Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 12
1988 34
1989 51
1990 78
1991 101
1992 196
1993 274
1994 327
1995 349
1996 391
1997 422
1998 404
1999 419
2000 458
2001 500
2002 478
2003 538
2004 508
2005 550
2006 593
2007 622
2008 604
2009 532
2010 559
2011 589
2012 559
2013 541
2014 538
2015 485
2016 416
2017 393
2018 355
2019 338
2020 389
2021 378
2022 348
2023 305
2024 335
2025 321
2026 255

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

14,227 results

Results by year

Filters applied: . Clear all
Page 1
A Narrative Review on Plasminogen Activator Inhibitor-1 and Its (Patho)Physiological Role: To Target or Not to Target?
Sillen M, Declerck PJ. Sillen M, et al. Int J Mol Sci. 2021 Mar 8;22(5):2721. doi: 10.3390/ijms22052721. Int J Mol Sci. 2021. PMID: 33800359 Free PMC article. Review.
Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of plasminogen activators (PAs) and is therefore an important inhibitor of the plasminogen/plasmin system. ...
Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of plasminogen activators (PAs) an …
Good or bad: Paradox of plasminogen activator inhibitor 1 (PAI-1) in digestive system tumors.
Wang B, Gu B, Zhang T, Li X, Wang N, Ma C, Xiang L, Wang Y, Gao L, Yu Y, Song K, He P, Wang Y, Zhu J, Chen H. Wang B, et al. Cancer Lett. 2023 Apr 10;559:216117. doi: 10.1016/j.canlet.2023.216117. Epub 2023 Mar 6. Cancer Lett. 2023. PMID: 36889376 Review.
The fibrinolytic system is involved in many physiological functions, among which the important members can interact with each other, either synergistically or antagonistically to participate in the pathogenesis of many diseases. Plasminogen activator inhibitor …
The fibrinolytic system is involved in many physiological functions, among which the important members can interact with each other, either …
The Role of Plasminogen Activator Inhibitor Type-1 in Fibrosis.
Flevaris P, Vaughan D. Flevaris P, et al. Semin Thromb Hemost. 2017 Mar;43(2):169-177. doi: 10.1055/s-0036-1586228. Epub 2016 Aug 24. Semin Thromb Hemost. 2017. PMID: 27556351 Review.
The persistent activation of interstitial myofibroblasts, coupled with defects in matrix proteolysis, ultimately disrupts tissue architecture and leads to biochemical and mechanical organ dysfunction with eventual organ failure. Plasminogen activator inhibitor …
The persistent activation of interstitial myofibroblasts, coupled with defects in matrix proteolysis, ultimately disrupts tissue architectur …
Plasminogen activator inhibitor-1 in cancer research.
Li S, Wei X, He J, Tian X, Yuan S, Sun L. Li S, et al. Biomed Pharmacother. 2018 Sep;105:83-94. doi: 10.1016/j.biopha.2018.05.119. Epub 2018 May 28. Biomed Pharmacother. 2018. PMID: 29852393 Review.
[Despite as a major inhibitor of urokinase (uPA), paradoxically,] Plasminogen activator inhibitor-1 (PAI-1) has been validated to be highly expressed in various types of tumor biopsy tissues or plasma compared with controls based on huge clinical data …
[Despite as a major inhibitor of urokinase (uPA), paradoxically,] Plasminogen activator inhibitor-1 (PAI-1) has …
Plasminogen activator inhibitor 1 promotes aortic aging-like pathophysiology in humans and mice.
Khoddam A, Kalousdian A, Eren M, Soberanes S, Decker A, Lux EJ, Zywicki BW, Dinh B, Boztepe B, Cheema BS, Cuda CM, Abdala-Valencia H, Sivakumar A, Miyata T, Wilsbacher LD, Vaughan DE. Khoddam A, et al. J Clin Invest. 2025 Sep 30;135(23):e196714. doi: 10.1172/JCI196714. eCollection 2025 Dec 1. J Clin Invest. 2025. PMID: 41026613 Free PMC article.
Plasminogen activator inhibitor 1 (PAI-1), encoded by SERPINE1, contributes to age-related cardiovascular disease (CVD) and other aging-related pathologies. ...
Plasminogen activator inhibitor 1 (PAI-1), encoded by SERPINE1, contributes to age-related cardiovascular diseas …
Plasminogen Activator Inhibitor-1 in the Pathophysiology of Late Life Depression.
Métivier L, Vivien D, Goy R, Agin V, Bui E, Benbrika S. Métivier L, et al. Int J Geriatr Psychiatry. 2024 Nov;39(11):e70015. doi: 10.1002/gps.70015. Int J Geriatr Psychiatry. 2024. PMID: 39578639 Review.
The expression and functions of the serine protease inhibitor, Plasminogen Activator Inhibitor-1 (PAI-1) is known to be altered by aging, vascular damage, insulin levels associated with a sedentary lifestyle, chronic stress leading to hypercortisolemia …
The expression and functions of the serine protease inhibitor, Plasminogen Activator Inhibitor-1 (PAI-1) is know …
Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of Senescence.
Vaughan DE, Rai R, Khan SS, Eren M, Ghosh AK. Vaughan DE, et al. Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1446-1452. doi: 10.1161/ATVBAHA.117.309451. Epub 2017 Jun 1. Arterioscler Thromb Vasc Biol. 2017. PMID: 28572158 Free PMC article. Review.
PAI-1 (plasminogen activator inhibitor-1) is a member of the evolutionarily conserved serine protease inhibitor family and a potent and rapid-acting inhibitor of both of the mammalian plasminogen activators. ...
PAI-1 (plasminogen activator inhibitor-1) is a member of the evolutionarily conserved serine protease inh …
Plasminogen activator inhibitor-1 serum levels in frontotemporal lobar degeneration.
Angelucci F, Veverova K, Katonová A, Vyhnalek M, Hort J. Angelucci F, et al. J Cell Mol Med. 2024 Mar;28(5):e18013. doi: 10.1111/jcmm.18013. Epub 2024 Feb 22. J Cell Mol Med. 2024. PMID: 38386354 Free PMC article.
Plasminogen activator inhibitor-1 (PAI-1) impedes brain plasmin synthesis. Reduced plasmin activity facilitates cumulation of amyloid beta (Abeta) in Alzheimer's disease (AD). ...
Plasminogen activator inhibitor-1 (PAI-1) impedes brain plasmin synthesis. Reduced plasmin activity facilitates …
Latency transition of plasminogen activator inhibitor type 1 is evolutionarily conserved.
Jendroszek A, Sønnichsen MS, Muñoz AC, Leyman K, Christensen A, Petersen SV, Wang T, Bendixen C, Panitz F, Andreasen PA, Jensen JK. Jendroszek A, et al. Thromb Haemost. 2017 Aug 30;117(9):1688-1699. doi: 10.1160/TH17-02-0102. Epub 2017 Aug 3. Thromb Haemost. 2017. PMID: 28771275
Plasminogen activator inhibitor type 1 (PAI-1) is a central regulator of fibrinolysis and tissue remodelling. ...
Plasminogen activator inhibitor type 1 (PAI-1) is a central regulator of fibrinolysis and tissue remodell …
Functional stability of plasminogen activator inhibitor-1.
Yasar Yildiz S, Kuru P, Toksoy Oner E, Agirbasli M. Yasar Yildiz S, et al. ScientificWorldJournal. 2014;2014:858293. doi: 10.1155/2014/858293. Epub 2014 Oct 15. ScientificWorldJournal. 2014. PMID: 25386620 Free PMC article. Review.
Plasminogen activator inhibitor-1 (PAI-1) is the main inhibitor of plasminogen activators, such as tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA), and a major regulator of the fibrinolytic system. ...
Plasminogen activator inhibitor-1 (PAI-1) is the main inhibitor of plasminogen activators, such as tissue-type p …
14,227 results
You have reached the last available page of results. Please see the User Guide for more information.