Clinical outcomes following intradiscal injections of higher-concentration platelet-rich plasma in patients with chronic lumbar discogenic pain.
Int Orthop. 2022.
PMID: 35344055
Free PMC article.
Search Page
Filters
Results by year
Table representation of search results timeline featuring number of search results per year.
| Year | Number of Results |
|---|---|
| 2015 | 1 |
| 2016 | 2 |
| 2017 | 1 |
| 2018 | 2 |
| 2019 | 3 |
| 2020 | 4 |
| 2021 | 5 |
| 2022 | 12 |
| 2023 | 7 |
| 2024 | 12 |
| 2025 | 7 |
| 2026 | 11 |
Search Results
62 results
Results by year
Citations
4
articles
found by citation matching
Comparative Outcomes of Lumbar Platelet-Rich Plasma Injection Versus Conservative Treatment for Chronic Discogenic and/or Radicular Pain: A Retrospective Cohort Study.
Biomedicines. 2026.
PMID: 42193386
Free PMC article.
Safety and Efficacy of Platelet Rich Plasma for Treatment of Lumbar Discogenic Pain: A Prospective, Multicenter, Randomized, Double-blind Study.
Pain Physician. 2022.
PMID: 35051141
Clinical Trial.
Search results
Page 1
The High-Intensity Zone: A Dynamic Inflammatory Hub in Lumbar Disc Degeneration.
Orthop Surg. 2026 Jul 25:10.1111/os.70389. doi: 10.1111/os.70389. Online ahead of print.
Orthop Surg. 2026.
PMID: 42500814
Free PMC article.
Review.
The molecular pathology involves a self-perpetuating "inflammation-matrix degradation" vicious cycle driven by cytokines (e.g., TNF-alpha, IL-1beta) and matrix-degrading enzymes (e.g., MMPs, ADAMTS), underscoring its central role in the chronicization of discogenic low …
The molecular pathology involves a self-perpetuating "inflammation-matrix degradation" vicious cycle driven by cytokines (e.g., TNF-alpha, I …
Evolving Landscape of Regenerative Therapies: Cell-Based and Cell-Free Approaches for Chronic Low Back Pain.
J Clin Med. 2026 Jul 4;15(13):5235. doi: 10.3390/jcm15135235.
J Clin Med. 2026.
PMID: 42452694
Free PMC article.
Review.
Background: Chronic low back pain (CLBP) is the leading cause of years lived with disability globally, affecting over 600 million individuals. ...Regenerative medicine has introduced a spectrum of biological therapies for IVDD, including cell-based mesenchyma …
Background: Chronic low back pain (CLBP) is the leading cause of years lived with disability globally, affecting over 6 …
Lumbar Provocative Discography.
2026 Jun 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–.
2026 Jun 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–.
PMID: 34283485
Free Books & Documents.
Low back pain (LBP) represents a major global health concern, with a point prevalence of approximately 7% to 8% worldwide and affecting more than 570 million individuals. ...Renewed interest in discography has followed the emergence of regenerative therapies …
Low back pain (LBP) represents a major global health concern, with a point prevalence of approximately 7% to 8% worldwi …
Comparative Outcomes of Lumbar Platelet-Rich Plasma Injection Versus Conservative Treatment for Chronic Discogenic and/or Radicular Pain: A Retrospective Cohort Study.
Biomedicines. 2026 May 7;14(5):1061. doi: 10.3390/biomedicines14051061.
Biomedicines. 2026.
PMID: 42193386
Free PMC article.
Background/Objectives: Few previous studies have evaluated both radiological changes and the clinical effectiveness of platelet-rich plasma (PRP) injections, a biomedical therapy, in patients with chronic discogenic and/or radicular low back …
Background/Objectives: Few previous studies have evaluated both radiological changes and the clinical effectiveness of platelet-ri …
Platelet-rich plasma therapy for low back pain: A comprehensive systematic review and meta-analysis.
J Back Musculoskelet Rehabil. 2026 May 9:10538127261448983. doi: 10.1177/10538127261448983. Online ahead of print.
J Back Musculoskelet Rehabil. 2026.
PMID: 42105106
Review.
BackgroundLow back pain (LBP) is a major global disability, yet the promise of regenerative medicine using platelet-rich plasma (PRP) remains debated.ObjectiveTo systematically evaluate the efficacy of PRP injections in reducing pain inte …
BackgroundLow back pain (LBP) is a major global disability, yet the promise of regenerative medicine using platelet- …
Medicine regenerative versus steroids: time to reconsider treatment of chronic inflammatory pain.
Minerva Anestesiol. 2026 Jul-Aug;92(7-8):726-738. doi: 10.23736/S0375-9393.26.19712-0. Epub 2026 May 6.
Minerva Anestesiol. 2026.
PMID: 42089640
Free article.
The most commonly used regenerative treatment is platelet-rich plasma (PRP), which modulates inflammation and extracellular matrix turnover and partly affects nociceptive signalling. ...Given the heterogeneity in the PRP formulations (leukocyte-poor/leukocyte …
The most commonly used regenerative treatment is platelet-rich plasma (PRP), which modulates inflammation and extracell …
Current Perspective on Orthobiology Applications for the Treatment of Intervertebral Disc Degeneration (IDD)-A Narrative Review.
Medicina (Kaunas). 2026 Apr 15;62(4):758. doi: 10.3390/medicina62040758.
Medicina (Kaunas). 2026.
PMID: 42075629
Free PMC article.
Review.
Background and Objectives: Low back pain (LBP) is a leading cause of disability worldwide and is frequently associated with intervertebral disc degeneration (IVDD). ...Orthobiologic therapies represent a minimally invasive option for patients with discogen …
Background and Objectives: Low back pain (LBP) is a leading cause of disability worldwide and is frequently associated …
Intradiscal Platelet-Rich Plasma Delivery via Modified Transdural Interlaminar Computed Tomography-Guided Access in Severe L5-S1 Disc Collapse: A Technical Case Report.
Pain Med Case Rep. 2026 Apr;10(2):223-226.
Pain Med Case Rep. 2026.
PMID: 42066283
Free article.
BACKGROUND: Intradiscal platelet-rich plasma (PRP) has emerging evidence for the treatment of discogenic low back pain. ...CASE REPORT: A 42-year-old man with chronic discogenic low back pain demonstrate …
BACKGROUND: Intradiscal platelet-rich plasma (PRP) has emerging evidence for the treatment of discogenic low …
Intradiscal Procedures for Discogenic Low Back Pain: Considerations and Implications - A Narrative Review.
J Pain Res. 2026 Jan 24;19:579829. doi: 10.2147/JPR.S579829. eCollection 2026.
J Pain Res. 2026.
PMID: 41884674
Free PMC article.
Review.
Discogenic low back pain (DLBP) is a prevalent contributor to chronic low back pain, often resulting from intervertebral disc degeneration associated with inflammation. Various intradiscal therapeutic procedures have been developed …
Discogenic low back pain (DLBP) is a prevalent contributor to chronic low back pain, often …
Intradiscal platelet-rich plasma for discogenic low back pain: a prospective cohort study of early clinical outcomes and quantitative MRI findings.
Sci Rep. 2026 Mar 24;16(1):14161. doi: 10.1038/s41598-026-42909-x.
Sci Rep. 2026.
PMID: 41876737
Free PMC article.
Discogenic low back pain (DLBP) is a major cause of disability. Platelet-rich plasma (PRP) has shown regenerative potential in preclinical models, but clinical results remain heterogeneous and early biological responses in humans a …
Discogenic low back pain (DLBP) is a major cause of disability. Platelet-rich plasma (PRP) …
Emerging Biologics in Lumbar Disc Degeneration: PRP, Stem Cell Therapy, and Pharmacotherapy in Mobility Restoration and Rehabilitation.
J Spine Res Surg. 2026;8(1):14-21. doi: 10.26502/fjsrs0097. Epub 2026 Feb 20.
J Spine Res Surg. 2026.
PMID: 41852545
Free PMC article.
Lumbar disc degeneration is a leading contributor to chronic low back pain and functional limitation worldwide, driven by progressive extracellular matrix breakdown, disc dehydration, inflammation, and cellular senescence. ...This narrative review exam …
Lumbar disc degeneration is a leading contributor to chronic low back pain and functional limitation worldwide, …
Comprehensive Evidence-Based Guidelines for Regenerative Therapies in the Management of Chronic Low Back Pain: 2025 Update from the American Society Of Interventional Pain Physicians (ASIPP).
Pain Physician. 2025 Dec;28(S7):S1-S119.
Pain Physician. 2025.
PMID: 41481869
Free article.
OBJECTIVE: To provide updated, evidence-based recommendations for the role of regenerative therapies in managing moderate to severe chronic low back pain. METHODS: A multidisciplinary panel of experts, convened by the American Society of Interventional Pai …
OBJECTIVE: To provide updated, evidence-based recommendations for the role of regenerative therapies in managing moderate to severe chronic …
Long-Term Effectiveness of Intradiscal Culture-Expanded Mesenchymal Stem Cells (MSCs) with Platelet Products for Discogenic Low Back Pain.
Biomedicines. 2025 Sep 26;13(10):2365. doi: 10.3390/biomedicines13102365.
Biomedicines. 2025.
PMID: 41153652
Free PMC article.
Background/Objectives: Low back pain (LBP) remains one of the leading causes of disability globally and contributes significantly to healthcare expenditures. ...Regenerative orthobiologic therapies, including platelet-rich plasma (PRP), …
Background/Objectives: Low back pain (LBP) remains one of the leading causes of disability globally and contributes sig …
Platelet-rich plasma for the treatment of discogenic low back pain: a prospective randomized controlled trial.
Front Pain Res (Lausanne). 2025 Aug 13;6:1648772. doi: 10.3389/fpain.2025.1648772. eCollection 2025.
Front Pain Res (Lausanne). 2025.
PMID: 40881828
Free PMC article.
OBJECTIVE: This study aimed to compare the therapeutic effect of PRP and methylene blue injection in patients with discogenic low back pain. METHODS: A total of 40 patients with discogenic low back pain were randomly divided …
OBJECTIVE: This study aimed to compare the therapeutic effect of PRP and methylene blue injection in patients with discogenic low …
14. Discogenic Low Back Pain.
Pain Pract. 2025 Sep;25(7):e70062. doi: 10.1111/papr.70062.
Pain Pract. 2025.
PMID: 40717265
Free PMC article.
Review.
INTRODUCTION: Discogenic low back pain can be severely disabling, clinically challenging to diagnose, and expensive to treat. ...A primary focus should be on increasing the evidence base for diagnosing discogenic low back pain …
INTRODUCTION: Discogenic low back pain can be severely disabling, clinically challenging to diagnose, and expens …
Bone marrow concentrate intradiscal injection for chronic discogenic low back pain: A double-blind randomized sham-controlled trial.
Interv Pain Med. 2025 Jul 17;4(3):100611. doi: 10.1016/j.inpm.2025.100611. eCollection 2025 Sep.
Interv Pain Med. 2025.
PMID: 40704141
Free PMC article.
SUMMARY OF BACKGROUND: The field of orthobiologics has attempted to address the challenge of discogenic low back pain (LBP). Research in areas such as stem cells, platelet-rich plasma, and specific growth factor injections has seen …
SUMMARY OF BACKGROUND: The field of orthobiologics has attempted to address the challenge of discogenic low back pai …
Clinical Efficacy and Risks of Intradiscal Orthobiological Injections: A Narrative Review.
Curr Pain Headache Rep. 2025 Jul 11;29(1):99. doi: 10.1007/s11916-025-01414-y.
Curr Pain Headache Rep. 2025.
PMID: 40646365
Review.
PURPOSE OF REVIEW: Chronic discogenic low back pain (LBP) is a common cause of disability worldwide. Current management options include conservative, surgical, and minimally invasive interventional injections. Intradiscal orthobiological injections of …
PURPOSE OF REVIEW: Chronic discogenic low back pain (LBP) is a common cause of disability worldwide. Current man …
Role of Platelet-Rich Plasma (PRP) in the Management of Stage III and IV Degenerative Disc Disease.
Cureus. 2025 Feb 23;17(2):e79504. doi: 10.7759/cureus.79504. eCollection 2025 Feb.
Cureus. 2025.
PMID: 40144405
Free PMC article.
Review.
Degenerative disc disease is a common disorder that can significantly impact patients' quality of life, leading to chronic pain and disability. Platelet-rich plasma (PRP) therapy is emerging as a potential treatment for degenerative disc disease. ...Th …
Degenerative disc disease is a common disorder that can significantly impact patients' quality of life, leading to chronic pain and d …
Effectiveness of Intradiscal Regenerative Medicine Therapies for Long-Term Relief of Chronic Low Back Pain: A Systematic Review and Meta-Analysis.
Pain Physician. 2024 Dec;27(10):E995-E1032.
Pain Physician. 2024.
PMID: 39688822
Free article.
BACKGROUND: Recent research underscores the potential of intradiscal biologics, such as mesenchymal stem cells (MSCs), platelet-rich plasma (PRP), and alpha-2-macroglobulin, in promoting chondrogenesis within lumbar intervertebral discs as a treatment …
BACKGROUND: Recent research underscores the potential of intradiscal biologics, such as mesenchymal stem cells (MSCs), platelet-ri …
Long-term Investigation of Annulargrams and Intra-annular Fibrin to Treat Chronic Discogenic Low Back Pain and Radiculopathy: 1-, 2-, and 3-Year Outcome Comparisons of Patients with and without Prior Surgery.
Pain Physician. 2024 Nov;27(8):537-553.
Pain Physician. 2024.
PMID: 39621982
Free article.
BACKGROUND: Discogenic chronic low back pain (cLBP) and radiculopathy are the most prevalent causes of disability worldwide. ...Other regenerative medicine treatments, including "stem cell" (centrifuged bone marrow aspirate, BMC), and platelet- …
BACKGROUND: Discogenic chronic low back pain (cLBP) and radiculopathy are the most prevalent causes of disabilit …
Association Between Spinopelvic Parameters and Clinical Outcomes of Patients Treated With Transforaminal Platelet-Rich Plasma Injections for Lumbar Disc Prolapse.
Cureus. 2024 Aug 16;16(8):e66995. doi: 10.7759/cureus.66995. eCollection 2024 Aug.
Cureus. 2024.
PMID: 39280506
Free PMC article.
Because of its autologous blood origin, platelet-rich plasma (PRP) therapy has minimal risks associated with immunogenic reactions and side consequences. We evaluated the extent of pain reduction and improvement of functional outcomes in patients havin …
Because of its autologous blood origin, platelet-rich plasma (PRP) therapy has minimal risks associated with immunogeni …
An evaluation of the effectiveness of platelet rich plasma epidural injections for low back pain suspected to be of disc origin - A pilot study with one-year follow-up.
Interv Pain Med. 2024 Apr 3;3(2):100403. doi: 10.1016/j.inpm.2024.100403. eCollection 2024 Jun.
Interv Pain Med. 2024.
PMID: 39238590
Free PMC article.
SUMMARY OF BACKGROUND DATA: Low back pain of disc origin is common yet challenging to treat. Intradiscal platelet rich plasma (PRP) has been advocated, but is associated with risk of discitis. ...Few studies exist evaluating effectiveness …
SUMMARY OF BACKGROUND DATA: Low back pain of disc origin is common yet challenging to treat. Intradiscal platelet …
Intradiscal Autologous Biologics for the Treatment of Chronic Discogenic Low Back Pain.
Curr Pain Headache Rep. 2024 Nov;28(11):1079-1095. doi: 10.1007/s11916-024-01294-8. Epub 2024 Jul 17.
Curr Pain Headache Rep. 2024.
PMID: 39017984
Review.
RECENT FINDINGS: Recently published literature highlights the therapeutic potential of intradiscal biologics, such as mesenchymal stem cells, platelet-rich plasma, and alpha-2-macroglobulin, in promoting chondrogenesis within the lumbar intervertebral …
RECENT FINDINGS: Recently published literature highlights the therapeutic potential of intradiscal biologics, such as mesenchymal stem cells …
A comprehensive review of cell transplantation and platelet-rich plasma therapy for the treatment of disc degeneration-related back and neck pain: A systematic evidence-based analysis.
JOR Spine. 2024 Jun 24;7(2):e1348. doi: 10.1002/jsp2.1348. eCollection 2024 Jun.
JOR Spine. 2024.
PMID: 38919468
Free PMC article.
Review.
Low back pain (LBP) and neck pain predominate as the primary causes of disability. Cell- and platelet-rich plasma (PRP) products are potential therapies with clinical trials and reviews promoting their efficacy. ...An electronic da …
Low back pain (LBP) and neck pain predominate as the primary causes of disability. Cell- and platelet- …
The Role of Platelet Rich Plasma in Vertebrogenic and Discogenic Pain: A Systematic Review and Meta-Analysis.
Curr Pain Headache Rep. 2024 Aug;28(8):825-833. doi: 10.1007/s11916-024-01274-y. Epub 2024 Jun 8.
Curr Pain Headache Rep. 2024.
PMID: 38850492
Free PMC article.
PURPOSE OF REVIEW: The present investigation evaluates clinical uses and roles of platelet rich plasma in the management of vetrebrogenic and discogenic mediated pain states. ...Platelet-rich plasma use has evolved and gaine …
PURPOSE OF REVIEW: The present investigation evaluates clinical uses and roles of platelet rich plasma in the managemen …
Revolutionizing Back Pain Management: Is Epidural Platelet-Rich Plasma the Superior Choice Over Steroids?
Cureus. 2024 Mar 3;16(3):e55423. doi: 10.7759/cureus.55423. eCollection 2024 Mar.
Cureus. 2024.
PMID: 38567224
Free PMC article.
While local anesthetic-free and combined epidural steroid injections have been used for many years, their usefulness is limited to shorter periods. In the field of orthopedics, platelet-rich plasma (PRP) has gained widespread recognition as an adjuvant compon …
While local anesthetic-free and combined epidural steroid injections have been used for many years, their usefulness is limited to shorter p …
Perspective on Intradiscal Therapies for Lumbar Discogenic Pain: State of the Science, Knowledge Gaps, and Imperatives for Clinical Adoption.
J Pain Res. 2024 Mar 18;17:1171-1182. doi: 10.2147/JPR.S441180. eCollection 2024.
J Pain Res. 2024.
PMID: 38524692
Free PMC article.
Specific clinical diagnostic criteria have established a consensus for defining patients with lumbar discogenic pain. However, if conservative medical management fails, these patients have few treatment options short of surgery involving discectomy often coup …
Specific clinical diagnostic criteria have established a consensus for defining patients with lumbar discogenic pain. H …
The Safety and Effectiveness of Orthobiologic Injections for Discogenic Chronic Low Back Pain: A Multicenter Prospective, Crossover, Randomized Controlled Trial with 12 Months Follow-up.
Pain Physician. 2024 Jan;27(1):E65-E77.
Pain Physician. 2024.
PMID: 38285032
Free article.
Clinical Trial.
BACKGROUND: Chronic low back pain is one of the most common causes of disability, affecting more than 600 million people worldwide with major social and economic costs. ...Novel therapeutic treatment options continue to develop, targeting the biological casca …
BACKGROUND: Chronic low back pain is one of the most common causes of disability, affecting more than 600 million peopl …
Preclinical Animal Study and Pilot Clinical Trial of Using Enriched Peripheral Blood-Derived Mononuclear Cells for Intervertebral Disc Degeneration.
Cell Transplant. 2024 Jan-Dec;33:9636897231219733. doi: 10.1177/09636897231219733.
Cell Transplant. 2024.
PMID: 38173231
Free PMC article.
Low back pain (LBP) is a leading cause of long-term disability globally. Intervertebral disk degeneration (IVDD) is mainly responsible for discogenic pain in LBP-affected young patients. ...Based on the animal results, 36 patients with chronic …
Low back pain (LBP) is a leading cause of long-term disability globally. Intervertebral disk degeneration (IVDD) is mai …
Current Review of Regenerative Medicine Therapies for Spine-Related Pain.
Curr Pain Headache Rep. 2024 Sep;28(9):949-955. doi: 10.1007/s11916-023-01194-3. Epub 2023 Dec 19.
Curr Pain Headache Rep. 2024.
PMID: 38112985
Review.
Regenerative medicine is a novel biotechnology targeting mechanical, degenerative, and inflammatory conditions believed to cause pain. Preparations including platelet-rich plasma, mesenchymal stem cells (adipose tissue and bone marrow aspirate concentr …
Regenerative medicine is a novel biotechnology targeting mechanical, degenerative, and inflammatory conditions believed to cause pain …
Systematic Review of Platelet-Rich Plasma for Low Back Pain.
Biomedicines. 2023 Aug 28;11(9):2404. doi: 10.3390/biomedicines11092404.
Biomedicines. 2023.
PMID: 37760845
Free PMC article.
Review.
BACKGROUND: Low back pain (LBP) has a high economic burden and is strongly related to the degenerative process of the spine, especially in the intervertebral disc and of the facet joints. Numerous treatment modalities have been proposed for the management of …
BACKGROUND: Low back pain (LBP) has a high economic burden and is strongly related to the degenerative process of the s …
The Clinical Efficacy of Autologous Platelet-Rich Plasma Interventional Circulatory Perfusion Combined with Radiofrequency Ablation and Thermocoagulation in the Treatment of Discogenic Low Back Pain.
Int J Clin Pract. 2023 Jul 18;2023:1489905. doi: 10.1155/2023/1489905. eCollection 2023.
Int J Clin Pract. 2023.
PMID: 37497125
Free PMC article.
OBJECTIVE: In this study, we aimed to explore the efficacy of the autologous platelet-rich plasma (PRP) interventional circulatory perfusion combined with radiofrequency ablation and thermocoagulation (RFAT) in the treatment of discogenic low …
OBJECTIVE: In this study, we aimed to explore the efficacy of the autologous platelet-rich plasma (PRP) interventional …
Transforaminal Injections of Platelet-Rich Plasma Compared with Steroid in Lumbar radiculopathy: A Prospective, Double-Blind Randomized Study.
Indian J Orthop. 2023 May 5;57(7):1126-1133. doi: 10.1007/s43465-023-00898-3. eCollection 2023 Jul.
Indian J Orthop. 2023.
PMID: 37384009
Free PMC article.
PURPOSE: To evaluate and compare the clinical efficacy of transforaminal steroid and platelet-rich plasma (PRP) injections in patients with discogenic lumbar radiculopathy. ...Clinical assessment was done with Visual analogue scale (VAS), modifi …
PURPOSE: To evaluate and compare the clinical efficacy of transforaminal steroid and platelet-rich plasma (PRP) injecti …
Retrospective Analysis of Factors Associated with the Treatment Outcomes of Intradiscal Platelet-Rich Plasma-Releasate Injection Therapy for Patients with Discogenic Low Back Pain.
Medicina (Kaunas). 2023 Mar 23;59(4):640. doi: 10.3390/medicina59040640.
Medicina (Kaunas). 2023.
PMID: 37109598
Free PMC article.
Clinical Trial.
Background and Objectives: Recently, the clinical application of platelet-rich plasma (PRP) has gained popularity for the treatment of degenerative disc diseases. ...Materials and Methods: A retrospective analysis of a previous randomized clinical trial of in …
Background and Objectives: Recently, the clinical application of platelet-rich plasma (PRP) has gained popularity for t …
[Research progress of platelet-rich plasma in treatment of discogenic low back pain].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2023 Mar 15;37(3):377-382. doi: 10.7507/1002-1892.202211047.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2023.
PMID: 36941000
Free PMC article.
Chinese.
OBJECTIVE: To summarize the research progress of platelet-rich plasma (PRP) for the treatment of discogenic low back pain (DLBP). METHODS: The literature on the treatment of DLBP with PRP was extensively reviewed, and the classific …
OBJECTIVE: To summarize the research progress of platelet-rich plasma (PRP) for the treatment of discogenic l …
Efficacy of intradiscal injection of platelet-rich plasma in the treatment of discogenic low back pain: A single-arm meta-analysis.
Medicine (Baltimore). 2023 Mar 10;102(10):e33112. doi: 10.1097/MD.0000000000033112.
Medicine (Baltimore). 2023.
PMID: 36897725
Free PMC article.
BACKGROUND: Discogenic low back pain (DLBP) has been influencing people's quality of life. Research on platelet-rich plasma (PRP) for DLBP has increased in recent years, but systematic summaries are lacking. ...There was no signifi …
BACKGROUND: Discogenic low back pain (DLBP) has been influencing people's quality of life. Research on platel …
Intradiscal Autologous Platelet-Rich Plasma Injection for Discogenic Low Back Pain: A Clinical Trial.
Biomed Res Int. 2022 Oct 10;2022:9563693. doi: 10.1155/2022/9563693. eCollection 2022.
Biomed Res Int. 2022.
PMID: 36262971
Free PMC article.
Clinical Trial.
BACKGROUND: Platelet-rich plasma (PRP) contains high concentrations of growth factors and cytokines and may promote healing and tissue formation and exert anti-inflammatory effects. ...This study is aimed at evaluating the effectiveness of autologous PRP on …
BACKGROUND: Platelet-rich plasma (PRP) contains high concentrations of growth factors and cytokines and may promote hea …
Comment on "Safety and Efficacy of Platelet Rich Plasma for Treatment of Lumbar Discogenic Pain: A Prospective, Multicenter, Randomized, Double-blind Study".
Pain Physician. 2022 Sep;25(6):E881.
Pain Physician. 2022.
PMID: 36122276
Free article.
No abstract available.
Platelet-Rich Plasma Injections: Pharmacological and Clinical Considerations in Pain Management.
Curr Pain Headache Rep. 2022 Oct;26(10):741-749. doi: 10.1007/s11916-022-01082-2. Epub 2022 Sep 10.
Curr Pain Headache Rep. 2022.
PMID: 36087238
Review.
Platelet-rich plasma (PRP), defined as a sample of plasma with a platelet concentration 3 to 5 times greater than the physiologic platelet concentration found in healthy whole blood, releases bioactive proteins which can restore anatomica …
Platelet-rich plasma (PRP), defined as a sample of plasma with a platelet concentration 3 to 5 times grea …
Regenerative Medicine: Pharmacological Considerations and Clinical Role in Pain Management.
Curr Pain Headache Rep. 2022 Oct;26(10):751-765. doi: 10.1007/s11916-022-01078-y. Epub 2022 Sep 8.
Curr Pain Headache Rep. 2022.
PMID: 36074255
Free PMC article.
Review.
PURPOSE OF REVIEW: Low back pain affects at least 80% of individuals at some point in their lifetime and is the fifth most common reason for physician visits in the USA. ...PRP and MSCs are used autogenously to help facilitate the healing process, and their i …
PURPOSE OF REVIEW: Low back pain affects at least 80% of individuals at some point in their lifetime and is the fifth m …
Clinical outcomes following intradiscal injections of higher-concentration platelet-rich plasma in patients with chronic lumbar discogenic pain.
Int Orthop. 2022 Jun;46(6):1381-1385. doi: 10.1007/s00264-022-05389-y. Epub 2022 Mar 28.
Int Orthop. 2022.
PMID: 35344055
Free PMC article.
PURPOSE: This study aimed to assess clinical outcomes following intradiscal injections of higher-concentration (> 10 ) platelet-rich plasma (PRP) in patients with chronic lumbar discogenic pain and to compare outcomes with a historica …
PURPOSE: This study aimed to assess clinical outcomes following intradiscal injections of higher-concentration (> 10 ) platelet- …
Platelet-Rich Plasma-Releasate (PRPr) for the Treatment of Discogenic Low Back Pain Patients: Long-Term Follow-Up Survey.
Medicina (Kaunas). 2022 Mar 16;58(3):428. doi: 10.3390/medicina58030428.
Medicina (Kaunas). 2022.
PMID: 35334604
Free PMC article.
Background and Objectives: Clinical studies of platelet-rich plasma (PRP) for the treatment of low back pain (LBP) have been reported; however, less is known about its long-term efficiency. ...Further large-scale studies would be needed t …
Background and Objectives: Clinical studies of platelet-rich plasma (PRP) for the treatment of low back …
Platelet-Rich Plasma Releasate versus Corticosteroid for the Treatment of Discogenic Low Back Pain: A Double-Blind Randomized Controlled Trial.
J Clin Med. 2022 Jan 7;11(2):304. doi: 10.3390/jcm11020304.
J Clin Med. 2022.
PMID: 35053999
Free PMC article.
Clinical application of platelet-rich plasma is gaining popularity in treating low back pain (LBP). This study investigated the efficacy and safety of platelet-rich plasma releasate (PRPr) injection into degenerated d …
Clinical application of platelet-rich plasma is gaining popularity in treating low back pain (LBP) …
Effectiveness of intradiscal platelet rich plasma for discogenic low back pain without Modic changes: A randomized controlled trial.
Interv Pain Med. 2022 Jan 21;1(1):100011. doi: 10.1016/j.inpm.2022.100011. eCollection 2022 Mar.
Interv Pain Med. 2022.
PMID: 39238810
Free PMC article.
OBJECTIVE: To determine if autologous platelet-rich plasma (PRP) injection into a degenerative intervertebral disc, without Modic changes on magnetic resonance imaging (MRI), improve pain and function. ...SETTING: Outpatient spine practice (Stichting R …
OBJECTIVE: To determine if autologous platelet-rich plasma (PRP) injection into a degenerative intervertebral disc, wit …
Safety and Efficacy of Platelet Rich Plasma for Treatment of Lumbar Discogenic Pain: A Prospective, Multicenter, Randomized, Double-blind Study.
Pain Physician. 2022 Jan;25(1):29-34.
Pain Physician. 2022.
PMID: 35051141
Free article.
Clinical Trial.
A 2016 study of platelet rich plasma (PRP) for chronic discogenic pain previously demonstrated clinically significant response among active group patients compared with controls. ...METHODS: Twenty-six (12 men, 14 women) human patients, ages 25 …
A 2016 study of platelet rich plasma (PRP) for chronic discogenic pain previously demonstrated clinically …
The effectiveness of intradiscal biologic treatments for discogenic low back pain: a systematic review.
Spine J. 2022 Feb;22(2):226-237. doi: 10.1016/j.spinee.2021.07.015. Epub 2021 Aug 2.
Spine J. 2022.
PMID: 34352363
BACKGROUND CONTEXT: There are limited treatments for discogenic low back pain. Intradiscal injections of biologic agents such as platelet-rich plasma (PRP) or stem cells (SC) are theorized to have regenerative properties and have g …
BACKGROUND CONTEXT: There are limited treatments for discogenic low back pain. Intradiscal injections of biologi …
Are injectable regenerative therapies effective in the treatment of degenerative disc disease? A systematic review.
J Neurosurg Sci. 2022 Oct;66(5):399-405. doi: 10.23736/S0390-5616.21.05389-3. Epub 2021 Aug 3.
J Neurosurg Sci. 2022.
PMID: 34342196
The aim of this systematic review was to summarize the current knowledge about injectable regenerative therapies (mesenchymal stem cells [MSC] or platelet rich plasma [PRP]) in degenerative disc disease. EVIDENCE ACQUISITION: A research and analysis of the li …
The aim of this systematic review was to summarize the current knowledge about injectable regenerative therapies (mesenchymal stem cells [MS …
Ultrasound-guided L5/S1 intradiscal needle placement using biplanar approach with the patient in the lateral decubitus position: A report of three cases.
Pain Pract. 2022 Jan;22(1):117-122. doi: 10.1111/papr.13027. Epub 2021 May 22.
Pain Pract. 2022.
PMID: 33949082
Therefore, we describe an innovative technique of US-guided platelet-rich plasma (PRP) administration in the lumbar intervertebral disc (IVD) of 3 patients with chronic lower back pain who failed to improve with conservative management. . …
Therefore, we describe an innovative technique of US-guided platelet-rich plasma (PRP) administration in the lumbar …
The Effect of Intradiscal Platelet-Rich Plasma Injection for Management of Discogenic Lower Back Pain: A Meta-Analysis.
J Pain Res. 2021 Feb 19;14:505-512. doi: 10.2147/JPR.S292335. eCollection 2021.
J Pain Res. 2021.
PMID: 33642874
Free PMC article.
OBJECTIVE: Although several researches of animal and human subjects have yielded promising results regarding intradiscal injection of platelet-rich plasma (PRP) for the management of intervertebral disc (IVD) pathologies, small sample sizes and unstandardized …
OBJECTIVE: Although several researches of animal and human subjects have yielded promising results regarding intradiscal injection of pla …
Intradiscal Platelet-Rich Plasma Injection for Discogenic Low Back Pain and Correlation with Platelet Concentration: A Prospective Clinical Trial.
Pain Med. 2020 Nov 1;21(11):2719-2725. doi: 10.1093/pm/pnaa254.
Pain Med. 2020.
PMID: 32869064
OBJECTIVE: Discogenic pain is common cause of low back ache and may result in significant morbidity. Platelet-rich plasma (PRP) is an upcoming regenerative therapy that has treatment potential for this condition. ...
OBJECTIVE: Discogenic pain is common cause of low back ache and may result in significant morbidity. Platelet …
Intradiscal Platelet-Rich Plasma for Discogenic Low Back Pain Owing to a Degenerated and Previously Discectomized L5-S1 Disc.
Pain Med. 2021 May 21;22(5):1235-1236. doi: 10.1093/pm/pnaa241.
Pain Med. 2021.
PMID: 32783050
No abstract available.
Human mesenchymal stem cells respond differentially to platelet preparations and synthesize hyaluronic acid in nucleus pulposus extracellular matrix.
Spine J. 2020 Nov;20(11):1850-1860. doi: 10.1016/j.spinee.2020.06.011. Epub 2020 Jun 19.
Spine J. 2020.
PMID: 32565315
BACKGROUND CONTEXT: In recent years, autologous platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) have been used as treatments for disc-related pain. A better understanding of the effects of leukocyte-rich (LR) versus leukoc …
BACKGROUND CONTEXT: In recent years, autologous platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) …
Ultrasound-Guided Lumbar Intradiscal Injection for Discogenic Pain: Technical Innovation and Presentation of Two Cases.
J Pain Res. 2020 May 19;13:1103-1107. doi: 10.2147/JPR.S253047. eCollection 2020.
J Pain Res. 2020.
PMID: 32547174
Free PMC article.
We described two cases and the techniques for using the ultrasound (US) to guide lumbar intradiscal injection with platelet-rich plasma (PRP). The two cases suffered from chronic low back pain. ...At the follow-up, both patients ha …
We described two cases and the techniques for using the ultrasound (US) to guide lumbar intradiscal injection with platelet- …
Injections of concentrated bone marrow aspirate as treatment for Discogenic pain: a retrospective analysis.
BMC Musculoskelet Disord. 2020 Feb 28;21(1):135. doi: 10.1186/s12891-020-3126-7.
BMC Musculoskelet Disord. 2020.
PMID: 32111220
Free PMC article.
BACKGROUND: There are an overwhelming number of patients suffering from low back pain (LBP) resulting from disc pathology. Although several strategies are being developed pre-clinically, simple strategies to treat the large number of patients currently affect …
BACKGROUND: There are an overwhelming number of patients suffering from low back pain (LBP) resulting from disc patholo …
Treatment of symptomatic degenerative intervertebral discs with autologous platelet-rich plasma: follow-up at 5-9 years.
Regen Med. 2019 Sep;14(9):831-840. doi: 10.2217/rme-2019-0040. Epub 2019 Aug 29.
Regen Med. 2019.
PMID: 31464577
Free PMC article.
Clinical Trial.
Aim: This study assessed pain and function at 5-9 years postinjection in a subset of patients who received intradiscal platelet-rich plasma (PRP) injections for moderate-to-severe lumbar discogenic pain. ...Conclusion: This subset …
Aim: This study assessed pain and function at 5-9 years postinjection in a subset of patients who received intradiscal platelet …
Platelet-rich plasma in the management of chronic low back pain: a critical review.
J Pain Res. 2019 Feb 25;12:753-767. doi: 10.2147/JPR.S153085. eCollection 2019.
J Pain Res. 2019.
PMID: 30881089
Free PMC article.
Review.
Low back pain (LBP) is now regarded as the first cause of disability worldwide and should be a priority for future research on prevention and therapy. Intervertebral disc (IVD) degeneration is an important pathogenesis of LBP. Platelet-rich p …
Low back pain (LBP) is now regarded as the first cause of disability worldwide and should be a priority for future rese …
Responsible, Safe, and Effective Use of Biologics in the Management of Low Back Pain: American Society of Interventional Pain Physicians (ASIPP) Guidelines.
Pain Physician. 2019 Jan;22(1S):S1-S74.
Pain Physician. 2019.
PMID: 30717500
Free article.
The grading for recommendation was provided as described by the Agency for Healthcare Research and Quality (AHRQ). SUMMARY OF EVIDENCE: Lumbar Disc Injections: Based on the available evidence regarding the use of platelet-rich plasma (PRP), including o …
The grading for recommendation was provided as described by the Agency for Healthcare Research and Quality (AHRQ). SUMMARY OF EVIDENCE: L …
Do Regenerative Medicine Therapies Provide Long-Term Relief in Chronic Low Back Pain: A Systematic Review and Metaanalysis.
Pain Physician. 2018 Nov;21(6):515-540.
Pain Physician. 2018.
PMID: 30508983
Free article.
BACKGROUND: Several cell-based therapies have been proposed in recent years the management of low back pain, including the injection of medicinal signaling cells or mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP). ...KEY WORD …
BACKGROUND: Several cell-based therapies have been proposed in recent years the management of low back pain, including …
Platelet-rich plasma injections: an emerging therapy for chronic discogenic low back pain.
J Spine Surg. 2018 Mar;4(1):115-122. doi: 10.21037/jss.2018.03.04.
J Spine Surg. 2018.
PMID: 29732431
Free PMC article.
Review.
Autologous platelet-rich plasma (PRP) injections have been investigated in recent years as an emerging therapy for various musculoskeletal conditions, including lumbar degenerative disc disease. ...In this article, we review the current literature on P …
Autologous platelet-rich plasma (PRP) injections have been investigated in recent years as an emerging therapy for vari …
Intradiscal Injection of Autologous Platelet-Rich Plasma Releasate to Treat Discogenic Low Back Pain: A Preliminary Clinical Trial.
Asian Spine J. 2017 Jun;11(3):380-389. doi: 10.4184/asj.2017.11.3.380. Epub 2017 Jun 15.
Asian Spine J. 2017.
PMID: 28670405
Free PMC article.
PURPOSE: To determine the safety and initial efficacy of intradiscal injection of autologous platelet-rich plasma (PRP) releasate in patients with discogenic low back pain. OVERVIEW OF LITERATURE: PRP, which is comprised of autolog …
PURPOSE: To determine the safety and initial efficacy of intradiscal injection of autologous platelet-rich plasma (PRP) …
Intradiscal platelet-rich plasma (PRP) injections for discogenic low back pain: an update.
Int Orthop. 2016 Jun;40(6):1321-8. doi: 10.1007/s00264-016-3178-3. Epub 2016 Apr 12.
Int Orthop. 2016.
PMID: 27073034
Review.
PURPOSE: The aim of this article is to provide an overview of clinical and translational research on intradiscal platelet-rich plasma (PRP) as a minimally invasive treatment for discogenic low back pain. ...RESULTS: There is strong …
PURPOSE: The aim of this article is to provide an overview of clinical and translational research on intradiscal platelet-rich …
Intradiscal Platelet-Rich Plasma Injection for Chronic Discogenic Low Back Pain: Preliminary Results from a Prospective Trial.
Pain Med. 2016 Jun;17(6):1010-22. doi: 10.1093/pm/pnv053. Epub 2015 Dec 26.
Pain Med. 2016.
PMID: 26814283
Clinical Trial.
BACKGROUND: Platelet-rich plasma (PRP) has been found to be effective for a variety of musculoskeletal conditions. The treatment of discogenic pain with PRP is under investigation. OBJECTIVE: To assess changes in pain and function in pati …
BACKGROUND: Platelet-rich plasma (PRP) has been found to be effective for a variety of musculoskeletal conditions. The …
Cite