Kolesnikova IA, Utina DM, Lyakhova KN, Gaevsky VN. Severyukhin YS, et al. Radiat Environ Biophys. 2021 Mar;60(1):73-86. doi: 10.1007/s00411-020-00886-3. Epub 2021 Jan 4. Radiat Environ Biophys. 2021. PMID: 33394131
This research was aimed at examining the effect of piracetam on behavioral reactions and morphological changes in the brain of adult rats after fractionated gamma irradiation with a total dose of 5 Gy. ...Since it is the first experiment with piracetam we attempted, …
This research was aimed at examining the effect of piracetam on behavioral reactions and morphological changes in the brain of adult …
The importance of intramolecular hydrogen bonds on the translocation of the small drug piracetam through a lipid bilayer.
Coimbra JTS, Feghali R, Ribeiro RP, Ramos MJ, Fernandes PA. Coimbra JTS, et al. RSC Adv. 2021 Jan 4;11(2):899-908. doi: 10.1039/d0ra09995c. eCollection 2020 Dec 24. RSC Adv. 2021. PMID: 35423709 Free PMC article.
In this paper, we used molecular dynamics to describe the effect of intramolecular hydrogen bonding on the passive diffusion of a small drug (piracetam) through a lipid membrane. The results indicated that the formation of an intramolecular hydrogen bond decreases the barr …
In this paper, we used molecular dynamics to describe the effect of intramolecular hydrogen bonding on the passive diffusion of a small drug …
Time course evaluation of lacosamide alone and in polypharmacy on behavioral manifestations and oxidative stress in lithium-pilocarpine-induced model.
Shakeel W, Javaid S, Anjum SMM, Rasool MF, Samad N, Alasmari F, Alasmari AF, Alaqil FA, Alqarni SA, Alotaibi FM, Alqahtani F, Imran I. Shakeel W, et al. J Physiol Pharmacol. 2020 Aug;71(4). doi: 10.26402/jpp.2020.4.10. Epub 2020 Dec 12. J Physiol Pharmacol. 2020. PMID: 33316769 Free article.
Here we investigated the impact of lacosamide alone and in combination with other drugs (pregabalin, piracetam and scopolamine) on spontaneous recurrent seizures (SRSs) and behavioral parameters during the time frame of 6 weeks after SE. ...Pharmacological manipulation for …
Here we investigated the impact of lacosamide alone and in combination with other drugs (pregabalin, piracetam and scopolamine) on sp …
The potential for one drug, administered at the earliest preclinical stage, to prevent the subsequent decline of cognition that eventuates in dementia.
Fessel J. Fessel J. Alzheimers Dement (N Y). 2020 Oct 1;6(1):e12084. doi: 10.1002/trc2.12084. eCollection 2020. Alzheimers Dement (N Y). 2020. PMID: 33024811 Free PMC article.
If started at that early point in time, when there is subjective but not objective memory loss plus abnormal brain imaging with fluorodeoxyglucose and Pittsburgh compound B, treatment with a single drug directed at synaptic dysfunction might prevent development of cognitive impai …
If started at that early point in time, when there is subjective but not objective memory loss plus abnormal brain imaging with fluorodeoxyg …
Comparison of Ischemic Preconditioning and Systemic Piracetam for Prevention of Ischemia-Reperfusion Injury in Musculocutaneous Flaps.
Demiröz A, Derebaşınlıoğlu H, Ercan A, Arslan H, Aydın Ö, Ekmekçi H, Balcı Ekmekçi Ö, Aydın Y. Demiröz A, et al. J Reconstr Microsurg. 2021 May;37(4):322-335. doi: 10.1055/s-0040-1716822. Epub 2020 Sep 24. J Reconstr Microsurg. 2021. PMID: 32971545
RESULTS: Myeloperoxidase activity in both preconditioning and piracetam groups, was significantly lower than the ischemia-reperfusion group. Acute inflammatory cell response was similarly decreased in both preconditioning and piracetam groups compared with ischemia- …
RESULTS: Myeloperoxidase activity in both preconditioning and piracetam groups, was significantly lower than the ischemia-reperfusion …
Evaluation of the effectiveness of valproic acid for treating cyanotic breath holding spells: A Pilot prospective study.
Hamed SA, Elhadad AF, Farghaly HS. Hamed SA, et al. Expert Rev Clin Pharmacol. 2020 Nov;13(11):1263-1270. doi: 10.1080/17512433.2020.1828059. Epub 2020 Nov 1. Expert Rev Clin Pharmacol. 2020. PMID: 32969724
Seizures, brain damage and sudden death have been rarely reported with BHS. Some reported spells' frequency reduction with iron or piracetam. We evaluated the effectiveness of valproic acid (VPA) to treat CBHS and predictors of improvement. ...
Seizures, brain damage and sudden death have been rarely reported with BHS. Some reported spells' frequency reduction with iron or pirace
High-Dose Levetiracetam for Neonatal Seizures: A Retrospective Review.
Hnaini M, Darwich M, Koleilat N, Jaafar F, Hanneyan S, Rahal S, Mikati IE, Shbarou RM, Nabout R, Maalouf FI, Obeid M. Hnaini M, et al. Seizure. 2020 Nov;82:7-11. doi: 10.1016/j.seizure.2020.08.030. Epub 2020 Sep 8. Seizure. 2020. PMID: 32950862 Free article.
[Choice of neuroprotective therapy regimens in patients with chronic cerebral ischemia, taking into account the synergy of drug interactions].
Gromova OA, Torshin IY, Putilina MV, Semenov VA, Rudakov KV. Gromova OA, et al. Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(8):42-50. doi: 10.17116/jnevro202012008142. Zh Nevrol Psikhiatr Im S S Korsakova. 2020. PMID: 32929923 Russian.
MATERIAL AND METHODS: Differential chemoreactomic analysis of the synergism of ethyl methyl hydroxypyridine succinate (EMHPS) and a number of monocomponent neuroprotective agents (piracetam, vinpocetine, citicoline, choline alfoscerate); proteomic analysis of polypeptide n …
MATERIAL AND METHODS: Differential chemoreactomic analysis of the synergism of ethyl methyl hydroxypyridine succinate (EMHPS) and a number o …
Neuroprotective Effect of Piracetam against Cocaine-Induced Neuro Epigenetic Modification of DNA Methylation in Astrocytes.
Sivalingam K, Samikkannu T. Sivalingam K, et al. Brain Sci. 2020 Sep 5;10(9):611. doi: 10.3390/brainsci10090611. Brain Sci. 2020. PMID: 32899583 Free PMC article.
However, the impact of cocaine-mediated epigenetic changes in astrocytes has not yet been elucidated. In this study, we explored the neuroprotective effect of piracetam against cocaine-induced epigenetic changes in DNA methylation in astrocytes. ...Our data provide evidenc …
However, the impact of cocaine-mediated epigenetic changes in astrocytes has not yet been elucidated. In this study, we explored the neuropr …
Neuroprotective effects of the aerial parts of Polygala tenuifolia Willd extract on scopolamine-induced learning and memory impairments in mice.
Wang X, Zhang D, Song W, Cai CF, Zhou Z, Fu Q, Yan X, Cao Y, Fang M. Wang X, et al. Biomed Rep. 2020 Nov;13(5):37. doi: 10.3892/br.2020.1344. Epub 2020 Aug 19. Biomed Rep. 2020. PMID: 32874571 Free PMC article.
Mice were orally administered with APT (25, 50 and 100 mg/kg) and piracetam (750 mg/kg) for 14 days, and intraperitoneally injected with scopolamine (2 mg/kg) from days 8 to 14. ...
Mice were orally administered with APT (25, 50 and 100 mg/kg) and piracetam (750 mg/kg) for 14 days, and intraperitoneally injected w …
Levetiracetam-Induced Hepatic Dysfunction.
Gayatri P, Selvam MM, Sreeharsha SV. Gayatri P, et al. Neurol India. 2020 Jul-Aug;68(4):910-912. doi: 10.4103/0028-3886.293452. Neurol India. 2020. PMID: 32859841 Free article.
Extract of the Aerial Part of Polygala tenuifolia Attenuates d-Galactose/NaNO2-induced Learning and Memory Impairment in Mice.
Zhang D, Wang X, Li R, Wang L, Zhou Z, Fu Q, Cao Y, Fang M. Zhang D, et al. Planta Med. 2020 Dec;86(18):1389-1399. doi: 10.1055/a-1212-3212. Epub 2020 Aug 14. Planta Med. 2020. PMID: 32797467
The aerial part of P. tenuifolia (25, 50, and 100 mg/kg) and piracetam (200 mg/kg) were simultaneously administered orally on days 15 - 60. ...
The aerial part of P. tenuifolia (25, 50, and 100 mg/kg) and piracetam (200 mg/kg) were simultaneously administered orally on days 15 …
Aqueous Root Bark Extract of Daniellia oliveri (Hutch. & Dalz.) (Fabaceae) Protects Neurons against Diazepam-Induced Amnesia in Mice.
Beppe GJ, Kenko Djoumessie LB, Keugong Wado E, Ngatanko Abaïssou HH, Nkwingwa BK, Damo Kamda JL, Nhouma RR, Foyet HS. Beppe GJ, et al. Evid Based Complement Alternat Med. 2020 Jul 21;2020:7815348. doi: 10.1155/2020/7815348. eCollection 2020. Evid Based Complement Alternat Med. 2020. PMID: 32774429 Free PMC article.
Thirty-six adult male mice were distributed into six groups: the three test groups received Daniellia oliveri root bark extract (100, 200, and 300 mg/kg), the normal control group received distilled water (10 ml/kg), a positive control group received piracetam (150 mg/kg), …
Thirty-six adult male mice were distributed into six groups: the three test groups received Daniellia oliveri root bark extract (100, 200, a …
Detemplated and Pillared 2-Dimensional Zeolite ZSM-55 with Ferrierite Layer Topology as a Carrier for Drugs.
Strzempek W, Korzeniowska A, Kowalczyk A, Roth WJ, Gil B. Strzempek W, et al. Molecules. 2020 Jul 31;25(15):3501. doi: 10.3390/molecules25153501. Molecules. 2020. PMID: 32752039 Free PMC article.
This study was conducted with model drugs ciprofloxacin and piracetam, and ZSM-55 with ca 1 nm thick layers, in detemplated and pillared forms. ...FT-IR studies showed that strong interaction carrier-drug may be responsible for the modified, slowed down release of pirac
This study was conducted with model drugs ciprofloxacin and piracetam, and ZSM-55 with ca 1 nm thick layers, in detemplated and pilla …
Management of Tardive Syndrome: Medications and Surgical Treatments.
Factor SA. Factor SA. Neurotherapeutics. 2020 Oct;17(4):1694-1712. doi: 10.1007/s13311-020-00898-3. Neurotherapeutics. 2020. PMID: 32720245 Free PMC article. Review.
Anti-dyskinetic drugs are separated into 3 tiers: 1) vesicular monoamine transporter type 2 inhibitors, which have level A evidence, are approved for use in TS and are recommended first-choice agents; 2) drugs with lower level of evidence for efficacy including clonazepam, Ginkgo …
Anti-dyskinetic drugs are separated into 3 tiers: 1) vesicular monoamine transporter type 2 inhibitors, which have level A evidence, are app …
The "ART" of facial filler injections: Avoid, recognize, and treat hyaluronic acid-induced complications.
Zeltzer A, Geeroms M, Antoniazzi E, Giunta G, De Baerdemaeker R, Hendrickx B, Hamdi M. Zeltzer A, et al. J Cosmet Dermatol. 2020 Sep;19(9):2229-2236. doi: 10.1111/jocd.13611. Epub 2020 Aug 2. J Cosmet Dermatol. 2020. PMID: 32649055
METHOD: Treatment consisted of an immediate hyaluronidase injection, supplemented with administration of acetylsalicylic acid, piracetam, low molecular weight heparin (LMWH), corticosteroids, analgesics, prophylactic antibiotics, application of topical nitroglycerin and wa …
METHOD: Treatment consisted of an immediate hyaluronidase injection, supplemented with administration of acetylsalicylic acid, piracetam
Progressive Myoclonic Epilepsy Type 1.
Lehesjoki AE, Kälviäinen R. Lehesjoki AE, et al. 2004 Jun 24 [updated 2020 Jul 2]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2004 Jun 24 [updated 2020 Jul 2]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301321 Free Books & Documents. Review.
MANAGEMENT: Treatment of manifestations: Symptomatic pharmacologic and rehabilitative management, including psychosocial support, are the mainstay of care; valproic acid, the first drug of choice, diminishes myoclonus and the frequency of generalized seizures; clonazepam, approve …
MANAGEMENT: Treatment of manifestations: Symptomatic pharmacologic and rehabilitative management, including psychosocial support, are the ma …
In Silico Study and Pharmacological Evaluation of Eplerinone as an Anti-Alzheimer's Drug in STZ-Induced Alzheimer's Disease Model.
Hira S, Saleem U, Anwar F, Raza Z, Rehman AU, Ahmad B. Hira S, et al. ACS Omega. 2020 Jun 4;5(23):13973-13983. doi: 10.1021/acsomega.0c01381. eCollection 2020 Jun 16. ACS Omega. 2020. PMID: 32566864 Free PMC article.
Group I-normal control (CMC 1 mL/kg), group II-diseased [streptozotocin (STZ), 3 mg/kg, intracerebroventricular (i.c.v.)], group III-standard (piracetam, 200 mg/kg, i.p.), and groups IV-VI designated as the treatment group (eplerinone at dose levels of 4, 8, and 16 mg/kg, …
Group I-normal control (CMC 1 mL/kg), group II-diseased [streptozotocin (STZ), 3 mg/kg, intracerebroventricular (i.c.v.)], group III-standar …
Pharmacodynamic evaluation of L-carnitine and piracetam in muscle injury induced by the chronic use of simvastatin.
Dezena RMB, Antunes NJ, Campos R, Ilha J, Moreno RA, Mendes GD, Rosa PCP, De Nucci G. Dezena RMB, et al. Int J Clin Pharmacol Ther. 2020 Sep;58(9):482-490. doi: 10.5414/CP203496. Int J Clin Pharmacol Ther. 2020. PMID: 32469304
OBJECTIVES: To evaluate the effect of L-carnitine and piracetam on the muscle injury induced by simvastatin in healthy male subjects during the therapy with oral doses of 10 mL of a solution containing L-carnitine 100 mg/mL + piracetam 80 mg/mL (test group) or place …
OBJECTIVES: To evaluate the effect of L-carnitine and piracetam on the muscle injury induced by simvastatin in healthy male subjects …
Development and validation of stability indicating chromatographic methods for simultaneous determination of citicoline and piracetam.
Abdelrahman MM, Ahmed AB, Omar MA, Derayea SM, Abdelwahab NS. Abdelrahman MM, et al. J Sep Sci. 2020 Aug;43(15):2981-2988. doi: 10.1002/jssc.202000346. Epub 2020 Jun 15. J Sep Sci. 2020. PMID: 32431004
Citicoline and piracetam were subjected separately to different stress conditions as recommended by the international conference on harmonization. In addition, new stability indicating thin layer chromatographic and ultra high performance liquid chromatographic methods hav …
Citicoline and piracetam were subjected separately to different stress conditions as recommended by the international conference on h …
Antiepileptic drugs as prophylaxis for postcraniotomy seizures.
Greenhalgh J, Weston J, Dundar Y, Nevitt SJ, Marson AG. Greenhalgh J, et al. Cochrane Database Syst Rev. 2020 Apr 28;4(4):CD007286. doi: 10.1002/14651858.CD007286.pub5. Cochrane Database Syst Rev. 2020. PMID: 32343399 Free PMC article.
Spectrofluorimetric approach for determination of citicoline in the presence of co-formulated piracetam through fluorescence quenching of eosin Y.
Omar MA, Ahmed AB, Abdelwahab NS, Abdelrahman MM, Derayea SM. Omar MA, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2020 Aug 5;236:118337. doi: 10.1016/j.saa.2020.118337. Epub 2020 Apr 2. Spectrochim Acta A Mol Biomol Spectrosc. 2020. PMID: 32320917
The selectivity of the proposed method was investigated by studying the interference of piracetam as co-formulated drug with CIT in pharmaceutical formulation, therefore the developed method could be used for routine quality control of citicoline in its pharmaceutical form …
The selectivity of the proposed method was investigated by studying the interference of piracetam as co-formulated drug with CIT in p …
Perampanel for nonepileptic myoclonus in Angelman syndrome.
Kawano O, Egawa K, Shiraishi H. Kawano O, et al. Brain Dev. 2020 May;42(5):389-392. doi: 10.1016/j.braindev.2020.02.007. Epub 2020 Mar 10. Brain Dev. 2020. PMID: 32164978 Free article.
The involuntary movement in AS has not been defined patho-physiologically and the drugs used such as levetiracetam and piracetam are not always effective. Recently, the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor antagonist, perampanel (PER), was …
The involuntary movement in AS has not been defined patho-physiologically and the drugs used such as levetiracetam and piracetam are …
Positive Experiences With Piracetam.
Beutner FU. Beutner FU. Dtsch Arztebl Int. 2020 Feb 14;116(7):116. doi: 10.3238/arztebl.2020.0116a. Dtsch Arztebl Int. 2020. PMID: 32164824 Free PMC article. No abstract available.
In Vitro and In Vivo Anti-AChE and Antioxidative Effects of Schisandra chinensis Extract: A Potential Candidate for Alzheimer's Disease.
Song X, Wang T, Guo L, Jin Y, Wang J, Yin G, Jiang K, Wang L, Huang H, Zeng L. Song X, et al. Evid Based Complement Alternat Med. 2020 Feb 20;2020:2804849. doi: 10.1155/2020/2804849. eCollection 2020. Evid Based Complement Alternat Med. 2020. PMID: 32148536 Free PMC article.
To confirm these results, the scopolamine-induced mice models were utilized in this study. Compared with the positive drug (piracetam), SC could also exhibit similar effects to alleviate the mice's cognitive deficits. ...
To confirm these results, the scopolamine-induced mice models were utilized in this study. Compared with the positive drug (piracetam
Memory-enhancing effects of 7,3',4'-trihydroxyisoflavone by regulation of cholinergic function and BDNF signaling pathway in mice.
Kim SK, Ko YH, Lee SY, Jang CG. Kim SK, et al. Food Chem Toxicol. 2020 Mar;137:111160. doi: 10.1016/j.fct.2020.111160. Epub 2020 Jan 25. Food Chem Toxicol. 2020. PMID: 31991199
The positive control groups were given donepezil (5 mg/kg, p.o.) or piracetam (200 mg/kg, i.p.) and the treated groups were given 7,3',4'-THIF (0.25, 0.5 and 1 mg/kg, p.o.). 7,3',4'-THIF at 1 mg/kg and donepezil at 5 mg/kg effectively ameliorated memory impairments induced …
The positive control groups were given donepezil (5 mg/kg, p.o.) or piracetam (200 mg/kg, i.p.) and the treated groups were given 7,3 …
Levetiracetam-induced de novo psychosis: Is there a type of patient with epilepsy who is neurostructural and/or biologically more vulnerable to developing it?
León Ruiz M, Rodríguez Sarasa ML, Sanjuán Rodríguez L, Benito-León J, Álvarez de Toledo O, Pérez Nieves MT, Arce Arce S. León Ruiz M, et al. Neurologia (Engl Ed). 2020 Nov-Dec;35(9):684-687. doi: 10.1016/j.nrl.2019.10.009. Epub 2019 Dec 31. Neurologia (Engl Ed). 2020. PMID: 31899009 Free article. English, Spanish. No abstract available.
ANTIOXIDATIVE EFFICACY OF NEUROPROTECTIVE THERAPY IN PATIENTS WITH CHRONIC CEREBRAL ISCHEMIA.
Demchenko A, Horbachova S, Revenko A. Demchenko A, et al. Georgian Med News. 2019 Nov;(296):62-66. Georgian Med News. 2019. PMID: 31889706
The patients from the control group were intravenously administered infusions of Tiocetam with the dosage of 20 ml (for 10 days, then changed for Tiocetam forte (400 mg of Piracetam and 100 mg of Tiotriazoline) with the dosage of 1 pill thrice a day during 30 days. ...
The patients from the control group were intravenously administered infusions of Tiocetam with the dosage of 20 ml (for 10 days, then change …
The analysis of the use of potentially inappropriate medications in elderly in the Slovak Republic.
Jankyova S, Rubintova D, Foltanova T. Jankyova S, et al. Int J Clin Pharm. 2020 Feb;42(1):100-109. doi: 10.1007/s11096-019-00944-x. Epub 2019 Dec 9. Int J Clin Pharm. 2020. PMID: 31820202

Patients using at least one PIM took two times more drugs compared to patients without PIM (8.77 0.17 vs. 3.98 0.39 drugs/patient/day, p < 0.001). The most common PIM were PPI (36% of patients), piracetam (17.2%) and alprazolam (16.80%). Conclusions The risk of PIM was

Patients using at least one PIM took two times more drugs compared to patients without PIM (8.77 0.17 vs. 3.98 0.39 drugs/patient/day, p < …
Psychostimulant Use for Neuroenhancement (Smart Drugs) among College Students in Brazil.
de Oliveira Cata Preta B, Miranda VIA, Bertoldi AD. de Oliveira Cata Preta B, et al. Subst Use Misuse. 2020;55(4):613-621. doi: 10.1080/10826084.2019.1691597. Epub 2019 Dec 2. Subst Use Misuse. 2020. PMID: 31790311
Smart drug usage was defined as taking methylphenidate, modafinil or piracetam at any point in life and in the preceding 12 months. We characterized the means of obtaining smart drugs, reasons for using and students' residential situation. ...
Smart drug usage was defined as taking methylphenidate, modafinil or piracetam at any point in life and in the preceding 12 months. W …
Anticholinesterase and Antioxidant Potential of Hydromethanolic Extract of Ziziphus mucronata (Rhamnaceae) Leaves on Scopolamine-Induced Memory and Cognitive Dysfunctions in Mice.
Foyet HS, Keugong Wado E, Ngatanko Abaissou HH, Assongalem EA, Eyong OK. Foyet HS, et al. Evid Based Complement Alternat Med. 2019 Oct 24;2019:4568401. doi: 10.1155/2019/4568401. eCollection 2019. Evid Based Complement Alternat Med. 2019. PMID: 31781268 Free PMC article.
Alzheimer-type amnesia was induced by an intraperitoneal injection of scopolamine (1 mg/kg) to mice for 7 consecutive days. ZM (150 mg/kg, 300 mg/kg, and 600 mg/kg) and piracetam (150 mg/kg) were orally administrated to mice daily for a period of 14 days. ...
Alzheimer-type amnesia was induced by an intraperitoneal injection of scopolamine (1 mg/kg) to mice for 7 consecutive days. ZM (150 mg/kg, 3 …
Presence of Piracetam in Cognitive Enhancement Dietary Supplements.
Cohen PA, Zakharevich I, Gerona R. Cohen PA, et al. JAMA Intern Med. 2020 Mar 1;180(3):458-459. doi: 10.1001/jamainternmed.2019.5507. JAMA Intern Med. 2020. PMID: 31764936 Free PMC article.
This study analyzes 5 brands of dietary supplements to determine the prevalence of the nootropic drug piracetam in supplements advertised as cognitive enhancers....
This study analyzes 5 brands of dietary supplements to determine the prevalence of the nootropic drug piracetam in supplements advert …
Prevention of Alzheimer's disease by treating mild cognitive impairment with combinations chosen from eight available drugs.
Fessel J. Fessel J. Alzheimers Dement (N Y). 2019 Nov 16;5:780-788. doi: 10.1016/j.trci.2019.09.019. eCollection 2019. Alzheimers Dement (N Y). 2019. PMID: 31763432 Free PMC article. Review.
Published reports show that eight drugs, that is, dantrolene, erythropoietin, lithium, memantine, minocycline, piracetam, riluzole, and silymarin, address many of the pathways underlying MCI and AD. ...
Published reports show that eight drugs, that is, dantrolene, erythropoietin, lithium, memantine, minocycline, piracetam, riluzole, a …
Zataria multiflora Boiss. extract improves spatial memory and learning capacity in scopolamine-induced amnesic rats.
Sheibani V, Mandegary A, Vazifekhahan E, Kasbzade Z, Asadi A, Sharififar F. Sheibani V, et al. Avicenna J Phytomed. 2019 Nov-Dec;9(6):587-596. doi: 10.22038/AJP.2019.13540. Avicenna J Phytomed. 2019. PMID: 31763217 Free PMC article.
Anticholinesterase activity was studied using Ellman's method. Physostigmine (0.3 mg/kg) and piracetam (200 mg/kg) were used as positive controls. RESULTS: All doses of Zm extract significantly decreased the distance and time spent to find the platform in MWM and increased …
Anticholinesterase activity was studied using Ellman's method. Physostigmine (0.3 mg/kg) and piracetam (200 mg/kg) were used as posit …
Wuzang Wenyang Huayu decoction regulates differentially expressed transcripts in the rats' hippocampus after cerebral hypoperfusion.
Xia M, Ruan Z, Chen B, Wang Y, Zhou Z, Ren S, Wu L, Tang N. Xia M, et al. J Cell Mol Med. 2020 Jan;24(1):294-303. doi: 10.1111/jcmm.14723. Epub 2019 Nov 9. J Cell Mol Med. 2020. PMID: 31705584 Free PMC article.
Two groups of rats were intragastrically treated Wuzang Wenyang Huayu 2.5 g/kg vs or Piracetam 0.15 g/kg for 2 weeks. Learning and memory abilities were measured with Morris water maze. ...
Two groups of rats were intragastrically treated Wuzang Wenyang Huayu 2.5 g/kg vs or Piracetam 0.15 g/kg for 2 weeks. Learning and me …
MANAGEMENT OF AMNESTIC AND BEHAVIORAL DISORDERS AFTER KETAMINE ANESTHESIA.
Belenichev I, Burlaka B, Puzyrenko A, Ryzhenko O, Kurochkin M, Yusuf J. Belenichev I, et al. Georgian Med News. 2019 Sep;(294):141-145. Georgian Med News. 2019. PMID: 31687967
We discovered that the intranasal administration of noopept after ketamine anesthesia significantly decreases anxiety and excitability, raises the animal's activity, shows an intensive antiamnesic effects and increases animal's training ability. Noopept significantly exceeds p
We discovered that the intranasal administration of noopept after ketamine anesthesia significantly decreases anxiety and excitability, rais …
Neurotrophic Factors in the Treatment of Acute Brain Hypoxia Secondary to Cardiac Arrest: a Case Report.
Węgrzyn D, Kutwin-Chojnacka A, Bilski J, Mroszczyk K, Węgrzyn K. Węgrzyn D, et al. J Med Life. 2019 Jul-Sep;12(3):233-235. doi: 10.25122/jml-2019-1007. J Med Life. 2019. PMID: 31666823 Free PMC article.
Finding neuroprotective agents to counteract the deleterious effects of hypoxia on neuronal cells successfully is one of the most critical targets of clinical research since preclinical studies have identified potential neuroprotective strategies. In clinical practice, amantadine …
Finding neuroprotective agents to counteract the deleterious effects of hypoxia on neuronal cells successfully is one of the most critical t …
Conservative Treatment Possibilities of Ménière Disease, Involving Vertigo Diaries.
Molnár A, Maihoub S, Tamás L, Szirmai Á. Molnár A, et al. Ear Nose Throat J. 2021 Aug;100(7):536-542. doi: 10.1177/0145561319881838. Epub 2019 Oct 16. Ear Nose Throat J. 2021. PMID: 31617407 Free article.
The aim of the present research is to examine the effectiveness of betahistine and piracetam in the reduction of vertigo attacks in Meniere disease. To verify our hypothesis, 105 (31 male and 74 females, mean age [standard deviation], 57.4 [11.05]) adult patients with defi …
The aim of the present research is to examine the effectiveness of betahistine and piracetam in the reduction of vertigo attacks in M …
Effectiveness Oral Theophylline, Piracetam, and Iron Treatments in Children With Simple Breath-Holding Spells.
Dai AI, Demiryürek AT. Dai AI, et al. J Child Neurol. 2020 Jan;35(1):25-30. doi: 10.1177/0883073819871854. Epub 2019 Sep 10. J Child Neurol. 2020. PMID: 31502508
This is a retrospective study to compare the effectiveness of oral theophylline, piracetam, and iron treatments in children with simple BHS. A total of 146 children (75 girls and 71 boys) with simple BHS were included to this retrospective study. Children were divided into …
This is a retrospective study to compare the effectiveness of oral theophylline, piracetam, and iron treatments in children with simp …
Levetiracetam in Neonatal seizures.
Swami M, Kaushik JS. Swami M, et al. Indian Pediatr. 2019 Aug 15;56(8):639-640. Indian Pediatr. 2019. PMID: 31477641 Free article. No abstract available.
Co-treatment of piracetam with risperidone rescued extinction deficits in experimental paradigms of post-traumatic stress disorder by restoring the physiological alterations in cortex and hippocampus.
Uniyal A, Singh R, Akhtar A, Bansal Y, Kuhad A, Sah SP. Uniyal A, et al. Pharmacol Biochem Behav. 2019 Oct;185:172763. doi: 10.1016/j.pbb.2019.172763. Epub 2019 Aug 22. Pharmacol Biochem Behav. 2019. PMID: 31445955
With the objective to enhance the outcomes of exposure therapy by targeting the extinction window using pharmacological agents in PTSD, the present study was aimed to explore the effect of piracetam, risperidone and their combinations in experimentally-induced PTSD-like ph …
With the objective to enhance the outcomes of exposure therapy by targeting the extinction window using pharmacological agents in PTSD, the …
An update on the efficacy of anti-inflammatory agents for patients with schizophrenia: a meta-analysis.
Çakici N, van Beveren NJM, Judge-Hundal G, Koola MM, Sommer IEC. Çakici N, et al. Psychol Med. 2019 Oct;49(14):2307-2319. doi: 10.1017/S0033291719001995. Epub 2019 Aug 23. Psychol Med. 2019. PMID: 31439071 Free PMC article. Review.
RESULTS: Our search yielded 56 studies that provided information on the efficacy of the following components on symptom severity: aspirin, bexarotene, celecoxib, davunetide, dextromethorphan, estrogens, fatty acids, melatonin, minocycline, N-acetylcysteine (NAC), pioglitazone, …
RESULTS: Our search yielded 56 studies that provided information on the efficacy of the following components on symptom severity: aspirin, b …
The Effect of the Repression of Oxidative Stress on Tenocyte Differentiation: A Preliminary Study of a Rat Cell Model Using a Novel Differential Tensile Strain Bioreactor.
Hsiao MY, Lin PC, Liao WH, Chen WS, Hsu CH, He CK, Wu YW, Gefen A, Iafisco M, Liu L, Lin FH. Hsiao MY, et al. Int J Mol Sci. 2019 Jul 12;20(14):3437. doi: 10.3390/ijms20143437. Int J Mol Sci. 2019. PMID: 31336919 Free PMC article.
TDCs subjected to 8% strain were treated with epigallocatechin gallate (EGCG), piracetam, or no medication. Genes representing non-tenocyte lineage (Pparg, Sox9, and Runx2) and type I and type III collagen were analyzed by quantitative polymerase chain reaction. The 8% str …
TDCs subjected to 8% strain were treated with epigallocatechin gallate (EGCG), piracetam, or no medication. Genes representing non-te …
Nootropic drugs: Methylphenidate, modafinil and piracetam - Population use trends, occurrence in the environment, ecotoxicity and removal methods - A review.
Wilms W, Woźniak-Karczewska M, Corvini PF, Chrzanowski Ł. Wilms W, et al. Chemosphere. 2019 Oct;233:771-785. doi: 10.1016/j.chemosphere.2019.06.016. Epub 2019 Jun 4. Chemosphere. 2019. PMID: 31200137 Review.
This review summarises the current state of knowledge on nootropic drugs in terms of their population use trends and ethics, occurrence in the environment and detection techniques, toxicity and removal methods, in example of methylphenidate, modafinil and piracetam - three …
This review summarises the current state of knowledge on nootropic drugs in terms of their population use trends and ethics, occurrence in t …
Lawsonia Inermis Markedly Improves Cognitive Functions in Animal Models and Modulate Oxidative Stress Markers in the Brain.
Mir NT, Saleem U, Anwar F, Ahmad B, Ullah I, Hira S, Ismail T, Ali T, Ayaz M. Mir NT, et al. Medicina (Kaunas). 2019 May 22;55(5):192. doi: 10.3390/medicina55050192. Medicina (Kaunas). 2019. PMID: 31121979 Free PMC article.
Memory-enhancing potentials of the samples were assessed using two methods including "without inducing amnesia" and "induction of amnesia" by administration of diazepam (1 mg/kg, intraperitoneally. Piracetam at 400 mg/kg (i.p.) was used as positive control. Cognitive behav …
Memory-enhancing potentials of the samples were assessed using two methods including "without inducing amnesia" and "induction of amnesia" b …
Drug screening for Pelizaeus-Merzbacher disease by quantifying the total levels and membrane localization of PLP1.
Kouga T, Koizume S, Aoki S, Jimbo E, Yamagata T, Inoue K, Osaka H. Kouga T, et al. Mol Genet Metab Rep. 2019 May 7;20:100474. doi: 10.1016/j.ymgmr.2019.100474. eCollection 2019 Sep. Mol Genet Metab Rep. 2019. PMID: 31110947 Free PMC article.
Finally, we tested the in vivo effectiveness using myelin synthesis deficient (msd) mice with Plp (A243V) . RESULTS AND CONCLUSION: Piracetam significantly increased the PLP1(A243V) intensity and membrane localization and decreased the ER stress. It was also shown to rever …
Finally, we tested the in vivo effectiveness using myelin synthesis deficient (msd) mice with Plp (A243V) . RESULTS AND CONCLUSION: Pirac
Pharmacotherapeutic management of epilepsy in MERRF syndrome.
Finsterer J. Finsterer J. Expert Opin Pharmacother. 2019 Jul;20(10):1289-1297. doi: 10.1080/14656566.2019.1609941. Epub 2019 May 7. Expert Opin Pharmacother. 2019. PMID: 31063406 Review.
Treatment of myoclonic epilepsy relies on expert judgments recommending levetiracetam, together with clonazepam, or topiramate, zonisamide, or piracetam in monotherapy as the first line AEDs....
Treatment of myoclonic epilepsy relies on expert judgments recommending levetiracetam, together with clonazepam, or topiramate, zonisamide, …
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