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Bovine Colostrum: Its Constituents and Uses.
Playford RJ, Weiser MJ. Playford RJ, et al. Nutrients. 2021 Jan 18;13(1):265. doi: 10.3390/nu13010265. Nutrients. 2021. PMID: 33477653 Free PMC article. Review.
Colostrum is important for supporting the growth, development, and immunologic defence of neonates. Colostrum is naturally packaged in a combination that helps prevent its destruction and maintain bioactivity until it reaches more distal gut regions and enabl
Colostrum is important for supporting the growth, development, and immunologic defence of neonates. Colostrum is naturally pac
The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes.
Marchbank T, Davison G, Oakes JR, Ghatei MA, Patterson M, Moyer MP, Playford RJ. Marchbank T, et al. Am J Physiol Gastrointest Liver Physiol. 2011 Mar;300(3):G477-84. doi: 10.1152/ajpgi.00281.2010. Epub 2010 Dec 9. Am J Physiol Gastrointest Liver Physiol. 2011. PMID: 21148400 Free article. Clinical Trial.
Twelve volunteers completed a double-blind, placebo-controlled, crossover protocol (14 days colostrum/placebo) prior to standardized exercise. Gut permeability utilized 5 h urinary lactulose-to-rhamnose ratios. ...In both study arms, exercise increased blood lactate …
Twelve volunteers completed a double-blind, placebo-controlled, crossover protocol (14 days colostrum/placebo) prior to standardized …
Bovine colostrum is a health food supplement which prevents NSAID induced gut damage.
Playford RJ, Floyd DN, Macdonald CE, Calnan DP, Adenekan RO, Johnson W, Goodlad RA, Marchbank T. Playford RJ, et al. Gut. 1999 May;44(5):653-8. doi: 10.1136/gut.44.5.653. Gut. 1999. PMID: 10205201 Free PMC article.
Addition of milk preparation was ineffective. Colostrum increased proliferation and cell migration of RIE-1 and HT-29 cells. These effects were mainly due to constituents of the colostrum with molecular weights greater than 30 kDa. CONCLUSIONS: Bovine colostrum
Addition of milk preparation was ineffective. Colostrum increased proliferation and cell migration of RIE-1 and HT-29 cells. These ef …
Zinc carnosine works with bovine colostrum in truncating heavy exercise-induced increase in gut permeability in healthy volunteers.
Davison G, Marchbank T, March DS, Thatcher R, Playford RJ. Davison G, et al. Am J Clin Nutr. 2016 Aug;104(2):526-36. doi: 10.3945/ajcn.116.134403. Epub 2016 Jun 29. Am J Clin Nutr. 2016. PMID: 27357095 Clinical Trial.
BACKGROUND: Heavy exercise causes gut symptoms and, in extreme cases, heat stroke that is due to the increased intestinal permeability of luminal toxins. ...DESIGN: Eight volunteers completed a 4-arm, double-blind, placebo-controlled crossover protocol (14 d of placebo, Zn …
BACKGROUND: Heavy exercise causes gut symptoms and, in extreme cases, heat stroke that is due to the increased intestinal permeabilit …
Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders.
Playford RJ, Macdonald CE, Johnson WS. Playford RJ, et al. Am J Clin Nutr. 2000 Jul;72(1):5-14. doi: 10.1093/ajcn/72.1.5. Am J Clin Nutr. 2000. PMID: 10871554 Review.
In this article we review some of these constituents of human and bovine colostrum in comparison with those of mature milk. Recent studies suggest that colostral fractions, or individual peptides present in colostrum, might be useful for the treatment of a wide vari …
In this article we review some of these constituents of human and bovine colostrum in comparison with those of mature milk. Recent st …
Pasteurized Chicken Egg Powder Stimulates Proliferation and Migration of AGS, RIE1, and Caco-2 Cells and Reduces NSAID-Induced Injury in Mice and Colitis in Rats.
Playford RJ, Garbowsky M, Marchbank T. Playford RJ, et al. J Nutr. 2020 Jun 1;150(6):1434-1442. doi: 10.1093/jn/nxaa083. J Nutr. 2020. PMID: 32286629
CONCLUSIONS: Studies using AGS, RIE1, and Caco-2 cells, C57BL/6 mice, and Sprague Dawley rats showed protective effects of egg against gut injury. Enhanced results were seen if colostrum and egg were coadministered. Egg powder with or without colostrum may ha …
CONCLUSIONS: Studies using AGS, RIE1, and Caco-2 cells, C57BL/6 mice, and Sprague Dawley rats showed protective effects of egg against gu
Intestinal fatty acid-binding protein and gut permeability responses to exercise.
March DS, Marchbank T, Playford RJ, Jones AW, Thatcher R, Davison G. March DS, et al. Eur J Appl Physiol. 2017 May;117(5):931-941. doi: 10.1007/s00421-017-3582-4. Epub 2017 Mar 13. Eur J Appl Physiol. 2017. PMID: 28290057 Free PMC article. Clinical Trial.
The aim of this study was to assess changes in plasma intestinal fatty acid-binding protein (I-FABP) in response to exercise (with bovine colostrum supplementation, Col, positive control) and compare this to intestinal barrier integrity/permeability (5 h urinary lactulose/ …
The aim of this study was to assess changes in plasma intestinal fatty acid-binding protein (I-FABP) in response to exercise (with bovine …
Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability.
Playford RJ, MacDonald CE, Calnan DP, Floyd DN, Podas T, Johnson W, Wicks AC, Bashir O, Marchbank T. Playford RJ, et al. Clin Sci (Lond). 2001 Jun;100(6):627-33. Clin Sci (Lond). 2001. PMID: 11352778 Clinical Trial.
We therefore examined whether spray-dried, defatted colostrum could reduce the rise in gut permeability (a non-invasive marker of intestinal injury) caused by NSAIDs in volunteers and patients taking NSAIDs for clinical reasons. Healthy male volunteers (n=7) partici …
We therefore examined whether spray-dried, defatted colostrum could reduce the rise in gut permeability (a non-invasive marker …
Effects of Bovine Colostrum with or without Egg on In Vitro Bacterial-Induced Intestinal Damage with Relevance for SIBO and Infectious Diarrhea.
Playford RJ, Choudhry N, Kelly P, Marchbank T. Playford RJ, et al. Nutrients. 2021 Mar 22;13(3):1024. doi: 10.3390/nu13031024. Nutrients. 2021. PMID: 33809940 Free PMC article.
Small intestinal bacterial overgrowth (SIBO) occurs commonly, is difficult to treat, and frequently recurs. Bovine colostrum (BC) and chicken eggs contain immunoglobulins and other components that possess antimicrobial, immunoregulatory, and growth factor activities; howev …
Small intestinal bacterial overgrowth (SIBO) occurs commonly, is difficult to treat, and frequently recurs. Bovine colostrum (BC) and …
Protease Inhibitors Protect Bovine Colostrum or Chicken Egg Growth Factors from Pancreatic Enzyme Digestion in AGS Cells or Colitic Rats.
Marchbank T, Ten Bruggencate SJM, Playford RJ. Marchbank T, et al. J Nutr. 2021 Oct 1;151(10):3036-3044. doi: 10.1093/jn/nxab197. J Nutr. 2021. PMID: 34132332 Free PMC article.
BACKGROUND: Bovine colostrum (BC) and chicken egg contain proteins possessing growth factor activity. ...
BACKGROUND: Bovine colostrum (BC) and chicken egg contain proteins possessing growth factor activity. ...
11 results